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Molecular Partners AG (NASDAQ: MOLN) is a clinical-stage biopharmaceutical company headquartered in Zurich-Schlieren, Switzerland, with an additional office in Concord, Massachusetts. The company specializes in the development of DARPin therapeutics, a new class of custom-built protein drugs designed to tackle complex diseases such as cancer and sight-threatening disorders.
Molecular Partners has a diversified product pipeline focusing primarily on oncology and ophthalmology. In the field of oncology, the firm is advancing multiple DARPin candidates including MP0533, a novel tetra-specific T cell-engaging DARPin for acute myeloid leukemia, which is currently in Phase 1/2a clinical trials. The company's latest innovation, the Switch-DARPin platform, aims to deliver multispecific candidates for conditional activation of targeted immune responses. Another exciting area of development is the Radio-DARPin Therapy (RDT) platform, which uses DARPin technology to enhance tumor uptake and reduce kidney reabsorption of radiopharmaceutical drugs, with lead candidate MP0712 targeting DLL3 in small-cell lung cancer.
On the ophthalmology front, Molecular Partners is developing therapies for retinal diseases, including wet age-related macular degeneration and diabetic macular edema. The firm's dedication to innovation is further evidenced by its strategic collaborations with prominent pharmaceutical companies such as Novartis and Orano Med.
Financially, the company reported CHF 186.9 million in cash and short-term deposits as of year-end 2023 and maintains a strong cash runway well into 2026. Despite a net loss of CHF 62 million for 2023, Molecular Partners continues to invest in its robust pipeline and transformative research initiatives.
Recent news highlights Molecular Partners' presentation at the 42nd Annual J.P. Morgan Healthcare Conference where they provided a business overview and 2024 outlook. The company anticipates significant milestones in 2024, including further clinical data from its lead oncology program MP0533 and progression of its RDT and Switch-DARPin platforms.
For more information, visit www.molecularpartners.com, or follow them on LinkedIn and X @MolecularPrtnrs.
Molecular Partners (NASDAQ: MOLN) has outlined its clinical expansion plans for 2025, highlighting key developments in its Radio-DARPin and Switch-DARPin programs. The company's Radio-DARPin MP0712, targeting DLL3, will enter first-in-human studies in 2025, while Mesothelin has been selected as the second target in their Radio-DARPin pipeline. Both programs are being co-developed with Orano Med, with their partnership now expanded to 10 programs.
The company reported encouraging results from MP0533's clinical trials, with improved response rates in cohort 8 using more frequent dosing. As of December 31, 2024, the company maintains a strong financial position with CHF 149 million in cash and cash equivalents.
The CD3 Switch-DARPin platform has demonstrated proof-of-concept in solid tumors, showing conditional T cell activation and CD2 co-stimulation, with further data expected in Q2 2025. The company plans to submit an IND application for MP0712 in H1 2025.
Molecular Partners (MOLN) and Orano Med have expanded their strategic collaboration in targeted alpha radio-therapies for cancer, increasing their joint programs from four to ten. The partnership combines Molecular Partners' Radio-DARPin Platform with Orano Med's 212Pb supply and development capabilities.
Under the new agreement, Molecular Partners will lead the development of six additional programs with a royalty arrangement. Orano Med has the option to move two of these programs into 50/50 co-development with commercialization rights. The most advanced program, MP0712, a DLL3-targeted radio-DARPin, is expected to begin human trials in 2025.
The initial agreement from January 2024 covered four programs with equally shared costs and profits. Molecular Partners holds commercialization rights for MP0712 and a second mesothelin-targeting program, while Orano Med has rights to programs three and four. Financial terms weren't disclosed, and MOLN maintains its funding guidance into 2027.
Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN), a clinical-stage biotech company specializing in DARPin therapeutics, has announced its participation in two major investor conferences in January. Chief Operating Officer Alexander Zürcher will present at the Baader Helvea Swiss Equities Conference on January 8 in Bad Ragaz, Switzerland. Subsequently, CEO Patrick Amstutz will present at the 43rd Annual JP Morgan Healthcare Conference on January 15 at 9:00am PT in San Francisco. The presentations will showcase the company's latest developments and outlook for 2025, with webcasts available on the Molecular Partners website.
Molecular Partners (NASDAQ: MOLN) presented data from two programs at ASH 2024: MP0533 phase 1/2a study and preclinical data on MP0621. The MP0533 study, targeting relapsed/refractory AML or MDS/AML, showed an acceptable safety profile in 37 patients across seven cohorts, with initial antileukemic and pharmacodynamic activity. Despite lower than anticipated drug exposure, four responders were reported. The company is amending the protocol to optimize dosing schedules.
