Palisade Bio Receives Canadian Patent Covering Composition of Lead Program in Development, LB1148

Rhea-AI Summary

Palisade Bio, a biopharmaceutical company focused on gastrointestinal therapies, has received Canadian Patent No. 2,942,358 for LB1148, a serine protease inhibitor that may reduce intestinal damage by neutralizing digestive enzymes. This patent extends protection until 2035. The patent covers the composition of LB1148, which has shown promising results in clinical studies for reducing post-surgical abdominal adhesions and improving gastrointestinal function. Currently, LB1148 is undergoing a Phase 2 study to evaluate its effectiveness in subjects undergoing elective bowel resection, with topline data expected in Q2 2023. The CEO emphasized the importance of strengthening the intellectual property portfolio around LB1148 as part of their development strategy.

Positive

• Received Canadian Patent No. 2,942,358 for LB1148, extending protection until 2035.
• LB1148 has shown promise in reducing post-surgical abdominal adhesions.
• Ongoing Phase 2 study aims to improve gastrointestinal function, with data expected in Q2 2023.

Negative

• None.

Carlsbad, CA, April 06, 2023 (GLOBE NEWSWIRE) -- Palisade Bio, Inc. (Nasdaq: PALI) (the “Company”), a biopharmaceutical company advancing therapies for acute and chronic gastrointestinal (GI) complications, today announced that the Canadian Intellectual Property Office (CIPO) has issued Canadian Patent No. 2,942,358 titled, “Compositions for the Treatment of Autodigestion.” This key patent covers the composition of LB1148, the Company’s broad-spectrum serine protease inhibitor that acts to neutralize digestive enzymes, potentially reducing intestinal damage, until 2035.

“As we continue to execute on our development path forward for LB1148, strengthening the intellectual property portfolio around this asset remains a priority. We are pleased to receive this Patent, which further bolsters our growing IP estate for LB114,” commented J.D. Finley, interim Chief Executive Officer of Palisade Bio.

The allowed patent claims cover the proprietary composition LB1148. In clinical studies, LB1148 has demonstrated promising results in reducing the incidence and severity of post-surgical abdominal adhesions. LB1148 is currently being evaluated in a Phase 2 study for its effectiveness in reducing intra-abdominal adhesions, accelerating return of gastrointestinal function, and the prevention of post-operative ileus in subjects undergoing elective bowel resection (PROFILE). Palisade expects to report topline data from the 35 patients enrolled in the study in the second quarter of 2023.

About Palisade Bio

Palisade Bio is a biopharmaceutical company focused on developing therapeutics that protect the integrity of the intestinal barrier. The Company utilizes over three decades of research and established science that links the role of intestinal barrier biology and human disease to develop novel therapeutics that target and improve the integrity of the intestinal barrier.

The Company’s lead program, LB1148, is a broad-spectrum serine protease inhibitor that acts to neutralize digestive enzymes, potentially reducing intestinal damage. In clinical studies, LB1148 has demonstrated positive results in reducing the incidence and severity of post-surgical abdominal adhesions and potentially accelerating the time to return of postoperative bowel function. LB1148’s current Phase 2 study is evaluating its effectiveness in reducing intra-abdominal adhesions, accelerating return of gastrointestinal function, and the prevention of post-operative ileus in subjects undergoing elective bowel resection (PROFILE).

The Company believes that addressing the disruption of the intestinal barrier can fundamentally change the way diseases are treated and establish new standards of patient care. For more information, please go to www.palisadebio.com.

Forward Looking Statements

This communication contains “forward-looking” statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include statements regarding the Company’s intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things: progress of studies, including opening additional clinical trial sites, timing of results or data, progress and completion of patient enrollment, including timing thereof and the Company’s co-development partner’s expectation to complete enrollment; regulatory progress and strategy, including potential registration and commercialization of LB1148; the extent of the cash runway; the closing of the underwritten public offering; and expected proceeds from financings. Any statements contained in this communication that are not statements of historical fact may be deemed to be forward-looking statements. These forward-looking statements are based upon the Company’s current expectations. Forward-looking statements involve risks and uncertainties. The Company’s actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, the Company’s ability to advance its clinical programs, the uncertain and time-consuming regulatory approval process; the Company’s ability to achieve additional financing to fund future operations and the Company’s ability to comply with the continued listing requirements for Nasdaq. Additional risks and uncertainties can be found in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2021, filed with the Securities and Exchange Commission (“SEC”) on March 17, 2022, Quarterly Report on Form 10-Q for the quarter ended September 30, 2022, filed with the SEC on November 14, 2022, as well as discussions of potential risks, uncertainties, and other important factors in our subsequent filings with the Securities and Exchange Commission. These forward-looking statements speak only as of the date hereof and the Company expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in the Company’s expectations with regard thereto or any change in events, conditions or circumstances on which any such statements are based.

Investor Relations Contact
JTC Team, LLC
Jenene Thomas
833-475-8247
PALI@jtcir.com

Source: Palisade Bio

FAQ

What is the significance of the Canadian Patent No. 2,942,358 issued to Palisade Bio?

The patent protects LB1148, a serine protease inhibitor, until 2035, strengthening the company's intellectual property portfolio.

What are the clinical studies indicating about LB1148?

LB1148 has shown promising results in reducing the incidence and severity of post-surgical abdominal adhesions.

When will Palisade Bio report data from its Phase 2 study of LB1148?

Topline data from the ongoing Phase 2 study of LB1148 is expected to be reported in the second quarter of 2023.

What is LB1148 and its potential impact on gastrointestinal health?

LB1148 neutralizes digestive enzymes to potentially reduce intestinal damage and improve gastrointestinal function.