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PacBio Announces Fourth Quarter and Fiscal Year 2024 Financial Results

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PacBio (PACB) reported Q4 2024 financial results with revenue of $39.2 million, marking a 33% decrease from $58.4 million in the prior year. The quarter saw instrument revenue of $15.3 million, including 23 Revio® and 7 Vega™ systems, while consumables revenue remained flat at $18.8 million.

The company reported a GAAP net income of $3.6 million ($0.01 per share), compared to a loss of $82.0 million in Q4 2023, primarily due to a $154.4 million gain from debt restructuring. Non-GAAP net loss was $55.3 million. Cash position stood at $389.9 million, down from $631.4 million year-over-year.

Notable developments included the early launch of the Vega sequencing platform, implementation of SPRQ chemistry enabling sub-$500 genome sequencing, and a debt restructuring that reduced convertible notes by $259 million.

PacBio (PACB) ha riportato i risultati finanziari del quarto trimestre 2024, con un fatturato di 39,2 milioni di dollari, segnando una diminuzione del 33% rispetto ai 58,4 milioni di dollari dell'anno precedente. Nel trimestre, il fatturato degli strumenti è stato di 15,3 milioni di dollari, includendo 23 sistemi Revio® e 7 sistemi Vega™, mentre il fatturato dei consumabili è rimasto stabile a 18,8 milioni di dollari.

L'azienda ha riportato un utile netto GAAP di 3,6 milioni di dollari (0,01 dollari per azione), rispetto a una perdita di 82,0 milioni di dollari nel quarto trimestre 2023, principalmente a causa di un guadagno di 154,4 milioni di dollari dalla ristrutturazione del debito. La perdita netta non-GAAP è stata di 55,3 milioni di dollari. La posizione di cassa si è attestata a 389,9 milioni di dollari, in calo rispetto ai 631,4 milioni di dollari dell'anno precedente.

Sviluppi significativi hanno incluso il lancio anticipato della piattaforma di sequenziamento Vega, l'implementazione della chimica SPRQ che consente il sequenziamento del genoma a meno di 500 dollari e una ristrutturazione del debito che ha ridotto le note convertibili di 259 milioni di dollari.

PacBio (PACB) informó los resultados financieros del cuarto trimestre de 2024, con ingresos de 39,2 millones de dólares, lo que representa una disminución del 33% en comparación con los 58,4 millones de dólares del año anterior. En el trimestre, los ingresos por instrumentos fueron de 15,3 millones de dólares, incluyendo 23 sistemas Revio® y 7 sistemas Vega™, mientras que los ingresos por consumibles se mantuvieron estables en 18,8 millones de dólares.

La compañía reportó una ganancia neta GAAP de 3,6 millones de dólares (0,01 dólares por acción), en comparación con una pérdida de 82,0 millones de dólares en el cuarto trimestre de 2023, principalmente debido a una ganancia de 154,4 millones de dólares por la reestructuración de la deuda. La pérdida neta no-GAAP fue de 55,3 millones de dólares. La posición de efectivo se situó en 389,9 millones de dólares, por debajo de los 631,4 millones de dólares del año anterior.

Los desarrollos notables incluyeron el lanzamiento anticipado de la plataforma de secuenciación Vega, la implementación de la química SPRQ que permite la secuenciación del genoma por menos de 500 dólares y una reestructuración de la deuda que redujo las notas convertibles en 259 millones de dólares.

PacBio (PACB)는 2024년 4분기 재무 결과를 보고했으며, 수익은 3,920만 달러로 전년 5,840만 달러에 비해 33% 감소했습니다. 이번 분기에는 기기 수익이 1,530만 달러였으며, 여기에는 23개의 Revio® 시스템과 7개의 Vega™ 시스템이 포함되었고, 소모품 수익은 1,880만 달러로 변동이 없었습니다.

회사는 GAAP 순이익이 360만 달러(주당 0.01달러)라고 보고했으며, 이는 2023년 4분기에 8,200만 달러의 손실에 비해 개선된 수치로, 주로 1억 5,440만 달러의 부채 재구성으로 인한 이익 덕분입니다. 비GAAP 순손실은 5,530만 달러였습니다. 현금 보유액은 3억 8,990만 달러로, 전년 동기 6억 3,140만 달러에서 감소했습니다.

