Welcome to our dedicated page for ProQR Therapeutics N.V. Ordinary Shares news (Ticker: PRQR), a resource for investors and traders seeking the latest updates and insights on ProQR Therapeutics N.V. Ordinary Shares stock.
ProQR Therapeutics N.V., trading under the symbol PRQR, is a pioneering biotech company headquartered in Leiden, Netherlands, and Cambridge, Massachusetts. The company is at the forefront of developing RNA therapeutics for patients suffering from severe genetic rare diseases. ProQR's core focus is on leveraging a proprietary RNA editing technology platform known as Axiomer™ to create transformative RNA therapies.
The Axiomer™ technology utilizes a natural cellular mechanism called ADAR (Adenosine Deaminase Acting on RNA) to make precise edits at the RNA level, correcting disease-causing mutations, modulating protein expression, or adding new protein functions to treat diseases. This innovative approach has the potential to yield treatments for various genetic disorders such as cystic fibrosis, Leber's congenital amaurosis type 10, dystrophic epidermolysis bullosa, and beyond.
Recently, ProQR announced a notable collaboration with the Rett Syndrome Research Trust (RSRT) to develop editing oligonucleotides (EONs) using Axiomer™ technology to correct mutations in the transcription factor Methyl CpG binding protein 2 (MECP2), which is associated with Rett syndrome. This collaboration could significantly advance therapeutic options for this rare neurodevelopmental disorder.
Furthermore, the company continues to impress with its cutting-edge research and intellectual property milestones. ProQR has robustly defended its patents globally, ensuring a strong IP estate around its Axiomer technology. Notably, the company successfully defended its patents in Japan and Europe, showcasing the innovative and proprietary nature of its RNA editing platform.
ProQR's pipeline is rapidly advancing, with key programs targeting cholestatic diseases and cardiovascular diseases. The AX-0810 program, targeting the NTCP gene, has shown promising preclinical proof of concept, indicating its potential to become a disease-modifying treatment for conditions like primary sclerosing cholangitis (PSC) and biliary atresia (BA). The AX-1412 program aims to tackle cardiovascular diseases by introducing protective gene variants.
The company also reported positive financial results for the year ended December 31, 2023, with a solid cash position of €118.9 million, up from €94.8 million in 2022. ProQR continues to invest in advancing its RNA editing platform and pipeline, with a strategic focus on entering clinical trials in late 2024 or early 2025.
Under the leadership of CEO Daniel A. de Boer, ProQR is well-positioned to continue its mission of changing lives through transformative RNA therapies, backed by strong scientific evidence, a robust IP portfolio, and strategic collaborations, including a fruitful partnership with Eli Lilly. Keep up with the latest updates and developments by visiting their website at www.proqr.com.
ProQR Therapeutics NV (Nasdaq: PRQR) announced its participation in several upcoming investor conferences to discuss its innovative RNA therapies using the Axiomer® RNA editing technology platform. Key events include:
- Van Lanschot Kempen Life Sciences Conference – April 26, Amsterdam (1x1 meetings only)
- JMP Securities Life Sciences Conference – May 16, New York (Fireside chat at 12:30 PM EDT)
- Stifel 2023 Tailoring Genes: Genetic Medicines Day – May 30, Virtual (Fireside chat, time TBC)
Details on presentations and webcasts will be available on the company’s website. ProQR is focused on advancing RNA therapies that address both rare and common diseases, utilizing its unique Axiomer® technology for precise RNA editing.
ProQR Therapeutics NV (Nasdaq: PRQR) announced its Annual General Meeting (AGM) of Shareholders scheduled for May 17, 2023, at 16:00 CET, in Amsterdam. Key updates include the nomination of Begoña Carreño and Theresa Heggie to the Supervisory Board, along with Bart Filius for re-election. Notably, Antoine Papiernik will rotate off the Board. Carreño brings over 20 years of experience in pharmaceutical development and strategy from Novartis, while Heggie has a strong background in commercial operations at Alnylam Pharmaceuticals. ProQR focuses on transformative RNA therapies utilizing its proprietary Axiomer® RNA editing technology, aiming to provide innovative treatment options for diseases with unmet needs.
