Oragenics Completes Acquisition of Odyssey Health’s Neurological Assets

Rhea-AI Summary

Oragenics, Inc. (NYSE American: OGEN) has completed the acquisition of assets related to Odyssey Health, Inc.'s proprietary neurological drug therapies and technologies, including ONP-002 and a unique nasal delivery device. The acquisition aims to develop innovative treatments for moderate-to-severe concussion and Niemann Pick Type-C Disease (NPC), addressing a significant market opportunity. Michael Redmond has been named President of Oragenics, bringing 35 years of commercial experience with medical device companies to oversee the growth of Oragenics' neurology product pipeline and intranasal drug delivery technologies.

Positive

• Acquisition of assets related to Odyssey Health, Inc.'s proprietary neurological drug therapies and technologies expands Oragenics' market opportunity
• ONP-002 demonstrated rapid and broad biodistribution throughout the brain while reducing swelling, inflammation, and oxidative stress in preclinical animal studies
• ONP-002 has completed a Phase 1 clinical trial in healthy human subjects, showing it is safe and well tolerated
• Michael Redmond named President of Oragenics brings 35 years of commercial experience with medical device companies to oversee the growth of Oragenics' neurology product pipeline and intranasal drug delivery technologies

Negative

• None.

Insights

Pharmaceutical Industry Analyst

The acquisition of Odyssey Health, Inc.'s assets by Oragenics, Inc. represents a strategic expansion into neurological drug therapies, a sector poised for significant growth. The addition of ONP-002, a drug for treating moderate-to-severe concussion, addresses a market with a high incidence rate and a notable gap in effective treatments. The preclinical success and Phase 1 trial results suggest a promising trajectory for the drug, with the potential to capture a share of the projected $8.9 billion market by 2027. The acquisition not only diversifies Oragenics' portfolio but also leverages their existing expertise in intranasal drug delivery, a method that could offer a competitive advantage in terms of drug bioavailability and patient compliance.

Furthermore, the inclusion of ONP-001 for Niemann Pick Type-C Disease expands Oragenics' reach into rare disease treatment, which often benefits from regulatory incentives and can command high prices due to limited competition. The strategic move may positively influence Oragenics' valuation, given the market's favorable response to companies with diversified and innovative pipelines. However, the financial impact will largely depend on the successful progression of the drugs through Phase 2 trials and beyond, as well as the ability to navigate the complex regulatory landscape.

Biotech Market Analyst

Oragenics' acquisition is a calculated step towards capturing a larger share of the biotech market, particularly in the burgeoning field of treatments for traumatic brain injuries (mTBI) and rare neurological disorders. The market for mTBI treatments is currently underserved, presenting a significant opportunity for Oragenics to establish a foothold. The company's focus on intranasal delivery is noteworthy, as it aligns with the industry trend towards non-invasive and patient-friendly drug administration methods. This could foster greater market adoption upon regulatory approval and commercialization.

The appointment of Michael Redmond as President, given his extensive commercial experience and track record in growth acceleration, signals a strong commitment to the successful development and future commercialization of the acquired assets. His expertise in capital raising and licensing deals could prove invaluable in navigating the capital-intensive phases of clinical development and potential strategic partnerships. Investors will likely monitor the integration of Odyssey's team and technology closely, as efficient synergy could expedite the development timeline and enhance R&D capabilities, potentially impacting Oragenics' stock performance positively in anticipation of future clinical milestones.

Medical Research Analyst

The intranasal delivery of ONP-002 for concussion treatment promises a novel approach in a therapeutic area where current options are limited. Intranasal delivery systems are particularly advantageous for central nervous system disorders as they can bypass the blood-brain barrier and deliver drugs directly to the brain, potentially improving efficacy and reducing systemic side effects. The preclinical findings indicating reduced swelling, inflammation and oxidative stress, alongside improved behavioral outcomes, are indicative of a potentially transformative treatment for patients with mTBI.

ONP-001's targeting of Niemann Pick Type-C Disease, a rare and typically fatal genetic disorder, underscores the importance of developing treatments for orphan diseases, which often lack attention from larger pharmaceutical companies. The drug's progression through the clinical pipeline will be closely watched, as successful treatments for NPC are scarce and the need is significant. The safety and tolerability demonstrated in Phase 1 trials for ONP-002 set a positive precedent for the upcoming Phase 2 trials, although efficacy in a larger patient population will be the critical determinant for the drug's long-term prospects.

