Welcome to our dedicated page for Precigen news (Ticker: PGEN), a resource for investors and traders seeking the latest updates and insights on Precigen stock.
Overview of Precigen Inc (PGEN)
Precigen Inc is a clinical stage biopharmaceutical company that develops and refines innovative gene and cell therapies using cutting-edge synthetic biology and precision technology. With proprietary platforms such as UltraCAR-T and AdenoVerse, the company designs, builds, and regulates complex gene expression programs to address intractable diseases. Its expertise in non-viral gene transfer methods and advanced DNA construction techniques positions the company as a significant innovator across multiple therapeutic areas including immuno-oncology, autoimmune disorders, and infectious diseases.
Core Business and Technological Platforms
Precigen leverages a comprehensive suite of technologies to discover and develop next generation therapeutics. The company utilizes an advanced UltraVector platform for DNA construction, facilitating the design and assembly of gene components. Its UltraCAR-T platform, which employs a non-viral Sleeping Beauty system, enables the rapid manufacturing of personalized cell therapies with an improved safety profile and simplified logistics. Additionally, the AdenoVerse platform uses a library of engineered adenovector serotypes that efficiently deliver gene therapies aimed at modulating immune responses.
Business Model and Collaborations
The business model of Precigen is centered on leveraging its proprietary technology platforms through strategic collaborations with industry experts who bring extensive development, manufacturing, and commercial capabilities. These partnerships generate revenue primarily via technology access fees, milestone payments, royalties, and reimbursement of collaborative costs. This model provides a stable framework for continuous innovation and the effective translation of preclinical discoveries into viable clinical therapies.
Market Position and Competitive Landscape
In the competitive biotechnology arena, Precigen distinguishes itself through its robust research capabilities and a diversified portfolio of therapeutic candidates. Its unique non-viral gene transfer methods and rapid manufacturing techniques set it apart from traditional gene and cell therapy developers. By focusing resources on technologies with high clinical and commercial potential, the company addresses critical unmet needs in the therapeutic landscape, thereby reinforcing its market significance.
Operational Focus and Expertise
Precigen’s operations are built on years of scientific expertise in genetic engineering and computational model integration for therapeutic design. The company’s detailed approach to tailoring gene expression programs allows for improved functional characteristics of immune cells and precise control over therapeutic outcomes. Its methodical approach and dedication to iterative clinical development underscore its commitment to advancing medicine with precision.
Summary of Value Proposition
Precigen excels in translating complex genetic information into transformative therapies with the potential to modify the disease course in challenging therapeutic areas. By continually streamlining its research and operational models, the company ensures that its innovative techniques remain at the forefront of scientific excellence and commercial relevance. The integrated approach of technology, clinical expertise, and strategic partnerships makes Precigen a notable entity within the biopharmaceutical industry.
Precigen, Inc. (Nasdaq: PGEN) announced that Dr. Helen Sabzevari, President and CEO, will participate in a virtual fireside chat at the Guggenheim Healthcare Talks Oncology Day on February 12, 2021, at 11:30 AM ET. Investors can access the live webcast through Precigen's website in the Events & Presentations section. Precigen focuses on innovative gene and cell therapies targeting serious diseases, with an emphasis on immuno-oncology, autoimmune disorders, and infectious diseases. For more information, visit www.precigen.com.
Precigen (Nasdaq: PGEN) announced the successful closing of its public offering of common stock, selling 17,250,000 shares at $7.50 each, including an exercised option for 2,250,000 shares. The offering generated approximately $129.4 million in gross proceeds before expenses. Wells Fargo Securities and Stifel served as joint book-running managers, and the offering was made under an effective shelf registration statement. Precigen aims to advance gene and cell therapies in immuno-oncology and other areas.
