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Plus Therapeutics, Inc. (symbol: PSTV) is a cutting-edge clinical-stage pharmaceutical company based in Austin, Texas. Founded in 1996 and initially known as Cytori Therapeutics, Inc., the company rebranded to Plus Therapeutics in July 2019 to better reflect its mission and evolving focus. Specializing in the discovery, development, and manufacture of innovative treatments for cancer and other debilitating diseases, Plus Therapeutics aims to bring new hope to patients through cutting-edge medical solutions.
The company's lead product candidate is DocePLUS, a protein-stabilized, pegylated liposomal formulation of docetaxel specifically designed for the treatment of small cell lung cancer. Additionally, Plus Therapeutics is developing DoxoPLUS, a generic pegylated liposomal encapsulated doxorubicin aimed at treating breast and ovarian cancer, multiple myeloma, and Kaposi's sarcoma.
In a significant partnership, Plus Therapeutics has entered into a license agreement with NanoTx, Corp. to develop and commercialize NanoTx's glioblastoma treatment. This collaboration aims to propel the company further into the forefront of cancer treatment research.
One of the company's groundbreaking developments is the novel injectable radiotherapy called Rhenium (186Re) obisbemeda. This treatment is specifically formulated to deliver targeted high-dose radiation in Central Nervous System (CNS) tumors, optimizing patient outcomes while minimizing off-target risks. The product's efficacy and safety are being evaluated for recurrent glioblastoma and leptomeningeal metastases in the ReSPECT-GBM and ReSPECT-LM clinical trials. These trials are supported by grants from the National Cancer Institute (NCI) and the Cancer Prevention & Research Institute of Texas (CPRIT), totaling millions in funding.
Financially, Plus Therapeutics recently secured $6.5 million in upfront gross proceeds, with the potential to receive up to an additional $11.5 million through potential warrant exercise, amounting to approximately $18 million in total gross proceeds. These funds will be essential in advancing the company’s robust pipeline and bringing innovative treatments to market.
Investors and stakeholders can stay informed of the latest developments and financial updates by reaching out to key contacts such as Corey Davis, Ph.D. of LifeSci Advisors, and Charles Y. Huang, MBA, Director of Capital Markets and Investor Relations.
Plus Therapeutics (Nasdaq: PSTV) has signed a master services agreement (MSA) with Piramal Pharma Solutions for the development of its Rhenium NanoLiposome (RNL™), aimed at treating rare cancers, including glioblastoma. The agreement entails transferring analytical and microbiological methods, production processes, and stability studies, executed at Piramal's facility in Lexington, Kentucky. This partnership is expected to pave the way for future clinical and commercial supply agreements. The collaboration marks a significant milestone in advancing RNL towards regulatory approval.
Plus Therapeutics (Nasdaq: PSTV) announced that CEO Marc Hedrick will present at two upcoming virtual conferences. The first event is the BIO-Europe Spring Digital 2021 from March 22-25, with presentations available on demand starting March 22. The second event is the Q1 Virtual Investor Summit, taking place March 23-25, with a scheduled presentation on March 23 at 11:30 a.m. ET. Investors interested in meetings should contact conference coordinators. Webcasts will be available on Plus Therapeutics' website under 'Events' in the Investor Relations section.
Plus Therapeutics (Nasdaq: PSTV) has announced that Marc Hedrick, M.D., the Company’s President and CEO, will present at two upcoming virtual conferences. The first is the H.C. Wainwright Global Life Sciences Conference on March 9-10, 2021, with the presentation available on demand starting March 9. The second is the Maxim Emerging Growth Conference on March 17-18, 2021, with on-demand access beginning March 17. Investors interested in meetings can contact conference coordinators. For more details, visit PlusTherapeutics.com.
Plus Therapeutics (PSTV) reported financial results for Q4 and FY 2020, highlighting significant clinical advancements in the ReSPECT™ Phase 1 trial for recurrent glioblastoma. The company completed its sixth dosing cohort and showcased positive interim data, supported by a NIH/NCI grant. As of Dec 31, 2020, cash reserves stood at $8.3 million, down from $17.6 million the previous year. The net loss for 2020 was $8.2 million, improving from $11.4 million in 2019. Plus Therapeutics aims to advance its CNS oncology portfolio and expand its pipeline in 2021.
Plus Therapeutics (Nasdaq: PSTV) will report its fourth quarter and full year 2020 financial results on February 22, 2021, after market close. A conference call will follow at 5:00 PM ET for a discussion of the results and corporate update. The company focuses on developing targeted treatments for rare cancers utilizing nanotechnology to enhance drug delivery and efficacy. Interested parties can access a live webcast and subsequent replay on their investor relations website.
Plus Therapeutics (Nasdaq: PSTV) announced participation in the BIO CEO & Investor Digital Conference from February 16-18, 2021. CEO Marc Hedrick will present, with the presentation available on demand for registered attendees. Additionally, Plus Therapeutics was recognized as this year’s Public Therapeutic Company 'Buzz of BIO' for its innovative work in developing therapies for rare cancers like recurrent glioblastoma. The company focuses on nanoliposome-encapsulated radionuclide therapies designed to improve cancer treatment delivery and efficacy.
Plus Therapeutics (Nasdaq: PSTV) has announced that Marc Hedrick, M.D., CEO, will present at three upcoming virtual conferences in January 2021. The conferences are:
- H.C. Wainwright BioConnect Conference: January 11-14, 2021
- Biotech Showcase 2021: January 11-15, 2021
- ICR Conference 2021: January 14, 2021, at 1:45 p.m. ET
Plus Therapeutics (Nasdaq: PSTV) has completed the sixth dosing cohort in the ReSPECT™ Phase 1 clinical trial for Rhenium NanoLiposome (RNL™) in recurrent glioblastoma patients. This cohort included increased drug volume to 8.8 milliliters and radiation dose to 22.3 millicuries. Eighteen patients have been treated to date. RNL has received Orphan Drug and Fast Track designations from the FDA, enhancing its development status. No dose-limiting toxicities were observed in interim data, indicating a favorable safety profile.
Plus Therapeutics (Nasdaq: PSTV) announced that Marc Hedrick, M.D., President and CEO, will present a company overview at the 13th Annual LD Micro Main Event Conference on December 14 at 10:40 a.m. ET. Investors can attend via a live webcast available on the event’s homepage. Additionally, an archived recording will be accessible later on Plus Therapeutics' website. The company focuses on developing innovative treatments using nanotechnology targeting rare cancers, enhancing safety and efficacy for patients.
Plus Therapeutics (PSTV) has announced that the University of Texas MD Anderson Cancer Center is now an active clinical trial site for its ReSPECT™ Phase 1 clinical trial. This trial investigates the company's lead candidate, Rhenium NanoLiposome (RNL™), in patients with recurrent glioblastoma (GBM). The trial is supported by the National Cancer Institute. The sixth dose escalation cohort is currently underway, with enrollment expected to complete by the end of 2020. RNL has also received Orphan Drug and Fast Track designations from the FDA for glioblastoma treatment.
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