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ProQR Announces Third Quarter 2024 Operating and Financial Results

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ProQR Therapeutics reported Q3 2024 financial results, highlighting €89.4 million in cash and cash equivalents, plus $82.1 million from October financing extending runway into mid-2027. The company's first Axiomer™ RNA editing program, AX-0810, targets NTCP for cholestatic diseases and is advancing toward clinical trials. Q3 net loss was €8.1 million (€0.10 per share), compared to €5.4 million (€0.07 per share) in Q3 2023. R&D costs increased to €9.4 million from €5.4 million year-over-year, while G&A costs remained stable at €3.3 million. The company achieved $5.5 million in milestones from its Eli Lilly collaboration during the first three quarters of 2024.

ProQR Therapeutics ha riportato i risultati finanziari del terzo trimestre 2024, evidenziando 89,4 milioni di euro in contanti e equivalenti, oltre a 82,1 milioni di dollari provenienti dal finanziamento di ottobre che estende il periodo di operatività fino a metà 2027. Il primo programma di editing RNA Axiomer™, AX-0810, mira all'NTCP per le malattie colestatiche e sta avanzando verso la sperimentazione clinica. La perdita netta del terzo trimestre è stata di 8,1 milioni di euro (0,10 euro per azione), rispetto ai 5,4 milioni di euro (0,07 euro per azione) del terzo trimestre 2023. I costi di ricerca e sviluppo sono aumentati a 9,4 milioni di euro rispetto ai 5,4 milioni di euro dell'anno precedente, mentre i costi generali e amministrativi sono rimasti stabili a 3,3 milioni di euro. L'azienda ha raggiunto 5,5 milioni di dollari in traguardi dalla collaborazione con Eli Lilly durante i primi tre trimestri del 2024.

ProQR Therapeutics reportó los resultados financieros del tercer trimestre de 2024, destacando 89.4 millones de euros en efectivo y equivalentes, además de 82.1 millones de dólares provenientes de la financiación de octubre, lo que extiende la disponibilidad de fondos hasta mediados de 2027. El primer programa de edición de ARN Axiomer™, AX-0810, se dirige al NTCP para enfermedades colestáticas y avanza hacia ensayos clínicos. La pérdida neta del tercer trimestre fue de 8.1 millones de euros (0.10 euros por acción), en comparación con 5.4 millones de euros (0.07 euros por acción) en el tercer trimestre de 2023. Los costos de I+D aumentaron a 9.4 millones de euros desde 5.4 millones de euros interanualmente, mientras que los costos de administración y generales se mantuvieron estables en 3.3 millones de euros. La compañía logró 5.5 millones de dólares en hitos de su colaboración con Eli Lilly durante los primeros tres trimestres de 2024.

ProQR Therapeutics는 2024년 3분기 재무 결과를 보고했으며, 현금 및 현금 등가물이 8940만 유로, 2027년 중반까지 운영 자금을 연장하는 8210만 달러의 10월 자금 조달을 포함하여 강조했습니다. 회사의 첫 번째 Axiomer™ RNA 편집 프로그램 AX-0810은 담즙 정체성 질환을 위한 NTCP를 목표로 하며 임상 시험으로 나아가고 있습니다. 3분기 순손실은 810만 유로(주당 0.10 유로)로, 2023년 3분기의 540만 유로(주당 0.07 유로)에 비해 증가했습니다. 연구 개발 비용은 전년 대비 540만 유로에서 940만 유로로 증가했으며, 관리 및 일반 비용은 330만 유로로 안정세를 유지했습니다. 회사는 2024년 첫 세 분기 동안 Eli Lilly와의 협업으로부터 550만 달러의 마일스톤을 달성했습니다.

ProQR Therapeutics a annoncé les résultats financiers du troisième trimestre 2024, mettant en avant 89,4 millions d'euros en liquidités et équivalents de liquidités, ainsi que 82,1 millions de dollars provenant d'un financement d'octobre qui prolonge le délai d'exécution jusqu'à mi-2027. Le premier programme d'édition d'ARN Axiomer™, AX-0810, cible l'NTCP pour les maladies cholestatiques et avance vers les essais cliniques. La perte nette du troisième trimestre s'élevait à 8,1 millions d'euros (0,10 euro par action), contre 5,4 millions d'euros (0,07 euro par action) au cours du troisième trimestre 2023. Les coûts de R&D ont augmenté à 9,4 millions d'euros contre 5,4 millions d'euros d'une année sur l'autre, tandis que les coûts G&A sont restés stables à 3,3 millions d'euros. L'entreprise a atteint 5,5 millions de dollars de jalons grâce à sa collaboration avec Eli Lilly au cours des trois premiers trimestres de 2024.

