Purple Biotech Ltd. American Depositary Shares - PPBT STOCK NEWS

Purple Biotech (NASDAQ/TASE: PPBT), a clinical-stage company focused on innovative cancer therapies, will present a corporate overview at the Jefferies London Healthcare Conference on November 17, 2021, at 12:20 pm GMT. The conference runs from November 16-19, 2021, with opportunities for one-on-one meetings. Purple Biotech is advancing therapies to overcome tumor immune evasion and drug resistance, including NT219 and CM24, which target various cancer indications. A replay of the presentation will be available on the company’s website.

Purple Biotech (NASDAQ/TASE: PPBT) has announced the expansion of its research collaboration with The University of Texas MD Anderson Cancer Center to assess the efficacy of NT219 combined with immuno-oncology agents. NT219, a dual inhibitor targeting IRS1/2 and STAT3, has shown promise in overcoming treatment resistance in preclinical studies. This collaboration aims to translate these findings into clinical applications, potentially converting resistant tumors into responsive ones. Positive initial clinical data from NT219 monotherapy was also presented at ASCO 2021, further supporting its advancement.

Purple Biotech (NASDAQ: PPBT) announced a publication in Nature Cancer, revealing insights into cancer cell resistance mechanisms linked to IRS1. The study demonstrated that NT219, a dual inhibitor targeting IRS1/2 and STAT3, combined with anti-EGFR therapy, enhances tumor regression and delays recurrence. The publication outlines how IRS1 phosphorylation influences EGFR inhibition persistence, indicating NT219's potential in overcoming drug resistance. This supports ongoing Phase 1/2 clinical trials of NT219 in treating squamous cell carcinoma of the head and neck and colorectal adenocarcinoma.

Purple Biotech (NASDAQ/TASE: PPBT) announced encouraging results from its ongoing Phase 1b/2 clinical trial of CM24, a monoclonal antibody for advanced cancer treatment. One patient with refractory pancreatic cancer showed a partial response with a 40% reduction in tumor size after two courses of CM24 combined with nivolumab, alongside a 56% decrease in CA19-9 tumor marker levels. The second dose cohort has completed enrollment, and the study is expanding to new U.S. and Israeli sites. Top-line data suggests that CM24 is both safe and potentially effective.

Purple Biotech (PPBT) reported no revenue for the six months ended June 30, 2021, compared to $1 million in the same period of 2020. Operating loss increased by 139% to $10.3 million, driven by rising research and development costs related to ongoing clinical trials for NT219 and CM24. Despite these challenges, the company has a solid financial position with $53.4 million in cash, projected to last through 2024. Initial clinical trial results for NT219 showed promising safety and efficacy, including a complete remission in one patient. The company aims to provide additional trial data later this year.

Purple Biotech (NASDAQ/TASE: PPBT) announced promising initial results from a Phase 1/2 clinical trial of NT219 for advanced solid tumors. As of April 25, 2021, six patients were enrolled, with NT219 demonstrating a favorable safety profile and minimal adverse events. Notably, a patient with refractory gastroesophageal junction cancer achieved a partial response after 22 weeks. This dual inhibitor targets IRS1/2 and STAT3, potentially overcoming drug resistance. The company expects to release further data from higher doses in the latter half of 2021.

Purple Biotech Ltd. (NASDAQ/TASE: PPBT), a clinical-stage company focused on developing innovative therapies to combat tumor immune evasion and drug resistance, announced its participation in the Jefferies Virtual Healthcare Conference. Management will present on June 4, 2021, at 8:30am EST. The conference occurs from June 1-4, 2021, and allows for one-on-one meetings. Purple Biotech's pipeline includes NT219 and CM24, aimed at treating various cancers. Interested parties can access the live and replay webinars on their official website.

Purple Biotech Ltd. (NASDAQ/TASE: PPBT) announced it will present interim data from its ongoing Phase 1/2 clinical trial of NT219 on June 4, 2021, at the ASCO Annual Meeting. NT219 is a dual inhibitor targeting IRS1/2 and STAT3, being evaluated as a monotherapy and in combination with cetuximab for advanced solid tumors, including head and neck cancer. The company anticipates further top-line data in the second half of 2021, showcasing its commitment to developing therapies that address tumor immune evasion and drug resistance.

Purple Biotech has appointed Suzana Nahum-Zilberberg to its Board of Directors, enhancing its leadership team. Nahum-Zilberberg, a seasoned biopharmaceutical executive, aims to leverage her operational expertise to advance the company's anti-cancer product candidates, NT219 and CM24. Dr. Eric Rowinsky, the Board Chairman, expressed excitement about her addition, highlighting the importance of her background in driving the company's mission to develop impactful therapeutics. Purple Biotech's pipeline includes innovative therapies targeting tumor immune evasion and drug resistance, with ongoing clinical studies and partnerships with major firms.