Navidea Biopharmaceuticals Announces Research Agreement with the University of Pennsylvania Evaluating Tc99m Tilmanocept as a Prognostic Marker for Glioblastoma

Rhea-AI Summary

Navidea Biopharmaceuticals (NYSE American: NAVB) has signed a Sponsored Research Agreement with the University of Pennsylvania to explore Tc99m tilmanocept imaging in glioblastoma. This imaging aims to evaluate tumor growth rates and overall survival, targeting M2-type Tumor Associated Macrophages (TAMs). The project, led by Dr. Ali Nabavizadeh, seeks to correlate imaging results with therapeutic responses. Navidea emphasizes the potential of its tilmanocept platform to improve cancer treatment outcomes.

Positive

• Collaboration with University of Pennsylvania can enhance research credibility.
• Potential to use Tc99m tilmanocept as a prognostic biomarker in glioblastoma.
• Research may lead to valuable applications for improving patient treatment.

Negative

• Dependence on successful outcomes from preclinical studies to progress to human trials.
• Risks involved in obtaining regulatory approvals for drug candidates.

DUBLIN, Ohio--(BUSINESS WIRE)-- Navidea Biopharmaceuticals, Inc. (NYSE American: NAVB) (“Navidea” or the “Company”), a company focused on the development of precision immunodiagnostic agents and immunotherapeutics, today announced the signing of a Sponsored Research Agreement with the University of Pennsylvania (“Penn”) for a project to evaluate the use of Tc99m tilmanocept imaging in glioblastoma as a prognostic agent for tumor growth rate and overall survival. The research is led by Principal Investigator Ali Nabavizadeh, MD, of the Department of Radiology in the Perelman School of Medicine at Penn.

Glioblastoma (“GBM”) is the most aggressive and most common primary central nervous system tumor in adults and there is an urgent need for new therapies. Macrophages play an important role in tumor biology. They are a major population of non-cancer cells in GBM, representing as many as half of all cells in some cases. These Tumor Associated Macrophages (“TAMs”) may then be a viable target for tumor therapies or serve as a biomarker for monitoring tumor status.

Broadly, active macrophages can be of a tumor suppressing type (M1 macrophages) or of a tumor promoting type (M2 macrophages). The TAMs are typically M2-like and are known to express high levels of CD206, the macrophage mannose receptor that Tc99m tilmanocept targets. This research has as its hypothesis that the M2 TAMs in GBM can be imaged with Tc99m tilmanocept, and that this imaging can serve as a predictive tool for outcome with and without use of an immunotherapy that works in part to change the M2-like macrophage population to a more M1-like state, promoting tumor killing.

In these preclinical studies, Tc99m tilmanocept imaging will be evaluated in correlation with tumor growth rate, and in separate studies Tc99m tilmanocept imaging will be performed before and after anti-interleukin-6 therapy, which has been shown to promote TAM switching from the M2 to M1 state. Study endpoints will include quantitative imaging compared to pathology and overall survival.

Dr. Michael Rosol, Chief Medical Officer for Navidea, said, “We are pleased to sponsor this important work with Dr. Nabavizadeh at Penn. This is another in a line of research collaborations we have had with the highest level of researchers at top tier institutions.” Dr. Rosol continued, “Today’s announcement exemplifies the broad reach of our tilmanocept platform. The development of applications of Tc99m tilmanocept as a prognostic biomarker in cancers could have far-reaching implications for monitoring patient treatment and making decisions about therapeutic benefit. We are excited to continue to develop new and valuable applications for our core technology.”

“TAMs are a very important component of immune microenvironment in GBM, and it is crucial to have reliable imaging biomarkers to quantify and monitor TAMs during the course of treatment,” Dr. Nabavizadeh said. “The advantage of Tc99m tilmanocept is that it is already being used in patients for another research indication which means that we can move forward to human GBM patients under an Investigational New Drug Application (IND) if our preclinical studies show promising results.”

About Navidea

Navidea Biopharmaceuticals, Inc. (NYSE American: NAVB) is a biopharmaceutical company focused on the development of precision immunodiagnostic agents and immunotherapeutics. Navidea is developing multiple precision-targeted products based on its Manocept™ platform to enhance patient care by identifying the sites and pathways of disease and enable better diagnostic accuracy, clinical decision-making, and targeted treatment. Navidea’s Manocept platform is predicated on the ability to specifically target the CD206 mannose receptor expressed on activated macrophages. The Manocept platform serves as the molecular backbone of Tc99m tilmanocept, the first product developed and commercialized by Navidea based on the platform. Navidea’s strategy is to deliver superior growth and shareholder return by bringing to market novel products and advancing the Company’s pipeline through global partnering and commercialization efforts. For more information, please visit www.navidea.com.

Forward-Looking Statements

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Investor Relations Contact

Navidea Biopharmaceuticals, Inc.

Jeffrey Smith

Vice President of Operations

614-822-2365

jsmith@navidea.com

Source: Navidea Biopharmaceuticals, Inc.

FAQ

What is Navidea Biopharmaceuticals' latest announcement regarding glioblastoma?

Navidea announced a Sponsored Research Agreement with the University of Pennsylvania to evaluate Tc99m tilmanocept imaging in glioblastoma.

What is the purpose of the Tc99m tilmanocept imaging study?

The study aims to assess the imaging's ability to predict tumor growth rates and overall survival in glioblastoma patients.

Who is leading the glioblastoma research at the University of Pennsylvania?

Dr. Ali Nabavizadeh is the Principal Investigator for the glioblastoma research.

What are the potential benefits of the research collaboration for Navidea?

The collaboration may improve the application of Tc99m tilmanocept as a biomarker and enhance cancer treatment strategies.

How does Tc99m tilmanocept relate to tumor-associated macrophages?

Tc99m tilmanocept targets M2-type Tumor Associated Macrophages, which play a significant role in glioblastoma.