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Milestone Pharmaceuticals Inc. (Symbol: MIST) is a biopharmaceutical company headquartered at 6100 Royalmount Ave, Montreal, QC, Canada. The company specializes in developing and commercializing innovative treatments for cardiovascular conditions, with a key focus on its lead investigational product, etripamil.
Milestone's primary product, etripamil, is a calcium channel blocker designed for rapid onset as a nasal spray. This unique formulation allows patients to self-administer the medication to terminate episodes of paroxysmal supraventricular tachycardia (PSVT). PSVT is a condition characterized by an abnormally fast heart rate, which can be both sudden and recurrent.
The company is also conducting a Phase 2 clinical trial to evaluate the efficacy of etripamil for patients with atrial fibrillation experiencing a rapid ventricular rate (AFib-RVR). This trial marks another significant step in expanding the usage of etripamil to address additional cardiovascular indications.
Recent Achievements and Current Projects:
- Milestone intends to use the proceeds from its latest offering to further the development of etripamil for PSVT and AFib-RVR, along with other general corporate purposes.
- The company has secured a shelf registration statement on Form S-3, effective as of February 2, 2022, allowing for streamlined securities offering.
- Milestone actively participates in educational initiatives, such as partnering with the Arrhythmia Alliance for SVT Awareness Day, aimed at raising awareness about heart rhythm disorders.
Financial Condition and Partnerships: Milestone maintains a strong financial position, supported by recent offerings and strategic partnerships. The company's collaborations with healthcare organizations and participation in global awareness campaigns underline its commitment to improving cardiovascular health.
Key Highlights:
- Innovative treatment for PSVT with a patient-administered nasal spray.
- Ongoing Phase 2 trial for AFib-RVR.
- Effective use of proceeds for development and expansion.
- Active involvement in cardiovascular health awareness initiatives.
With a robust pipeline and strategic initiatives, Milestone Pharmaceuticals Inc. is dedicated to addressing unmet needs in cardiovascular care, making significant strides in the biopharmaceutical industry.
Milestone Pharmaceuticals Inc. (Nasdaq: MIST) announced its participation in two upcoming investor conferences. Management will present at the Cowen 42nd Annual Health Care Conference on March 8, 2022, at 2:10 p.m. ET, and at the Oppenheimer 32nd Annual Healthcare Conference on March 16, 2022, at 11:20 a.m. ET. Live webcasts of these presentations will be available on Milestone's website, with archived replays accessible for 90 days post-event. Milestone focuses on innovative cardiovascular medicines, with its lead candidate, etripamil, in Phase 3 trials for paroxysmal supraventricular tachycardia.
Milestone Pharmaceuticals (Nasdaq: MIST) appointed David Bharucha, M.D., Ph.D., as Chief Medical Officer, effective February 15, 2022. Dr. Bharucha, a cardiac electrophysiologist with over 30 years of experience, replaces Francis Plat, M.D., who will transition to Chief Scientific Officer and serve in an advisory role post-Phase 3 RAPID trial. Dr. Bharucha aims to advance etripamil, a treatment for paroxysmal supraventricular tachycardia and atrial fibrillation. An inducement stock option for 330,000 shares has been granted to him, aligning his interests with shareholder value.
Milestone Pharmaceuticals Inc. (Nasdaq: MIST) announced that CEO Joseph Oliveto will participate in a prerecorded fireside chat at the H.C. Wainwright BIOCONNECT Virtual Conference from January 10-13, 2022. The chat will be available on January 10, 2022, at 7:00 am ET on Milestone's website. Milestone focuses on innovative cardiovascular medicines, with its lead product, etripamil, in Phase 3 trials for paroxysmal supraventricular tachycardia and Phase 2 trials for atrial fibrillation.
Milestone Pharmaceuticals (Nasdaq: MIST) announced significant findings from a post-hoc analysis of the Phase 3 NODE-301 trial for etripamil, a novel nasal spray treatment for paroxysmal supraventricular tachycardia (PSVT). The analysis revealed that etripamil significantly reduced heart rates during SVT episodes within 5 minutes, sustained for up to 60 minutes. Notably, patients experienced greater heart rate reductions compared to placebo (p<0.0001). These results, presented at the AHA Scientific Sessions 2021, support etripamil’s potential as an effective at-home treatment for PSVT and possibly atrial fibrillation with rapid ventricular response.
Milestone Pharmaceuticals (MIST) reported its Q3 2021 financial results, highlighting progress in the etripamil program for PSVT. The Phase 3 RAPID trial is on track to report topline data in H2 2022, targeting 180 adjudicated events among 500 patients. The recent PRO market research study revealed significant disease burden among PSVT patients, with a median of 12-15 episodes annually. The company holds $126.4 million in cash and reported a Q3 operating loss of $14.3 million, an increase from the previous year.
Milestone Pharmaceuticals (Nasdaq: MIST) announced presentations by CEO Joseph Oliveto at key investor conferences. The 2021 Jefferies London Virtual Healthcare Conference presentation becomes available on-demand on November 18, 2021, at 3:00 a.m. ET. Additionally, at the Piper Sandler 33rd Annual Virtual Healthcare Conference, a fireside chat will be accessible starting at 10:00 a.m. ET on November 22, 2021. Replays will be found on Milestone's website for approximately 30 days after the events, reinforcing their commitment to innovative cardiovascular medicine.
Milestone Pharmaceuticals (Nasdaq: MIST) has announced that Amit Hasija, CFO, will present at the 2021 Cantor Fitzgerald Virtual Global Healthcare Conference on September 29, 2021, at 10:00 a.m. ET. The presentation will occur virtually, and a live webcast can be accessed on Milestone's website, with an archived replay available afterward. Milestone is developing innovative cardiovascular medicines, including etripamil, which is in Phase 3 for treating paroxysmal supraventricular tachycardia and in Phase 2 for atrial fibrillation.
Milestone Pharmaceuticals (Nasdaq: MIST) announced that CEO Joseph Oliveto will participate in a fireside chat at the H.C. Wainwright 23rd Annual Global Investment Conference from September 13-15, 2021. The chat will be pre-recorded and accessible from September 13, 2021, at 7:00 am ET on Milestone's website. Milestone focuses on innovative cardiovascular medicines, with its lead product candidate, etripamil, in Phase 3 trials for paroxysmal supraventricular tachycardia and in Phase 2 trials for atrial fibrillation treatment.
Milestone Pharmaceuticals (MIST) reported Q2 2021 financial results, highlighting a revenue of $15 million from an exclusive license agreement. As of June 30, the company had $135.8 million in cash and investments. Operating income reached $0.7 million, a significant improvement from a loss of $13.1 million in Q2 2020. Progress continues in clinical trials for etripamil, with increasing enrollment rates for the Phase 3 RAPID trial and positive potential indicated for AFib-RVR treatment. The company remains on track to report topline data in H2 2022.
Milestone Pharmaceuticals (Nasdaq: MIST) announced that Joseph Oliveto, President and CEO, will present at the Jefferies Virtual Healthcare Conference on June 2, 2021, at 4:00 PM ET. The event will be held virtually, and a live webcast can be accessed on Milestone's website, with an archived replay available afterward. Milestone focuses on innovative cardiovascular medicines, with its lead product candidate, etripamil, in Phase 3 trials for paroxysmal supraventricular tachycardia and Phase 2 for atrial fibrillation. For more details, visit www.milestonepharma.com.
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