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Monopar Therapeutics Inc. (Nasdaq: MNPR) is a clinical-stage biopharmaceutical company focused on developing proprietary therapeutics aimed at prolonging life and enhancing the quality of life for cancer patients. Founded in 2014 and headquartered in Wilmette, Illinois, the company has made significant strides in the oncology sector with a robust pipeline of innovative treatments.
Monopar's leading candidate, Validive®, is a clonidine mucobuccal tablet currently in Phase III clinical trials. It aims to treat severe oral mucositis in patients undergoing radiation therapy for oropharyngeal cancer. Another key product, camsirubicin, is a next-generation analog of doxorubicin designed to limit cardiotoxicity while retaining its anticancer efficacy. This compound is presently in a Phase 1b dose-escalation trial for soft tissue sarcoma.
Additionally, Monopar is developing MNPR-101, a humanized monoclonal antibody targeting the urokinase plasminogen activator receptor (uPAR) for the treatment of advanced solid tumors and severe COVID-19. The company's MNPR-101-Zr is currently enrolling patients in a Phase 1 dosimetry clinical trial to evaluate its safety and biodistribution in various advanced cancers.
Monopar has established strategic partnerships to bolster its research and development efforts. The collaboration with Grupo Español de Investigación en Sarcomas is pivotal for advancing camsirubicin, while the partnership with NorthStar Medical Radioisotopes focuses on developing radio-immuno-therapeutics, including the supply of actinium-225 (Ac-225) for MNPR-101.
Financially, Monopar reported significant progress in reducing net loss from $10.5 million in 2022 to $8.4 million in 2023. The company ended 2023 with $7.3 million in cash and additional funding of $3.2 million expected in Q1 2024. These resources are projected to sustain operations through June 2025, enabling Monopar to reach key clinical milestones.
For more information on Monopar Therapeutics and their groundbreaking work in oncology, visit www.monopartx.com.
Monopar Therapeutics Inc. (Nasdaq: MNPR) announced key updates in their latest press release dated May 13, 2021. The company reported the first patient dosed in the Phase 2b/3 VOICE clinical trial for Validive, aimed at preventing severe oral mucositis in cancer patients. They also received patent allowances for Validive and a novel family of camsirubicin analogs. Financially, Monopar holds $25.7 million in cash, though net losses increased to $1.9 million in Q1 2021.
Monopar Therapeutics (Nasdaq: MNPR) announced the publication of a peer-reviewed study demonstrating the potential of its uPA antibody fragment for imaging triple-negative breast cancer. The study suggests that this technology could facilitate rapid PET imaging to identify and monitor uPA overexpression in tumors, which is crucial for treatment decisions. The company is optimistic about leveraging its panel of uPA-targeted antibodies for cancer imaging and treatment development.
Monopar Therapeutics (Nasdaq: MNPR) recently announced key developments and financial results for Q4 and full-year 2020. The company commenced the Phase 2b/3 VOICE clinical trial for Validive, aimed at preventing severe oral mucositis in oropharyngeal cancer patients. A Phase 2 trial for camsirubicin is set to begin in Q2 2021, evaluating its effectiveness against doxorubicin. The company reported a net loss of $6.3 million for 2020, showing an increase from $4.2 million in 2019, with cash reserves of $16.7 million to support operations at least through March 2022.
Monopar Therapeutics Inc. (Nasdaq: MNPR) has announced a collaboration with Andrew Cittadine to explore strategic options for MNPR-101 as an imaging agent in bladder cancer surgeries. Cittadine, a seasoned entrepreneur in medtech, brings a wealth of experience in oncology diagnostics. The partnership aims to leverage MNPR-101's potential following promising early data published in the European Journal of Cancer. The company focuses on developing therapeutics that improve the quality of life for cancer patients, including its pipeline products.
Monopar Therapeutics Inc. (Nasdaq: MNPR), a biopharmaceutical company focused on cancer therapeutics, announced upcoming presentations by CEO Chandler D. Robinson at several investor conferences in March. The presentations include:
- H.C. Wainwright Global Life Sciences Conference on March 9, 2021, at 7:00 a.m. ET.
- 33rd Annual Roth Conference on March 16, 2021, at 12:00 p.m. ET.
- Maxim’s 2021 Emerging Growth Virtual Conference on March 17, 2021, with the timing to be determined.
Monopar develops therapeutics aimed at improving cancer patients' lives.
Monopar Therapeutics (Nasdaq: MNPR) has appointed Laura Kelly as the new Director of Clinical Operations. With extensive experience in clinical research, particularly in oncology, she will oversee the Phase 2b/3 VOICE trial for Validive and other clinical programs. CEO Chandler Robinson emphasized her role is timely given the company's development efforts. Her leadership is expected to enhance clinical trial execution and enrollment. This strategic appointment aims to strengthen Monopar's capabilities in advancing its pipeline for cancer therapies.
Monopar Therapeutics (Nasdaq: MNPR) announced the dosing of the first patient in its Phase 2b/3 VOICE trial for Validive aimed at preventing chemoradiotherapy-induced severe oral mucositis (SOM) in oropharyngeal cancer patients. Validive's formulation allows for easy self-administration and targets a significant unmet need as approximately 40,000 patients in the US suffer from SOM annually. The previous Phase 2 trial indicated a 40% reduction in SOM incidence with Validive. The current trial plans to enroll around 260 patients.
Monopar Therapeutics Inc. (Nasdaq: MNPR) has published a peer-reviewed study in the European Journal of Cancer, highlighting the potential of MNPR-101 as a uPAR imaging agent to enhance surgical outcomes in bladder cancer. The study indicates that MNPR-101 may assist surgeons in better visualizing tumor boundaries, potentially resulting in more successful tumor resections. Given that bladder cancer has a high recurrence rate, the development of this imaging probe could significantly impact treatment efficacy if validated in clinical settings.
Monopar Therapeutics Inc. (Nasdaq: MNPR) announced a new patent for MNPR-101 in Canada, enhancing its global patent protection, which already includes the US, Europe, and Japan. MNPR-101 is a first-in-class antibody targeting the urokinase Plasminogen Activator Receptor (uPAR), prevalent in certain cancer types. This patent allows Monopar to expand its research on MNPR-101, which may also be utilized in treating severe COVID-19. The company is strategically positioned to explore MNPR-101's potential in multiple therapeutic areas.
Monopar Therapeutics (Nasdaq: MNPR) announced the issuance of a new U.S. patent (US 10,450,340), enhancing its camsirubicin intellectual property portfolio, which may expire in 2038. This patent covers a novel family of 2-pyrrilino camsirubicin analogs designed to maintain a non-cardiotoxic profile while exhibiting broad-spectrum antitumor activity. The company is on track to initiate a Phase 2 clinical trial in early 2021, evaluating camsirubicin against doxorubicin for advanced soft tissue sarcoma. Successful development could lead to better patient outcomes by overcoming dosing limitations associated with doxorubicin.
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