ProQR Therapeutics hat die Finanzergebnisse für das dritte Quartal 2024 veröffentlicht und hebt 89,4 Millionen Euro in bar und in Barmitteln sowie 82,1 Millionen Dollar aus der Finanzierung im Oktober hervor, die den finanziellen Spielraum bis Mitte 2027 verlängert. Das erste Axiomer™ RNA-Bearbeitungsprogramm, AX-0810, zielt auf NTCP bei cholestatischen Krankheiten ab und schreitet auf klinische Studien zu. Der Nettoverlust im dritten Quartal betrug 8,1 Millionen Euro (0,10 Euro pro Aktie), im Vergleich zu 5,4 Millionen Euro (0,07 Euro pro Aktie) im dritten Quartal 2023. Die F&E-Kosten stiegen im Jahresvergleich von 5,4 Millionen Euro auf 9,4 Millionen Euro, während die allgemeinen Verwaltungs- und Betriebskosten mit 3,3 Millionen Euro stabil blieben. Das Unternehmen erzielte 5,5 Millionen Dollar an Meilensteinen aus der Zusammenarbeit mit Eli Lilly in den ersten drei Quartalen 2024.

Positive
  • Secured $82.1 million in additional funding through public offering and private placement
  • Cash runway extended into mid-2027
  • Achieved $5.5 million in milestone payments from Eli Lilly collaboration
  • First RNA editing program AX-0810 advancing to clinical trials
Negative
  • Net loss increased to €8.1 million from €5.4 million year-over-year
  • R&D costs increased 74% to €9.4 million compared to previous year
  • Cash position decreased to €89.4 million from €118.9 million at end of 2023

Insights

The Q3 results show mixed financial performance with notable strategic developments. €89.4 million in cash and equivalents, bolstered by a significant $82.1 million financing round, extends runway into mid-2027, providing strong operational stability. However, increased R&D costs of €9.4 million (up from €5.4 million YoY) and wider net loss of €8.1 million (€0.10 per share) indicate accelerated investment in pipeline development.

The Eli Lilly partnership continues to yield results with $5.5 million in milestone payments. Operating cash burn improved to €5.7 million from €7.5 million YoY, demonstrating better cost management. The recent equity financing, including Lilly's participation, validates investor confidence in ProQR's RNA editing platform and strengthens their competitive position in the oligonucleotide therapeutics space.

The advancement of AX-0810 targeting NTCP for cholestatic diseases represents a significant milestone in ProQR's Axiomer™ platform development. The upcoming clinical trial initiation marks the platform's first human testing, a important validation point. The pipeline expansion with AX-1412 for cardiovascular diseases demonstrates platform versatility.

The December investor event will be pivotal in assessing the technology's potential, particularly regarding translational data and biomarker strategy. The continued partnership with Eli Lilly and presentation at the Oligonucleotide Therapeutics Society meeting suggest growing scientific validation of the RNA editing approach. However, clinical success remains unproven, making the upcoming trial results critical for platform validation.

  • AX-0810 targeting NTCP for cholestatic diseases to be first ProQR Axiomer™ RNA editing program to enter the clinic
  • Company to host virtual Investor and Analyst Event in December to highlight translational data and clinical plans for AX-0810, as well as AX-1412, targeting B4GALT1 for cardiovascular diseases, and progress made across the Axiomer platform
  • €89.4 million cash and cash equivalents as of end of Q3, plus $82.1 million gross proceeds from October financing providing runway into mid-2027

LEIDEN, Netherlands & CAMBRIDGE, Mass., Nov. 07, 2024 (GLOBE NEWSWIRE) --  ProQR Therapeutics NV. (Nasdaq: PRQR) (ProQR), a company dedicated to changing lives through transformative RNA therapies based on its proprietary Axiomer RNA editing technology platform, today reported its financial and operating results for the third quarter ended September 30, 2024, and provided a business update.

