Outlook Therapeutics® Reports Financial Results for Second Quarter Fiscal Year 2024 and Provides Corporate Update
Outlook Therapeutics (Nasdaq: OTLK), a biopharmaceutical company focused on retinal disease treatments, announced its Q2 FY2024 financial results and provided a corporate update. The company reported a net loss of $114.3 million ($8.01 per share), up from $6.7 million ($0.52 per share) last year. Adjusted net loss was $22.1 million ($1.55 per share), influenced by warrant-related expenses. As of March 31, 2024, Outlook Therapeutics had $47.2 million in cash.
Key milestones include a CHMP positive opinion for ONS-5010 in the EU, UK MAA submission, NORSE EIGHT trial progress, and planned resubmission of the ONS-5010 BLA by end of CY2024. The company anticipates potential FDA approval and commercial launch of ONS-5010 in 2025.
Outlook Therapeutics hosted its inaugural quarterly update call on May 16, 2024, discussing these developments and future plans.
- CHMP positive opinion for ONS-5010 in EU.
- UK MAA submission for ONS-5010.
- NORSE EIGHT trial on schedule; topline readout expected in Q4 CY2024.
- Resubmission of ONS-5010 BLA planned by end of CY2024.
- Potential commercial launches in EU and UK in Q1 CY2025.
- Sufficient capital access to support FDA approval and commercial launch.
- 30% of subjects enrolled in NORSE EIGHT trial.
- Potential to commercialize ONS-5010 as first approved ophthalmic formulation of bevacizumab.
- Net loss of $114.3 million ($8.01 per share) in Q2 FY2024, compared to $6.7 million ($0.52 per share) last year.
- Adjusted net loss of $22.1 million ($1.55 per share).
- Significant warrant-related expenses impacting financials.
- Increased fair value expenses for warrant liability and convertible promissory notes.
Insights
The financial results for Outlook Therapeutics in Q2 FY2024 reveal a significant increase in net loss attributable to common stockholders, rising from
On the positive side, the company has managed to secure a healthy level of upfront gross proceeds from recent private placements, amounting to
However, the high adjusted net loss could be concerning for investors, particularly retail investors who might be wary of the company's current financial health. The substantial increase in losses year-over-year warrants close monitoring of how the company manages its capital and the progress of its regulatory approvals and commercialization plans.
For retail investors, understanding the distinction between net loss and adjusted net loss is important. The adjusted net loss strips out non-cash and one-time expenses, providing a clearer view of the company's operational performance.
The regulatory progress and clinical trial updates provide critical information for stakeholders. The positive opinion from the CHMP for ONS-5010 in the EU is a significant milestone, suggesting that the drug is on track for marketing authorization by the European Commission. This could lead to an initial ten years of market exclusivity, a substantial competitive advantage.
The NORSE EIGHT trial in the US, which is fully underway with over 30% of the required subjects enrolled, is another critical component. The trial's design as a non-inferiority study against ranibizumab focuses on a primary endpoint at 8 weeks, intending to meet FDA requirements for addressing previous deficiencies noted in the Complete Response Letter.
For retail investors, the key takeaway here is that successful regulatory approvals and trial results could position ONS-5010 as the first FDA, EMA and MHRA approved ophthalmic formulation of bevacizumab. This would significantly enhance its marketability and revenue potential.
From a market perspective, the planned commercialization strategies in the US and Europe are crucial. Should ONS-5010 gain approval, Outlook Therapeutics plans direct commercialization in the US, with potential partnerships in Europe and other regions. This dual approach could optimize market penetration and manage regional regulatory complexities more effectively.
The company's focus on addressing the retinal anti-VEGF space is particularly noteworthy given the growing prevalence of retinal diseases. By establishing ONS-5010 as the only approved ophthalmic formulation of bevacizumab, Outlook Therapeutics could capture significant market share, leveraging the existing clinical efficacy of bevacizumab for retinal treatments.
