STOCK TITAN

PANBELA THERAPEUTICS INC - PBLA STOCK NEWS

Welcome to our dedicated page for PANBELA THERAPEUTICS news (Ticker: PBLA), a resource for investors and traders seeking the latest updates and insights on PANBELA THERAPEUTICS stock.

Panbela Therapeutics, Inc. (NASDAQ: PBLA) is a clinical-stage biopharmaceutical company focused on developing innovative therapeutics to address unmet medical needs in cancer treatment and prevention. Headquartered in Minneapolis, Panbela's primary assets include Ivospemin (SBP-101) and Flynpovi.

Panbela's core business revolves around advancing its drug pipeline through clinical trials. The company has made significant strides in 2023 and early 2024, particularly with its Phase III ASPIRE trial, which targets untreated metastatic pancreatic ductal adenocarcinoma. This trial has surpassed 50% enrollment, bringing it closer to its goal of enrolling approximately 600 patients by Q1 2025. The recent approval of Onivyde in the same therapeutic area for the first time in over a decade augments Panbela's optimism regarding its interim analysis and potential for providing additional treatment options.

Financially, Panbela reported a net loss of $6.5 million in 2023's fourth quarter, with general and administrative expenses decreasing to $0.9 million. Research and development expenses rose to $6.1 million, reflecting the company's robust commitment to its clinical programs. As of December 31, 2023, Panbela had $2.6 million in cash and current assets totaling $3.1 million against current liabilities of $12.3 million. The completion of a public offering in January 2024 raised approximately $9 million in gross proceeds, bolstering the company's financial standing.

Panbela collaborates with renowned institutions like Johns Hopkins University School of Medicine, enhancing its research capabilities. The company's development programs encompass various cancers, including familial adenomatous polyposis (FAP), first-line metastatic pancreatic cancer, neoadjuvant pancreatic cancer, colorectal cancer prevention, ovarian cancer, and diabetes.

  • Ivospemin (SBP-101): This proprietary polyamine analogue aims to inhibit polyamine metabolism in pancreatic ductal adenocarcinoma and other tumors. Clinical studies have shown promising results, including a median overall survival of 14.6 months and an objective response rate of 48%, outperforming standard chemotherapy regimens. Ivospemin has not exacerbated chemotherapy-related adverse events, supporting its continued evaluation in the ASPIRE trial.
  • Flynpovi™: A combination of CPP-1X (eflornithine) and sulindac, Flynpovi inhibits polyamine synthesis and enhances polyamine catabolism. Phase III trials have demonstrated its efficacy in preventing precancerous sporadic adenomas and delaying surgical events in FAP patients. The safety profile of Flynpovi supports its ongoing evaluation.
  • CPP-1X (Eflornithine): Developed as a single agent for indications like gastric cancer prevention and recent onset Type 1 diabetes, CPP-1X has shown potential activity and tolerability in preclinical and early-phase trials.

Panbela's common stock is listed on the OTCQB market under the symbol “PBLA”. The company remains dedicated to advancing its clinical programs and maximizing stockholder value through strategic initiatives and potential regulatory approvals.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
1.05%
Tags
-
Rhea-AI Summary
Panbela Therapeutics, Inc. provides a business update and reports financial results for Q1 2023. Highlights include positive results for ivospemin in ovarian cancer, enrollment of first patient in diabetes study, regained rights for Flynpovi in patients with FAP, and new research agreements. Financially, the company had a decrease in general and administrative expenses and an increase in research and development expenses. Net loss in Q1 2023 was $5.1 million. Total cash was $5.2 million.
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-3.33%
Tags
-
Rhea-AI Summary

Panbela Therapeutics (Nasdaq: PBLA) announced a conference call scheduled for May 4, 2023, at 4:30 PM ET to discuss its Q1 2023 financial results. The call will include participation details and options for a replay. Panbela's pipeline features innovative therapies targeting urgent medical needs, including Ivospemin (SBP-101), which showed promising results in metastatic pancreatic cancer, achieving a median overall survival of 14.6 months and an objective response rate of 48%. Another product, Flynpovi, has demonstrated significant effectiveness in preventing pre-cancerous adenomas in Phase 3 trials. Despite these advancements, the company acknowledges potential risks concerning funding and regulatory approvals, which may impact future performance.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-9.87%
Tags
conferences earnings
Rhea-AI Summary

Panbela Therapeutics (Nasdaq: PBLA) presented results for ivospemin (SBP-101) at the AACR conference, demonstrating its potential in treating platinum-resistant ovarian cancer.

The study, in collaboration with Johns Hopkins University, shows that SBP-101 significantly improves survival rates when combined with chemotherapy agents like doxorubicin, gemcitabine, and topotecan. The addition of SBP-101 resulted in a 265% increase in median survival compared to untreated controls. Future plans include initiating a clinical trial program in ovarian cancer.