“We’re grateful for the strong support from investors and our partner Lilly in our $82.1 million equity financing last month, which further strengthens our financial position and extends our runway into mid-2027,” said Daniel A. de Boer, Founder and CEO of ProQR Therapeutics. “As we approach the clinic with AX-0810 for cholestatic diseases, we look forward to sharing updates on this program, including preclinical data, clinical trial design, and biomarkers that will be assessed, along with pipeline highlights at our Investor and Analyst Event in December. With our Axiomer™ RNA editing platform, a differentiated pipeline, a productive partnership, and the leading IP position in the field, we remain focused on advancing transformative therapies for the unmet needs of patients.”

Recent Progress and Anticipated Upcoming Events

Financial Highlights

At September 30, 2024, ProQR held cash and cash equivalents of €89.4 million, compared to €118.9 million cash and cash equivalents at December 31, 2023. Net cash used in operating activities during the three-month period ended September 30, 2024 was €5.7 million, compared to €7.5 million used for the same period last year. During the first three quarters of 2024, the Company achieved certain milestones in the collaboration agreement with Eli Lilly amounting to $5.5 million. In October, the Company closed an underwritten public offering of 18,000,000 ordinary shares and a concurrent private placement of 3,523,538 ordinary shares with Eli Lilly, as well as exercise of the underwriter’s option for 1,940,072 additional shares for gross proceeds totaling approximately $82.1 million.

Research and development (R&D) costs were €9.4 million for the quarter ended September 30, 2024 compared to €5.4 million for the same period last year.

General and administrative costs were €3.3 million for the quarter ended September 30, 2024 in line with €3.3 million for the same period last year.

Net loss for the three-month period ended September 30, 2024 was €8.1 million, or €0.10 per diluted share, compared to €5.4 million, or €0.07 per diluted share, for the same period last year. For further financial information for the period ended September 30, 2024, please refer to the Q3 financial report filing.

About Axiomer

ProQR is pioneering a next-generation RNA base editing technology called Axiomer, which could potentially yield a new class of medicines for diverse types of diseases. Axiomer “Editing Oligonucleotides”, or EONs, mediate single nucleotide changes to RNA in a highly specific and targeted way using molecular machinery that is present in human cells called ADAR (Adenosine Deaminase Acting on RNA). Axiomer EONs are designed to recruit and direct endogenously expressed ADARs to change an Adenosine (A) to an Inosine (I) in the RNA – an Inosine is translated as a Guanosine (G) – correcting an RNA with a disease-causing mutation back to a normal (wild type) RNA, modulating protein expression, or altering a protein so that it will have a new function that helps prevent or treat disease.

About Biliary Atresia (BA) and Primary Sclerosing Cholangitis (PSC)

Cholestatic disorders refer to a group of diseases presenting excessive and toxic buildup of bile acids in the liver due to bile ducts dysfunction. This leads to liver damage and a range of debilitating symptoms. Without treatment, liver damage can progress through various stages, ultimately leading to liver failure and elevated risk of liver malignancy, affecting life expectancy. Cholestatic diseases remain leading causes of liver transplantation. There are no approved therapies for primary sclerosing cholangitis (PSC) for adults and biliary atresia (BA) for pediatrics. It is estimated that 80,000 and 20,000 individuals have PSC and BA, respectively, in North America and in Europe.

About AX-0810 targeting NTCP

The majority of the bile acids present in the liver cells originate from the enterohepatic reuptake cycle. The key transporter responsible for hepatic uptake of bile acids from portal circulation is the sodium (Na+)-taurocholate cotransporting polypeptide (NTCP, SLC10A1 gene) expressed in the liver. AX-0810 is designed to introduce a loss of function variant in SLC10A1 RNA that has been found in human genetics to prevent re-uptake of bile acids in liver via NTCP. Based on its mechanism of action, AX-0810 has the potential to become a disease modifying treatment for PSC and BA primarily among other cholestatic diseases.

About Cardiovascular Diseases

Cardiovascular diseases (CVDs) are a group of health conditions that affect the heart and blood vessels, such as atherosclerosis which can lead to severe problems like heart attacks, heart failure, and stroke. CVDs represent the leading cause of disability and death in the world. Approximately 18 million people die every year from CVDs representing one third of all the global deaths. Despite available lipid lowering therapies and hypertension medications, the risk of CVDs is still projected to increase rapidly over the coming years.