주요 발전 사항으로는 Vega 시퀀싱 플랫폼의 조기 출시, 500달러 이하의 유전체 시퀀싱을 가능하게 하는 SPRQ 화학물질의 구현, 그리고 2억 5,900만 달러의 전환사채를 감소시킨 부채 재구성이 포함되었습니다.

PacBio (PACB) a annoncé les résultats financiers du quatrième trimestre 2024, avec des revenus de 39,2 millions de dollars, marquant une diminution de 33 % par rapport à 58,4 millions de dollars l'année précédente. Au cours du trimestre, les revenus des instruments se sont élevés à 15,3 millions de dollars, comprenant 23 systèmes Revio® et 7 systèmes Vega™, tandis que les revenus des consommables sont restés stables à 18,8 millions de dollars.

L'entreprise a déclaré un revenu net GAAP de 3,6 millions de dollars (0,01 dollar par action), contre une perte de 82,0 millions de dollars au quatrième trimestre 2023, principalement en raison d'un gain de 154,4 millions de dollars provenant de la restructuration de la dette. La perte nette non-GAAP s'élevait à 55,3 millions de dollars. La position de trésorerie était de 389,9 millions de dollars, en baisse par rapport à 631,4 millions de dollars d'une année sur l'autre.

Les développements notables comprenaient le lancement anticipé de la plateforme de séquençage Vega, la mise en œuvre de la chimie SPRQ permettant le séquençage du génome à moins de 500 dollars, et une restructuration de la dette qui a réduit les billets convertibles de 259 millions de dollars.

PacBio (PACB) hat die finanziellen Ergebnisse für das vierte Quartal 2024 bekannt gegeben, mit Einnahmen von 39,2 Millionen Dollar, was einem Rückgang von 33% im Vergleich zu 58,4 Millionen Dollar im Vorjahr entspricht. Im Quartal betrugen die Einnahmen aus Geräten 15,3 Millionen Dollar, einschließlich 23 Revio®- und 7 Vega™-Systemen, während die Einnahmen aus Verbrauchsmaterialien stabil bei 18,8 Millionen Dollar blieben.

Das Unternehmen berichtete von einem GAAP-Nettoeinkommen von 3,6 Millionen Dollar (0,01 Dollar pro Aktie), verglichen mit einem Verlust von 82,0 Millionen Dollar im vierten Quartal 2023, hauptsächlich aufgrund eines Gewinns von 154,4 Millionen Dollar aus der Umstrukturierung von Schulden. Der Nettoverlust nach GAAP betrug 55,3 Millionen Dollar. Die Barposition belief sich auf 389,9 Millionen Dollar, ein Rückgang von 631,4 Millionen Dollar im Jahresvergleich.

Zu den bemerkenswerten Entwicklungen gehörten der vorzeitige Start der Vega-Sequenzierungsplattform, die Implementierung der SPRQ-Chemie zur Ermöglichung von Genomsequenzierungen unter 500 Dollar und eine Schuldenumstrukturierung, die die wandelbaren Anleihen um 259 Millionen Dollar reduzierte.

Positive
  • GAAP gross margin improved to 26% from 16% YoY
  • Non-GAAP operating expenses decreased to $68.6M from $88.4M YoY
  • Successful debt restructuring reduced convertible notes by $259M
  • Early launch of Vega sequencing platform
  • Introduction of SPRQ chemistry enabling sub-$500 genome sequencing
Negative
  • Revenue declined 33% YoY to $39.2M
  • Instrument revenue decreased 56% YoY to $15.3M
  • Cash position decreased to $389.9M from $631.4M YoY
  • $90.1M non-cash impairment charges for goodwill and R&D
  • Non-GAAP net loss of $55.3M

Insights

PacBio's Q4 2024 results paint a complex picture of a company in transition. The 33% revenue decline to $39.2 million reflects significant market headwinds, but several strategic developments suggest potential for future recovery.

The debt restructuring, which reduced outstanding convertible notes by $259 million, significantly improves the company's financial flexibility. While the $90.1 million goodwill impairment charge signals near-term challenges, the improved gross margins (GAAP: 26% vs. 16% YoY) and reduced non-GAAP operating expenses ($68.6 million vs. $88.4 million) demonstrate effective cost management.

Two key developments could drive future growth:

  • The SPRQ chemistry launch enables sub-$500 HiFi long-read human genome sequencing while reducing DNA input requirements by 75%, potentially expanding the addressable market significantly.
  • The Berry Genomics collaboration opens opportunities in the Chinese clinical market, particularly in prenatal and newborn screening.