The ongoing research highlights SBP-101's unique ability to enhance chemotherapy effectiveness and aims to address urgent medical needs for ovarian cancer patients where treatment options are limited.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-13.69%
Tags
none
-
Rhea-AI Summary
Panbela Therapeutics announces enrollment of first patient in Phase II study for treatment of recent onset type 1 diabetes
Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
29.33%
Tags
none
-
Rhea-AI Summary

Panbela Therapeutics (Nasdaq: PBLA) announced the regained North American rights to develop and commercialize Flynpovi, a combination therapy for patients with familial adenomatous polyposis (FAP), following the termination of its licensing agreement with Cancer Prevention Pharmaceuticals. This allows Panbela to lead the global trial protocol and engage with the FDA and EMA for registration approval. The new trial will focus on FAP patients with intact lower gastrointestinal anatomy, building on the successful FAP-310 trial that showed a 100% risk reduction in surgery needs. With no approved drug therapies for FAP, Panbela aims to meet this urgent medical need, utilizing its internal expertise to design a compelling registration trial, seeking global market launch.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
4.84%
Tags
none
Rhea-AI Summary

Panbela Therapeutics (Nasdaq: PBLA) announced that an abstract about CPP-1X (Eflornithine) has been accepted for poster presentation at the upcoming Immunology of Diabetes Society (IDS) meeting from May 23-27, 2023. This study is part of a multi-site clinical trial led by Indiana University, with funding from JDRF. Panbela is providing the drug for free to researchers.

The poster presentation will focus on the inhibition of polyamine biosynthesis and its effects on β cell function in type 1 diabetes. Panbela’s product pipeline includes assets for treating several conditions, including pancreatic cancer and familial adenomatous polyposis. Notable developments include promising results for Ivospemin indicating a median overall survival of 14.6 months and an objective response rate of 48% in clinical trials.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
16.34%
Tags
none
-
Rhea-AI Summary

Panbela Therapeutics (Nasdaq: PBLA) announced that its abstract on CPP-1X (DFMO or Eflornithine) has been accepted for a poster presentation at the Endocrine Society meeting from June 15-18, 2023. The research is part of a multi-site clinical trial led by Indiana University School of Medicine, funded by JDRF. Panbela is providing the drug at no cost to researchers.

The poster presentation will explore the effects of Ornithine Decarboxylase deletion on preserving β-cell health in recent-onset Type 1 diabetes patients. The company’s pipeline includes other investigational drugs like Ivospemin (SBP-101) and Flynpovi, targeting conditions such as familial adenomatous polyposis and pancreatic cancer, showing promising outcomes in clinical studies.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
8.23%
Tags
none
-
Rhea-AI Summary

Panbela Therapeutics (Nasdaq: PBLA) announced a new research partnership with Johns Hopkins University School of Medicine on April 3, 2023. The collaboration aims to advance the development of ivospemin (SBP-101), focusing on its activity in ovarian cancer and other cancer types, along with potential combinations with existing therapies. This partnership will be co-led by esteemed researchers in polyamine biology. Notably, ivospemin has shown promising results with a median overall survival of 14.6 months in clinical studies. Panbela's pipeline includes ongoing trials for various cancers, positioning the company for future growth.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-5.43%
Tags
none
Rhea-AI Summary

Panbela Therapeutics (Nasdaq: PBLA) announced a new patent issue in Japan for its lead product SBP-101, developed in collaboration with Syngene International Ltd.. This patent, valid until 2039, details a novel process that reduces the number of synthetic steps from 17 to 6, enhancing manufacturing efficiency. The shorter synthesis not only allows for faster drug supply but also supports the company's global clinical programs. SBP-101 has shown promising results in clinical studies, including a median overall survival of 14.6 months in metastatic pancreatic cancer, indicating its potential impact on treatment regimens.

Rhea-AI Impact
Rhea-AI Sentiment
End-of-Day
-- %
Tags
none

FAQ

What is the current stock price of PANBELA THERAPEUTICS (PBLA)?

The current stock price of PANBELA THERAPEUTICS (PBLA) is $0.38 as of October 15, 2024.

What is the market cap of PANBELA THERAPEUTICS (PBLA)?

The market cap of PANBELA THERAPEUTICS (PBLA) is approximately 1.7M.

What is Panbela Therapeutics' primary focus?

Panbela Therapeutics is focused on developing innovative therapeutics for cancer treatment and prevention, addressing unmet medical needs.

What are Panbela's lead assets?

Panbela's lead assets include Ivospemin (SBP-101) and Flynpovi, both of which are in clinical trials targeting various types of cancer.

What is the status of the Phase III ASPIRE trial?

The Phase III ASPIRE trial for untreated metastatic pancreatic ductal adenocarcinoma has exceeded 50% enrollment, with full enrollment expected by Q1 2025.

What recent financial achievements has Panbela reported?

Panbela reported a net loss of $6.5 million for Q4 2023, with significant investments in research and development. The company raised approximately $9 million through a public offering in January 2024.

What collaborations does Panbela engage in?

Panbela collaborates with prestigious institutions like Johns Hopkins University School of Medicine to enhance its research and clinical trial capabilities.

What are the potential benefits of Ivospemin (SBP-101)?

Ivospemin has shown promising results in inhibiting tumor growth in pancreatic cancer, with a median overall survival of 14.6 months and an objective response rate of 48%.

What results have been observed with Flynpovi?

Flynpovi has demonstrated efficacy in preventing precancerous sporadic adenomas and delaying surgical events in FAP patients, with a supportive safety profile.

What is CPP-1X (Eflornithine) being developed for?

CPP-1X is being developed for several indications, including the prevention of gastric cancer and treating recent onset Type 1 diabetes.

Where is Panbela's stock listed?

Panbela's common stock is listed on the OTCQB market under the symbol 'PBLA'.

What is the significance of Panbela's recent public offering?

The recent public offering, which raised approximately $9 million, strengthens Panbela's financial position, enabling continued progress in its clinical programs.

PANBELA THERAPEUTICS INC

Nasdaq:PBLA

PBLA Rankings

PBLA Stock Data

1.70M
4.85M
0%
3.07%
Biotechnology
Healthcare
Link
United States of America
Waconia