Mindset Pharma Announces Further Preclinical Results Demonstrating Strong Efficacy and Improved Safety Profile for its 5-MeO-DMT-Inspired Drug Candidate, MSP-4018
Mindset Pharma Inc. (OTCQB: MSSTF) announced preclinical proof-of-concept data showcasing its candidate MSP-4018, demonstrating superior efficacy and safety compared to 5-MeO-DMT. The company is optimistic about advancing to human clinical trials due to this promising data. Observations indicated that MSP-4018 maintained locomotor activity and rearing behavior across various doses, contrasting the declines noted in 5-MeO-DMT. Mindset's proprietary Family 4 compounds highlight a commitment to developing optimized psychedelic medicines for neurological and psychiatric disorders.
- MSP-4018 shows strong efficacy and improved safety profile compared to 5-MeO-DMT.
- Maintained locomotor activity and rearing behavior in trials, indicating a safer profile.
- The company is positioned to quickly advance MSP-4018 into human clinical trials.
- None.
TORONTO, Sept. 20, 2021 (GLOBE NEWSWIRE) -- Mindset Pharma Inc. (CSE: MSET) (FSE: 9DF) (OTCQB: MSSTF) ("Mindset" or the "Company"), a drug discovery and development company focused on creating optimized and patentable next-generation psychedelic medicines to treat neurological and psychiatric disorders with unmet medical needs, today announced that preclinical proof-of-concept data comparing its clinical candidate, MSP-4018, against 5-MeO-DMT further demonstrated strong efficacy and an improved safety profile as a next generation psychedelic medicine.
“Given the strong preclinical efficacy and safety data in support of MSP-4018, combined with our expedited manufacturing process, we believe our Family 4 clinical candidate has the potential to provide a safer and more scalable therapeutic alternative to first-generation 5-MeO-DMT. We believe this preclinical data will enable us to quickly advance this novel compound into human clinical trials,” said James Lanthier, CEO of Mindset.
“The latest preclinical proof-of-concept data showed that, in addition to its strong efficacy, both locomotor activity and rearing behavior for MSP-4018 did not decline at a range of doses tested, compared to the profound decline observed in 5-MeO-DMT, indicating a remarkably improved safety profile for MSP-4018. In addition, we saw further evidence of psychedelic activity, reflected in the head twitch response of mice,” concluded Joseph Araujo, Chief Scientific Officer of Mindset.
Mindset’s Family 4 compounds are DMT and 5-MeO-DMT-inspired novel drug candidates that offer a broad range of pharmacological diversity suitable for in-clinic settings. The Company has run a battery of specialized in-vitro and in-vivo tests on its patent-pending novel compounds to select the optimal psychedelic drug candidates for progressing towards human clinical trials.
To watch a video of Mindset’s CEO discussing the announcement in greater detail, please visit: https://youtu.be/JeyBUp2klXk.
For more information, please contact:
Investor Contact:
Allison Soss/Tim Regan
KCSA Strategic Communications
Email: MindSet@kcsa.com
Phone: 212-896-1267/ 347-487-6788
Company Contact:
James Lanthier, CEO
Email: jlanthier@mindsetpharma.com
Jason Atkinson, VP, Corporate Development
Email: jatkinson@mindsetpharma.com
Phone: 416-479-4094
About Mindset Pharma Inc.
Mindset Pharma Inc. is a drug discovery and development company focused on creating optimized and patentable next-generation psychedelic medicines to treat neurological and psychiatric disorders with unmet needs. Mindset was established in order to develop next generation pharmaceutical assets that leverage the breakthrough therapeutic potential of psychedelic drugs. Mindset is developing several novel families of next generation psychedelic compounds, as well as an innovative process to chemically synthesize psilocybin as well as its own proprietary compounds.
For further information on Mindset, please visit our website at www.mindsetpharma.com.
Forward-Looking Information
This news release contains certain "forward-looking information" within the meaning of applicable securities law. Forward looking information is frequently characterized by words such as "plan", "expect", "project", "intend", "believe", "anticipate", "estimate", "may", "will", "would", "potential", "proposed" and other similar words, or statements that certain events or conditions "may" or "will" occur. These statements are only predictions. Forward-looking information is based on the opinions and estimates of management at the date the information is provided and is subject to a variety of risks and uncertainties and other factors that could cause actual events or results to differ materially from those projected in the forward-looking information. Additional information regarding risks and uncertainties relating to the Company's business are contained under the heading "Risk Factors" in the Company's annual information form for the financial year ended June 30, 2020 dated March 5, 2021. The forward-looking information included in this news release is made as of the date of this news release and the Company does not undertake an obligation to publicly update such forward-looking information to reflect new information, subsequent events or otherwise, except as required by applicable law.
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