However, the declining cash position ($389.9 million vs. $631.4 million YoY) and reduced instrument placements (23 Revio and 7 Vega systems) indicate continued market challenges. The company's ability to convert technological advantages into sustainable revenue growth while maintaining cost discipline will be important for 2025 performance.

MENLO PARK, Calif., Feb. 13, 2025 (GLOBE NEWSWIRE) -- PacBio (NASDAQ: PACB) today announced financial results for the quarter and fiscal year ended December 31, 2024.

Fourth quarter results

  • Revenue of $39.2 million, a 33% decrease compared with $58.4 million in the prior-year period.
  • Instrument revenue of $15.3 million compared with $35.1 million in the prior-year period. Instrument revenue in the fourth quarter of 2024 included 23 Revio® sequencing systems and 7 Vega™ sequencing systems.
  • Consumables revenue of $18.8 million compared with $18.9 million in the prior-year period.
  • Service and other revenue of $5.1 million compared with $4.4 million in the prior-year period.

Gross margin, operating expenses, net income (loss), and net income (loss) per share are reported on a GAAP and non-GAAP basis. The non-GAAP measures are described below and reconciled to the corresponding GAAP measures at the end of this release.

GAAP gross margin of 26% in the fourth quarter of 2024 compared to 16% for the fourth quarter of 2023. Non-GAAP gross margin of 31% in the fourth quarter of 2024 compared to 19% in the fourth quarter of 2023.

GAAP operating expenses totaled $161.9 million for the fourth quarter of 2024, compared to $97.1 million for the fourth quarter of 2023. Non-GAAP operating expenses totaled $68.6 million for the fourth quarter of 2024, compared to $88.4 million for the fourth quarter of 2023. GAAP and non-GAAP operating expenses for the fourth quarter of 2024 and the fourth quarter of 2023 included non-cash share-based compensation of $14.8 million and $15.4 million, respectively.  

Operating expenses, net income, and basic net income per share for the quarter ended December 31, 2024 include the impact of estimated preliminary non-cash impairment charges of approximately $90.1 million related to goodwill and in-process research and development. The impairments were driven by macroeconomic headwinds and a revised outlook on future cash flows, among other factors. These preliminary estimates are subject to finalization as the Company completes its interim assessment and year-end financial reporting procedures. The final impairment charges reported in the Annual Report on Form 10-K may differ materially from these estimates.

GAAP net income for the fourth quarter of 2024 was $3.6 million, compared to a GAAP net loss of $82.0 million for the fourth quarter of 2023. GAAP basic net income per share for the fourth quarter of 2024 was $0.01 compared to GAAP basic net loss per share of $0.31 for the fourth quarter of 2023. GAAP net income and GAAP basic net income per share for the quarter ended December 31, 2024 include a $154.4 million gain on debt restructuring in relation to our note exchange that closed on November 21, 2024. Non-GAAP net loss was $55.3 million for the fourth quarter of 2024, compared to $72.5 million for the fourth quarter of 2023. Non-GAAP basic net loss per share for the fourth quarter of 2024 was $0.20 compared to $0.27 for the fourth quarter of 2023.

Cash, cash equivalents, and investments, excluding restricted cash, at December 31, 2024, totaled $389.9 million, compared to $631.4 million at December 31, 2023.

Highlights since PacBio's last earnings release

  • Accelerated Launch of Vega: Commenced shipments of Vega, our benchtop sequencing platform, ahead of schedule—expanding access to HiFi long-read sequencing for a broader range of customers.
  • Clinical Collaboration with Berry Genomics: Delivered the first Vega systems as part of an early access agreement, supporting targeted assay development for prenatal health, carrier screening, and newborn screening programs in China and other markets. Additionally, Berry plans to obtain NMPA approval for its thalassemia carrier screening assay on existing PacBio technology.
  • Breakthrough in Cost and Efficiency with SPRQ Chemistry: Commenced shipment of SPRQ chemistry, enabling sub-$500 HiFi long-read human genome sequencing while reducing DNA input requirements by 75%, driving increased sample throughput and helped drive Revio instrument placements at new customers in the fourth quarter.
  • Strengthened Financial Position: Executed the convertible note exchange, reducing the outstanding principal balance of the convertible notes by $259 million by replacing $459 million in 1.5% convertible notes due 2028 with $200 million in new 1.5% convertible notes due August 2029, 20.5 million shares of common stock and $50 million in cash.
  • Scientific Leadership in Genetic Disease Research:
    • Radboud University Medical Center Study: Used Revio to identify 93% of pathogenic variants in samples that had been difficult to detect and required multiple testing modalities.
    • University of Washington & UDN Research: Demonstrated PacBio’s ability to simultaneously analyze the genome, methylome, epigenome, and transcriptome, providing novel insights into a rare and complex Mendelian condition.
  • Leadership Appointments:
    • Appointed David Ruggiero as Head of Global Sales and Service, bringing deep experience in sales leadership across technology and life sciences, including Zoom Video Communications, Microsoft Corporation, and Thermo Fisher Scientific.
    • Added Chris Smith, Chief Executive Officer of NeoGenomics, Inc., to the Board of Directors, leveraging his expertise in genomics, diagnostics, and corporate strategy to support PacBio’s growth initiatives.

