Pharming Group reports financial results for the first quarter of 2023
- FDA approval and commercial launch of Joenja® (leniolisib) in the
U.S. - Joenja® launch off to strong start with 23 U.S. patients on paid therapy
- Revenues decreased by
9% toUS , compared to the first quarter of 2022, primarily due to temporary reimbursement disruptions for some patients on government insurance programs. This issue, affecting all of the HAE market, has since resolved$42.5 million - Continue to anticipate low single digit growth in annual revenues from RUCONEST® in 2023
- Continued significant investments made in leniolisib launch preparations and organizational structure
- Overall cash balance of
US at the end of the quarter$184.8 million
LEIDEN,
Chief Executive Officer, Sijmen de Vries commented:
"In the first quarter of 2023, we reached an important milestone with the approval and launch of Joenja® (leniolisib), the first and only approved treatment for patients with APDS in
The launch of Joenja® is off to a strong start. In April, we announced that the first commercial product had been shipped to patients with payor reimbursement and we can confirm that we now have 23 patients on paid therapy.
Turning to RUCONEST®, as we guided on our 2022 full year results call on March 16, we continue to anticipate low single digit revenue growth with quarterly fluctuations. In the first quarter, there were a number of fluctuations that impacted RUCONEST® revenues and the HAE market across acute and prophylactic products. These factors were mainly due to disruptions in reimbursement for some patients on government insurance programs, which delayed shipments.
These impacts to the business have since resolved and we can confirm that we have seen a recovery and catch up in revenues. Additionally, we are observing strong underlying in-market demand for RUCONEST® and have a high number of new patient enrollments in the
Looking ahead, we continue to progress leniolisib through regulatory pathways in
We also began the first of two pediatric clinical trials for children with APDS, whom we believe account for some
Finally, with a focus on rare disease assets, we are continuously investigating in-licensing and acquisition opportunities which can further enhance our portfolio."
First Quarter and subsequent highlights
Commercialized assets
On March 24, 2023, Pharming announced that the US Food and Drug Administration (FDA) approved Joenja® (leniolisib) for the treatment of activated phosphoinositide 3-kinase delta (PI3Kδ) syndrome (APDS) in adult and pediatric patients 12 years of age and older. Joenja®, an oral, selective PI3Kδ inhibitor, is the first and only treatment approved in the
With the approval of Joenja®, as a treatment for primary immunodeficiency, the FDA granted Pharming a priority review voucher ("PRV"). Pursuant to the terms of Pharming's 2019 exclusive license agreement with Novartis for leniolisib, Novartis has the right to purchase the PRV from Pharming for a small minority share of the value of the PRV. Pursuant to the agreement with Novartis, the first commercial sale of Joenja® in the second quarter of 2023 triggered a
Additional information on the PRV, as well as milestone and royalty payments can be found in our 2022 Annual Report or in the Form 20-F filed with the SEC.
Joenja®
Based on available literature, Pharming estimates that over 1,500 patients are affected by APDS in the
The first commercial shipments of Joenja® to APDS patient in the
We anticipate providing updates on our commercial outlook for Joenja® in the second half of 2023.
RUCONEST® marketed for the treatment of acute HAE attacks
In the first quarter of 2023, RUCONEST® revenues were
The decrease in overall revenues were primarily due to temporary disruptions in reimbursement for some patients on government insurance programs, which impacted the overall HAE market across all acute and prophylactic products. As a result, shipments to these patients were delayed and impacted February sales in particular. The HAE market disruptions seen in the first quarter have since resolved and we have seen a recovery in sales.
We are therefore maintaining our full-year outlook for low single digit growth in RUCONEST® revenues for 2023.
Underlying in-market demand for RUCONEST® continued to be strong, including a high number of new patient enrollments in the first quarter.
Strategic Highlights - regulatory and clinical updates
Leniolisib for APDS
Pharming made significant progress in the quarter towards our objective of obtaining regulatory approvals for leniolisib for APDS in additional key markets and for pediatric patients, and to identify additional indications for development of leniolisib beyond APDS.