Retail investors should recognize that the company's strategic planning and market positioning, if successfully executed, will likely lead to substantial long-term growth. Nevertheless, the inherent risks associated with drug approvals and market entry strategies should not be overlooked.
- Positive opinion received from Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) for ONS-5010/LYTENAVA™ (bevacizumab gamma)
- United Kingdom (UK) Marketing Authorization Application (MAA) submitted
- NORSE EIGHT fully underway in the US; Topline readout expected in Q4 CY2024
- Resubmission of the ONS-5010 Biologics License Application (BLA) planned by the end of CY2024
- Company to host inaugural quarterly update conference call and webcast on Thursday, May 16th at 8:30 AM ET
ISELIN, N.J., May 15, 2024 (GLOBE NEWSWIRE) -- Outlook Therapeutics, Inc. (Nasdaq: OTLK), a biopharmaceutical company working to achieve regulatory approval for the first authorized use of an ophthalmic formulation of bevacizumab for the treatment of retinal diseases, today announced financial results for the second quarter of fiscal year 2024 and provided a corporate update. As previously announced, the Company will host its inaugural quarterly conference call and live audio webcast, on Thursday, May 16, 2024, at 8:30 AM ET (details below).
“We are extremely pleased with our corporate, clinical, and regulatory progress. On the regulatory front, we continue to drive toward anticipated marketing authorization of ONS-5010 in the EU and have also submitted our marketing application for authorization in the UK. In the US, we are executing on our NORSE EIGHT clinical trial and advancing toward a topline data readout expected in the fourth quarter of calendar year 2024. On the financial front, assuming full exercise of the warrants issued in our recent private placement transactions, we believe we now have access to sufficient capital to take ONS-5010 through potential FDA approval and funding of the commercial launch,” commented Russell Trenary, President and Chief Executive Officer of Outlook Therapeutics. “We remain steadfast in our mission to enhance the standard of care in the retinal anti-VEGF space. On behalf of the entire team, I would like to thank all our partners and stakeholders for their continued support and look forward to what we believe will be an exciting remainder of the year for Outlook Therapeutics.”
Lawrence Kenyon, Chief Financial Officer of Outlook Therapeutics, added, “Our adjusted financial results for the quarter met our expectations as we initiated the NORSE EIGHT clinical trial and began enrolling patients. We believe we are well positioned financially to continue executing on NORSE EIGHT enrollment, resubmission of the ONS-5010 BLA by the end of calendar 2024, and launch of ONS 5010 in 2025, if approved.”
Upcoming Anticipated Milestones
- MAA decision in the European Union (EU) for ONS-5010 anticipated in Q2 CY2024;
- Full enrollment of NORSE EIGHT clinical trial in the US expected in Q3 CY2024;
- Topline readout of NORSE EIGHT clinical trial planned in Q4 CY2024;
- Resubmission of the ONS-5010 BLA targeted for the end of CY2024;
- Planning underway for potential commercial launches in the EU and UK to begin in first quarter of CY2025; and
- Potential for US FDA approval of ONS-5010 in 2025.
ONS-5010 / LYTENAVA™ (bevacizumab-vikg) Regulatory Update
As previously announced, following Type A meetings with the FDA in Q4 CY2023, the FDA informed Outlook Therapeutics that it can conduct a non-inferiority study evaluating ONS-5010 versus ranibizumab in a 3-month study of treatment naïve patients with a primary efficacy endpoint at 2 months (NORSE EIGHT). In January 2024, Outlook Therapeutics announced that it received written agreement on the NORSE EIGHT trial protocol and statistical analysis plan from the FDA under a SPA for NORSE EIGHT. The SPA also confirms in writing that if the NORSE EIGHT trial is successful, it would satisfy the FDA’s requirement for a second adequate and well-controlled clinical trial to fully address the clinical deficiency identified in the Complete Response Letter (CRL). In addition, through a Type A meeting and additional interactions, Outlook Therapeutics has identified the approaches needed to resolve the Chemistry, Manufacturing and Controls (CMC) comments in the CRL. Outlook Therapeutics has scheduled a series of Type C and Type D meetings with the FDA to address the open CMC items in the CRL and expects to resolve these comments prior to the expected completion of NORSE EIGHT.