"2024 was a challenging yet transformative year for PacBio, marked by the successful launch of new products, disciplined cost management, and strategic progress in our clinical strategy. Despite macroeconomic pressures, we have continued to innovate and expand accessibility to HiFi sequencing,” said Christian Henry, President and CEO of PacBio. "Looking ahead to 2025, while the macro environment remains uncertain, I believe PacBio can return to growth and expand market share as the Vega benchtop platform and SPRQ chemistry enable more researchers, clinical labs, and smaller institutions to harness the power of HiFi sequencing."

Quarterly Conference Call Information

Management will host a quarterly conference call to discuss its fourth quarter ended December 31, 2024 results today at 4:30 p.m. Eastern Time. Investors may listen to the call by dialing 1-888-349-0136 if outside the U.S., by dialing 1-412-317-0459, requesting to join the “PacBio Q4 Earnings Call". The call will be webcast live and available for replay at PacBio's website at https://investor.pacificbiosciences.com.

About PacBio

PacBio (NASDAQ: PACB) is a premier life science technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our products and technologies stem from two highly differentiated core technologies focused on accuracy, quality and completeness which include our HiFi long-read sequencing and our SBB® short-read sequencing technologies. Our products address solutions across a broad set of research applications including human germline sequencing, plant and animal sciences, infectious disease and microbiology, oncology, and other emerging applications. For more information, please visit www.pacb.com and follow @PacBio.

PacBio products are provided for Research Use Only. Not for use in diagnostic procedures.

Statement regarding use of non‐GAAP financial measures

PacBio reports non‐GAAP results for basic net income and loss per share, net income, net loss, gross margins, gross profit and operating expenses in addition to, and not as a substitute for, or because it believes that such information is superior to, financial measures calculated in accordance with GAAP. PacBio believes that non-GAAP financial information, when taken collectively, may be helpful to investors because it provides consistency and comparability with past financial performance. However, non-GAAP financial information is presented for supplemental informational purposes only, has limitations as an analytical tool and should not be considered in isolation or as a substitute for financial information presented in accordance with GAAP. In addition, other companies may calculate similarly titled non-GAAP measures differently or may use other measures to evaluate their performance, all of which could reduce the usefulness of PacBio’s non-GAAP financial measures as tools for comparison.

PacBio's financial measures under GAAP include substantial charges that are listed in the itemized reconciliations between GAAP and non‐GAAP financial measures included in this press release, such as impairment charges, merger-related expenses, changes in fair value of contingent consideration, loss on extinguishment of debt, gain on debt restructuring, amortization of acquired intangible assets, income tax benefits, restructuring costs and other adjustments and rounding differences. The amortization of acquired intangible assets excluded from GAAP financial measures relates to acquired intangible assets. The amortization related to these intangible assets will occur in future periods until they are fully amortized. Management has excluded the effects of these items in non‐GAAP measures to assist investors in analyzing and assessing past and future operating performance. In addition, management uses non-GAAP measures to compare PacBio’s performance relative to forecasts and strategic plans and to benchmark its performance externally against competitors.

PacBio encourages investors to carefully consider its results under GAAP, as well as its supplemental non‐GAAP information and the reconciliation between these presentations, to more fully understand its business. A reconciliation of PacBio’s non-GAAP financial measures to their most directly comparable financial measure stated in accordance with GAAP has been provided in the financial statement tables included in this press release.

Statement regarding preliminary financial results

This press release contains preliminary financial results which are unaudited and based on current expectations and may be adjusted as a result of, among other things, completion of annual audit procedures.