EEA and
In February 2023, Pharming announced that the European Medicines Agency's (EMA) Committee for Human Medicinal Products (CHMP) decided to shift its assessment of the Marketing Authorisation Application (MAA) for leniolisib to a standard review timetable. The list of questions received by Pharming from EMA included a request to submit updated data from the ongoing long-term extension study collected after the interim analysis included in the original MAA. As previously announced, we anticipate responding to the CHMP's list of questions in May 2023 and expect that the CHMP will issue its opinion on the leniolisib MAA in the second half of 2023. We anticipate that European marketing authorisation will follow approximately two months later.
In the
On March 9, 2023, we filed an Orphan Drug Designation (ODD) application with the Ministry of Health, Labor and Welfare (MHLW) in
Pediatric clinical trial
In February 2023, as part of Pharming's Pediatric Investigational Plan (PIP), the Company announced that the first patient had been enrolled in its Phase III clinical trial evaluating the investigational drug leniolisib in children with APDS, at sites in
The second pediatric clinical trial for patients 1 to 6 years of age is scheduled to commence in the third quarter of 2023 and is also part of the PIP for leniolisib as a treatment for APDS in children.
Leniolisib for additional indications (PI3Kδ platform)
As announced in our Joenja® approval conference call on March 27, we have commenced working towards prioritizing other indications where leniolisib has the potential to deliver value for patients. PI3Kδ has been identified as an important factor in a variety of disease states, and leniolisib has demonstrated an attractive, long-term efficacy, safety and tolerability profile in clinical trials conducted in both healthy volunteers and patients. This provides a solid basis for our plans for the investigation and investment in further leniolisib indications. We are exploring further indications and will update the market later on this year.
Pre-Clinical Pipeline
OTL-105
We anticipate providing further updates as we move towards preparing an Investigational New Drug (IND) filing. If the data from pre-clinical HAE animal studies meet scientific requirements, then we expect to start IND-enabling pre-clinical studies in 2023.
Pompe
Based on our preclinical investigations and evaluations for potential differentiating features of the product candidate, it has been decided that the further development of this asset will be discontinued.
Other events during the quarter
On March 12 and 13, 2023, Pharming issued three press releases regarding the events surrounding Silicon Valley Bank. Pharming confirms that it has full access to its deposits.
Financial summary
Amounts in US $m except per share data | 1Q 2023 | 1Q 2022 |
Consolidated Income Statement | ||
Revenues | 42.5 | 46.6 |
Gross profit | 38.5 | 41.7 |
Operating profit (loss) | (13.7) | 2.8 |
Finance result, net | (2.7) | 1.8 |
Income tax expense | 4.5 | (0.8) |
Net Profit (loss) | (12.2) | 3.5 |
Consolidated Balance Sheet | ||
Cash & marketable securities | 186.2 | 190.7 |
Share Information | ||
Basic earnings per share (US$) | (0.019) | 0.005 |
Diluted earnings per share (US$) | (0.017) | 0.005 |
Financial highlights
Total revenues for the first quarter of 2023 decreased by
Gross profit decreased by
Operating profit decreased to a loss of
The Company had a net loss of
Negative cash flows from operations amounted to
Outlook
For 2023, the Company anticipates:
- Continued low, single digit growth in annual revenues from RUCONEST®. Quarterly fluctuations are expected.
- Following FDA approval, we are commercializing Joenja® (leniolisib) in the
U.S. commencing early April 2023. - We anticipate a positive CHMP opinion for leniolisib in 2H 2023, Marketing Authorisation in
Europe expected ~2 months later, followed by commercial launches in individual EU countries - Following an anticipated positive CHMP opinion in 2H 2023, we intend to submit an ECDRP filing for leniolisib with the
U.K. MHRA shortly thereafter. Approval expected several months later. - Pharming will continue to allocate resources to accelerate future growth. Investments in launch preparations, commercialization and focused clinical developments for leniolisib including to support pediatric and Japanese approvals, as well as for the development of leniolisib in additional indications, will continue to impact profit throughout 2023. Our current cash on hand, including the continued cash flow of RUCONEST® are expected to be sufficient to fund these investments.
- Further details on our plans to develop leniolisib in additional indications to be provided in 2H 2023.
- Investments and continued focus on potential acquisitions and in-licensing of mid to late stage opportunities in rare diseases. Financing, if required, would come via a combination of our strong balance sheet and access to capital markets.
No further specific financial guidance for 2023 is provided.
Additional information
Presentation
The conference call presentation is available on the Pharming.com website from 07:30 CET, May 11.