The preclinical data for MP0621, a Switch-DARPin candidate for hematopoietic stem cell transplantation conditioning, demonstrated its intended mechanism of HSC depletion while reducing off-target effects. However, non-human primate data doesn't support its use in AML patients as previously hypothesized. The company is now evaluating MP0621 for partnering opportunities.
Molecular Partners announced data presentations at SITC 2024 for two programs: a novel CD3 Switch-DARPin T cell engager and MP0317. The CD3 Switch-DARPin platform demonstrated preclinical proof-of-concept for conditional T cell activation in solid tumors, specifically in ovarian cancer models. The technology features an 'on/off' switch mechanism that activates only in the presence of defined tumor antigens.
For MP0317, comprehensive biomarker analyses from its completed Phase 1 trial showed successful CD40 activation in tumor microenvironments across various solid tumors. The data revealed increases in dendritic cells, M1 macrophages, and other immune cells, supporting its tumor-localized approach. The company is now discussing potential investigator-initiated combination trials.
Molecular Partners will present data from its MP0533 and MP0621 programs at the upcoming ASH Annual Meeting. The clinical update on the ongoing MP0533 phase 1/2a dose escalation study shows an acceptable safety profile and initial antileukemic and pharmacodynamic activity. The Switch-DARPin MP0621 demonstrates cKit+ cell killing while reducing off-target effects associated with systemic anti-CD47 blockade. The presentations will take place at the San Diego Convention Center on December 8-9, 2024, featuring data on these DARPin therapeutics for treating AML/MDS and stem cell transplantation conditioning.
Molecular Partners (MOLN) reported its Q3 2024 interim results, highlighting progress across its portfolio. The company's Radio-DARPin candidate MP0712 is preparing for clinical entry in 2025. The company strengthened its agreement with Orano Med to co-develop four 212Pb-based Radio-DARPin candidates. Financial outlook remains strong with CHF 143.6 million in cash as of September 30, 2024, funding operations into 2027. The company expects total operating expenses of CHF 65-70 million in 2024. A recent US offering raised approximately USD 20 million through ADS sales at USD 5.49 per share.
Molecular Partners announced the pricing of an underwritten offering of 3,642,988 American Depositary Shares at $5.49 per ADS, raising approximately $20.0 million in gross proceeds. The offering, expected to close on October 29, 2024, includes participation from new investor HBM Healthcare Investments and existing investors. The company plans to use the proceeds for developing its radiopharmaceutical pipeline (Radio-DARPin Therapeutics), working capital, and general corporate purposes. Leerink Partners and TD Cowen are serving as joint bookrunning managers, with LifeSci Capital as lead manager and Zürcher Kantonalbank as settlement agent.
Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN) and Orano Med presented positive preclinical data for their Radio-DARPin Therapeutic (RDT) candidate MP0712 at the EANM Congress 2024. MP0712, targeting delta-like ligand 3 (DLL3), showed:
- Dose-dependent efficacy with a favorable safety profile
- Attractive tumor to kidney ratios in biodistribution studies
- Picomolar affinity and high specificity for DLL3
The companies plan to initiate first-in-human studies in 2025, pending regulatory clearance. MP0712 demonstrated strong tumor uptake in models with clinically relevant DLL3 expression levels, while maintaining low kidney exposure. The treatment was well-tolerated at clinically relevant dosages and showed strong efficacy compared to a radiolabelled anti-DLL3 antibody.
DLL3 is expressed in >85% of small cell lung cancer tumors and other aggressive neuroendocrine tumors, making it a highly relevant target for radiopharmaceutical therapy.
Molecular Partners AG (SIX: MOLN; NASDAQ: MOLN) has strengthened its co-development agreement with Orano Med for 212Pb-based Radio-DARPin Therapeutics. The revised agreement now includes four Radio-DARPin programs, with each company holding commercialization rights to two programs. Molecular Partners retains rights to the first program, MP0712 targeting DLL3, and gains rights to the second nominated Radio-DARPin Candidate.
The companies plan to initiate first-in-human studies for MP0712 in 2025, pending regulatory clearance. Molecular Partners expects no immediate impact on its 2024 financial forecast and maintains its funding guidance into 2027. The company's estimated cash and cash equivalents as of September 30, 2024, are approximately CHF 140 million (unaudited).
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