Forward-Looking Statements

This press release contains “forward-looking statements” within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and the U.S. Private Securities Litigation Reform Act of 1995. All statements other than statements of historical fact are forward-looking statements, including statements relating to the availability, uses, accuracy, coverage, advantages, quality or performance of, or benefits or expected benefits of using, PacBio products or technologies; expectations with respect to commercialization, development and shipment of PacBio products; PacBio’s financial guidance and expectations for future periods; the amounts of the preliminary estimated non-cash impairment charges; and developments affecting our industry and the markets in which we compete, including the impact of new products and technologies. Reported results and orders for any instrument system should not be considered an indication of future performance. You should not place undue reliance on forward-looking statements because they are subject to assumptions, risks, and uncertainties and could cause actual outcomes and results to differ materially from currently anticipated results, including, challenges inherent in developing, manufacturing, launching, marketing and selling new products, and achieving anticipated new sales; potential cancellation of existing instrument orders; assumptions, risks and uncertainties related to the ability to attract new customers and retain and grow sales from existing customers; risks related to PacBio's ability to successfully execute and realize the benefits of acquisitions; the impact of U.S. export restrictions on the shipment of PacBio products to certain countries; rapidly changing technologies and extensive competition in genomic sequencing; unanticipated increases in costs or expenses; interruptions or delays in the supply of components or materials for, or manufacturing of, PacBio products and products under development; potential product performance and quality issues and potential delays in development timelines; the possible loss of key employees, customers, or suppliers; customers and prospective customers curtailing or suspending activities using PacBio's products; third-party claims alleging infringement of patents and proprietary rights or seeking to invalidate PacBio's patents or proprietary rights; risks associated with international operations; other risks associated with general macroeconomic conditions and geopolitical instability; additional sustained declines in PacBio’s stock price and further changes in the timing of expected future cash flows; and adjustments arising in connection with the preparation and audit of PacBio’s financial statements as of and for the year ended December 31, 2024 resulting in changes to the amounts of the preliminary estimated non-cash impairment charges and other preliminary financial results presented in this press release. Additional factors that could materially affect actual results can be found in PacBio's most recent filings with the Securities and Exchange Commission, including PacBio's most recent reports on Forms 8-K, 10-K, and 10-Q, and include those listed under the caption “Risk Factors.” These forward-looking statements are based on current expectations and speak only as of the date hereof; except as required by law, PacBio disclaims any obligation to revise or update these forward-looking statements to reflect events or circumstances in the future, even if new information becomes available.

The unaudited condensed consolidated financial statements that follow should be read in conjunction with the notes set forth in PacBio's Annual Report on Form 10-K when filed with the Securities and Exchange Commission.

Contacts

Investors:

Todd Friedman
ir@pacb.com 

Media:
pr@pacb.com 


Pacific Biosciences of California, Inc.
Unaudited Condensed Consolidated Statements of Operations
  
 Three Months Ended
(in thousands, except per share amounts)December 31, 2024 September 30, 2024 December 31, 2023
Revenue:     
Product revenue$34,098  $35,296  $54,001 
Service and other revenue 5,126   4,671   4,356 
Total revenue 39,224   39,967   58,357 
Cost of Revenue:     
Cost of product revenue (1) 23,476   23,278   40,421 
Cost of service and other revenue 3,469   3,484   3,496 
Amortization of acquired intangible assets 2,221   3,201   1,433 
Loss on purchase commitment       3,436 
Total cost of revenue 29,166   29,963   48,786 
Gross profit 10,058   10,004   9,571 
Operating Expense:     
Research and development 27,466   25,516   44,544 
Sales, general and administrative (2) 41,641   43,746   45,996 
Impairment charges (3) 90,100       
Merger-related expenses (4)       63 
Change in fair value of contingent consideration (5) (1,950)  1,170   1,100 
Amortization of acquired intangible assets 4,629   3,649   5,416 
Total operating expense 161,886   74,081   97,119 
Operating loss (151,828)  (64,077)  (87,548)
Gain on debt restructuring (6) 154,407       
Interest expense (2,757)  (3,538)  (3,571)
Other income, net 4,065   6,890   8,383 
Income (loss) before income taxes 3,887   (60,725)  (82,736)
Income tax provision (benefit) (7) 316      (718)
Net income (loss) 3,571   (60,725)  (82,018)
      
