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PharmaMar (MSE: PHM) announced the publication of a study in the Life Science Alliance journal on plitidepsin's efficacy against COVID-19. The research indicates that plitidepsin exhibits potent antiviral activity against SARS-CoV-2 variants, including Omicron, at low concentrations. In vivo studies showed a 99% reduction in viral loads in treated animals. The Phase I-II APLICOV-PC trial, involving 45 patients, confirmed safety and clinical efficacy, with 74% of moderate disease patients discharged within a week. These findings support the ongoing Phase III NEPTUNO trial in 17 hospitals across Europe and Latin America.