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Nurix Therapeutics, Inc. (Nasdaq: NRIX) is a clinical-stage biopharmaceutical company dedicated to discovering, developing, and commercializing innovative therapies that modulate cellular protein levels. Leveraging their proprietary drug discovery platform, DELigase, Nurix focuses on a novel approach to target E3 ubiquitin ligases within the ubiquitin-proteasome system (UPS). This system regulates protein stabilization and degradation, providing therapeutic opportunities across various disease areas.
Founded by experts in the UPS field and initially funded by leading investors such as Third Rock Ventures and The Column Group, Nurix has positioned itself as a leader in developing first-in-class therapies. The company’s pipeline includes drug candidates that target protein degraders of Bruton's tyrosine kinase (BTK) and inhibitors of Casitas B-lineage lymphoma proto-oncogene B (CBL-B). Their lead product candidate, NX-2127, is an orally available BTK degrader designed to treat relapsed or refractory B-cell malignancies. Another key candidate, NX-1607, is an orally available CBL-B inhibitor aimed at immuno-oncology indications.
Partnering with industry giants like Celgene, Sanofi, Gilead, and Pfizer, Nurix continues to expand its reach and capabilities. One significant collaboration with Sanofi targets the STAT6 pathway, a critical player in type 2 inflammation. The extension of this collaboration underscores the success and productivity of their ongoing research efforts. Nurix’s innovative approach is also evident in their BTK degrader NX-5948, demonstrating promising clinical activity in patients with CNS involvement.
In its recent financial update, Nurix reported strong results for the first quarter of 2024, with increased revenue driven by collaborations and research milestones. Despite reporting a net loss, the company holds substantial cash reserves to support ongoing and future projects. Leadership transitions within Nurix, such as the appointment of Julia P. Gregory as the new board chair, reflect the company’s commitment to strategic growth and innovation.
Headquartered in San Francisco, California, Nurix remains at the forefront of drug discovery and development, aiming to bring transformative therapies to patients with cancer, inflammatory conditions, and other challenging diseases. For more information, visit http://www.nurixtx.com.
Nurix Therapeutics, Inc. (NRIX) announced advancements in its clinical programs, including the initiation of Phase 1b for NX-2127 in chronic lymphocytic leukemia (CLL) due to promising Phase 1a results. The first patient was dosed in the Phase 1a trial for NX-5948 targeting B-cell malignancies. Financially, collaboration revenue rose to $11.4 million, driven by partnerships with Gilead and Sanofi. However, the net loss increased to $45.4 million for Q2 2022. As of May 31, 2022, cash and investments stood at $348.8 million.
Nurix Therapeutics (Nasdaq: NRIX) has received FDA clearance for its Investigational New Drug (IND) application to expand its NX-1607 Phase 1 clinical program into the U.S. Previously enrolling patients in the U.K., this trial will assess the safety and tolerability of NX-1607, a first-in-class CBL-B inhibitor targeting advanced malignancies.
The company aims to share initial biomarker data from the trial in the latter half of 2022, highlighting its commitment to developing innovative therapies for solid tumors.
Nurix Therapeutics (Nasdaq: NRIX) presented details about its Phase 1 clinical trials for NX-2127 and NX-5948 at the EHA2022 Hybrid Congress held from June 9-12, 2022. Both investigational therapies target patients with relapsed and refractory B-cell malignancies. Initial results from NX-2127 show clinically meaningful degradation of BTK in all patients, including those with mutations causing resistance to standard care. Further data is expected in the latter half of 2022. Posters are available for on-demand viewing on the EHA website.
Nurix Therapeutics (Nasdaq: NRIX) announced the presentation of clinical trial designs for its three investigational therapies: NX-2127, DeTIL-0255, and NX-1607 at the ASCO Annual Meeting from June 3-7, 2022. NX-2127 targets relapsed/refractory B-cell malignancies, DeTIL-0255 is focused on advanced gynecologic tumors, and NX-1607 aims to enhance anti-tumor immunity in solid tumors. Initial data from NX-2127 demonstrated significant BTK degradation. Additional data is expected in H2 2022.
Nurix Therapeutics (Nasdaq: NRIX) has initiated Phase 1b expansion cohorts of its ongoing trial for NX-2127, a BTK degrader, focusing on patients with chronic lymphocytic leukemia (CLL). This decision follows promising results from the Phase 1a study, revealing significant clinical benefits in heavily pre-treated patients. Key findings include confirmed responses in patients resistant to current therapies and robust BTK degradation. The R&D Day on May 26 will detail further data and future plans for NX-2127, which aims to address unmet needs in cancer treatment.
Nurix Therapeutics (Nasdaq: NRIX) announced the dosing of the first patient in its Phase 1a/1b trial for NX-5948, a selective degrader of Bruton’s tyrosine kinase (BTK), targeting relapsed B-cell malignancies. This open-label, dose escalation trial is ongoing across multiple UK centers, focusing on safety and tolerability. Initial data is expected in H2 2022. NX-5948 aims to address resistance seen with current BTK inhibitors. Nurix has four clinical trials running, with upcoming data catalysts anticipated over the next year.
Nurix Therapeutics, a clinical stage biopharmaceutical company (Nasdaq: NRIX), announced that CEO Arthur T. Sands will participate in a fireside chat at the 2022 RBC Capital Markets Global Healthcare Conference on May 18th, 2022, at 11:00 a.m. ET. The event will be available via a live webcast and replay on the company's website. Nurix is focused on developing targeted protein modulation drugs through its DELigase platform, aimed at innovating cancer and other disease treatments.
Nurix Therapeutics, Inc. (Nasdaq: NRIX) will host an R&D Day on May 26, 2022, from 8:00 a.m. to 11:00 a.m. ET in New York City. The event will feature Dr. Anthony Mato, Director of the CLL Program at Memorial Sloan Kettering Cancer Center, discussing unmet needs in hematologic malignancies. Nurix's management will present updates on their four clinical programs and the DELigase® discovery platform. A live webcast will be available on their website.
Nurix Therapeutics, Inc. (Nasdaq: NRIX) shared preclinical data at the AACR Annual Meeting, showcasing the potential of investigative therapies NX-2127 and DeTIL-0255 for treating B-cell malignancies and solid tumors. Key findings include NX-2127's unique ability to degrade Bruton’s tyrosine kinase (BTK) and IMiD neosubstrates, enhancing tumor cell killing. Additionally, NX-0255 was shown to enhance T-cell persistence and anti-tumor response in animal models. Nurix expects to provide clinical updates from both programs in H2 2022, following promising initial trial results.
Nurix Therapeutics (NRIX) reported encouraging developments, including the first patient dosed in the Phase 1 trial of DeTIL-0255, a drug-enhanced cell therapy for advanced gynecologic cancers. The company secured an Innovation Passport for NX-1607 from the UK for solid tumor treatment, facilitating faster market access. Financially, Nurix holds $385.7 million in cash and investments as of February 28, 2022, despite a net loss of $42.5 million for Q1 2022, compared to $24.3 million in Q1 2021. Collaboration revenue increased to $9.6 million, driven by milestones from Gilead and Sanofi.
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