Welcome to our dedicated page for Passage Bio news (Ticker: PASG), a resource for investors and traders seeking the latest updates and insights on Passage Bio stock.
Passage Bio, Inc. (NASDAQ: PASG) is a pioneering genetic medicines company dedicated to the development of transformative therapies for rare monogenic central nervous system (CNS) diseases. Leveraging cutting-edge gene therapy techniques, Passage Bio is advancing a robust pipeline aimed at addressing unmet medical needs in both pediatric and adult CNS disorders.
The company's key initiatives include the development of PBGM01 for infantile GM1 gangliosidosis, PBFT02 for frontotemporal dementia (FTD) caused by progranulin deficiency, and PBKR03 for infantile Krabbe disease. These therapies utilize proprietary adeno-associated virus (AAV) capsids to deliver functional genes directly to the brain and peripheral tissues, promising significant therapeutic benefits.
Passage Bio collaborates with leading institutions to bolster its research and development efforts. This includes a strategic research partnership with the University of Pennsylvania's Gene Therapy Program and a collaboration agreement with Catalent Maryland, Inc. Such alliances enhance Passage Bio's capacity to innovate and expedite the clinical development of its promising therapies.
Financially, Passage Bio is in a strong position, with a cash runway extending into the fourth quarter of 2025, allowing the company to diligently progress its clinical programs. Recent achievements include positive interim data from the Imagine-1 study, a Phase 1/2 clinical trial of PBGM01, demonstrating a favorable safety profile and initial evidence of efficacy in early and late infantile GM1 gangliosidosis.
Additionally, the company is making strides with PBFT02. Initial data from the upliFT-D clinical trial indicate promising safety and biomarker outcomes, showing elevated cerebrospinal fluid (CSF) progranulin levels. Such results underscore the potential of PBFT02 to address the underlying pathology of FTD and other neurodegenerative conditions.
Passage Bio is also committed to fostering the next generation of scientists through initiatives like the Tachi Yamada Scholarship program, which supports students in life sciences disciplines.
Passage Bio has announced its participation in the 19th Annual WORLD Symposium™ from February 22-26, 2023, in Orlando, Florida, where it will share updated interim data from the Phase 1/2 Imagine-1 study of PBGM01 for GM1 gangliosidosis. The presentations by Jeanine Jarnes, Pharm D., from the University of Minnesota, are scheduled for February 24, 2023, with the oral presentation at 2:00 p.m. ET and a poster session at 3:00 p.m. ET. PBGM01, a gene therapy using AAV technology, targets GM1 gangliosidosis, a rare lysosomal storage disorder affecting the CNS. The FDA has granted it several designations, including Fast Track and Orphan Drug.
On January 20, 2023, Passage Bio (Nasdaq: PASG) announced the granting of stock options to a new employee as an inducement for employment, in accordance with Nasdaq Listing Rule 5635(c)(4). The options, totaling 7,600 shares, have an exercise price of $1.67 per share, equal to its closing price on the grant date, January 17, 2023. These stock options will vest over four years, with 25% vesting on the first anniversary and the remainder in monthly installments thereafter. Passage Bio focuses on developing therapies for CNS disorders with ongoing clinical programs targeting conditions like GM1 gangliosidosis and frontotemporal dementia.
Passage Bio (NASDAQ: PASG) provided interim safety and biomarker results from its Phase 1/2 Imagine-1 clinical study of PBGM01 in pediatric patients with GM1 Gangliosidosis. The low and high doses of PBGM01 were well tolerated, with no serious adverse events reported. The therapy showed promising results, including dose-dependent increases in CSF β-Gal activity and decreases in GM1 gangliosides. Initial results from the completed dosing of Cohort 4 are expected by mid-2023, highlighting the ongoing development of this potential treatment.
Passage Bio, Inc. (NASDAQ: PASG) has provided updates on its clinical trials and financial results for Q3 2022. The company dosed the first patient in the final cohort of the Imagine-1 trial for GM1 gangliosidosis and the upliFT-D trial for frontotemporal dementia. While cash reserves were $213.8 million, R&D expenses decreased to $15.4 million, and G&A expenses dropped to $10.7 million. Despite a net loss of $26.7 million, the cash runway is extended into 2025. The company plans to present safety data in December 2022 and refocus on key trials.
Passage Bio (NASDAQ: PASG), a clinical-stage genetic medicines company, announced CEO William Chou will participate in a fireside chat at the Guggenheim 4th Annual Immunology & Neurology Day on November 15, 2022, at 10:10 a.m. ET in New York City. A live webcast will be accessible on their website, and a replay will be available for 30 days post-event. The company is focused on developing therapies for CNS disorders, with ongoing programs in GM1 gangliosidosis, Krabbe disease, and frontotemporal dementia, enhancing treatment access through its collaboration with the University of Pennsylvania.
Passage Bio (NASDAQ: PASG) will host a conference call on November 10, 2022, at 8:30 a.m. ET to discuss its third quarter 2022 financial results and recent business updates. The company focuses on genetic therapies for CNS disorders and is advancing three clinical programs targeting GM1 gangliosidosis, Krabbe disease, and frontotemporal dementia. Passage Bio collaborates with the University of Pennsylvania’s Gene Therapy Program for its research and development efforts. Archived webcasts will be available post-event for 30 days.
Passage Bio (Nasdaq: PASG) announced the appointment of Dr. William Chou as its new CEO, granting him inducement stock options for 665,500 shares at an exercise price of $1.32 per share. These options will vest over four years, with 25% vesting after the first year and the remainder in monthly installments. The company focuses on developing gene therapies for central nervous system disorders, including GM1 gangliosidosis and Krabbe disease, and has established a collaboration with the University of Pennsylvania's Gene Therapy Program.
Passage Bio (Nasdaq: PASG) has appointed Dr. William Chou as CEO, effective immediately. Dr. Chou, an experienced executive with a background in gene therapies, succeeds interim CEO Edgar Cale, who will remain as general counsel. The leadership change aims to enhance the company’s focus on developing transformative therapies for central nervous system disorders. Dr. Chou is expected to leverage his expertise to advance ongoing clinical programs and establish the company as a leader in genetic medicine.
Passage Bio (NASDAQ: PASG) announced that CFO Simona King will present at the Chardan Genetic Medicines Conference from October 3-4, 2022, in New York City. The presentation will be a fireside chat on October 3 at 1:00 p.m. ET, and it will be accessible via live webcast on their Investors & Media page. Passage Bio focuses on developing therapies for central nervous system disorders and is advancing multiple clinical programs aimed at conditions like GM1 gangliosidosis and Krabbe disease. More details can be found on their official website.
Passage Bio (Nasdaq: PASG) announced the grant of 54,000 stock options to new employees as part of their employment inducements. The options have an exercise price of $2.20 per share, matching the stock's closing price on August 15, 2022. Vesting occurs over four years, with 25% vesting after one year and the remainder in monthly installments. This move aligns with Nasdaq Listing Rule 5635(c)(4) and reflects Passage Bio's commitment to attracting talent in the competitive biotech sector.
FAQ
What is the current stock price of Passage Bio (PASG)?
What is the market cap of Passage Bio (PASG)?
What does Passage Bio, Inc. specialize in?
What are some of the key products in Passage Bio’s pipeline?
Who are Passage Bio’s key collaborators?
What is the focus of the Imagine-1 clinical study?
What recent advancements has Passage Bio made?
What is PBGM01?
What is the purpose of the Tachi Yamada Scholarship program?
When does Passage Bio expect to release additional data from their clinical trials?
What are the financial highlights of Passage Bio?
What is PBFT02 and what conditions does it target?
