Natera, Inc. - NTRA STOCK NEWS

Natera, Inc. (NASDAQ: NTRA) announced initial results from the Trifecta study, the largest biopsy-matched evaluation of donor-derived cell-free DNA (dd-cfDNA) in kidney transplant recipients. The study analyzed over 300 biopsy-matched samples, revealing that the Prospera test with quantification demonstrated an AUC of 0.81 for rejection detection, improving to 0.91 when differentiating rejection from quiescence. Natera anticipates publishing comprehensive results in early 2022, reinforcing its leadership in cfDNA technology.

Natera, Inc. (NASDAQ: NTRA) will announce its third-quarter 2021 financial results on November 4, 2021, after market close. A conference call to discuss these results, along with business activities and financial outlook, will take place at 1:30 p.m. PT (4:30 p.m. ET). Investors can join the call via live dial-in or webcast, with options for domestic and international participants. A replay of the webcast will be available later at investor.natera.com.

Natera, Inc. (NASDAQ: NTRA) has launched the Prospera Lung test, expanding its organ health offerings to include lung transplant assessments. Validated in the VALID study, this non-invasive test achieves a negative predictive value of 97.33% and 89.06% sensitivity, distinguishing between stable patients and acute rejection effectively. Natera also announced two new studies to compare Prospera against traditional biopsy methods. The company aims to improve patient outcomes among lung transplant recipients, addressing a significant clinical need for accurate monitoring.

Natera, Inc. (NASDAQ: NTRA) announced a new study published in Clinical Cancer Research validating its Signatera test for assessing tumor growth rates and predicting survival in early-stage colorectal cancer. This multi-center study involved 168 patients and demonstrated that MRD-positive patients can be stratified based on circulating tumor DNA (ctDNA) growth rates. Key findings included a 9.8-month lead time for recurrence detection and the association of ctDNA clearance with improved survival outcomes, showcasing the value of personalized ctDNA analysis in clinical decision-making.

Natera has completed the VALID Study, the largest clinical validation of a commercial cell-free DNA test for lung transplantation. The study involved 204 plasma samples from 104 lung transplant recipients and was accepted as a late-breaking abstract for presentation at CHEST 2021 (October 17-20). This study highlights the significance of donor-derived cell-free DNA (dd-cfDNA) testing in improving patient outcomes. Natera's Prospera test has previously shown success in kidney and heart transplant assessments, indicating its potential in lung transplant situations as well.

Natera, Inc. (NASDAQ: NTRA) received a favorable ruling from the Delaware Federal District Court, invalidating all three patents asserted against it by CareDx. The court determined these patents are legally invalid due to their patent-ineligible subject matter. Natera anticipates this decision will withstand an appeal and is actively pursuing its own infringement claims against CareDx concerning its '658 and '724 patents. These patents are part of Natera's extensive organ health intellectual property portfolio, showcasing the company's contribution to cfDNA-based diagnostics.

Natera, Inc. (NASDAQ: NTRA) showcased new data on the Signatera personalized molecular residual disease (MRD) technology at the 2021 ESMO Congress. The studies highlighted include the predictive capacity of ctDNA for relapse in gastroesophageal cancers, the use of ctDNA dynamics in assessing treatment response in uveal melanoma, and the impact of CHIP mutations on patient outcomes. Results indicated ctDNA detected in 93.3% of samples at baseline for gastroesophageal cancer, and ctDNA reduction was linked to improved overall survival in uveal melanoma.

Natera (NASDAQ: NTRA) has launched Prospera with Quantification, a groundbreaking cfDNA test for kidney rejection analysis. This test uniquely reports three critical metrics — the quantity of donor-derived cfDNA (dd-cfDNA), the fraction of dd-cfDNA, and total cfDNA — enhancing sensitivity in detecting transplant rejection. A recent study published in JASN confirmed that the new test improved sensitivity from 78% to 100% in active rejection cases. The test is now commercially available, underlining Natera's commitment to innovation in transplantation.

Natera, Inc. (NASDAQ: NTRA) has partnered with NRG Oncology to utilize the Signatera personalized molecular residual disease (MRD) test in the CIRCULATE-US study, a significant clinical trial for early-stage colon cancer treatment. The trial will enroll about 2,000 patients and will assess MRD-guided chemotherapy strategies. Signatera aims to refine treatment approaches, reducing unnecessary chemotherapy for 20-25% of patients who may not benefit from it. This collaboration could enhance the role of ctDNA technology in cancer management and potentially improve patient outcomes.