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Nuvation Bio Inc. (symbol: NUVB) is a biopharmaceutical company pioneering the development of innovative therapies to treat various forms of cancer. Founded in 2018 by industry veteran David Hung, M.D., who previously established Medivation, Inc., the company has quickly positioned itself as a leader in oncology therapeutics. Nuvation Bio operates out of New York and San Francisco, focusing on unmet medical needs in the cancer treatment landscape.
The company's core business revolves around its proprietary portfolio of six novel oncology therapeutic product candidates. These therapies are mechanistically distinct and aim to tackle some of the hardest-to-treat cancers. Among its product pipeline, the flagship clinical-stage candidate is NUV-868, an oral small molecule BET inhibitor that selectively targets BD2. This inhibitor disrupts the BRD4 protein, a crucial member of the BET family involved in tumor growth regulation. NUV-868's mechanism of action includes the inhibition of oncogenes such as c-myc, which are often altered in human cancers.
Nuvation Bio is also breaking new ground with its small molecule Drug-Drug Conjugate (DDC) platform. This approach is a novel category within anti-cancer therapies, closely related to Antibody-Drug Conjugates (ADCs). The DDC platform aims to deliver targeted therapy with improved efficacy and reduced side effects compared to traditional chemotherapy.
In addition to its robust product pipeline, Nuvation Bio has formed strategic partnerships and collaborations to enhance its research and development capabilities. These alliances are key to accelerating the development and commercialization of its therapeutic candidates, ensuring that new treatments can reach patients who need them the most.
Financially, Nuvation Bio is well-positioned, leveraging its strong foundation and innovative pipeline to attract investor interest and funding. The company's commitment to revolutionizing cancer treatment is evident in its continuous pursuit of groundbreaking therapies and clinical trials that aim to provide better outcomes for cancer patients.
ShouTi Inc., a clinical-stage biopharmaceutical firm, has appointed Daniel Welch as Chairman of its board. Welch brings over 40 years of experience in the pharmaceutical industry, having led companies like InterMune and Triangle Pharmaceuticals. His extensive background in drug development is expected to bolster ShouTi's mission to deliver innovative, small molecule medicines addressing chronic diseases. CEO Raymond Stevens emphasized Welch's invaluable leadership as the company seeks to enhance its impact on patients awaiting life-changing treatments.
Nuvation Bio (NYSE: NUVB) has received FDA clearance for its IND application to evaluate NUV-868, a selective BET inhibitor, for treating advanced solid tumors, including ovarian and pancreatic cancers. This milestone marks the fourth IND clearance in 14 months, reflecting the company's robust pipeline. NUV-868 aims for improved tolerability due to its 1,500 times selectivity for BD2 over BD1, reducing potential toxicity. Upcoming studies will explore NUV-868's efficacy as a monotherapy and in combination therapies. The Phase 1 study begins in mid-2022.
Nuvation Bio (NYSE: NUVB) provided a corporate update ahead of the J.P. Morgan Healthcare Conference on January 11, 2022. The company anticipates multiple trial initiations and IND filings in 2022, including Phase 2 studies for NUV-422 and a Phase 1 study for NUV-868. Nuvation Bio reported a strong balance sheet with approximately $765 million in cash as of December 31, 2021. The CEO, David Hung, emphasized continued advancements in oncology therapeutics to address unmet patient needs in challenging cancer types.
Nuvation Bio (NYSE: NUVB) announced that the FDA has granted Fast Track designation to its investigational drug NUV-422, aimed at treating high-grade gliomas, including glioblastoma multiforme. This designation highlights the unmet needs in brain cancer treatment and allows for expedited development and communication with the FDA. NUV-422 also received Orphan Drug Designation in Q1 2021. Currently, the drug is undergoing Phase 1/2 trials, with promising preclinical results showing effective blood-brain barrier penetration. The company focuses on developing innovative oncology therapies.
Nuvation Bio Inc. (NYSE: NUVB) has received FDA clearance for its investigational new drug (IND) application to evaluate NUV-422, a CDK 2/4/6 inhibitor, for prostate cancer treatment. This marks the third IND approval after previous clearances for high-grade gliomas and advanced breast cancer. The company plans to initiate a Phase 1b/2 study focusing on metastatic castration-resistant prostate cancer (mCRPC) patients who previously underwent treatment with abiraterone acetate. The clinical trial will assess the safety and efficacy of NUV-422 combined with enzalutamide.
Nuvation Bio Inc. (NYSE: NUVB) announced the FDA's clearance of its IND application for NUV-422, a CDK 2/4/6 inhibitor aimed at treating advanced breast cancer. This marks a significant advancement as it follows the acceptance of NUV-422 for high-grade gliomas in 2020. The company will initiate a Phase 1/2 study on patients with HR+/HER2- advanced breast cancer who have undergone prior hormonal therapy. Nuvation Bio plans to share data from ongoing studies in late 2022, highlighting its commitment to developing innovative cancer therapies.
Nuvation Bio Inc. (NYSE: NUVB) reported Q3 financial results, showing a net loss of $22.0 million, or $(0.11) per share, compared to a net loss of $11.0 million, or $(0.12) per share in Q3 2020. R&D expenses surged to $17.1 million from $8.6 million due to increased research services and personnel costs. G&A expenses also rose to $5.7 million from $2.9 million. As of September 30, 2021, the company had $791.8 million in cash and marketable securities. Nuvation is advancing its CDK inhibitor program NUV-422, with top-line data expected in 2022.
Nuvation Bio Inc. (NYSE: NUVB) has reported its financial results for Q2 2021, highlighting significant progress in its drug development pipeline. The company is conducting a Phase 1/2 study of NUV-422, expanding patient enrollment to include those with recurrent glioblastoma and other cancers. Financially, Nuvation Bio holds $806.6 million in cash and equivalents. Q2 R&D expenses rose to $14 million from $7.3 million year-over-year, while general and administrative expenses increased to $6.4 million. The net loss for the quarter was $19.3 million, or $(0.09) per share, compared to a net loss of $8.6 million in Q2 2020.
Nuvation Bio Inc. (NYSE: NUVB) announced the appointment of David C. Hanley, Ph.D., as Chief Technical Operations Officer. Dr. Hanley will oversee all aspects of pharmaceutical development, including supply chain and product manufacturing, while collaborating with various teams on commercial planning.
Dr. Hanley brings 20 years of experience from leading roles at BioXcel Therapeutics and Radius Health, focusing on oncology and drug development. His expertise is expected to enhance Nuvation Bio's ongoing Phase 1/2 study of lead candidate NUV-422 and strengthen technical operations.
Nuvation Bio (NYSE: NUVB) announced that Dr. David Hung, CEO, will participate in a fireside chat at the Jefferies Virtual Healthcare Conference on June 2, 2021, at 9:00 a.m. ET. The event will be available for live viewing on the company's website under 'Events & Presentations' and archived for 30 days post-event. Nuvation Bio focuses on developing innovative oncology therapies, with a portfolio of six distinct product candidates aimed at challenging cancer types. Founded in 2018, Nuvation Bio is headquartered in New York and San Francisco.
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