NORSE EIGHT is a randomized, controlled, parallel-group, masked, non-inferiority study of approximately 400 newly diagnosed, wet age-related macular degeneration (wet AMD) subjects randomized in a 1:1 ratio to receive 1.25 mg ONS-5010 or 0.5 mg ranibizumab intravitreal injections. Subjects will receive injections at Day 0 (randomization), Week 4, and Week 8 visits. The primary endpoint is mean change in BCVA from baseline to week 8. Currently, over
In March 2024, the CHMP issued a positive opinion concerning the EU Marketing Authorization Application (MAA) of ONS-5010/LYTENAVA™ (bevacizumab gamma), an investigational ophthalmic formulation of bevacizumab for the treatment of wet AMD in the EU. The CHMP positive opinion was based on results from Outlook Therapeutics’ wet AMD clinical program for ONS-5010, which consists of three completed registration clinical trials - NORSE ONE, NORSE TWO and NORSE THREE, as well as studies and peer reviewed literature substituting or supporting certain tests and studies.
This positive opinion supports the grant of marketing authorization by the European Commission for Outlook Therapeutics’ application for ONS-5010 in the EU. The European Commission is expected to make a decision on approval within approximately 67 days following the CHMP opinion. The decision will apply automatically in all 27 EU Member States, and, within 30 days, also to Iceland, Norway and Liechtenstein. If approved, an initial ten years of market exclusivity in the EU is expected for ONS-5010/LYTENAVA™.
Additionally, the Company recently announced the submission of its MAA to the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK seeking authorization of ONS-5010/LYTENAVA™ (bevacizumab gamma) for the treatment of wet AMD. The submission was completed under the new International Recognition Procedure (IRP), which allows the MHRA to rely on a positive opinion by the CHMP concerning an application for grant of marketing authorization for the same product in the EU. The IRP is available for new UK MAAs of a medicinal product (having the same qualitative and quantitative composition, and the same pharmaceutical form) that has previously been authorized by a Reference Regulator (RR). In this case this is the EMA.
If ONS-5010/LYTENAVA™ (bevacizumab-vikg or bevacizumab gamma) is approved, Outlook Therapeutics expects to commercialize it as the first and only European Commission, MHRA or FDA approved ophthalmic formulation of bevacizumab for use in treating retinal diseases in the EU, UK, and United States. Authorization may also be sought in other European markets, Japan, and elsewhere. If approved, Outlook Therapeutics plans to commercialize ONS-5010/LYTENAVA™ (bevacizumab-vikg) directly in the US and is assessing both direct commercialization and partnering for ONS-5010/LYTENAVA™ (bevacizumab gamma) in Europe and other regions outside of the US.
Financial Highlights for the Fiscal Second Quarter Ended March 31, 2024
For the fiscal second quarter ended March 31, 2024, Outlook Therapeutics reported a net loss attributable to common stockholders of
Adjusted net loss attributable to common stockholders for the fiscal second quarter ended March 31, 2024 includes
In March and April 2024, the Company closed its previously announced private placements of common stock and accompanying warrants. In addition to the upfront gross proceeds of
As of March 31, 2024, Outlook Therapeutics had cash and cash equivalents of
Conference Call and Webcast
Outlook Therapeutics management will host its inaugural quarterly conference call and live audio webcast for investors, analysts, and other interested parties on Thursday, May 16, 2024 at 8:30 AM ET.
Interested participants and investors may access the conference call by dialing (877) 407-8291 (domestic) or (201) 689-8345 (international) and referencing the Outlook Therapeutics Conference Call. The live webcast will be accessible on the Events page of the Investors section of the Outlook Therapeutics website, outlooktherapeutics.com, and will be archived for 90 days.
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1 Adjusted net loss attributable to common stockholders and adjusted net loss attributable to common stockholders per share of common stock – basic and diluted are non-U.S. GAAP financial measures. See “Non-GAAP Financial Measures” below.
