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Portage Biotech Announces Plans to Expand its Evaluation of Strategic Alternatives

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Portage Biotech Inc. (PRTG) pauses adenosine clinical development to evaluate strategic alternatives and extend cash runway. Board of Directors halts ADPORT-601 trial enrollment for adenosine inhibitors PORT-6 and PORT-7.
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  • Evaluation of strategic alternatives may not lead to agreements or successful transactions, potentially requiring restructuring or company wind down in the absence of a deal.

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The decision by Portage Biotech to halt further enrollment in the ADPORT-601 clinical trial represents a pivotal moment for the company's financial strategy. In the pharmaceutical and biotech sectors, the progression of clinical trials is a key driver of investor confidence and stock valuation. This pause not only signals a potential delay in the development and commercialization of PORT-6 and PORT-7, but also reflects broader concerns about the company's ability to secure necessary capital in the current market.

Investors typically look for consistent progress in clinical trials as an indicator of a company's growth prospects. A pause like this can lead to a decline in investor sentiment and possibly a decrease in stock price, as it introduces uncertainty regarding the company's future. Moreover, the exploration of strategic alternatives suggests that the company is considering significant changes to its operational structure, which could range from partnerships to a complete sale of the company or its assets. These options carry their own risks and potential rewards and the lack of a set timetable for this evaluation could contribute to prolonged investor uncertainty.

From a medical research perspective, the suspension of enrollment in the ADPORT-601 trial has implications for the field of immuno-oncology. Adenosine antagonists like PORT-6 and PORT-7 are part of a class of compounds that have been gaining attention for their potential to modulate the tumor microenvironment and enhance anti-tumor immune responses. The decision to pause the trial might slow down the advancement of knowledge in this therapeutic area.

For stakeholders, this delay could mean a setback in the availability of new treatments that could benefit patients with cancer. Furthermore, the company's need to explore strategic alternatives to extend its cash runway could impact the continuity of research and development efforts. This strategic pivot could lead to a reallocation of resources away from research and development, which is often seen as the lifeblood of biotech firms, towards maintaining operational viability.

Assessing the impact of Portage Biotech's announcement from a market research standpoint involves understanding the competitive landscape of immuno-oncology treatments. The pause in clinical development may provide an opportunity for competitors to advance their own therapies and potentially occupy the market space that Portage's products might have filled. This could lead to a shift in the competitive dynamics within the sector.

Moreover, the company's exploration of strategic alternatives indicates a search for a viable path forward amidst challenging capital raising conditions. This reflects a broader trend in the biotech industry, where funding has become increasingly selective and companies with promising but early-stage assets struggle to progress without solid financial backing. The outcome of Portage's strategic evaluation will be closely watched by market participants, as it could signal broader shifts in the industry's approach to funding and partnerships.

-Adenosine clinical development paused

WESTPORT, Conn., April 12, 2024 (GLOBE NEWSWIRE) -- Portage Biotech Inc. (NASDAQ: PRTG), a clinical-stage immuno-oncology company advancing novel multi-targeted therapies for use as monotherapy and in combination, today reported that it is expanding its evaluation of strategic alternatives and implementing additional measures to extend its available cash runway.

After a review of the Company’s future funding needs for clinical development of its adenosine antagonist platform as well as the current capital raising market for the Company, the Board of Directors has made the decision to pause further enrollment in the ADPORT-601 clinical trial of PORT-6 (adenosine 2A inhibitor) and PORT-7 (adenosine 2B inhibitor). The Company will explore strategic alternatives, which may include finding a partner for one or more of its assets, a potential sale of one or more of its assets, a sale of the Company, a merger, restructurings, both in and out of court, company wind down or other strategic action.

There can be no assurance that the evaluation of strategic alternatives will result in any agreements or transactions, or that, if completed, any agreements or transactions will be successful or on attractive terms. If the Company is unable to complete a transaction, it may be required to seek a restructuring or company wind down. There is no set timetable for this evaluation and Portage does not intend to disclose developments with respect to this evaluation unless and until it determines that further disclosure is appropriate or legally required.