Conference Call
The conference call will begin at 13:30 CET / 07:30 EDT on Thursday, May 11. A transcript of the call will be made available on the Pharming.com website the following day, Friday, May 12 from 16:30 CET.
Please note, the Company will only take questions from dial-in attendees.
Dial-in numbers for conference call
Global Dial-In Numbers
Access code: 598957
Webcast Link: https://webcast.openbriefing.com/pharming1q23/
Financial Calendar 2023
Annual General Meeting of Shareholders May 17
2Q/1H 2023 financial results August 3
3Q 2023 financial results October 26
For further public information, contact:
Pharming Group N.V., Leiden,
Michael Levitan, VP Investor Relations & Corporate Communications
T: +1 (908) 705 1696
Heather Robertson, Investor Relations & Corporate Communications Manager
E: investor@pharming.com
FTI Consulting,
Victoria Foster Mitchell/Alex Shaw
T: +44 203 727 1000
LifeSpring Life Sciences Communication,
Leon Melens
T: +31 6 53 81 64 27
E: pharming@lifespring.nl
About Pharming Group N.V.
Pharming Group N.V. (EURONEXT Amsterdam: PHARM/Nasdaq: PHAR) is a global biopharmaceutical company dedicated to transforming the lives of patients with rare, debilitating, and life-threatening diseases. Pharming is commercializing and developing an innovative portfolio of protein replacement therapies and precision medicines, including small molecules, biologics, and gene therapies that are in early to late-stage development. Pharming is headquartered in Leiden,
For more information, visit www.pharming.com and find us on LinkedIn.
Forward-looking Statements
This press release may contain forward-looking statements. Forward-looking statements are statements of future expectations that are based on management's current expectations and assumptions and involve known and unknown risks and uncertainties that could cause actual results, performance, or events to differ materially from those expressed or implied in these statements. These forward-looking statements are identified by their use of terms and phrases such as "aim", "ambition", ''anticipate'', ''believe'', ''could'', ''estimate'', ''expect'', ''goals'', ''intend'', ''may'', "milestones", ''objectives'', ''outlook'', ''plan'', ''probably'', ''project'', ''risks'', "schedule", ''seek'', ''should'', ''target'', ''will'' and similar terms and phrases. Examples of forward-looking statements may include statements with respect to timing and progress of Pharming's preclinical studies and clinical trials of its product candidates, Pharming's clinical and commercial prospects, and Pharming's expectations regarding its projected working capital requirements and cash resources, which statements are subject to a number of risks, uncertainties and assumptions, including, but not limited to the scope, progress and expansion of Pharming's clinical trials and ramifications for the cost thereof; and clinical, scientific, regulatory and technical developments. In light of these risks and uncertainties, and other risks and uncertainties that are described in Pharming's 2022 Annual Report and the Annual Report on Form 20-F for the year ended December 31, 2022, filed with the
Inside Information
This press release relates to the disclosure of information that qualifies, or may have qualified, as inside information within the meaning of Article 7(1) of the EU Market Abuse Regulation.
Pharming Group N.V.
