Welcome to our dedicated page for Olema Pharmaceuticals news (Ticker: OLMA), a resource for investors and traders seeking the latest updates and insights on Olema Pharmaceuticals stock.
Olema Pharmaceuticals, Inc. (Nasdaq: OLMA), also known as Olema Oncology, is a clinical-stage biopharmaceutical company committed to the discovery, development, and commercialization of targeted therapies for women's cancers. Headquartered in San Francisco with operations in Cambridge, Massachusetts, Olema is advancing a pipeline of novel therapies aimed at improving treatment options for women living with cancer. The core focus of the company centers on endocrine-driven cancers, nuclear receptors, and mechanisms of acquired resistance.
Olema's lead product candidate, palazestrant (OP-1250), is a proprietary, orally-available small molecule with dual activity as both a complete estrogen receptor (ER) antagonist (CERAN) and a selective ER degrader (SERD). Palazestrant is currently in Phase 3 clinical trials under the OPERA-01 study for patients with recurrent, locally advanced, or metastatic ER-positive (ER+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer. This innovative therapy has demonstrated significant potential by completely blocking ER-driven transcriptional activity in both wild-type and mutant forms of metastatic ER+ breast cancer, showing anti-tumor efficacy, favorable pharmacokinetics, CNS penetration, and combinability with CDK4/6 inhibitors.
In addition to palazestrant, Olema is developing a potent KAT6 inhibitor (OP-3136), which addresses an epigenetic target implicated in breast cancer and other cancers. This compound has shown promise in preclinical studies and is expected to move into clinical trials by the end of 2024.
Olema's financial health remains robust, with cash, cash equivalents, and marketable securities totaling $249.0 million as of March 31, 2024. The company reported a net loss of $31.0 million for the first quarter of 2024, primarily driven by increased spending on research and clinical development activities. However, Olema continues to make significant strides in advancing its clinical programs, supported by experienced scientists, healthcare investors, and partnerships with innovative pharmaceutical companies.
Recent corporate highlights include the initiation of a Phase 1/2 dose-escalation and expansion clinical trial of OP-1250, and the selection of a development candidate for the KAT6 program. Olema's commitment to transforming the standard of care for women's cancers is evident in its ongoing clinical studies and presentations at major oncology conferences such as the ESMO Breast Cancer Annual Congress.
For more information about Olema Pharmaceuticals, visit their website at www.olema.com.
Olema Pharmaceuticals (Nasdaq: OLMA) has granted stock options to one new employee as part of its inducement program. The grant includes options to purchase 2,500 shares of common stock at an exercise price of $11.62 per share. The options vest over four years, with 25% vesting after the first year and the remainder vesting monthly over three years. The options have a 10-year term and were granted under the company's 2022 Inducement Plan in accordance with Nasdaq Listing Rule 5635(c)(4).
Olema Oncology presented preclinical data at ENA 2024 showcasing anti-tumor activity of their drug candidates. OP-3136, a KAT6 inhibitor, demonstrated strong anti-tumor activity alone and enhanced effects when combined with palazestrant. The company plans to submit an IND application for OP-3136 by year-end. Additionally, palazestrant showed improved tumor suppression when combined with everolimus and capivasertib in ER+/HER2- breast cancer models. The studies revealed synergistic effects and significant tumor regression, particularly when palazestrant was combined with these agents, showing superior results compared to fulvestrant combinations.
Olema Oncology (Nasdaq: OLMA) announced upcoming poster presentations at the 36th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics (ENA 2024) in Barcelona, Spain, from October 23-25, 2024. The presentations will showcase new preclinical data on combination therapies for ER+/HER2- breast cancer.
Three posters will be presented on October 24, 2024:
- Combining palazestrant (CERAN) with everolimus (mTOR inhibitor)
- Combining palazestrant with capivasertib (pan-AKT inhibitor)
- Combining OP-3136 (KAT6 inhibitor) with endocrine therapy and CDK4/6 inhibitor
These studies demonstrate enhanced tumor suppression and anti-tumor activity in ER+/HER2- breast cancer models. Abstracts and posters will be available on the ENA website and Olema's website, respectively.
Olema Pharmaceuticals, a clinical-stage biopharmaceutical company focused on targeted therapies for women's cancers, has announced the granting of stock options to three new employees. These options allow the purchase of 118,800 shares of the company's common stock, effective October 1, 2024. The grants were approved by the Compensation Committee and issued under Olema's 2022 Inducement Plan, in compliance with Nasdaq Listing Rule 5635(c)(4).