Adds Clinical-Stage Product Pipeline, Expands Intranasal Drug Delivery Technologies,

Names Michael Redmond as President of Oragenics

TAMPA, Fla.--(BUSINESS WIRE)-- Oragenics, Inc. (NYSE American: OGEN) (“Oragenics” or the “Company”) announces it has completed its previously announced acquisition of assets related to Odyssey Health, Inc.’s (OTCQB: ODYY) (“Odyssey”) proprietary neurological drug therapies and technologies.

The acquired assets include ONP-002 and a unique nasal delivery device, Odyssey’s lead concussion asset, believed to be a first-in-class intranasal drug under development for the treatment of moderate-to-severe concussion in the acute through subacute phases. In preclinical animal studies, the asset demonstrated rapid and broad biodistribution throughout the brain while simultaneously reducing swelling, inflammation and oxidative stress, along with an excellent safety profile. Results from animals treated with the drug post-concussion showed positive behavioral outcomes using various testing platforms including improved memory and sensory-motor performance, and reduced anxiety. ONP-002 has completed a Phase 1 clinical trial in healthy human subjects showing it is safe and well tolerated. Oragenics anticipates preparing for Phase 2 clinical trials to further evaluate ONP-002’s safety and efficacy.

Also included in the acquired assets are all of Odyssey’s rights and interest in ONP-001, believed to be a first-in-class neurosteroid being developed for the treatment of Niemann Pick Type-C Disease (NPC), as well as Odyssey’s proprietary powder formulation and its intranasal delivery device. Odyssey will retain its other assets and operations.

“We are delighted to complete this pivotal transaction following a favorable vote of shareholders at both companies. We expect that Odyssey’s neurological pipeline will significantly expand our market opportunity and believe its technology complements our expertise in intranasal drug delivery. This acquisition also addresses a significant and growing health concern. There are an estimated 5 million concussions annually in the U.S., with up to half going unreported, underscoring a substantial market opportunity for an efficacious treatment,” said Kim Murphy, Chief Executive Officer of Oragenics.

“Our decision to invest in this innovative therapy is driven by our commitment to pioneering solutions that build upon our expertise in intranasal drug delivery and our dedication to improving patient outcomes. These new pipeline candidates hold potential to deliver innovative treatments for millions affected by mTBI and NPC, and introduce Oragenics into a market that is projected to grow to $8.9 billion annually by 2027,” added Ms. Murphy.

In conjunction with the transaction, Michael Redmond, who has served as President and CEO of Odyssey since 2018, was named President of Oragenics. Mr. Redmond has 35 years of commercial experience with medical device companies, having held various sales and marketing leadership positions that helped accelerate growth at companies to multiples of their previous revenue and valuation. Mr. Redmond also has significant experience in raising capital and securing licensing and distribution deals with major biotech and pharmaceutical companies. In his new position, Mr. Redmond will oversee the growth of Oragenics’ neurology product pipeline and intranasal drug delivery technologies.

Additionally, the Odyssey management and development team that led the ONP-002 clinical trial design and implementation for the treatment of concussion, will continue to oversee research and development of the newly acquired neurology assets at Oragenics. The team has experience in conducting clinical trials, developing drug formulations and commercializing pharmaceutical products across a broad range of indications.

“I’m proud to join the executive team at Oragenics and look forward to continuing the development of ONP-002 and ultimately utilizing my experience in commercializing therapeutics. We intend to leverage our joint expertise and resources to expedite the development of this drug, with the goal of filling a critical gap in concussion care as we prepare for a Phase 2 clinical study in the first half of 2024. We believe this transaction also strengthens Oragenics’ research and development capabilities, including the integration of key members of Odyssey’s research and development team with the Oragenics team,” said Mr. Redmond.

About ONP-002

ONP-002 is a fully synthetic neurosteroid being developed to treat mTBI. In preclinical studies, the drug demonstrated equivalent or better neuroprotective effects compared with related neurosteroids. Animal models of concussion showed the drug reduces the behavioral pathology associated with brain injury symptoms such as memory impairment, anxiety and motor/sensory performance. Additionally, ONP-002 is lipophilic and can cross the blood-brain barrier to rapidly eliminate swelling, oxidative stress and inflammation while restoring proper blood flow.

About Mild Traumatic Brain Injury (mTBI)

Concussions are an unmet medical need that affects millions worldwide. Repetitive concussions can increase the risk of developing chronic traumatic encephalopathy and other neuropsychiatric disorders. It is estimated that 5 million concussions occur in the U.S. annually and that up to 50% go unreported. The worldwide incidence is estimated at 69 million per year. The global market for concussion treatment was valued at $6.9 billion in 2020 and is forecast to reach $8.9 billion by 2027, according to Grandview Research. Common settings for concussion include contact sports, military training and operations, motor vehicle accidents, children at play and elderly assistive-living facilities due to falls.

