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OncoSec Provides Leadership Update

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OncoSec Medical Incorporated (NASDAQ:ONCS) announced the formation of a Leadership Committee focused on the development of its lead asset, TAVO™, following the departure of interim CEO Brian Leuthner. The Committee includes Dr. Margaret Dalesandro, Dr. Herbert Kim Lyerly, and Dr. Yuhang Zhao, all with extensive backgrounds in oncology and biotechnology. The search for a permanent CEO is ongoing. TAVO™ aims to stimulate the immune system to attack cancer through localized IL-12 delivery, with ongoing clinical trials demonstrating a promising safety profile and immune response.

Positive
  • Establishment of a Leadership Committee to advance TAVO™ development.
  • Experienced members on the Committee, including experts in oncology.
  • Positive results from clinical studies for TAVO™, showing local immune response.
  • Potential to address significant medical needs in oncology for anti-PD-1 non-responders.
Negative
  • Departure of interim CEO may indicate instability during leadership transition.
  • -

PENNINGTON, N.J. and SAN DIEGO, Aug. 16, 2021 /PRNewswire/ -- OncoSec Medical Incorporated (NASDAQ:ONCS) (the "Company" or "OncoSec") today announced the establishment of a Leadership Committee consisting of three board members, Margaret Dalesandro, Ph.D., Herbert Kim Lyerly, M.D. and Yuhang Zhao, Ph.D., MBA, to lead all development efforts, with a focus on the Company's lead asset, TAVO.  Effective immediately, OncoSec's interim CEO, Mr. Brian Leuthner, will be leaving the Company.  The search for a permanent CEO has been actively underway since late June 2021.

"On behalf of the Board of Directors, we wish Mr. Leuthner success in his next move," said, Dr. Dalesandro, Chair of the Board of Directors.  "As we look toward the future, our team continues to focus on execution of our corporate strategy and we remain surrounded by a team of experienced oncology and cytokine experts who are committed to OncoSec and the progress the Company has made."

Dr. Margaret Dalesandro has three decades of experience in the pharmaceutical, biotechnology and diagnostics industries.  Dr. Dalesandro previously held an executive leadership role at ImClone Systems where she contributed significantly to drug development and the sale of ImClone to Eli Lilly.

Dr. Herbert Kim Lyerly, Duke University School of Medicine, is an internationally recognized expert in cancer therapy and interleukin-12 (IL-12), and has published over 300 scientific articles and book chapters on surgery, cancer immunotherapy and novel cancer therapies.

Dr. Yuhang Zhao, received her Doctorate from Rockefeller University.  She previously held positions at PaineWebber, Deloitte, and Bayer.  She established Bayer's Global Development Asia organization in Beijing, which became one of Bayer's four global clinical development sites.

About OncoSec Medical Incorporated
OncoSec Medical Incorporated (the "Company," "OncoSec," "we" or "our") is a biotechnology company focused on developing cytokine-based intratumoral immunotherapies to stimulate the body's immune system to target and attack cancer.  OncoSec's lead immunotherapy investigational product candidate – TAVO™ (tavokinogene telseplasmid) – enables the intratumoral delivery of DNA-based interleukin-12 (IL-12), a naturally occurring protein with immune-stimulating functions.  The technology, which employs electroporation, is designed to produce a controlled, localized expression of IL-12 in the tumor microenvironment, enabling the immune system to target and attack tumors throughout the body.  OncoSec has built a deep and diverse clinical pipeline utilizing TAVO™ as a potential treatment for multiple cancer indications either as a monotherapy or in combination with leading checkpoint inhibitors; with the latter potentially enabling OncoSec to address a great unmet medical need in oncology: anti-PD-1 non-responders.  Results from recently completed clinical studies of TAVO™ have demonstrated a local immune response, and subsequently, a systemic effect as either a monotherapy or combination treatment approach along with an acceptable safety profile, warranting further development.  In addition to TAVO™, OncoSec is identifying and developing new DNA-encoded therapeutic candidates and tumor indications for use with its new Visceral Lesion Applicator (VLA), to target deep visceral lesions, such as liver, lung or pancreatic lesions.  For more information, please visit www.oncosec.com.

TAVO™ is a trademark of OncoSec Medical Incorporated.

Company Contact
Investor Contact
Mike Moyer
LifeSci Advisors
+1-617-308-4306
mmoyer@lifesciadvisors.com

Media Contact
Patrick Bursey
LifeSci Communications
+1-646-970-4688
pbursey@lifescicomms.com 

OncoSec Medical Incorporated logo (PRNewsfoto/OncoSec Medical Incorporated)

 

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SOURCE OncoSec Medical Incorporated

FAQ

What is the latest update from OncoSec Medical (ONCS) regarding leadership changes?

OncoSec has established a Leadership Committee and announced the departure of interim CEO Brian Leuthner.

Who are the new leaders at OncoSec Medical?

The Leadership Committee includes Dr. Margaret Dalesandro, Dr. Herbert Kim Lyerly, and Dr. Yuhang Zhao, focusing on advancing TAVO™.

What is TAVO™ from OncoSec Medical (ONCS)?

TAVO™ is an investigational product candidate designed to enhance the immune response against cancer via localized IL-12 delivery.

What results has OncoSec Medical reported for TAVO™?

Clinical studies for TAVO™ have shown a local immune response and an acceptable safety profile, supporting further development.

When did Brian Leuthner leave OncoSec Medical (ONCS)?

Brian Leuthner's departure was announced on August 16, 2021.

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