Precigen, Inc. (PGEN) announced a public offering of 15 million shares at $7.50 per share, generating approximately $112.5 million in gross proceeds. The underwriters have a 30-day option to purchase an additional 2.25 million shares. The offering, expected to close on January 26, 2021, will fund clinical and preclinical product development, working capital, and other corporate purposes. Wells Fargo Securities and Stifel are joint book-running managers.
Precigen, a biopharmaceutical company (Nasdaq: PGEN), has initiated an underwritten public offering of its common stock, granting underwriters a 30-day option for additional shares. The offering, subject to market conditions, will be conducted under an effective shelf registration statement. The offering details, including size and terms, will be disclosed in a preliminary prospectus supplement to be filed with the SEC. Wells Fargo Securities and Stifel are the joint book-running managers for this offering.
On January 13, 2021, Precigen (Nasdaq: PGEN) presented its clinical achievements and goals at the 39th Annual J.P. Morgan Healthcare Conference. Highlights included updates on PRGN-3005 and PRGN-3006 UltraCAR-T, alongside the new UltraCAR-T library approach aimed at personalized cancer therapies. Preliminary data from the Phase I/II study of PRGN-2009 for treating HPV-associated cancers was shared, indicating a strong immune response in patients. The company also announced advancements in other AdenoVerse immunotherapies targeting RRP and HBV, emphasizing its commitment to innovative therapies amidst COVID-19 challenges.
Precigen, Inc. (Nasdaq: PGEN) announced that Dr. Helen Sabzevari, President and CEO, will present at the 39th Annual J.P. Morgan Healthcare Conference on January 13, 2021, at 3:40 PM ET. She will also take part in a panel discussion on precision medicine at the H.C. Wainwright BioConnect 2021 Conference on the same day at 12:00 PM ET. Live webcasts are available on Precigen’s website. The company focuses on advancing gene and cell therapies, addressing major health challenges.
On January 5, 2021, Precigen (Nasdaq: PGEN) announced FDA clearance for its IND application to start a Phase I clinical trial for PRGN-2012, an investigational immunotherapy for recurrent respiratory papillomatosis (RRP), a rare disease caused by HPV types 6 and 11. This trial aims to evaluate the safety and tolerability of PRGN-2012, which utilizes Precigen's proprietary gorilla adenovector technology. The study will enroll 12 patients to assess the treatment's efficacy following surgical removal of the disease. Precigen's collaboration with the NCI aims to address unmet medical needs in RRP patients.
Precigen (Nasdaq: PGEN) held a virtual R&D event on Dec. 15, 2020, showcasing significant advancements in its clinical pipeline. Key updates include:
- PRGN-3005 UltraCAR-T: First clinical data reported with promising results in ovarian cancer showing 50% tumor regression among patients.
- PRGN-3006 UltraCAR-T: Positive data in acute myeloid leukemia (AML) with effective treatment responses.
- AG019 ActoBiotics: Demonstrated safety and potential in stabilizing C-peptide levels in Type 1 diabetes patients.
These results mark critical milestones for the company, indicating progress in innovative gene and cell therapies.
Precigen, a biopharmaceutical company (Nasdaq: PGEN), announced a virtual event on December 15, 2020, at 11:00 AM ET, to update stakeholders on its clinical pipeline. The event will feature data from key programs, including PRGN-3005 and PRGN-3006 UltraCAR-T, as well as AG019 ActoBiotics. Executives and leading investigators will participate, presenting advancements in the company's innovative gene and cell therapies targeting serious diseases. Registration is available via the investor relations website.
Precigen announced new data from its PRGN-3006 UltraCAR-T® phase 1/1b study for treating relapsed or refractory acute myeloid leukemia (AML) at the 62nd ASH Annual Meeting. The study shows promising results, with six patients treated and no dose-limiting toxicities reported. A 100% manufacturing success rate using their proprietary process was achieved. The UltraCAR-T cells demonstrated encouraging expansion and persistence in patients, with one case study showing robust cell activity seven months post-infusion. These advancements suggest a potential improvement over existing CAR-T therapies.
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