About Niemann-Pick Type C Disease

Niemann-Pick Type C disease is a rare neurodegenerative genetic disorder characterized by the inability of cells to metabolize and properly transport cholesterol and other lipids, leading to the abnormal accumulation in various tissues including brain tissue. The market for NPC therapeutics is expected to grow from $128 million in 2022 to $188 million in 2031 across the U.S., Germany and UKⁱ.

Forward-Looking Statements

This communication contains “forward-looking statements” within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995 including, without limitation, statements regarding the ability of the Company to timely and successfully achieve the anticipated benefits of acquiring the Odyssey assets and the Company’s future performance, business prospects, events and product development plans. These forward-looking statements are based on management’s beliefs and assumptions and information currently available. The words “believe,” “expect,” “anticipate,” “intend,” “estimate,” “project” and similar expressions that do not relate solely to historical matters identify forward-looking statements. Investors should be cautious in relying on forward-looking statements because they are subject to a variety of risks, uncertainties, and other factors that could cause actual results to differ materially from those expressed in any such forward-looking statements. These factors include, but are not limited to, the following: the Company’s ability to advance the development of its product candidates under the timelines and in accord with the milestones it projects; the Company’s ability to obtain funding, non-dilutive or otherwise, for the development of its product candidates, whether through its own cash on hand, or another alternative source; the regulatory application process, research and development stages, and future clinical data and analysis, decisions by regulatory authorities, such as the FDA and investigational review boards, whether favorable or unfavorable; the potential application of our research and development candidates; the Company’s ability to obtain, maintain and enforce necessary patent and other intellectual property protection; the nature of competition and development relating to concussion treatments, treatments for NPC and COVID-19 immunization and therapeutic treatments and demand for vaccines and antibiotics; the Company’s expectations as to the outcome of preclinical studies, nasal administration, transmission, manufacturing, storage and distribution; other potential adverse impacts due to the global COVID-19 pandemic, such as delays in regulatory review, interruptions to manufacturers and supply chains, adverse impacts on healthcare systems and disruption of the global economy; and general economic and market conditions and risks, as well as other uncertainties described in our filings with the U.S. Securities and Exchange Commission. All information set forth in this communication is as of the date hereof. You should consider these factors in evaluating the forward-looking statements included in this communication and not place undue reliance on such statements. We do not assume any obligation to publicly provide revisions or updates to any forward-looking statements, whether as a result of new information, future developments or otherwise, should circumstances change, except as otherwise required by law.

ⁱ Source: GlobalData https://www.globaldata.com/store/report/niemann-pick-type-c-market-analysis/

View source version on businesswire.com: https://www.businesswire.com/news/home/20231227658588/en/

Oragenics, Inc.

Janet Huffman, Chief Financial Officer

813-286-7900

jhuffman@oragenics.com

LHA Investor Relations

Tirth T. Patel

212-201-6614

tpatel@lhai.com

Source: Oragenics, Inc.

FAQ

What assets has Oragenics acquired related to Odyssey Health, Inc.'s proprietary neurological drug therapies and technologies?

Oragenics has acquired assets including ONP-002, a unique nasal delivery device, and all of Odyssey's rights and interest in ONP-001, believed to be a first-in-class neurosteroid being developed for the treatment of Niemann Pick Type-C Disease (NPC), as well as Odyssey's proprietary powder formulation and its intranasal delivery device.

What is ONP-002 and what has it demonstrated in preclinical animal studies?

ONP-002 is a lead concussion asset believed to be a first-in-class intranasal drug under development for the treatment of moderate-to-severe concussion. In preclinical animal studies, ONP-002 demonstrated rapid and broad biodistribution throughout the brain while reducing swelling, inflammation, and oxidative stress, along with an excellent safety profile.

What is the market opportunity for Oragenics' acquisition of Odyssey Health, Inc.'s neurological pipeline?

Oragenics' acquisition of Odyssey's neurological pipeline aims to develop innovative treatments for moderate-to-severe concussion and Niemann Pick Type-C Disease (NPC), addressing a market projected to grow to $8.9 billion annually by 2027.

Who has been named President of Oragenics and what experience does he bring?

Michael Redmond has been named President of Oragenics, bringing 35 years of commercial experience with medical device companies to oversee the growth of Oragenics' neurology product pipeline and intranasal drug delivery technologies.