Pieris Pharmaceuticals Reports Third Quarter 2021 Financial Results and Provides Corporate Update
Pieris Pharmaceuticals (PIRS) reported Q3 2021 financial results, showing a net loss of $16.5 million or $(0.24) per share, slightly improved from $(0.26) per share a year prior. The company holds over $125 million in cash, attributed to collaborations, despite rising R&D expenses totaling $18.9 million. Notably, dosing in part 1a of their phase 2a study for PRS-060/AZD1402 has been completed, with topline data expected next year. Pieris also advanced multiple studies, including cinrebafusp alfa and PRS-344. The firm announced executive promotions and partnerships with AstraZeneca, Seagen, and Genentech.
- Cash position increased to $125.1 million from $70.4 million year-over-year.
- Dosing completed in part 1a of phase 2a study for PRS-060/AZD1402.
- Regulatory approval received for phase 1/2 study of PRS-344 in multiple countries.
- Promoted Thomas Bures to CFO and Ahmed Mousa to CBO, strengthening leadership.
- Incurred a net loss of $16.5 million in Q3 2021, an increase from $14.3 million year-over-year.
- R&D expenses rose significantly to $18.9 million, reflecting higher costs in multiple programs.
Company To Host an Investor Conference Call on Tuesday, November 2, 2021 at 8:00 AM EDT
- Dosing completed in part 1a of phase 2a study of PRS-060/AZD1402
- Dosing to begin this quarter in phase 2 study of cinrebafusp alfa
- Received regulatory approval from multiple countries for phase 1/2 study of PRS-344/ S095012
- Presented preclinical data for PRS-220 at ERS; on track for 2022 clinical initiation
- Initiated second costim bispecific program in Seagen collaboration
- Initiated respiratory and ophthalmology programs with Genentech
- Promoted Thomas Bures to CFO and Ahmed Mousa to CBO
BOSTON, MA / ACCESSWIRE / November 2, 2021 / Pieris Pharmaceuticals, Inc. (NASDAQ: PIRS), a clinical-stage biotechnology company advancing novel biotherapeutics through its proprietary Anticalin® technology platform for respiratory diseases, cancer, and other indications, today reported financial results for the third quarter of 2021 ended September 30, 2021 and provided an update on the Company's recent and anticipated future developments.
"I am pleased to report that AstraZeneca has completed dosing in part 1a of the phase 2a study of PRS-060/AZD1402. We look forward to announcing the completion of the safety review by AstraZeneca before initiating the second part of that study and presenting topline data informing our co-development opt-in decision next year. Also within our respiratory franchise, we are progressing PRS-220 toward the clinic next year, and we recently presented preclinical data for that program, reinforcing our enthusiasm about it. Additionally, we have made important strides in getting the next phase of clinical trials for our immuno-oncology programs cinrebafusp alfa and PRS-344 activated, and we are excited to see those trials progress," said Stephen S. Yoder, President and Chief Executive Officer of Pieris. "We have a solid balance sheet of over
- PRS-060/AZD1402 and AstraZeneca Collaboration: Dosing has been completed in part 1a (safety) of the global phase 2a study of PRS-060/AZD1402, an inhaled IL-4 receptor alpha inhibitor under development in collaboration with AstraZeneca for the treatment of moderate-to-severe asthma. Data unblinding and review will now follow, the outcome of which the Company will publicly disclose, gating progression to the second part of the study, where efficacy will be assessed in moderate, uncontrolled asthmatics. Pieris and AstraZeneca expect to announce topline data from the entire phase 2a study next year.Upon completion of the study, which is being sponsored and funded by AstraZeneca, Pieris will have the options to co-develop and, separately, co-commercialize PRS-060/AZD1402 in the United States. Pieris and AstraZeneca continue to advance each of the four programs in the collaboration beyond PRS-060/AZD1402.
- Cinrebafusp Alfa (PRS-343): Pieris plans to dose the first patient in a two-arm phase 2 study for cinrebafusp alfa, a 4-1BB/HER2 bispecific for the treatment of HER2-expressing solid tumors, in gastric cancer this quarter and reconfirms its plan to report initial data from the arm evaluating cinrebafusp alfa in combination with tucatinib in HER2-low gastric cancer next year. The Company has decided to focus enrollment on second line patients and now expects to report data from the arm evaluating cinrebafusp alfa in combination with ramucirumab and paclitaxel in HER2-high gastric cancer in 2023.