Net income (loss) per share:     
Basic$0.01  $(0.22) $(0.31)
Diluted$(0.49) $(0.22) $(0.31)
      
Weighted average shares outstanding used in calculating ‎net income (loss) per share     
Basic 282,999   272,915   267,121 
Diluted 306,892   272,915   267,121 


(1)Balance for the three months ended September 30, 2024 includes restructuring costs. Refer to the Reconciliation of Non-GAAP Financial Measures table below for additional information on such costs and related amounts.
(2) Balances for the three months ended December 31, 2024 and September 30, 2024 include restructuring costs. Refer to the Reconciliation of Non-GAAP Financial Measures table below for additional information on such costs and related amounts.
(3)Preliminary estimated goodwill and in-process research and development impairment charges during the three months ended December 31, 2024 driven primarily by macroeconomic factors which have impacted our cash flow projections, among other factors.
(4)Merger-related expenses for the three months ended December 31, 2023 consisted of transaction costs arising from the acquisition of Apton.
(5)Change in fair value of contingent consideration during the three months ended December 31, 2024, September 30, 2024, and December 31, 2023 was due to fair value adjustments of milestone payments payable upon the achievement of the respective milestone event.
(6)Gain on debt restructuring during the three months ended December 31, 2024, represents the gain resulting from the November 2024 convertible notes exchange transaction.
(7)Deferred income tax benefits during the three months ended December 31, 2023 are related to the release of the valuation allowance for deferred tax assets due to the recognition of deferred tax liabilities in connection with the Apton acquisition.
  


Pacific Biosciences of California, Inc.
Unaudited Condensed Consolidated Statements of Operations
    
 Three Months Ended December 31, Twelve Months Ended December 31,
(in thousands, except per share amounts) 2024   2023   2024   2023 
Revenue:       
Product revenue$34,098  $54,001  $136,149  $183,872 
Service and other revenue 5,126   4,356   17,865   16,649 
Total revenue 39,224   58,357   154,014   200,521 
Cost of Revenue:       
Cost of product revenue(1) 23,476   40,421   92,284   127,568 
Cost of service and other revenue(1) 3,469   3,496   14,057   14,754 
Amortization of acquired intangible assets 2,221   1,433   9,393   1,983 
Loss on purchase commitment    3,436   998   3,436 
Total cost of revenue 29,166   48,786   116,732   147,741 
Gross profit 10,058   9,571   37,282   52,780 
Operating Expense:       
Research and development(1) 27,466   44,544   134,922   187,170 
Sales, general and administrative(2) 41,641   45,996   175,017   169,818 
Impairment charges(3) 90,100      183,300    
Merger-related expenses(4)    63      9,042 
Change in fair value of contingent consideration(5) (1,950)  1,100   (850)  15,060 
Amortization of acquired intangible assets 4,629   5,416   18,006   6,157 
Total operating expense 161,886   97,119   510,395   387,247 
Operating loss (151,828)  (87,548)  (473,113)  (334,467)
Loss on extinguishment of debt(6)          (2,033)
Gain on debt restructuring(7) 154,407      154,407    
Interest expense (2,757)  (3,571)  (13,412)  (14,343)
Other income, net 4,065   8,383   23,783   32,684 
Income (loss) before income taxes 3,887   (82,736)  (308,335)  (318,159)
Income tax provision (benefit)(8) 316   (718)  316   (11,424)
Net income (loss) 3,571   (82,018)  (308,651)  (306,735)
        
Net income (loss) per share:       
Basic$0.01  $(0.31) $(1.12) $(1.21)
Diluted$(0.49) $(0.31) $(1.58) $(1.21)
        
Weighted average shares outstanding used in calculating ‎net income (loss) per share       
Basic 282,999   267,121   274,488   253,629 
Diluted 306,892   267,121   288,366   253,629 