About AX-1412 targeting B4GALT1

Gene–based analysis of rare beta-1,4-galactosyltransferase 1 (B4GALT1) missense variant (p.Asn352Ser) is known to lead to B4GALT1 protein loss of function and showed an association with decreased coronary artery disease. These beneficial effects are mediated by hypo-galactosylation of the apolipoprotein B100 and fibrinogen, known – independent – drivers of increased risk of CVDs. AX-1412 introduces a protective variant into B4GALT1 RNA to address the remaining residual risk of developing cardiovascular diseases. ProQR intends to advance AX-1412 targeting B4GALT1 to early clinical proof of concept stage, then would seek to partner this program.

About ProQR

ProQR Therapeutics is dedicated to changing lives through the creation of transformative RNA therapies. ProQR is pioneering a next-generation RNA technology called Axiomer, which uses a cell’s own editing machinery called ADAR to make specific single nucleotide edits in RNA to reverse a mutation or modulate protein expression and could potentially yield a new class of medicines for both rare and prevalent diseases with unmet need. Based on our unique proprietary RNA repair platform technologies we are growing our pipeline with patients and loved ones in mind.

Learn more about ProQR at www.proqr.com.

Forward Looking Statements

This press release contains forward-looking statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as “continue,” "anticipate," "believe," "could," "estimate," "expect," "goal," "intend," "look forward to", "may," "plan," "potential," "predict," "project," "should," "will," "would" and similar expressions. Such forward-looking statements include, but are not limited to, statements regarding our business, technology, strategy, preclinical model data, our initial pipeline targets and the upcoming strategic priorities and milestones related thereto, our Axiomer platform, including the continued development and advancement of our Axiomer platform, the therapeutic potential of our Axiomer RNA editing oligonucleotides and our ability to expand preclinical in vivo and in vitro data, the timing, progress and results of our preclinical studies and other development activities, including the release of data related thereto, our patent estate, including our anticipated strength and our continued investment in it, as well as the timing of our clinical development, the potential of our technologies and product candidates, the collaboration with Lilly and the intended and potential benefits thereof, including the receipt of milestone and royalty payments from commercial product sales, if any, from the products covered by the collaboration, our ability to selectively form new partnerships and enter into future collaborations, and our financial position and cash-runway. Forward-looking statements are based on management's beliefs and assumptions and on information available to management only as of the date of this press release. Our actual results could differ materially from those expressed or implied by these forward-looking statements for many reasons, including, without limitation, the risks, uncertainties and other factors in our filings made with the Securities and Exchange Commission, including certain sections of our annual report filed on Form 20-F. These risks and uncertainties include, among others, the cost, timing and results of preclinical studies and clinical trials and other development activities by us and our collaborative partners whose operations and activities may be slowed or halted shortage and pressure on supply and logistics on the global market; the likelihood of our preclinical and clinical programs being initiated and executed on timelines provided and reliance on our contract research organizations and predictability of timely enrollment of subjects and patients to advance our clinical trials and maintain their own operations; our reliance on contract manufacturers to supply materials for research and development and the risk of supply interruption from a contract manufacturer; the potential for future data to alter initial and preliminary results of early-stage clinical trials; the unpredictability of the duration and results of the regulatory review of applications or clearances that are necessary to initiate and continue to advance and progress our clinical programs; the ability to secure, maintain and realize the intended benefits of collaborations with partners, including the collaboration with Lilly; the possible impairment of, inability to obtain, and costs to obtain intellectual property rights; possible safety or efficacy concerns that could emerge as new data are generated in research and development; general business, operational, financial and accounting risks, and risks related to litigation and disputes with third parties; and risks related to macroeconomic conditions and market volatility resulting from global economic developments, geopolitical instability and conflicts. Given these risks, uncertainties, and other factors, you should not place undue reliance on these forward-looking statements, and we assume no obligation to update these forward-looking statements, even if new information becomes available in the future, except as required by law.

ProQR Therapeutics N.V.