Condensed Consolidated Interim Financial Statements in US Dollars (unaudited)
For the period ended 31 March 2023
- Condensed consolidated statement of profit or loss
- Condensed consolidated statement of -comprehensive income
- Condensed consolidated balance sheet
- Condensed consolidated statement of cash flow
Condensed Consolidated Statement of Profit or Loss For the period ended 31 March | ||
Amounts in US$ '000 | YTD 2023 | YTD 2022 |
Revenues | 42,541 | 46,617 |
Costs of sales | (4,075) | (4,877) |
Gross profit | 38,466 | 41,740 |
Other income | 579 | 873 |
Research and development | (15,620) | (14,863) |
General and administrative | (9,981) | (7,728) |
Marketing and sales | (27,107) | (17,197) |
Other Operating Costs | (52,708) | (39,788) |
Operating profit (loss) | (13,663) | 2,825 |
Other finance income | 123 | 3,228 |
Other finance expenses | (2,795) | (1,379) |
Finance result, net | (2,672) | 1,849 |
Share of net profits in associates using the equity method | (339) | (441) |
Profit (loss) before tax | (16,674) | 4,233 |
Income tax expense | 4,466 | (772) |
Profit (loss) for the year | (12,208) | 3,461 |
Basic earnings per share (US$) | (0.019) | 0.005 |
Diluted earnings per share (US$) | (0.017) | 0.005 |
Condensed Consolidated Statement of Comprehensive Income For the period ended 31 March | ||
Amounts in US$ '000 | YTD 2023 | YTD 2022 |
Profit for the year | (12,208) | 3,461 |
Currency translation differences | 3,813 | (3,216) |
Fair value remeasurement investments | 127 | (653) |
Items that may be subsequently reclassified to profit or loss | 3,940 | (3,869) |
Other comprehensive income (loss), net of tax | 3,940 | (3,869) |
Total comprehensive income for the year | (8,268) | (408) |
Condensed Consolidated Balance Sheet | ||
Amounts in US$ '000 | March 31, 2023 | December 31, 2022 |
Non-current assets | ||
Intangible assets | 75,606 | 75,121 |
Property, plant and equipment | 10,403 | 10,392 |
Right-of-use assets | 30,369 | 28,753 |
Long-term prepayments | 233 | 228 |
Deferred tax assets | 29,350 | 22,973 |
Investment accounted for using the equity method | 2,210 | 2,501 |
Investments in equity instruments designated as at FVTOCI | 585 | 403 |
Investment in debt instruments designated as at FVTPL | 6,972 | 6,827 |
Restricted cash | 1,212 | 1,099 |
Total non-current assets | 156,940 | 148,297 |
Current assets | ||
Inventories | 48,127 | 42,326 |
Trade and other receivables | 32,931 | 27,619 |
Restricted cash | 218 | 213 |
Cash and cash equivalents | 184,780 | 207,342 |
Total current assets | 266,056 | 277,500 |
Total assets | 422,996 | 425,797 |
Equity | ||
Share capital | 7,518 | 7,509 |
Share premium | 463,222 | 462,297 |
Other reserves | (4,906) | (8,737) |
Accumulated deficit | (266,491) | (256,431) |
Shareholders' equity | 199,343 | 204,638 |
Non-current liabilities | ||
Convertible bonds | 133,576 | 131,618 |
Lease liabilities | 31,074 | 29,843 |
Total non-current liabilities | 164,650 | 161,461 |
Current liabilities | ||
Convertible bonds | 1,805 | 1,768 |
Trade and other payables | 53,254 | 54,465 |
Lease liabilities | 3,944 | 3,465 |
Total current liabilities | 59,003 | 59,698 |
Total equity and liabilities | 422,996 | 425,797 |
Condensed Consolidated Statement of Cash Flow For the three months ended 31 March | ||
Amounts in US$'000 | YTD 2023 | YTD 2022 |
Profit (loss) before tax | (16,674) | 4,233 |
Non-cash adjustments: | ||
Depreciation, amortization, impairment of non-current assets | 2,306 | 2,190 |
Equity settled share based payments | 1,558 | 1,070 |
Other finance income | (123) | (3,228) |
Other finance expenses | 2,795 | 1,379 |
Share of net profits in associates using the equity method | 339 | 441 |
Other | (455) | — |
Operating cash flows before changes in working capital | (10,254) | 6,085 |
Changes in working capital: | ||
Inventories | (5,801) | (2,297) |
Trade and other receivables | (5,313) | (1,462) |
Payables and other current liabilities | (1,211) | (1,645) |
Restricted cash | 117 | (20) |
Total changes in working capital | (12,208) | (5,424) |
Interest received (paid) | 117 | (52) |
Income taxes paid | (440) | — |
Net cash flows generated from (used in) operating activities | (22,785) | 609 |
Capital expenditure for property, plant and equipment | (215) | (208) |
Investment intangible assets | — | (167) |
Net cash flows used in investing activities | (215) | (375) |
Payment of lease liabilities | (1,312) | (807) |
Interests on loans | (2,013) | (2,100) |
Proceeds of equity and warrants | 695 | 18 |
Net cash flows generated from (used in) financing activities | (2,630) | (2,889) |
Increase (decrease) of cash | (25,630) | (2,655) |
Exchange rate effects | 3,068 | 405 |
Cash and cash equivalents at 1 January | 207,342 | 191,924 |
Total Cash and cash equivalents at 31 March | 184,780 | 189,674 |
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SOURCE Pharming Group N.V.