(1)Balance for the twelve months ended December 31, 2024 includes restructuring costs. Refer to the Reconciliation of Non-GAAP Financial Measures table below for additional information on such costs and related amounts.
(2)Balances for the three and twelve months ended December 31, 2024 include restructuring costs. Refer to the Reconciliation of Non-GAAP Financial Measures table below for additional information on such costs and related amounts.
(3)Preliminary estimated goodwill and in-process research and development impairment charges during the three and twelve months ended December 31, 2024 of $90.1 million was driven primarily by macroeconomic factors which have impacted our cash flow projections, among other factors. Goodwill impairment of $93.2 million included in the twelve months ended December 31, 2024 was related to a sustained decrease in the Company's share price, among other factors.
(4)Merger-related expenses for the three months ended December 31, 2023 consisted of transaction costs arising from the acquisition of Apton. Merger-related expenses for the twelve months ended December 31, 2023 consisted of $4.9 million of transaction costs arising from the acquisition of Apton, $2.8 million of compensation expense resulting from the liquidity event bonus plan in connection with the Apton merger, and $1.3 million of compensation expense resulting from the acceleration of certain equity awards in connection with the Apton merger.
(5)Change in fair value of contingent consideration during the three and twelve months ended December 31, 2024 and December 31, 2023 was due to fair value adjustments of milestone payments payable upon the achievement of the respective milestone event.
(6)Loss on extinguishment of debt during the twelve months ended December 31, 2023 is related to the exchange of a portion of PacBio's 1.50% Convertible Senior Notes due 2028 for PacBio's 1.375% Convertible Senior Notes due 2030.
(7)Gain on debt restructuring during the three and twelve months ended December 31, 2024, represents the gain resulting from the November 2024 convertible notes exchange transaction.
(8)Deferred income tax benefits during the three and twelve months ended December 31, 2023 are related to the release of the valuation allowance for deferred tax assets due to the recognition of deferred tax liabilities in connection with the Apton acquisition.
  


Pacific Biosciences of California, Inc.
Unaudited Condensed Consolidated Balance Sheets
     
(in thousands) December 31,
2024
 December 31,
2023
Assets    
Cash and investments $389,931 $631,416
Accounts receivable, net  27,524  36,615
Inventory, net  58,755  56,676
Prepaid and other current assets  18,781  17,040
Property and equipment, net  30,505  36,432
Operating lease right-of-use assets, net  16,091  32,593
Restricted cash  2,222  2,722
Intangible assets, net (1)  394,572  456,984
Goodwill (2)  313,961  462,261
Other long-term assets  9,305  13,274
Total Assets $1,261,647 $1,746,013
     
Liabilities and Stockholders' Equity    
Accounts payable $16,590 $15,062
Accrued expenses  22,595  45,708
Deferred revenue  19,764  21,872
Operating lease liabilities  24,940  41,197
Contingent consideration liability  18,700  19,550
Convertible senior notes, net  647,494  892,243
Other liabilities  3,770  9,077
Stockholders' equity  507,794  701,304
Total Liabilities and Stockholders' Equity $1,261,647 $1,746,013


(1)Balance as of December 31, 2024 reflects preliminary estimated in-process research and development impairment charge of $35.0 million These preliminary estimates are subject to finalization as the Company completes its interim assessment and year-end financial reporting procedures. The final Intangible assets, net, balance reported in the Annual Report on Form 10-K may differ materially from these estimates.
(2)Balance as of December 31, 2024 reflects preliminary estimated goodwill impairment charge of $55.1 million These preliminary estimates are subject to finalization as the Company completes its interim assessment and year-end financial reporting procedures. The final Goodwill balance reported in the Annual Report on Form 10-K may differ materially from these estimates.
  


Pacific Biosciences of California, Inc.
Reconciliation of Non-GAAP Financial Measures
     
  Three Months Ended Twelve Months Ended
(in thousands, except per share amounts) December 31,
2024
 September 30,
2024
 December 31,
2023
 December 31,
2024
 December 31,
2023
GAAP net income (loss) $3,571  $(60,725) $(82,018) $(308,651) $(306,735)
Impairment charges (1)  90,100         183,300    
Merger-related expenses (2)        63      9,042 
Change in fair value of contingent consideration (3)  (1,950)  1,170   1,100   (850)  15,060 
Loss on extinguishment of debt (4)              2,033 
Gain on debt restructuring (5)  (154,407)        (154,407)   
Amortization of acquired intangible assets  6,850   6,850   6,849   27,399   8,244 
Income tax benefit (6)        (718)     (11,424)
Restructuring (7)  493   6,701   2,224   25,222   2,224 
Non-GAAP net loss $(55,343) $(46,004) $(72,500) $(227,987) $(281,556)
           
