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Natera, Inc. (Symbol: NTRA) is a leading diagnostic and research company based in San Carlos, CA, driven by a commitment to advance the science and application of prenatal testing. In the information age, medical diagnostics have lagged behind in adopting new technologies, but Natera is changing that narrative. The company specializes in preconception and prenatal genetic testing services, providing couples with crucial information throughout the pregnancy journey.
Natera offers a comprehensive range of tests, including Preimplantation Genetic Diagnosis (PGD) for IVF and Non-Invasive Prenatal Testing (NIPT). Their Panorama NIPT is particularly notable for its ability to screen for chromosomal abnormalities in a fetus, even in twin pregnancies, typically through a simple blood draw from the mother. Another significant product is the Horizon Carrier Screening (HCS), which determines carrier status for numerous severe genetic diseases that could be passed on to offspring.
The company's innovative approach leverages advances from the Human Genome Project and is powered by proprietary bioinformatics algorithms. This technology enables highly accurate genetic testing results. Natera's portfolio also includes the Signatera Molecular Residual Disease (MRD) Test, designed to detect circulating tumor DNA in cancer patients, helping to assess molecular residual disease and monitor recurrence. Additionally, the Prospera test assesses organ transplant rejection.
Through its pioneering genetic testing services and experienced genetic counseling, Natera provides valuable insights that help in informed decision-making for pregnancies and medical conditions. The company continues to make significant strides in the field of medical diagnostics, driven by a passion for innovation and excellence.
Natera, Inc. (NASDAQ: NTRA) presented new data on its Signatera test at the American Association for Cancer Research (AACR) meeting from April 14-19, 2023. The studies included findings on personalized MRD testing in various cancers, such as muscle-invasive bladder cancer and colorectal cancer. Key highlights include:
- Prediction of tumor response and recurrence using ctDNA in patients with esophago-gastric carcinoma and MIBC.
- Genomic profiling of more than 13,000 patients with colorectal cancer.
- ctDNA's potential to guide imaging-based surveillance for post-surgery patients.
- Data supporting ctDNA's role as a predictive biomarker in hepatocellular carcinoma.
These presentations emphasize Natera's commitment to advancing cancer care through innovative testing solutions.
Natera, Inc. (NASDAQ: NTRA) announced a study published in Cancer demonstrating the prognostic and predictive utility of its Signatera test for patients with stages III-IV melanoma. The study analyzed 555 plasma samples from 69 patients and revealed that MRD positivity post-surgery was linked to shorter distant metastasis-free survival (HR=10.77; p=0.01) and earlier detection of recurrence. Among unresectable patients, increasing ctDNA levels indicated shorter progression-free survival (HR=22; p=0.006). Signatera's accuracy in monitoring treatment response highlights its potential for personalized therapy decisions, addressing the unmet need for diagnostic tools in melanoma management.
Natera, Inc. (NASDAQ: NTRA) has announced significant advancements in commercial coverage for its Signatera molecular residual disease test. Effective March 1, 2023, Blue Shield of California will cover Signatera for all solid tumor patients, marking the company's first pan-cancer policy. Additionally, as of January 1, 2023, Blue Cross and Blue Shield of Louisiana will provide coverage for colorectal and bladder cancer monitoring. This underscores the medical necessity and enhanced access to Signatera testing, which has been validated through approximately 40 peer-reviewed publications for its efficacy in detecting cancer recurrence earlier than traditional methods.
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