- PRS-344/S095012 and Servier Collaboration: Regulatory approval for the phase 1/2 study of PRS-344/S095012, a 4-1BB/PD-L1 bispecific, has been granted by multiple countries. Pieris holds exclusive commercialization rights for PRS-344/S095012 in the United States and will receive royalties on ex-U.S. sales for this program, should it receive regulatory approval. Additionally, Servier is continuing development of PRS-352, an undisclosed Anticalin-based bispecific beyond 4-1BB.
- PRS-220: Pieris presented initial preclinical data for PRS-220, a proprietary inhaled Anticalin protein targeting connective tissue growth factor (CTGF) for the treatment of idiopathic pulmonary fibrosis (IPF), at the European Respiratory Society International Congress 2021 (ERS) demonstrating a more potent and durable target engagement profile compared to a clinical-stage, systemically delivered anti-CTGF antibody benchmark. Additionally, the targeting of CTGF locally in the lung showed increased attenuation of fibrotic lung remodeling in vivo compared to the systemically delivered antibody. This outcome correlates with superior lung tissue exposure of PRS-220 compared to that of the systemically administered antibody in head-to-head studies, where intratracheally administered PRS-220 efficiently penetrates the fibrotic, interstitial lung tissue of mice. Clinical development for the program in IPF and post-COVID pulmonary fibrosis, as supported by a grant from the Bavarian government, is expected to begin next year.
- Seagen Collaboration: Pieris has initiated the second program within the bispecific immuno-oncology collaboration with Seagen, a program that includes a co-promotion option for Pieris in the United States. Additionally, Seagen is continuing development of the first program, an undisclosed Anticalin-based bispecific.
- Genentech Collaboration: Pieris and Genentech initiated joint discovery activities for the two committed programs, one in respiratory and one in ophthalmology, as part of their research collaboration and license agreement to discover, develop, and commercialize locally delivered therapies that leverage Pieris' proprietary Anticalin technology.
- Executive Leadership: Pieris announced the promotion of Thomas Bures to Senior Vice President and Chief Financial Officer. Mr. Bures oversees all financial matters at the company, including treasury, tax, financial planning, procurement and investor relations. Pieris additionally announced the promotion of Ahmed Mousa to Senior Vice President and Chief Business Officer. In his new role, Mr. Mousa heads business development and portfolio strategy, in addition to serving as General Counsel and Boston site head.
First Quarter Financial Update:
Cash Position - Cash and cash equivalents totaled
R&D Expense - R&D expenses were
G&A Expense - G&A expenses were
Other Income - For the quarter ended September 30, 2021,
Net Loss - Net loss was
Conference Call:
Pieris management will host a conference call beginning at 8:00 AM EDT on Tuesday, November 2, 2021, to discuss finance results for the third quarter of 2021 and provide a corporate update. Individuals can join the call by dialing +1-877-407-8920 (US & Canada) or +1-412-902-1010 (International). Alternatively, a listen-only audio webcast of the call can be accessed here.
For those unable to participate in the conference call or listen to the webcast, a replay will be available on the Investors section of the Company's website, www.pieris.com.
About Pieris Pharmaceuticals:
Pieris is a clinical-stage biotechnology company that combines leading protein engineering capabilities and deep understanding into molecular drivers of disease to develop medicines that drive local biology to produce superior clinical outcomes for patients. Our pipeline includes inhalable Anticalin proteins to treat respiratory diseases and locally-activated bispecifics for immuno-oncology. Proprietary to Pieris, Anticalin proteins are a novel class of therapeutics validated in the clinic and by respiratory and immuno-oncology focused partnerships with leading pharmaceutical companies. For more information, visit www.pieris.com.
