Nurix Therapeutics to Present Preclinical Data from Its Novel BTK Degrader (NX-2127) and CBL-B Inhibitor (NX-0255) Programs at the American Association for Cancer Research Annual Meeting
Nurix Therapeutics (Nasdaq: NRIX) has announced that preclinical data for its NX-2127 and DeTIL-0255 programs will be showcased at the AACR Annual Meeting, scheduled from April 8-13, 2022, in New Orleans, LA. Key presentations include the impact of NX-0255 on T-cell anti-tumor activity and the tumor-killing mechanisms of NX-2127. The company is also advancing its Phase 1 clinical trials for both drug candidates, with patient dosing for DeTIL-0255 expected in the first half of 2022. Additional data updates are anticipated later in the year.
- Preclinical data supporting NX-2127 and DeTIL-0255 will be presented at the AACR Annual Meeting.
- NX-0255 enhances persistence and anti-tumor activity in CD8+ T cells.
- Initial Phase 1a clinical trial data for NX-2127 shows meaningful BTK degradation in patients.
- None.
SAN FRANCISCO, March 08, 2022 (GLOBE NEWSWIRE) -- Nurix Therapeutics, Inc. (Nasdaq: NRIX), a biopharmaceutical company developing targeted protein modulation drugs, today announced that preclinical data supporting its NX-2127 and DeTIL-0255 clinical programs will be presented at the upcoming American Association for Cancer Research (AACR) Annual Meeting, which is being held from April 8-13, 2022 in New Orleans, LA.
Details of the poster presentations are as follows:
Title: Ex-vivo inhibition of CBL-B with a novel small molecule inhibitor, NX-0255, enhances persistence and anti-tumor activity of adoptively transferred CD8+ T cells in mouse tumor models
Abstract: 573
Presenter: Marilena Gallotta, Ph.D.
Date and Time: Sunday Apr 10, 2022 1:30 PM - 5:00 PM.
Session Title: Adoptive Cell Therapy 2
Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 37
NX-0255 is an inhibitor of Casitas B-lineage lymphoma proto-oncogene B (CBL-B) designed to enhance the function of ex vivo expanded T cells for adoptive cell transfer. Data presented at the AACR meeting will include analysis of the effect of in vitro pre-treatment of CD8+ T cells with NX-0255 alone, IL-2 alone, or NX-0255 combined with IL-2 on expansion, cellular phenotype, and the subsequent effect on the treated cells’ ability to reject tumors following adoptive transfer in vivo into established models of lymphoma and melanoma. Nurix has an open Phase 1 clinical trial to evaluate NX-0255-treated TILs (DeTIL-0255) in adults with gynecological malignancies. Nurix anticipates dosing the first patient in the first half of 2022 and providing a clinical update from the run-in portion of the study in the second half of 2022. Additional information on the clinical trial can be accessed at www.clinicaltrials.gov (NCT05107739).
Title: Concurrent degradation of BTK and IMiD neosubstrates by NX-2127 enhances multiple mechanisms of tumor killing
Abstract: 1126
Presenter: Mark A. Noviski, Ph.D.
Date and Time: Monday Apr 11, 2022 9:00 AM - 12:30 PM
Session Title: Mechanisms of Drug Action 3
Location: New Orleans Convention Center, Exhibit Halls D-H, Poster Section 24
NX-2127 is a novel bifunctional molecule that degrades Bruton’s tyrosine kinase (BTK) and IMiD neosubstrates. At the AACR meeting data will be presented demonstrating that NX-2127 promotes superior in vitro killing of two different lymphoma cell lines compared to BTK inhibitors or IMiDs alone. NX-2127 is currently being evaluated in a Phase 1a/1b clinical trial in patients with relapsed or refractory B cell malignancies. Initial data from the Phase 1a dose-escalation portion of the study demonstrated clinically meaningful degradation of BTK in all patients, including in a chronic lymphocytic leukemia patient with significant mutations in the BTK gene associated with resistance to standard of care BTK inhibitors. Nurix expects to present additional data from this study in the second half of 2022. Additional information on the clinical trial can be accessed at www.clinicaltrials.gov (NCT04830137).
The abstracts are available on the AACR website. All presentations and posters will be available for registered attendees for on-demand viewing on the AACR website on April 8, 2022 at 1:00 PM ET.
About Nurix Therapeutics, Inc.
Nurix Therapeutics is a clinical-stage biopharmaceutical company focused on the discovery, development, and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and other challenging diseases. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels. Nurix’s wholly owned pipeline includes targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California. For more information, please visit http://www.nurixtx.com.
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Contacts:
| Investors: | Media: |
| Elizabeth Wolffe, Ph.D. | Brett Whelan |
| Wheelhouse Life Science Advisors | LifeSci Communications |
| lwolffe@wheelhouselsa.com | bwhelan@lifescicomms.com |
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