GAAP basic net income (loss) per share $0.01  $(0.22) $(0.31) $(1.12) $(1.21)
Impairment charges (1)  0.32         0.67    
Merger-related expenses (2)              0.04 
Change in fair value of contingent consideration (3)  (0.01)           0.06 
Loss on extinguishment of debt (4)              0.01 
Gain on debt restructuring (5)  (0.55)        (0.56)   
Amortization of acquired intangible assets  0.02   0.03   0.03   0.10   0.03 
Income tax benefit (6)              (0.05)
Restructuring (7)     0.02   0.01   0.09   0.01 
Other adjustments and rounding differences  0.01         (0.01)   
Non-GAAP basic net loss per share $(0.20) $(0.17) $(0.27) $(0.83) $(1.11)
           
GAAP gross profit $10,058  $10,004  $9,571  $37,282  $52,780 
Amortization of acquired intangible assets  2,221   3,201   1,433   9,393   1,983 
Restructuring (7)     (207)  112   4,443   112 
Non-GAAP gross profit $12,279  $12,998  $11,116  $51,118  $54,875 
           
GAAP gross profit %  26%  25%  16%  24%  26%
           
Non-GAAP gross profit %  31%  33%  19%  33%  27%
           
GAAP total operating expense $161,886  $74,081  $97,119  $510,395  $387,247 
Impairment charges (1)  (90,100)        (183,300)   
Merger-related expenses (2)        (63)     (9,042)
Change in fair value of contingent consideration (3)  1,950   (1,170)  (1,100)  850   (15,060)
Amortization of acquired intangible assets  (4,629)  (3,649)  (5,416)  (18,006)  (6,261)
Restructuring (7)  (493)  (6,908)  (2,112)  (20,779)  (2,112)
Non-GAAP total operating expense $68,614  $62,354  $88,428  $289,160  $354,772 


(1)Preliminary estimated goodwill and in-process research and development impairment charges during the three and twelve months ended December 31, 2024 of $90.1 million was driven primarily by macroeconomic factors which have impacted our cash flow projections, among other factors. Goodwill impairment of $93.2 million included in the twelve months ended December 31, 2024 was related to a sustained decrease in the Company's share price, among other factors.
(2)Merger-related expenses for the three months ended December 31, 2023 consisted of transaction costs arising from the acquisition of Apton. Merger-related expenses for the twelve months ended December 31, 2023 consisted of $4.9 million of transaction costs arising from the acquisition of Apton, $2.8 million of compensation expense resulting from the liquidity event bonus plan in connection with the Apton merger, and $1.3 million of compensation expense resulting from the acceleration of certain equity awards in connection with the Apton merger.
(3)Change in fair value of contingent consideration was due to fair value adjustments of milestone payments payable upon the achievement of the respective milestone event.
(4)Loss on extinguishment of debt is related to the exchange of a portion of PacBio's 1.50% Convertible Senior Notes due 2028 for PacBio's 1.375% Convertible Senior Notes due 2030.
(5)Gain on debt restructuring during the three and twelve months ended December 31, 2024, represents the gain resulting from the November 2024 convertible notes exchange transaction.
(6)Deferred income tax benefits during the three and twelve months ended December 31, 2023 are related to the release of the valuation allowance for deferred tax assets due to the recognition of deferred tax liabilities in connection with the Apton acquisition.
(7)Restructuring costs consist primarily of employee separation costs, accelerated amortization and depreciation for right-of-use assets, leasehold improvements, and furniture and fixtures relating to the abandonment of the San Diego office, including charges for excess inventory due to a decrease in internal demand relating to the expense reduction initiatives.

FAQ

What caused PACB's 33% revenue decline in Q4 2024?

The revenue decline was primarily driven by lower instrument revenue, which decreased from $35.1M to $15.3M, attributed to macroeconomic headwinds and challenging market conditions.

How many Revio and Vega systems did PACB sell in Q4 2024?

PacBio sold 23 Revio sequencing systems and 7 Vega sequencing systems in Q4 2024.

What is the impact of PACB's debt restructuring in Q4 2024?

The debt restructuring reduced convertible notes by $259M, resulting in a $154.4M gain and strengthening the company's financial position.

What are the key features of PACB's new SPRQ chemistry?

SPRQ chemistry enables sub-$500 HiFi long-read human genome sequencing and reduces DNA input requirements by 75%, improving sample throughput.

How much cash does PACB have as of December 31, 2024?

PacBio reported $389.9M in cash, cash equivalents, and investments, excluding restricted cash, as of December 31, 2024.

Pacific Biosc

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Medical Devices
Laboratory Analytical Instruments
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