Oncternal Therapeutics Participating in Oppenheimer & Co.’s Virtual Fireside Chat: Discussion of ROR1 CAR T Cell Therapy in Hematological Malignancies and Solid Tumors

Rhea-AI Summary

Oncternal Therapeutics, Inc. (Nasdaq: ONCT) is hosting a Virtual Fireside Chat on April 18, 2023, at 1:30 PM EDT, focused on ROR1 CAR-T Cell Therapy for hematological malignancies and solid tumors. Moderated by Oppenheimer's Hartaj Singh, the discussion features key opinion leaders, including Dr. Michael Wang and Dr. Angela Shen, alongside Oncternal's CEO, Dr. James Breitmeyer. This event will highlight Oncternal's investigational CAR-T therapy, ONCT-808, which targets ROR1 and demonstrates preclinical success against several cancers. The company is advancing its development pipeline for treatments addressing critical unmet medical needs in oncology, particularly in aggressive B-cell lymphoma and prostate cancer.

Positive

• ONCT-808 shows preclinical activity against hematological malignancies and solid tumors.
• A robust manufacturing process could reduce patient wait times for CAR T products.
• Final IND-enabling studies for ONCT-534 have been completed.

Negative

• None.

SAN DIEGO, April 13, 2023 (GLOBE NEWSWIRE) -- Oncternal Therapeutics, Inc. (Nasdaq: ONCT), a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies, today announced that two key industry opinion leaders and management will participate in Oppenheimer & Co.’s Virtual Fireside Chat: Discussion of ROR1 CAR-T Cell Therapy in Hematological Malignancies and Solid Tumors on Tuesday, April 18, 2023 at 1:30 p.m. EDT.

Oppenheimer & Co. Senior Research Biotech Analyst, Hartaj Singh, will moderate a discussion with:

• Michael Wang, M.D., Endowed Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center
• Angela Shen, M.D, Ph.D., Associate Professor, Medicine, Harvard Medical School Director of Cellular Immunotherapy, Cancer Center, Massachusetts General Hospital
• James Breitmeyer, M.D, Ph.D., Oncternal’s President and Chief Executive Officer
  

Please contact your Oppenheimer & Co. institutional salesperson to participate in the call. Links to the replay will be accessible on the Events & Presentations page of the Investors section on the Company’s website at investor.oncternal.com, for at least 30 days after the event.

About Oncternal Therapeutics
Oncternal Therapeutics is a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies for the treatment of patients with cancers that have critical unmet medical need. Oncternal pursues drug development targeting promising, yet untapped biological pathways implicated in cancer generation or progression, focusing on hematological malignancies and prostate cancer. ONCT-808 is an investigational autologous chimeric antigen receptor T (CAR T) cell therapy that targets Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) using the binding domain from zilovertamab. ONCT-808 has demonstrated activity in preclinical models against multiple hematological malignancies and solid tumors and has been shown to be specific for cancer cells expressing ROR1. Oncternal has developed a robust and reproducible manufacturing process that has the potential to reduce the time patients must wait for their individual CAR T product to be produced, compared with approved CAR T products. Oncternal has initiated Study ONCT-808-101 (NCT05588440) for the treatment of patients with relapsed or refractory aggressive B-cell lymphoma, including patients who have failed previous CD19 CAR T treatment. ONCT-534 is a dual-action androgen receptor inhibitor (DAARI) with preclinical activity in prostate cancer models against both unmutated androgen receptor (AR), and against multiple forms of AR mutation. It is a potential treatment for patients with mCRPC and unmet medical need because of resistance to androgen receptor inhibitors, including those with AR amplification, mutations in the AR ligand binding domain (LBD), or splice variants with loss of the AR LBD. Final IND-enabling studies for ONCT-534 have been completed. Zilovertamab is an investigational monoclonal antibody designed to inhibit the function of ROR1. Zilovertamab has been evaluated in Phase 1/2 Study CIRM-0001 (NCT03088878) in combination with ibrutinib for the treatment of patients with MCL, chronic lymphocytic leukemia (CLL) and marginal zone lymphoma (MZL). Zilovertamab is also being evaluated in two investigator-initiated studies: a Phase 2 clinical trial of zilovertamab in combination with venetoclax, a Bcl-2 inhibitor, in patients with R/R CLL (NCT04501939), and a Phase 1b study of zilovertamab in combination with docetaxel in patients with metastatic castration-resistant prostate cancer (NCT05156905). More information on our company and programs is available at https://oncternal.com/.

Contact Information:

Investors
Richard Vincent
858-434-1113
rvincent@oncternal.com

Media
Corey Davis, Ph.D.         
LifeSci Advisors         
212-915-2577        
cdavis@lifesciadvisors.com

FAQ

What is the date and time of the Oncternal Therapeutics Virtual Fireside Chat?

The Virtual Fireside Chat is scheduled for April 18, 2023, at 1:30 PM EDT.

Who will moderate the Oncternal Therapeutics Fireside Chat?

Hartaj Singh, Senior Research Biotech Analyst at Oppenheimer & Co., will moderate the chat.

What is ONCT-808?

ONCT-808 is an investigational CAR-T cell therapy targeting ROR1, showing preclinical activity against various cancers.

Who are the key opinion leaders participating in the Fireside Chat?

Key opinion leaders include Dr. Michael Wang and Dr. Angela Shen, alongside Oncternal's CEO, Dr. James Breitmeyer.