About ONS-5010 / LYTENAVA™ (bevacizumab-vikg, bevacizumab gamma)
ONS-5010/LYTENAVA™ is an investigational ophthalmic formulation of bevacizumab under development as an intravitreal injection for the treatment of wet AMD and other retinal diseases. Because no FDA or European Commission approved ophthalmic formulations of bevacizumab are currently available, clinicians wishing to treat retinal patients with bevacizumab have had to use repackaged IV bevacizumab authorized for a different therapeutic indication and provided by compounding pharmacies—products that have known risks of contamination and inconsistent potency and availability. If approved, ONS-5010/LYTENAVA™ would provide an authorized option for physicians to treat wet AMD in the United States, EU and the UK.
Bevacizumab-vikg (bevacizumab gamma in the EU and UK) is a recombinant humanized monoclonal antibody (mAb) that selectively binds with high affinity to all isoforms of human vascular endothelial growth factor (VEGF) and neutralizes VEGF’s biologic activity through a steric blocking of the binding of VEGF to its receptors Flt-1 (VEGFR-1) and KDR (VEGFR-2) on the surface of endothelial cells. Following intravitreal injection, the binding of bevacizumab to VEGF prevents the interaction of VEGF with its receptors on the surface of endothelial cells, reducing endothelial cell proliferation, vascular leakage, and new blood vessel formation in the retina.
About Outlook Therapeutics, Inc.
Outlook Therapeutics is a biopharmaceutical company working to achieve FDA, European Commission and MHRA approval for the launch of ONS-5010/LYTENAVA™ (bevacizumab-vikg or bevacizumab gamma) as the first approved ophthalmic formulation of bevacizumab for use in retinal indications, including wet AMD, DME and BRVO. If ONS-5010/LYTENAVA™ is approved, Outlook Therapeutics expects to commercialize it as the first and only European Commission, MHRA or FDA approved ophthalmic formulation of bevacizumab for use in treating retinal diseases in the United States, EU, and UK. Authorization may also be sought in other European markets, Japan, and other markets. As part of the Outlook Therapeutics multi-year commercial planning process, Outlook Therapeutics and Cencora have entered into a strategic commercialization agreement to expand Outlook Therapeutics’ reach for connecting to retina specialists and their patients. Cencora will provide third-party logistics (3PL) services and distribution, as well as pharmacovigilance services and other services in the United States, EU and UK.
Non-GAAP Financial Measures
Outlook Therapeutics prepares its consolidated financial statements in conformity with accounting principles generally accepted in the United States of America (U.S. GAAP) and pursuant to accounting requirements of the Securities and Exchange Commission (SEC). In an effort to provide investors with additional information regarding the results and to provide a meaningful period-over-period comparison of Outlook Therapeutics’ financial performance, Outlook Therapeutics sometimes uses non-U.S. GAAP financial measures (NGFM) as defined by the SEC. In this press release, Outlook Therapeutics uses “adjusted net loss attributable to common stockholders,” which is defined as net loss attributable to common stockholders excluding warrant related expenses (i.e., the excess of the fair value of the warrants upon issuance over the proceeds of the private placement that closed on March 18, 2024) and changes in fair value of warrants and convertible promissory notes, as well as “adjusted net loss attributable to common stockholders per share of common stock – basic and diluted,” which is defined as net loss attributable to common stockholders per share of common stock – basic and diluted excluding warrant related expenses and changes in fair value of warrants and convertible promissory notes. Management uses these NGFMs because they adjust for certain non-cash items that impact financial results but not cash flows and that management believes are not related to its core business. Management uses these NGFMs to evaluate Outlook Therapeutics financial performance against internal budgets and targets. Management believes that these NGFMs are useful for evaluating Outlook Therapeutics’ core operating results and facilitating comparison across reporting periods. Outlook Therapeutics believes these NGFMs should be considered in addition to, and not in lieu of, GAAP financial measures. Outlook Therapeutics’ NGFMs may be different from the same NGFMs used by other companies. Reconciliations to the closest U.S. GAAP financial measures are provided in the tables below.
