Ocugen Presents New Preclinical OCU200 Data at the Association for Research in Vision and Ophthalmology (ARVO) 2021 Annual Meeting
Ocugen has presented promising pre-clinical data for OCU200, a transferrin-tumstatin fusion protein, targeting ocular neovascular diseases such as Diabetic Macular Edema (DME), Diabetic Retinopathy (DR), and Wet-AMD. The study shows OCU200's efficacy in reducing retinal damage and neovascularization, demonstrating comparable activity to aflibercept in animal models. Key findings include a 68% reduction in avascular areas and significant reduction in neovascular tufts. The data was presented at the ARVO 2021 Annual Meeting.
- OCU200 significantly reduced avascular areas by 68% and neovascular tufts by up to 59% in preclinical models.
- Demonstrated comparable efficacy to aflibercept, a leading treatment for similar conditions.
- Potential to provide treatment options for patients unresponsive to current anti-VEGF therapies.
- Still in preclinical development; further clinical trials required before market entry.
- Dependence on preclinical data; results may not translate directly to human efficacy.
- OCU200, a transferrin-tumstatin fusion protein, demonstrates potential to treat DME, DR, and Wet-AMD
- OCU200 reduced neovascularization and damage to retina and demonstrated comparable/slightly improved activity to aflibercept in an animal disease model
MALVERN, Pa., May 06, 2021 (GLOBE NEWSWIRE) -- Ocugen, Inc. (NASDAQ: OCGN), a biopharmaceutical company focused on discovering, developing, and commercializing gene therapies to cure blindness diseases and developing a vaccine to save lives from COVID-19, today announced the presentation of a pre-clinical study to evaluate efficacy of OCU200 in in-vitro and in-vivo models for ocular neovascular diseases. The data will be featured in a virtual poster presentation entitled “OCU200 (transferrin-tumstatin fusion protein): A potential therapeutic for DME, DR, and wet-AMD” at the Association for Research in Vision and Ophthalmology (ARVO) 2021 Annual Meeting, taking place May 1-7, 2021.
OCU200 is a biologic product candidate in preclinical development for treating severely sight-threatening diseases like Diabetic Macular Edema (DME), Diabetic Retinopathy (DR), and Wet Age-Related Macular Degeneration (Wet-AMD). The purpose of this study was to evaluate efficacy of OCU200 in in-vitro and in-vivo models for ocular neovascular diseases. Angiogenesis and neovascularization are hallmarks for DME, DR, and wet-AMD. Most approved therapeutics target vascular endothelial growth factor (VEGF), a pro-angiogenic factor with neurotrophic and neuroprotective effects. However, approximately
OCU200 inhibited cell proliferation, cell invasion and tube formation by endothelial cells. In an oxygen induced retinopathy (OIR) mice model, OCU200 significantly reduced avascular areas at low dose (
“These data show that our novel biologic product candidate, OCU200, may offer potential benefits beyond anti-VEGF therapy and could benefit all patients who do not respond to current therapies,” said Dr. Shankar Musunuri, Chairman of the Board, Chief Executive Officer, and Co-founder of Ocugen. “We look forward to advancing our programs and are dedicated to making new treatment options available for patient populations affected by these diseases.”
| Details for the ARVO 2021 presentation are as follows: | |
| Title: | OCU200 (transferrin-tumstatin fusion protein): A potential therapeutic for DME, DR, and wet-AMD |
| Presenter: | Dr. Arun Upadhyay, VP and Head of R&D, Ocugen Inc. |
| Abstract No.: | 3542029 |
| Session Title: | Cytokines, growth factors, anti-inflammatory |
| Session Date/Time: | May 6, 2021 from 11:15 AM to 12:45 PM EDT |
| URL: | https://arvo2021.arvo.org/meetings/virtual/75NdGrQYwty2WvX96 |
About Ocugen, Inc.
Ocugen, Inc. is a biopharmaceutical company focused on discovering, developing, and commercializing gene therapies to cure blindness diseases and developing a vaccine to save lives from COVID-19. Our breakthrough modifier gene therapy platform has the potential to treat multiple retinal diseases with one drug – “one to many” and our novel biologic product candidate aims to offer better therapy to patients with underserved diseases such as wet age-related macular degeneration, diabetic macular edema, and diabetic retinopathy. We are co-developing Bharat Biotech’s COVAXIN™ vaccine candidate for COVID-19 in the U.S. market. For more information, please visit www.ocugen.com.
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Ocugen Contact:
Ocugen, Inc.
Sanjay Subramanian
CFO and Head of Corp. Dev.
IR@Ocugen.com
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