Ocuphire Pharma to Present at the Canaccord 43rd Annual Growth Conference and the H.C. Wainwright Ophthalmology Conference in August

Rhea-AI Summary

Ocuphire Pharma, a clinical-stage ophthalmic biopharmaceutical company (Nasdaq: OCUP), announced their participation in the Canaccord 43rd Annual Growth Conference and the H.C. Wainwright Ophthalmology Conference. Ronil Patel, MS, SVP of Operations and Business Development, and Charlie Hoffmann, MBA, SVP of Corporate Development, will present a company overview and participate in panel discussions. The company aims to develop and commercialize small-molecule therapies for retinal and refractive eye disorders.

FARMINGTON HILLS, Mich., Aug. 08, 2023 (GLOBE NEWSWIRE) -- Ocuphire Pharma, Inc. (Nasdaq: OCUP), a clinical-stage ophthalmic biopharmaceutical company focused on developing and commercializing small-molecule therapies for the treatment of retinal and refractive eye disorders, today announced that Ronil Patel, MS, SVP of Operations and Business Development and Charlie Hoffmann, MBA, SVP of Corporate Development, will participate in a Fireside Chat at the Canaccord 43^rd Annual Growth Conference being held August 7-10, 2023 in Boston, MA and will present a company overview and participate in a panel at the H.C. Wainwright Ophthalmology Conference being held virtually on August 16, 2023.

Canaccord 43rd Annual Growth Conference – August 9, 2023
Title:	Fireside Chat with Ocuphire Pharma (OCUP)
Date:	Wednesday, August 9, 2023 at 4:30-4:55pm ET
Host:	John Newman, Ph.D., Canaccord
Presenters:	Ronil Patel, MS, SVP of Operations & Business Development, Charlie Hoffmann, MBA, SVP of Corporate Development, Ocuphire
Format:	In-Person

H.C. Wainwright Ophthalmology Conference – August 16, 2023
Title:	Ocuphire Pharma (OCUP) Company Presentation
Date:	Available on-demand Wednesday, August 16, 2023 at 7:00am ET
Presenter:	Ronil Panel, MS, SVP of Operations & Business Development, Ocuphire
Format:	Virtual

Panel Title:	Novel Therapies in the Retina with Arshad Khanani, MD
Host:	Matthew Caufield, Vice President, Equity Research, H.C. Wainwright & Co.
Date:	Wednesday, August 16, 2023 at 12:00pm ET
Participant:	Ronil Patel, MS, SVP of Operations & Business Development, Ocuphire
Format:	Virtual

If you are interested in arranging a 1x1 meeting, please contact your conference representative or ir@ocuphire.com. For more details, please see the Investors and Events section of Ocuphire’s corporate website.

About Ocuphire Pharma

Ocuphire Pharma, Inc. is a clinical-stage ophthalmic biopharmaceutical company focused on developing and commercializing small-molecule therapies for the treatment of retinal and refractive eye disorders.

Ocuphire’s lead retinal product candidate, APX3330, is a first-in-class small-molecule inhibitor of Ref-1 (reduction oxidation effector factor-1 protein). Ref-1 is a regulator of transcription factors such as HIF-1a and NF-kB. Inhibiting REF-1 reduces levels of vascular endothelial growth factor (VEGF) and inflammatory cytokines which are known to play key roles in ocular angiogenesis and inflammation. Through inhibition of Ref-1, APX3330 normalizes the levels of VEGF to physiologic levels, unlike biologics that abolish the VEGF levels required for normal function. APX3330 is an oral tablet administered twice per day for the treatment of diabetic retinopathy (“DR”) and diabetic macular edema (“DME”). A Phase 2 study in subjects with DR or DME has recently completed, and an End-of-Phase 2 meeting is confirmed with the FDA in Q4 2023.

DR affects approximately 10 million people with diabetes and is projected to impact 14.6 million Americans by 2050. DR is classified as Non-Proliferative Diabetic Retinopathy (“NPDR”), the early stage of the disease in which symptoms may be mild or nonexistent or Proliferative Diabetic Retinopathy (“PDR”) which is the more advanced stage of diabetic eye disease that can be highly symptomatic with loss of vision. Approximately 80% of DR patients have NPDR that will progress to PDR if left untreated. Despite the risk for visual loss associated with this disease, over 90% of NPDR patients currently receive no course of treatment apart from observation by their eye care specialist until they develop sight-threatening complications. This is due to the burdensome and frequent eye injections currently required with currently approved therapies for this disease. APX3330 as an oral tablet has the potential to be an early, non-invasive treatment for the 8 million NPDR patients in the US. Treatment with APX3330 is expected to delay or prevent progression of NPDR, thereby reducing the need for expensive intravitreal injections with anti-VEGF therapies and reducing the likelihood of vision loss due to DR.

Ocuphire has also in-licensed APX2009 and APX2014, which are second-generation analogs of APX3330. The unique dual mechanism of action of these Ref-1 inhibitors of reducing angiogenesis and inflammation could potentially be beneficial in treating other retinal diseases such as age-related macular degeneration (“AMD”), and geographic atrophy (“GA”). Ocuphire is currently evaluating local delivery routes in addition to the systemic (oral) route as part of its pipeline expansion in retinal therapies.

Ocuphire has a partnership with Viatris, Inc. to develop and commercialize Nyxol^® eye drops as a preservative-free eye drop formulation of phentolamine mesylate, a non-selective alpha-1 and alpha-2 adrenergic antagonist designed to reduce pupil size by uniquely blocking the alpha-1 receptors found only on the iris dilator muscle without affecting the ciliary muscle. Nyxol has been studied in a total of 12 clinical trials across three indications, including single-use for reversal of pharmacologically-induced mydriasis (RM), and once-daily for treatment of presbyopia and dim light (night) vision disturbances (DLD), pending regulatory approvals. Nyxol’s NDA under the 505(b)(2) pathway for the first indication, RM, has been accepted with a PDUFA date assigned of September 28, 2023. Nyxol is currently in Phase 3 for presbyopia and DLD.

For more information, visit www.ocuphire.com. 

Contacts

Corporate	Investor Relations
Rick Rodgers, MBA  Interim CEO  ir@ocuphire.com	Corey Davis, Ph.D.  LifeSci Advisors  cdavis@lifesciadvisors.com

FAQ

What is the company name and ticker symbol mentioned in the press release?

The company mentioned in the press release is Ocuphire Pharma, Inc. and the ticker symbol is OCUP.

What is the focus of Ocuphire Pharma, Inc.?

Ocuphire Pharma, Inc. is focused on developing and commercializing small-molecule therapies for the treatment of retinal and refractive eye disorders.

Who will be participating in the Canaccord 43rd Annual Growth Conference and the H.C. Wainwright Ophthalmology Conference on behalf of Ocuphire Pharma, Inc.?

Ronil Patel, MS, SVP of Operations and Business Development, and Charlie Hoffmann, MBA, SVP of Corporate Development, will be representing Ocuphire Pharma, Inc. at the conferences.

When and where will the Canaccord 43rd Annual Growth Conference take place?

The Canaccord 43rd Annual Growth Conference will be held on August 7-10, 2023, in Boston, MA.

When and where will the H.C. Wainwright Ophthalmology Conference take place?

The H.C. Wainwright Ophthalmology Conference will be held virtually on August 16, 2023.