Forward-Looking Statements
This press release contains forward-looking statements. All statements other than statements of historical facts are “forward-looking statements,” including those relating to future events. In some cases, you can identify forward-looking statements by terminology such as “anticipate,” “believe,” “continue,” “expect,” “may,” “plan,” “potential,” “target,” “will,” or “would” the negative of terms like these or other comparable terminology, and other words or terms of similar meaning. These include, among others, expectations concerning decisions of regulatory bodies, including the European Commission, the MHRA and the FDA, and the timing thereof, expectations concerning Outlook Therapeutics’ ability to remediate or otherwise resolve deficiencies identified in the CRL issued by the FDA, including with respect to an additional clinical trial and CMC issues, expectations concerning NORSE EIGHT enrollment, the timing for completion of NORSE EIGHT and resubmission of the BLA for ONS-5010, the expected proceeds from the full exercise of warrants issued in recent private placement transactions, the sufficiency of Outlook Therapeutics’ resources, including funds from the full exercise of the warrants, to fund its operations through various milestones, ONS-5010’s potential as the first and only European Commission, MHRA or FDA-approved ophthalmic formulation of bevacizumab for use in treating retinal diseases in the EU, UK, and United States, plans for potential commercial launch of ONS-5010, expectations concerning the relationship with Cencora and the benefits and potential expansion thereof, and other statements that are not historical fact. Although Outlook Therapeutics believes that it has a reasonable basis for the forward-looking statements contained herein, they are based on current expectations about future events affecting Outlook Therapeutics and are subject to risks, uncertainties and factors relating to its operations and business environment, all of which are difficult to predict and many of which are beyond its control. These risk factors include those risks associated with developing pharmaceutical product candidates, risks of conducting clinical trials and risks in obtaining necessary regulatory approvals, the content and timing of decisions by the European Commission, MHRA and FDA, as well as those risks detailed in Outlook Therapeutics’ filings with the Securities and Exchange Commission (the SEC), including the Annual Report on Form 10-K for the fiscal year ended September 30, 2023, filed with the SEC on December 22, 2023, and future quarterly reports Outlook Therapeutics files with the SEC, which include uncertainty of market conditions and future impacts related to macroeconomic factors, including as a result of the ongoing overseas conflicts, high interest rates, inflation and potential future bank failures on the global business environment. These risks may cause actual results to differ materially from those expressed or implied by forward-looking statements in this press release. All forward-looking statements included in this press release are expressly qualified in their entirety by the foregoing cautionary statements. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Outlook Therapeutics does not undertake any obligation to update, amend or clarify these forward-looking statements whether as a result of new information, future events or otherwise, except as may be required under applicable securities law.