About Portage Biotech Inc.        
Portage is a clinical-stage immuno-oncology company advancing multi-targeted therapies to extend survival and significantly improve the lives of patients with cancer. The Company is focused on advancing its potentially best-in-class adenosine antagonists in the ADPORT-601 trial of PORT-6 (adenosine 2A inhibitor) and PORT-7 (adenosine 2B inhibitor). These programs are being advanced using innovative trial designs and translational data to identify the patient populations most likely to benefit from treatment. For more information about the trial please click here. The Company’s unique business model leverages a strong network of academic experts and large pharma partners to rapidly and efficiently advance multiple products. For more information, please visit www.portagebiotech.com, follow us on Twitter at @PortageBiotech or find us on LinkedIn at Portage Biotech Inc.

Forward-Looking Statements
All statements in this news release, other than statements of historical facts, including without limitation, statements about the Company that are forward-looking in nature and, business strategy, plans and objectives of management for future operations and those statements preceded by, followed by or that otherwise include the words "believe," "expect," "anticipate," "intend," "estimate," “will,” “may,” “plan,” “potential,” “continue,” or similar expressions or variations on such expressions are forward-looking statements. For example, statements regarding the Company’s plans to explore strategic alternatives, which may include finding a partner for one or more of its assets, a potential sale of one or more of its assets, a sale of the Company, a merger, restructurings, both in and out of court, company wind down, or other strategic action are forward-looking statements. As a result, forward-looking statements are subject to certain risks and uncertainties, including, but are not limited to: availability of suitable third parties with which to conduct potential strategic transactions; whether the Company will be able to pursue a strategic transaction, or whether any transaction, if pursued, will be completed on attractive terms or at all; whether the Company’s cash resources will be sufficient to fund its foreseeable and unforeseeable operating expenses and capital requirements; and other factors set forth in “Item 3 - Key Information-Risk Factors” in the Company’s Annual Report on Form 20-F for the year ended March 31, 2023 and in subsequent filings with the U.S. Securities and Exchange Commission. Although the Company believes that the expectations reflected in these forward-looking statements are reasonable, undue reliance should not be placed on them as actual results may differ materially from these forward-looking statements. The forward-looking statements contained in this news release are made as of the date hereof, and the Company undertakes no obligation to update publicly or revise any forward-looking statements or information, except as required by law.

FOR MORE INFORMATION, PLEASE CONTACT:

Investor Relations:
ir@portagebiotech.com

Media Relations:
media@portagebiotech.com


FAQ

Why did Portage Biotech Inc. (PRTG) pause adenosine clinical development?

Portage Biotech Inc. paused adenosine clinical development to evaluate strategic alternatives and extend its available cash runway.

What measures is Portage Biotech Inc. (PRTG) implementing to extend its cash runway?

Portage Biotech Inc. is expanding its evaluation of strategic alternatives and exploring options like finding a partner for its assets, potential sale of assets, merger, restructuring, or company wind down.

What decision did the Board of Directors make regarding the ADPORT-601 clinical trial of PORT-6 and PORT-7?

The Board of Directors decided to pause further enrollment in the ADPORT-601 trial of adenosine inhibitors PORT-6 and PORT-7.

What are the possible strategic alternatives that Portage Biotech Inc. (PRTG) is considering?

Portage Biotech Inc. is considering options like finding a partner for its assets, potential sale of assets, merger, restructuring, or company wind down as part of its strategic evaluation.

Is there a set timetable for the evaluation of strategic alternatives by Portage Biotech Inc. (PRTG)?

There is no set timetable for the evaluation of strategic alternatives by Portage Biotech Inc., and the company does not intend to disclose developments unless deemed appropriate or legally required.

Portage Biotech Inc.

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