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Vaximm AG, an OSR Holdings subsidiary, has announced final data from its Phase 2a clinical trial evaluating VXM01 in combination with avelumab for recurrent glioblastoma (GBM) treatment. The trial demonstrated:
- Good safety profile with mostly mild to moderate events
- 12.0% objective response rate in non-resected patients
- Median overall survival of 11.1 months
- Median time to progression of 2.7 months
The study (n=25) showed promising results compared to typical GBM prognosis. No serious adverse events were attributed to VXM01, while 81.8% were related to the disease itself. In resected patients, overall survival ranged from 2.2 to 46.5 months. The trial identified potential biomarkers for VXM01-mediated tumor response, supporting further investigation of the treatment combination.
OSR Holdings (NASDAQ: OSRH) has appointed Dr. Constance Höfer as its new Chief Scientific Officer (CSO). Dr. Höfer brings over 20 years of experience in drug development, specializing in oncology and immunology. She previously held leadership positions at Merck Healthcare, where she led global programs from preclinical to late-stage clinical development.
Dr. Höfer's extensive background includes senior roles at Sandoz Biopharmaceuticals, Priaxon AG, and Medigene AG, where she advanced therapeutic programs across various modalities including NBEs, NCEs, nucleotides, and viral and cell-based therapies. She holds a PhD in Pharmacology from the University of Newcastle and has expertise in clinical pharmacology and translational medicine.
The appointment aims to strengthen OSR Holdings' R&D capabilities and accelerate the development of breakthrough therapies. Dr. Höfer will oversee the company's scientific strategy, innovation pipeline, and focus on expanding its footprint in oncology and immunology.
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