Nuvalent, Inc. - NUVL STOCK NEWS

Nuvalent, Inc. (Nasdaq: NUVL), a biopharmaceutical company, announced participation in the 43rd Annual Cowen Healthcare Conference on March 8, 2023, at 9:10 a.m. ET in Boston. CEO James Porter, Ph.D., and CFO Alexandra Balcom will engage in a fireside chat.

A live webcast will be available in the Investors section of Nuvalent's website, with an archive accessible for 30 days post-event. Nuvalent focuses on developing targeted cancer therapies aimed at kinase targets, with ongoing programs for ROS1-positive and ALK-positive non-small cell lung cancer.

Nuvalent, Inc. (Nasdaq: NUVL) announced that CEO James Porter will present at the 41st Annual J.P. Morgan Healthcare Conference on January 10, 2023, at 7:30 a.m. PT in San Francisco. The company, focused on developing targeted therapies for cancer, aims to address the limitations of current treatments. A live webcast of the presentation will be available on the company's website and archived for 30 days. Nuvalent is advancing a pipeline targeting ROS1-positive and ALK-positive lung cancers, HER2 Exon 20 insertion-positive cancers, and other discovery-stage programs.

Nuvalent, Inc. (Nasdaq: NUVL) announced a manuscript publication detailing NVL-520’s design and characterization in Cancer Discovery. Currently in the ARROS-1 Phase 1/2 trial for ROS1-positive non-small cell lung cancer, NVL-520 aims to address limitations of existing ROS1 inhibitors. The publication presents extensive preclinical data and case studies showing NVL-520’s efficacy against ROS1 fusions, including the prevalent G2032R mutation, with no observed neurological toxicities. This underscores NVL-520's potential as a best-in-class ROS1 inhibitor.

Nuvalent, Inc. (NUVL) reported promising preliminary Phase 1 data for NVL-520 in ROS1-positive NSCLC at the EORTC-NCI-AACR Symposium, supporting its best-in-class potential. The company is progressing in the ALKOVE-1 trial for NVL-655 targeting ALK-positive NSCLC, while NVL-330 shows selectivity for HER2 Exon 20 mutations. A successful upsized public offering raised $264.5 million, extending the cash runway to late 2025. Q3 financials show a net loss of $19.7 million, with R&D expenses at $14.6 million, as the company advances its innovative oncology pipeline.

Nuvalent, Inc. (Nasdaq: NUVL) announced the closing of an upsized underwritten public offering of 7,895,522 shares of Class A common stock at $33.50 per share, generating gross proceeds of approximately $264.5 million. This includes 1,029,850 shares from the full exercise of underwriters' options. The shares were offered under a shelf registration statement effective since August 16, 2022. Notably, J.P. Morgan, Cowen, Piper Sandler, and BMO Capital Markets acted as joint book-running managers for this transaction.

Nuvalent, Inc. (Nasdaq: NUVL) has priced its underwritten public offering of 6,865,672 shares of Class A common stock at $33.50 per share, aiming for gross proceeds of approximately $230 million before expenses. The offering is expected to close on November 3, 2022, pending customary conditions. There is also a 30-day option for underwriters to buy an additional 1,029,850 shares. This offering is part of a shelf registration statement effective since August 16, 2022.

Nuvalent, Inc. (Nasdaq: NUVL) has launched an underwritten public offering of $200 million of Class A common stock, all offered by the company. A 30-day underwriters' option for an additional 15% of shares is also expected. The offering is subject to market conditions, and completion is uncertain. The offering is conducted under a shelf registration statement effective since August 16, 2022. Nuvalent specializes in targeted cancer therapies, focusing on kinase targets. J.P. Morgan and others are managing the offering.

Nuvalent reported preliminary Phase 1 data for NVL-520, a novel ROS1-selective inhibitor, at the EORTC-NCI-AACR Symposium. The treatment showed a favorable safety profile, with no dose-limiting toxicities or serious adverse events observed among 35 enrolled patients. Encouraging signs of efficacy were noted, with 48% of heavily pre-treated ROS1-positive NSCLC patients achieving partial responses. Notable response rates were 78% in patients with G2032R mutations and 73% in those with CNS metastases. NVL-520 aims to address challenges associated with existing treatments, including resistance mutations and CNS adverse effects.

Nuvalent, Inc. (Nasdaq: NUVL) announced new preclinical data for its selective kinase inhibitors NVL-330 and NVL-655 at the 34th EORTC-NCI-AACR symposium. NVL-330 targets HER2 exon 20 insertion mutations and demonstrates selectivity over wild-type EGFR, along with potential for treating brain metastases. Preclinical results indicate NVL-655's activity in ALK-positive tumors, overcoming resistance mutations. Nuvalent continues to advance its pipeline, showcasing significant therapeutic potential against hard-to-treat cancers.