Forward-looking Statements:
This press release contains forward-looking statements as that term is defined in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Statements in this press release that are not purely historical are forward-looking statements. Such forward-looking statements include, among other things, the potential for Pieris' development programs such as PRS-060/AZD1402, cinrebafusp alfa, PRS-344/S095012 and PRS-220 to address our core focus areas such as respiratory diseases and immuno-oncology; the advancement of our proprietary and co-development programs into and through the clinic and the expected timing for reporting data; making IND filings or achieving other milestones related to our programs, including PRS-060/AZD1402, cinrebafusp alfa, PRS-344/S095012 and PRS-220; the therapeutic potential of our Anticalin platform; our continued progress in the areas of co-stim bispecifics and inhaled therapeutics; and the advancement of our developmental programs generally. Actual results could differ from those projected in any forward-looking statements due to numerous factors. Such factors include, among others, our ability to raise the additional funding we will need to continue to pursue our business and product development plans; the inherent uncertainties associated with developing new products or technologies and operating as a development stage company; our ability to develop, complete clinical trials for, obtain approvals for and commercialize any of our product candidates, including our ability to recruit and enroll patients in our studies; our ability to address the requests of the U.S. Food and Drug Administration; competition in the industry in which we operate; delays or disruptions due to COVID-19; and market conditions. These forward-looking statements are made as of the date of this press release, and we assume no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those projected in the forward-looking statements, except as required by law. Investors should consult all of the information set forth herein and should also refer to the risk factor disclosure set forth in the reports and other documents we file with the Securities and Exchange Commission available at www.sec.gov, including, without limitation, the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2020 and the Company's Quarterly Reports on Form 10-Q.
Investor Relations Contact:
Pieris Pharmaceuticals, Inc.
Maria Kelman
Executive Director, Investor Relations
+1 857 362 9635
kelman@pieris.com
PIERIS PHARMACEUTICALS, INC.
CONDENSED CONSOLIDATED BALANCE SHEETS
(unaudited, in thousands)
September 30, 2021 | December 31, 2020 | |||||||
Assets: | ||||||||
Cash and cash equivalents | $ | 125,052 | $ | 70,436 | ||||
Short term investments | - | - | ||||||
Accounts receivable | 6,646 | 1,706 | ||||||
Prepaid expenses and other current assets | 5,949 | 3,579 | ||||||
Total current assets | 137,647 | 75,721 | ||||||
Property and equipment, net | 19,613 | 22,046 | ||||||
Operating lease right-of-use assets | 3,974 | 3,934 | ||||||
Other non-current assets | 2,950 | 3,309 | ||||||
Total Assets | $ | 164,184 | $ | 105,010 | ||||
Liabilities and stockholders' equity: | ||||||||
Accounts payable | $ | 3,562 | $ | 1,787 | ||||
Accrued expenses | 19,685 | 7,731 | ||||||
Deferred revenue, current portion | 26,449 | 12,627 | ||||||
Total current liabilities | 49,696 | 22,145 | ||||||
Deferred revenue, net of current portion | 46,190 | 35,900 | ||||||
Operating lease liabilities | 14,445 | 15,932 | ||||||
Other long-term liabilities | - | 6 | ||||||
Total Liabilities | 110,331 | 73,983 | ||||||
Total stockholders' equity | 53,853 | 31,027 | ||||||
Total liabilities and stockholders' equity | $ | 164,184 | $ | 105,010 | ||||
PIERIS PHARMACEUTICALS, INC
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
(unaudited, in thousands, except per share data)
Three months ended September 30, | Nine months ended September 30, | |||||||||||||||
2021 | 2020 | 2021 | 2020 | |||||||||||||
Revenues | $ | 4,057 | $ | 2,939 | $ | 22,975 | $ | 27,446 | ||||||||
Operating expenses | ||||||||||||||||
Research and development | 18,937 | 11,822 | 51,299 | 35,913 | ||||||||||||
General and administrative | 4,132 | 4,116 | 12,508 | 13,043 | ||||||||||||
Total operating expenses | 23,069 | 15,938 | 63,807 | 48,956 | ||||||||||||
Loss from operations | (19,012) | (12,999) | (40,832) | (21,510) | ||||||||||||
Interest income | 4 | 55 | 10 | 503 | ||||||||||||
Grant income | 1,794 | - | 2,590 | - | ||||||||||||
Other income (expense), net | 678 | (1,339) | 2,026 | (1,823) | ||||||||||||
Loss before income taxes | (16,536) | (14,283) | (36,206) | (22,830) | ||||||||||||
Provision for income tax | - | - | - | - | ||||||||||||
Net loss | $ | (16,536) | $ | (14,283) | $ | (36,206) | $ | (22,830) | ||||||||
Basic and diluted net loss per share | $ | (0.24) | $ | (0.26) | $ | (0.58) | $ | (0.42) | ||||||||
Basic and diluted weighted average shares outstanding | 67,730 | 54,340 | 62,019 | 53,976 | ||||||||||||
SOURCE: Pieris Pharmaceuticals, Inc.
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