Investor contact:
Sarah Kiely
ProQR Therapeutics N.V.
T: +1 617 599 6228
skiely@proqr.com
or
Peter Kelleher
LifeSci Advisors
T: +1 617 430 7579
pkelleher@lifesciadvisors.com

Media contact:
Robert Stanislaro
FTI Consulting
T: +1 212 850 5657
robert.stanislaro@fticonsulting.com

Financial Tables

PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Financial Position

         
    September 30,    December 31, 
    2024   2023
    €1,000   €1,000
Assets          
Property, plant and equipment   14,437   16,897
Investments in financial assets    
Non-current assets   14,437   16,897
         
Other taxes   535   523
Prepayments and other receivables   2,478   1,538
Cash and cash equivalents   89,401   118,925
Financial asset - current    
Current assets   92,414   120,986
Total assets   106,851   137,883
         
Equity and liabilities          
Equity         
Equity attributable to owners of the Company   24,982   41,390
Total equity   24,982   41,390
         
Liabilities          
Borrowings     4,292
Lease liabilities   11,501   13,828
Deferred income   30,728   44,170
Non-current liabilities   42,229   62,290
         
Borrowings   4,510  
Lease liabilities   1,386   1,614
Derivative financial instruments   45   311
Trade payables   31   1,541
Social securities and other taxes   1,369   1,659
Deferred income   24,860   20,569
Other current liabilities   7,439   8,509
Current liabilities   39,640   34,203
         
Total liabilities   81,869   96,493
         
Total equity and liabilities   106,851   137,883

PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Profit or Loss and OCI
(€ in thousands, except share and per share data)

                 
    Three month period   Nine month period
    ended September 30,    ended September 30, 
       2024   2023   2024   2023
    €1,000   €1,000   €1,000   €1,000
Revenue   3,843   1,370   14,598   3,230
                 
Other income   138     504   80
                 
Research and development costs   (9,414)   (5,446)   (25,745)   (17,415)
General and administrative costs   (3,283)   (3,315)   (9,748)   (11,486)
Total operating costs   (12,697)   (8,761)   (35,493)   (28,901)
                     
Operating result   (8,716)   (7,391)   (20,391)   (25,591)
Finance income and expense   469   363   1,470   289
Results related to associates and financial assets        
Result on derecognition of subsidiary     92     92
Results related to financial liabilities measured at fair value through profit or loss   139   118   266   1,009
Results on derecognition of financial liabilities     1,357     1,866
Result before corporate income taxes   (8,108)   (5,461)   (18,655)   (22,335)
Corporate income taxes     41   197   83
Result for the period   (8,108)   (5,420)   (18,458)   (22,252)
                 
Other comprehensive income                
Items that will not be reclassified subsequently to profit or loss                
Fair value loss on investment in financial asset designated as at FVTOCI     (621)     (621)
Items that may be reclassified subsequently to profit or loss                
Foreign exchange differences on translation of foreign operations   (377)   286   (101)   74
                     
Total comprehensive loss   (8,485)   (5,755)   (18,559)   (22,799)
                 
Result attributable to                    
Owners of the Company   (8,108)   (5,710)   (18,458)   (22,636)
Non-controlling interests     290     384
    (8,108)   (5,420)   (18,458)   (22,252)
Total comprehensive income attributable to                
Owners of the Company   (8,485)   (6,045)   (18,559)   (23,183)
Non-controlling interests     290     384
    (8,485)   (5,755)   (18,559)   (22,799)
                     
Share information                    
Weighted average number of shares outstanding1   81,682,296   81,000,320   81,639,533   80,942,881
                 
Earnings per share attributable to owners of the Company (Euro per share)                
Basic loss per share1   (0.10)   (0.07)   (0.23)   (0.28)
Diluted loss per share1   (0.10)   (0.07)   (0.23)   (0.28)

For these periods the potential exercise of share options is not included in the diluted earnings per share as the Company was loss-making. Due to the anti-dilutive nature of the outstanding options, basic and diluted earnings per share are equal.

PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Changes in Equity

                                     
    Attributable to owners of the Company        
     Number
of shares
   Share
Capital
   Share
Premium
   Equity settled
Employee
Benefit
Reserve
   Translation
Reserve
   Accumulated
Deficit
   Total    Non-
controlling
interests
   Total
Equity
         €1,000   €1,000   €1,000   €1,000   €1,000   €1,000   €1,000   €1,000
Balance at January 1, 2023   84,246,967   3,370   412,540   29,052   1,212   (379,110)   67,064   (384)   66,680
Result for the period             (22,636)   (22,636)   384   (22,252)
Other comprehensive income           74   (621)   (547)     (547)
Recognition of share-based payments         2,304       2,304     2,304
Treasury shares transferred   (341,492)                
Share options lapsed         (6,209)     6,209      
Share options exercised   341,492     155   (426)     426   155     155
                                     
Balance at September 30, 2023   84,246,967   3,370   412,695   24,721   1,286   (395,732)   46,340     46,340
                                     
Balance at January 1, 2024   84,248,384   3,370   412,894   25,159   817   (400,850)   41,390     41,390
Result for the period             (18,458)   (18,458)     (18,458)
Other comprehensive income           (101)     (101)     (101)
Recognition of share-based payments         1,976       1,976     1,976
Treasury shares transferred   (329,675)                
Share options lapsed         (994)     994      
Share options exercised / RSUs vested   328,597     175   (291)     291   175     175
                                              
Balance at September 30, 2024   84,247,306   3,370   413,069   25,850   716   (418,023)   24,982     24,982

PROQR THERAPEUTICS N.V.
Unaudited Condensed Consolidated Statement of Cash Flows

                 
    Three month period    Nine month period 
    ended September 30,    ended September 30, 
       2024   2023   2024   2023
    €1,000   €1,000   €1,000   €1,000
Cash flows from operating activities                    
Net result   (8,108)   (5,420)   (18,458)   (22,252)
Adjustments for:                
— Depreciation   688   642   2,090   1,785
— Share-based compensation   612   444   1,976   2,304
— Financial income and expenses   (469)   (363)   (1,470)   (289)
— Results on derecognition of subsidiary     (131)     (131)
— Results on derecognition of financial liabilities     (1,357)     (1,866)
— Results related to financial liabilities measured at fair value through profit or loss   (139)   (117)   (266)   (1,008)
— Income tax expenses     (83)   (197)   (83)
                 
Changes in working capital   1,117   (2,008)   (12,721)   46,660
Cash (used in) / generated by operations   (6,299)   (8,393)   (29,046)   25,120
                     
Corporate income tax received   1   83   197   83
Interest received   860   802   2,402   1,667
Interest paid   (219)     (598)  
                     
Net cash (used in) / generated by operating activities   (5,657)   (7,508)   (27,045)   26,870
                     
Cash flow from investing activities                
Increase in financial asset - current       (17,000)  
Decrease in financial asset - current   17,000     17,000  
Purchases of property, plant and equipment   (286)   (339)   (1,285)   (769)
Proceeds from sale of property, plant and equipment         47
                     
Net cash generated by / (used in) investing activities   16,714   (339)   (1,285)   (722)
                     
Cash flow from financing activities                    
Proceeds from exercise of share options   1   151   175   155
Repayment of lease liability   (454)   (432)   (1,329)   (1,338)
                     
Net cash used in financing activities   (453)   (281)   (1,154)   (1,183)
                     
Net increase / (decrease) in cash and cash equivalents   10,604   (8,128)   (29,484)   24,965
                     
Currency effect cash and cash equivalents   (173)   118   (40)   812
Cash and cash equivalents, at beginning of the period   78,970   128,562   118,925   94,775
                     
Cash and cash equivalents at the end of the period   89,401   120,552   89,401   120,552

FAQ

What was ProQR's (PRQR) net loss in Q3 2024?

ProQR reported a net loss of €8.1 million, or €0.10 per diluted share, in Q3 2024.

How much cash does ProQR (PRQR) have after the October 2024 financing?

ProQR had €89.4 million in cash and cash equivalents as of Q3 2024, plus $82.1 million gross proceeds from October financing.

What is ProQR's (PRQR) first clinical program from the Axiomer platform?

AX-0810, targeting NTCP for cholestatic diseases, will be ProQR's first Axiomer RNA editing program to enter clinical trials.

How much did ProQR (PRQR) raise in its October 2024 financing?

ProQR raised approximately $82.1 million through a public offering and private placement with Eli Lilly in October 2024.

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Biotechnology
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United States of America
Leiden