ProQR Therapeutics NV (Nasdaq: PRQR) announced initial pipeline programs focused on liver diseases, introducing AX-0810 targeting NTCP for cholestatic diseases and AX-1412 targeting B4GALT1 for cardiovascular disease. Clinical trials are expected to start in late 2024 or early 2025. The company reported year-end 2022 financials, with a cash reserve of €94.8 million, extended cash runway into mid-2026, and a net loss of €64.9 million. Notable preclinical activity was reported, with up to 50% RNA editing observed in both rodent and non-human primate models, showcasing the Axiomer platform's potential.
ProQR Therapeutics (Nasdaq: PRQR) recently defended its key patent for the Axiomer® RNA editing platform against two oppositions filed in February 2021. The European Patent Office ruled in favor of ProQR after a public hearing held on March 7 and 8, 2023. This patent is crucial for ProQR’s intellectual property, which includes 22 patents across 10 families. The company emphasizes that its robust patent estate positions it as a leader in the field of RNA editing technology. ProQR aims to develop transformative therapies for diseases using its innovations in RNA editing.
ProQR Therapeutics N.V. (Nasdaq: PRQR) announced key presentations at upcoming conferences to showcase its Axiomer® RNA editing platform. Events include the Oligonucleotide and Precision Therapeutics (OPT) Congress on March 14, 2023, where CSO Gerard Platenburg will discuss therapeutic potentials of Editing Oligonucleotides (EONs). Additionally, at the RNA Leaders Europe Congress on March 16, 2023, CEO Daniel A. de Boer will explore the transformative capabilities of Axiomer. The RNA Editing Gordon Research Conference on March 23, 2023, will feature Platenburg's insights into addressing liver disorders with Axiomer. This innovative platform aims to revolutionize RNA therapies for various unmet medical needs.
ProQR Therapeutics N.V. (Nasdaq: PRQR) will host a virtual R&D event on March 29, 2023, from 10:00 am to 12:30 pm EDT. The event will feature the Company’s Axiomer® RNA-editing technology and outline initial pipeline targets for development. Key speakers include CEO Daniel A. de Boer and Chief Scientific Officer Gerard Platenburg. The Company will also release its full year 2022 operating and financial results on the same date. Registration for the event is available on ProQR's website, and an archived webcast will be accessible for 30 days post-event. This initiative underscores ProQR's commitment to advancing RNA therapies aimed at treating diverse diseases.
ProQR Therapeutics N.V. (Nasdaq: PRQR) has announced an investor conference call and webcast on December 22, 2022, at 8:15am EST to discuss its Axiomer RNA editing technology, following an expanded partnership with Eli Lilly. The Axiomer platform utilizes the body's own ADAR machinery to edit RNA, potentially leading to new treatments for various diseases. The call will be accessible live and archived for 30 days. ProQR aims to develop transformative RNA therapies that address significant unmet medical needs.
ProQR Therapeutics and Eli Lilly expand their collaboration to develop genetic medicines using Axiomer technology. The updated agreement, initially forged in September 2021, aims to enhance RNA editing for liver and nervous system disorders. ProQR will receive $75 million in upfront payment and equity, with potential total earnings of $3.75 billion in milestones and royalties. The collaboration signifies a strong commitment to addressing high unmet medical needs.
Eli Lilly and ProQR Therapeutics announced an expanded collaboration on December 22, 2022, focusing on genetic medicines utilizing ProQR's Axiomer RNA editing technology. The partnership, originally established in September 2021, will now target additional disorders affecting the central and peripheral nervous systems. ProQR will receive $75 million upfront and an option for an additional $50 million. The total potential value of the collaboration is approximately $3.75 billion in milestones and royalties. This collaboration aims to develop innovative treatments for diseases with significant unmet needs.
On November 14, 2022, ProQR Therapeutics N.V. (Nasdaq: PRQR) announced their upcoming presentation at the TIDES Europe conference, scheduled for November 16-18, 2022, in Vienna, Austria. The oral presentation, titled Progress on Development of RNA Base Editing Technologies for Precision Medicines, will be delivered by Co-Founder and Chief Scientific Officer Gerard Platenburg on November 18, 2022, at 2:30 PM CET. ProQR is pioneering Axiomer® technology to create transformative RNA therapies aimed at correcting disease-causing mutations.
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