The stock options have a 10-year term and an exercise price of $12.30 per share, matching the last reported sale price on October 1, 2024. They vest over four years, with 25% vesting on the first anniversary and the remainder in 36 equal monthly installments, subject to continuous employment. This announcement is made in accordance with Nasdaq Listing Rule 5635(c)(4).
Olema Pharmaceuticals (Nasdaq: OLMA), a clinical-stage biopharmaceutical company focused on targeted therapies for women's cancers, has granted stock options to five new employees. The options allow the purchase of 130,600 shares of common stock at an exercise price of $11.35 per share, equal to the last reported sale price on September 3, 2024. These inducement grants, approved under Nasdaq Listing Rule 5635(c)(4), vest over four years with a 10-year term. The options were granted under Olema's 2022 Inducement Plan as part of the company's employee retention and attraction strategy.
Olema Oncology (Nasdaq: OLMA), a clinical-stage biopharmaceutical company specializing in targeted therapies for women's cancers, has announced its participation in the Morgan Stanley 22nd Annual Global Healthcare Conference. The event is scheduled for Wednesday, September 4, 2024, at 7:45 a.m. ET at the Marriott Marquis in New York, NY.
The company's management team will engage in a Fireside Chat format discussion. Investors and interested parties can access a live webcast of the chat through the News & Events section of Olema's investor relations website at ir.olema.com. The webcast will remain archived for at least 30 days after the event, providing an opportunity for those unable to attend live to catch up on the discussion.
Olema Oncology (Nasdaq: OLMA) reported Q2 2024 financial results and provided a corporate update. Key highlights:
- Presented promising interim clinical results for palazestrant-ribociclib combination at ESMO Breast Cancer Congress
- Completed IND-enabling studies for OP-3136, with FDA filing expected in late 2024
- Cash position of $239.1 million as of June 30, 2024
- Net loss of $30.4 million for Q2 2024, up from $20.1 million in Q2 2023
- GAAP R&D expenses increased to $29.1 million from $18.0 million year-over-year
- GAAP G&A expenses rose to $4.4 million from $3.6 million year-over-year
Upcoming milestones include initiating a Phase 1b/2 study of palazestrant with everolimus in Q3 2024 and presenting updated Phase 2 results for palazestrant-ribociclib combination at a future medical meeting.
Olema Oncology (Nasdaq: OLMA), a clinical-stage biopharmaceutical company focused on targeted therapies for women's cancers, has announced the granting of stock options to two new employees. The options allow the purchase of 11,800 shares of the company's common stock, effective August 1, 2024. These awards were approved by the Compensation Committee and granted under Olema's 2022 Inducement Plan.
The stock options have a 10-year term and an exercise price of $16.46 per share, equal to the last reported sale price on August 1, 2024. They vest over four years, with 25% vesting on the first anniversary and the remainder vesting in 36 equal monthly installments, subject to continuous employment. This grant is in accordance with Nasdaq Listing Rule 5635(c)(4) as an inducement for new employees.
Olema Oncology, a clinical-stage biopharmaceutical company, announced the granting of stock options to two new employees to purchase a total of 44,400 shares of its common stock. The stock options, approved by the Compensation Committee, were granted under the company's 2022 Inducement Plan as of July 1, 2024. Vesting occurs over four years, with 25% vesting after one year and the rest vesting monthly over the next three years. The exercise price is set at $11.14 per share, in line with the last reported sale price of the company's stock on July 1, 2024. This announcement complies with Nasdaq Listing Rule 5635(c)(4).
Olema Pharmaceuticals, a clinical-stage biopharmaceutical company specializing in women's cancer therapies, announced the granting of stock options to four new employees. Effective June 3, 2024, these options allow the purchase of 51,600 shares of Olema's common stock. Approved under the 2022 Inducement Plan, the grants are part of the company's strategy to attract new talent, in line with Nasdaq Listing Rule 5635(c)(4). The stock options vest over four years, with an initial 25% vesting after one year and the remainder vesting monthly over three years. The options have a 10-year term and an exercise price of $11.76 per share, matching the stock's last reported sale price on June 3, 2024.
FAQ
What is the current stock price of Olema Pharmaceuticals (OLMA)?
What is the market cap of Olema Pharmaceuticals (OLMA)?
What is Olema Pharmaceuticals' primary focus?
What is OP-1250?
What stage is OP-1250 currently in?
What other therapies is Olema developing?
How is Olema's financial health?
Who supports Olema's research and development?
Where is Olema Pharmaceuticals headquartered?
What recent achievements has Olema made?
What is the significance of the OPERA-01 study?
Where can I find more information about Olema Pharmaceuticals?
