Novavax to Present at International Society for Vaccines Virtual Congress COVID-19 Vaccine Update

Rhea-AI Summary

Novavax, Inc. (Nasdaq: NVAX) announced that Gregory M. Glenn, M.D., will present on NVX-CoV2373, its COVID-19 vaccine candidate, at the 2021 International Society for Vaccines Virtual Congress on May 25, 2021. The presentation will cover safety, efficacy, and immunogenicity data. A recent analysis from Phase 3 trials in the U.K. shows approximately 90% efficacy against COVID-19, with impressive results against variants. NVX-CoV2373 utilizes Novavax's proprietary recombinant nanoparticle technology and Matrix-M™ adjuvant to enhance immune response.

Positive

• NVX-CoV2373 demonstrated 90% efficacy in Phase 3 U.K. trial.
• Vaccine effective against emerging COVID-19 variants.
• NVX-CoV2373 is stable and can be stored at standard refrigeration temperatures.

Negative

• None.

GAITHERSBURG, Md., May 24, 2021 /PRNewswire/ -- Novavax, Inc. (Nasdaq: NVAX), a biotechnology company developing next-generation vaccines for serious infectious diseases, today announced that Gregory M. Glenn, M.D., President of Research and Development, will present on NVX-CoV2373, the company's recombinant nanoparticle COVID-19 vaccine candidate, during the 2021 International Society for Vaccines Virtual Congress 6^th COVID-19 Vaccine Update.

Presentation details are as follows:

Date:	Tuesday, May 25, 2021
Time:	9:50 a.m. – 10:30 a.m. Eastern Time (ET)
Presentation title:	Recombinant Protein COVID-19 Vaccine Update
Presenter:	Gregory M. Glenn, M.D.
Registration:	This event is open to the public. Register at: https://www.isvcongress.org/default.php

Dr. Glenn will discuss NVX-CoV2373, including analysis of the safety, efficacy and immunogenicity data to-date.

Earlier this year, Novavax announced a final analysis of data from its pivotal Phase 3 clinical trial in the United Kingdom (U.K.) for its protein-based COVID-19 vaccine candidate, demonstrating an overall efficacy of approximately 90% and confirming the vaccine's efficacy against variants. The data from this U.K. Phase 3 trial and a South Africa Phase 2b study were the first to demonstrate clinical efficacy against newer circulating U.K. and South Africa COVID-19 variants.

About NVX-CoV2373
NVX-CoV2373 is a protein-based vaccine candidate engineered from the genetic sequence of the first strain of SARS-CoV-2, the virus that causes COVID-19 disease. NVX-CoV2373 was created using Novavax' recombinant nanoparticle technology to generate antigen derived from the coronavirus spike (S) protein and is adjuvanted with Novavax' patented saponin-based Matrix-M™ to enhance the immune response and stimulate high levels of neutralizing antibodies. NVX-CoV2373 contains purified protein antigen and can neither replicate, nor can it cause COVID-19. In preclinical studies, NVX-CoV2373 induced antibodies that blocked the binding of spike protein to cellular receptors and provided protection from infection and disease. It was generally well-tolerated and elicited robust antibody response in Phase 1/2 clinical testing.

NVX-CoV2373 is being evaluated in two pivotal Phase 3 trials: a trial in the U.K. that demonstrated efficacy of 96.4% against the original virus strain, 86.3% against the B.1.1.7/501Y.V1 variant and 89.7% overall; and the PREVENT-19 trial in the U.S. and Mexico that began in December 2020. It is also being tested in two ongoing Phase 2 studies that began in August 2020: A Phase 2b trial in South Africa that demonstrated 48.6% efficacy against a newly emerging escape variant first described in South Africa, and a Phase 1/2 continuation in the U.S. and Australia.

NVX-CoV2373 is stored and stable at 2°- 8°C, allowing the use of existing vaccine supply chain channels for its distribution. It is packaged in a ready-to-use liquid formulation in 10-dose vials.

About Matrix-M™ Adjuvant
Novavax' patented saponin-based Matrix-M™ adjuvant has demonstrated a potent and well-tolerated effect by stimulating the entry of antigen-presenting cells into the injection site and enhancing antigen presentation in local lymph nodes, boosting immune response.

About Novavax
Novavax, Inc. (Nasdaq: NVAX) is a biotechnology company that promotes improved health globally through the discovery, development and commercialization of innovative vaccines to prevent serious infectious diseases. The company's proprietary recombinant technology platform combines the power and speed of genetic engineering to efficiently produce highly immunogenic nanoparticles designed to address urgent global health needs. Novavax is conducting late-stage clinical trials for NVX-CoV2373, its vaccine candidate against SARS-CoV-2, the virus that causes COVID-19. NanoFlu™, its quadrivalent influenza nanoparticle vaccine, met all primary objectives in its pivotal Phase 3 clinical trial in older adults and will be advanced for regulatory submission. Both vaccine candidates incorporate Novavax' proprietary saponin-based Matrix-M™ adjuvant to enhance the immune response and stimulate high levels of neutralizing antibodies.

For more information, visit www.novavax.com and connect with us on Twitter and LinkedIn.

Forward-Looking Statements
Statements herein relating to the future of Novavax and the ongoing development of its vaccine and adjuvant products are forward-looking statements. Novavax cautions that these forward-looking statements are subject to numerous risks and uncertainties, which could cause actual results to differ materially from those expressed or implied by such statements. These risks and uncertainties include those identified under the heading "Risk Factors" in the Novavax Annual Report on Form 10-K for the year ended December 31, 2020, as filed with the Securities and Exchange Commission (SEC). We caution investors not to place considerable reliance on forward-looking statements contained in this press release. You are encouraged to read our filings with the SEC, available at sec.gov, for a discussion of these and other risks and uncertainties. The forward-looking statements in this press release speak only as of the date of this document, and we undertake no obligation to update or revise any of the statements. Our business is subject to substantial risks and uncertainties, including those referenced above. Investors, potential investors, and others should give careful consideration to these risks and uncertainties.

Contacts:

Investors
Novavax, Inc.
Erika Schultz | 240-268-2022
ir@novavax.com

Solebury Trout
Alexandra Roy | 617-221-9197
aroy@soleburytrout.com 

Media
Laura Keenan | 202-709-7521
Alison Chartan | 240-720-7804
media@novavax.com

 

View original content to download multimedia:http://www.prnewswire.com/news-releases/novavax-to-present-at-international-society-for-vaccines-virtual-congress-covid-19-vaccine-update-301298080.html

SOURCE Novavax, Inc.

FAQ

What is the efficacy of NVAX's NVX-CoV2373 vaccine?

NVX-CoV2373 demonstrated approximately 90% efficacy in its Phase 3 clinical trial in the U.K.

When will Novavax present its COVID-19 vaccine data?

Novavax will present data on NVX-CoV2373 during the International Society for Vaccines Virtual Congress on May 25, 2021.

What technology does NVX-CoV2373 use?

NVX-CoV2373 uses Novavax's recombinant nanoparticle technology and is adjuvanted with Matrix-M™.

Where can I register for the International Society for Vaccines Congress?

You can register for the International Society for Vaccines Congress at their official website.

What variants is NVX-CoV2373 effective against?

NVX-CoV2373 has shown efficacy against newer circulating COVID-19 variants including the B.1.1.7/501Y.V1 variant.