Investor Inquiries:
Jenene Thomas
Chief Executive Officer
JTC Team, LLC
T: 833.475.8247
OTLK@jtcir.com
| Outlook Therapeutics, Inc. | |||||||||||||||
| Consolidated Statements of Operations | |||||||||||||||
| (Amounts in thousands, except per share data) | |||||||||||||||
| Three months ended March 31, | Six months ended March 31, | ||||||||||||||
| 2024 | 2023 | 2024 | 2023 | ||||||||||||
| Operating expenses: | |||||||||||||||
| Research and development | $ | 13,509 | $ | 545 | $ | 18,038 | $ | 10,407 | |||||||
| General and administrative | 5,431 | 6,293 | 11,225 | 12,119 | |||||||||||
| 18,940 | 6,838 | - | 29,263 | - | 22,526 | ||||||||||
| Loss from operations | (18,940 | ) | (6,838 | ) | (29,263 | ) | (22,526 | ) | |||||||
| Income on equity method investment | 30 | 17 | 28 | (5 | ) | ||||||||||
| Interest (income) expense, net | 3,084 | (188 | ) | 2,895 | 2,261 | ||||||||||
| Loss on extinguishment of debt | — | — | — | 578 | |||||||||||
| Change in fair value of promissory notes | 8,519 | 3 | 9,512 | 3 | |||||||||||
| Warrant related expenses | 34,098 | — | 34,098 | — | |||||||||||
| Change in fair value of warrant liability | 49,615 | (19 | ) | 49,668 | (49 | ) | |||||||||
| Loss before income taxes | (114,286 | ) | (6,651 | ) | (125,464 | ) | (25,314 | ) | |||||||
| Income tax expense | 3 | 3 | 3 | 3 | |||||||||||
| Net loss attributable to common stockholders | $ | (114,289 | ) | $ | (6,654 | ) | $ | (125,467 | ) | $ | (25,317 | ) | |||
| Per share information: | |||||||||||||||
| Net loss per share of common stock, basic and diluted | $ | (8.01 | ) | $ | (0.52 | ) | $ | (9.20 | ) | $ | (2.09 | ) | |||
| Weighted average shares outstanding, basic and diluted | 14,270 | 12,833 | 13,638 | 12,094 | |||||||||||
| Consolidated Balance Sheet Data | |||||||
| (Amounts in thousands) | |||||||
| March 31, 2024 | September 30, 2023 | ||||||
| Cash and cash equivalents | $ | 47,229 | $ | 23,392 | |||
| Total assets | $ | 59,029 | $ | 32,301 | |||
| Current liabilities | $ | 54,080 | $ | 46,732 | |||
| Total stockholders' deficit | $ | (134,236 | ) | $ | (14,438 | ) | |
| Reconciliation Between Reported Net Loss (GAAP) and Adjusted Net Loss (Non-GAAP), in each case | |||||||||||||||
| Attributable to Common Stockholders | |||||||||||||||
| (Amounts in thousands, except per share data) | |||||||||||||||
| Three months ended March 31, | Six months ended March 31, | ||||||||||||||
| 2024 | 2023 | 2024 | 2023 | ||||||||||||
| Net loss attributable to common stockholders, as reported (GAAP) | $ | (114,289 | ) | $ | (6,654 | ) | $ | (125,467 | ) | $ | (25,317 | ) | |||
| Adjustments for reconciled items: | |||||||||||||||
| Warrant related expenses | 34,098 | — | 34,098 | — | |||||||||||
| Change in fair value of warrant liability | 49,615 | (19 | ) | 49,668 | (49 | ) | |||||||||
| Change in fair value of promissory notes | 8,519 | 3 | 9,512 | 3 | |||||||||||
| Adjusted net loss attributable to common stockholders (non-GAAP) | $ | (22,057 | ) | $ | (6,670 | ) | $ | (32,189 | ) | $ | (25,363 | ) | |||
| Net loss attributable to common stockholders per share of common stock - basic and diluted, as reported (GAAP) | $ | (8.01 | ) | $ | (0.52 | ) | $ | (9.20 | ) | $ | (2.09 | ) | |||
| Adjustments for reconciled items: | |||||||||||||||
| Warrant related expenses | 2.39 | — | 2.50 | — | |||||||||||
| Change in fair value of warrant liability | 3.48 | — | 3.64 | (0.01 | ) | ||||||||||
| Change in fair value of promissory notes | 0.59 | — | 0.70 | — | |||||||||||
| Adjusted net loss attributable to common stockholders per share of common stock - basic and diluted (non-GAAP) | $ | (1.55 | ) | $ | (0.52 | ) | $ | (2.36 | ) | $ | (2.10 | ) | |||
FAQ
What were Outlook Therapeutics' Q2 FY2024 financial results?
What is the status of the ONS-5010 marketing authorization in the EU?
What is the progress of the NORSE EIGHT clinical trial in the US?
When is the resubmission of the ONS-5010 BLA planned?
What is the potential timeline for ONS-5010's FDA approval and commercial launch?
How much cash did Outlook Therapeutics have as of March 31, 2024?
What upcoming milestones are expected for ONS-5010?
