Panbela to Participate in the 34th Annual Roth Conference

Rhea-AI Summary

Panbela Therapeutics (Nasdaq: PBLA) announced participation in the 34th Annual Roth Conference on March 14, 2022, at 11:30 AM PT, with a webcast available online. The company is focused on developing SBP-101, a proprietary therapy for metastatic pancreatic ductal adenocarcinoma, showing promising clinical results including a median overall survival of 12 months and an objective response rate of 48%. Panbela aims to address urgent medical needs in cancer treatment, with significant potential for future development.

MINNEAPOLIS, March 10, 2022 (GLOBE NEWSWIRE) -- Panbela Therapeutics, Inc. (Nasdaq: PBLA), a clinical stage biopharmaceutical company developing disruptive therapeutics for the treatment of patients with cancer, announced today that management will participate in a fireside chat at the 34th Annual Roth Conference on March 14, 2022, at 11:30AM PT. The webcast will be available at: https://wsw.com/webcast/roth43/pbla/1805948   

To learn more or to schedule a one-on-one meeting with management, please contact your conference representative or James@HaydenIR.com.

About SBP-101

SBP-101 is a proprietary polyamine analogue designed to induce polyamine metabolic inhibition (PMI) by exploiting an observed high affinity of the compound for pancreatic ductal adenocarcinoma and other tumors. The molecule has shown signals of tumor growth inhibition in clinical studies of US and Australian metastatic pancreatic cancer patients, demonstrating a median overall survival (OS) of 12.0 months which is not yet final, and an objective response rate (ORR) of 48%, both exceeding what is seen typically with the standard of care of gemcitabine + nab-paclitaxel suggesting potential complementary activity with the existing FDA-approved standard chemotherapy regimen. In data evaluated from clinical studies to date, SBP-101 has not shown exacerbation of bone marrow suppression and peripheral neuropathy, which can be chemotherapy-related adverse events. Serious visual adverse events have been evaluated and patients with a history of retinopathy or at risk of retinal detachment will be excluded from future SBP-101 studies. The safety data and PMI profile observed in the current Panbela sponsored clinical trial provides support for continued evaluation of SBP-101 in a randomized clinical trial. For more information, please visit 
https://clinicaltrials.gov/ct2/show/NCT03412799 .

About Panbela
Panbela Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing disruptive therapeutics for patients with urgent unmet medical needs. The company’s initial product candidate, SBP-101, is for the treatment of patients with metastatic pancreatic ductal adenocarcinoma, the most common type of pancreatic cancer and in December 2021 announced positive preclinical data supporting the activity of SBP-101 in ovarian cancer cell lines. In February of 2022 Panbela announced it had entered into a definitive agreement to acquire Cancer Prevention Pharmaceuticals, Inc. The combined entity will have an expanded pipeline addressing an estimated aggregate $5 billion market opportunity for the areas of initial focus: familial adenomatous polyposis (FAP), first-line metastatic pancreatic cancer, neoadjuvant pancreatic cancer, colorectal cancer prevention and ovarian cancer. Further information can be found at www.panbela.com. Panbela Therapeutics, Inc. common stock is listed on The Nasdaq Stock Market LLC under the symbol PBLA.

Cautionary Statement Regarding Forward-Looking Statements
This press release contains “forward-looking statements,” including within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as: “design,” “expect,” “may,” “plan,” “potential,” and “seek.” All statements other than statements of historical fact are statements that should be deemed forward-looking statements.  Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations, and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results and financial condition may differ materially and adversely from the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Important factors that could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statements include, among others, the following: ( i ) our ability to obtain additional funding to complete this randomized clinical trial; (ii) completion and success of our Phase 1 clinical trial; (iii) the impact of the current COVID-19 pandemic on our ability to initiate clinical sites and complete enrollment in this clinical trial; (iv) our ability to demonstrate the safety and effectiveness of our SBP-101 product candidate (v) our ability to obtain regulatory approvals for our SBP-101 product candidate in the United States, the European Union or other international markets; (vi) the market acceptance and level of future sales of our SBP-101 product candidate; (vii) the cost and delays in product development that may result from changes in regulatory oversight applicable to our SBP-101 product candidate; (viii) the rate of progress in establishing reimbursement arrangements with third-party payors; (ix) the effect of competing technological and market developments; (x) the costs involved in filing and prosecuting patent applications and enforcing or defending patent claims; and (xi) such other factors as discussed in Part I, Item 1A under the caption “Risk Factors” in our most recent Annual Report on Form 10-K, any additional risks presented in our Quarterly Reports on Form 10-Q and our Current Reports on Form 8-K. Any forward-looking statement made by us in this press release is based on information currently available to us and speaks only as of the date on which it is made. We undertake no obligation to publicly update any forward-looking statement or reasons why actual results would differ from those anticipated in any such forward-looking statement, whether written or oral, whether as a result of new information, future developments or otherwise.

Contact Information:

Investors:
James Carbonara
Hayden IR
(646) 755-7412
james@haydenir.com

Media:
Tammy Groene
Panbela Therapeutics, Inc.
(952) 479-1196 ext. 170
IR@panbela.com

FAQ

What date will Panbela Therapeutics participate in the Roth Conference?

Panbela Therapeutics will participate in the Roth Conference on March 14, 2022.

What is SBP-101 and what potential does it have?

SBP-101 is a proprietary therapy designed for treating metastatic pancreatic ductal adenocarcinoma, showing a median overall survival of 12 months and an objective response rate of 48%.

Where can I watch the Panbela Therapeutics Roth Conference webcast?

The webcast of the Panbela Therapeutics presentation at the Roth Conference can be accessed online.

What is the stock ticker symbol for Panbela Therapeutics?

The stock ticker symbol for Panbela Therapeutics is PBLA.

What significant data was announced about SBP-101?

SBP-101 showed signals of tumor growth inhibition in clinical studies, significantly exceeding results typically seen with standard chemotherapy.