Mira Pharma Stock Price, News & Analysis

MIRA Pharmaceuticals (NASDAQ:MIRA) has announced a breakthrough in neuropathic pain treatment. Their novel oral ketamine analog, Ketamir-2, achieved 100% reversal of neuropathic pain in a pre-clinical rat study, outperforming traditional oral ketamine. Key findings include:

- Low doses led to significant pain reversal for 14-22 days post-operation
- Higher doses completely normalized pain thresholds
- Ketamir-2 showed superior efficacy compared to oral ketamine
- Additional studies are underway for cancer-induced depression and neuropathic pain
- Human efficacy could potentially be demonstrated as early as 2025

MIRA is now focusing on scaling production and preparing for clinical trials, positioning Ketamir-2 as a potential game-changer in neuropathic pain treatment.

MIRA Pharmaceuticals Inc. (NASDAQ:MIRA) has made significant progress in its drug development programs, particularly with its novel oral ketamine analog, Ketamir-2. The company has enhanced its leadership by appointing Dr. Itzchak Angel as Chief Scientific Advisor. Recent preclinical studies have shown that Ketamir-2 offers a superior safety profile compared to traditional ketamine, with potential applications in treating depression, anxiety, and PTSD.

MIRA has also advanced its MIRA-55 program, a novel oral pharmaceutical marijuana analog, which has demonstrated higher efficacy at cannabinoid receptors compared to THC. The company is finalizing its Investigational New Drug (IND) application for Ketamir-2, with plans to submit by year-end. This progress positions MIRA to potentially transform patient care in neurological and neuropsychiatric disorders with innovative, at-home treatment options.

MIRA Pharmaceuticals (NASDAQ:MIRA) has unveiled new preclinical data on Ketamir-2's principal metabolite, Nor-Ketamir-2. The findings show that Nor-Ketamir-2 selectively interacts with the NMDA PCP site, demonstrating high selectivity and lack of activity on other sites. A new salt, Ketamir-2 Pamoate, and associated formulation were developed to enhance pharmacokinetics and improve brain penetration.

Key advantages over traditional ketamine include:

• Nearly 100% oral bioavailability of Nor-Ketamir-2
• Sustained plasma residence and brain penetration
• Extended therapeutic efficacy
• Improved safety profile

MIRA is conducting studies for potential indications such as cancer neuropathic pain, chemo-induced depression, and PTSD. The company plans to submit an Investigational New Drug (IND) application by year-end.

MIRA Pharmaceuticals (NASDAQ:MIRA) has announced positive preclinical data for its novel oral ketamine analog, Ketamir-2, bringing it closer to a potential IND submission this year. The latest findings reveal that Ketamir-2 is a selective inhibitor of the NMDA receptor, specifically interacting at the PCP-binding site with 30-50-fold lower affinity compared to ketamine. This selectivity may lead to reduced side effects and an improved safety profile.

Toxicology studies in rats and dogs have shown no toxicity at high doses, indicating an excellent safety margin. Ketamir-2 also demonstrates pronounced antidepressant and anxiolytic activities at lower doses. The compound's unique selectivity and robust safety data enhance its potential as a transformative treatment for neurological and neuropsychiatric disorders, including depression, treatment-resistant depression, and PTSD.

MIRA Pharmaceuticals (NASDAQ:MIRA) has announced promising preclinical results for Ketamir-2, its novel oral ketamine analog. The drug shows potential advantages over traditional ketamine for treating neurological and neuropsychiatric disorders. Key findings include:

1. Better brain penetration due to non-interaction with P-glycoprotein
2. Higher oral bioavailability (80% vs. <30% for ketamine)
3. Improved safety profile with no hyper-locomotor activity or mu-opioid receptor interaction
4. Significant anti-depressive and anxiolytic effects in mouse models

MIRA aims to submit an IND application to the FDA by year-end for human testing. The company is also exploring orphan drug indications for conditions like multiple sclerosis-induced depression and Huntington's disease-induced depression.

MIRA Pharmaceuticals (Nasdaq: MIRA) has announced promising results from preclinical studies of its novel oral pharmaceutical marijuana analog, MIRA-55. The compound, being studied as a potential treatment for anxiety and cognitive decline, showed significant advantages over THC in multiple tests.

Key findings include:

• Higher efficacy at CB1 and CB2 cannabinoid receptors compared to THC
• More pronounced and sustained agonist activity as concentration increases
• Consistent, dose-dependent reduction in anxiety-like behaviors
• Maintained efficacy across a broader range of doses
• Promising toxicological profile, indicating potential safer profile for human use

These results confirm MIRA's earlier beliefs about MIRA-55's pharmacological profile and its potential for enhanced potency and efficacy in treating neurological and neuropsychiatric disorders.

MIRA Pharmaceuticals (NASDAQ: MIRA) has announced promising preclinical results for its oral ketamine analog, Ketamir-2, showing it does not induce hyper-locomotor activity, a psychotic symptom common with traditional ketamine use.

This indicates Ketamir-2 could offer safer mental health treatments. Conducted with Biotrial, the study evaluated Ketamir-2's effects on spontaneous locomotor activity in mice. Unlike traditional ketamine, Ketamir-2 did not trigger hyperlocomotion, suggesting reduced risks of psychotic behaviors and misuse.

MIRA plans to submit an IND application to the FDA by year-end. This development positions Ketamir-2 for broader psychiatric and neurologic applications, potentially reducing healthcare costs for conditions like treatment-resistant depression, which currently costs the U.S. $43.8 billion annually.

Further studies on Ketamir-2's safety and efficacy are ongoing, with potential applications for cancer pain and PTSD.

MIRA Pharmaceuticals announced positive preclinical results for Ketamir-2, an oral ketamine analog, suggesting it as a potential superior alternative to traditional ketamine for treating depression and treatment-resistant depression (TRD). The study conducted by Pharmaseed revealed that Ketamir-2 showed higher efficacy and safety compared to oral ketamine in male mice, with significant improvements in locomotor activity, reduced anxiety, and antidepressant effects. Unlike ketamine, Ketamir-2 can be administered orally, promising better patient compliance and is not a controlled substance under DEA rules. MIRA plans to submit an Investigational New Drug Application (IND) to the FDA later this year to initiate human trials.

Mira Pharmaceuticals announced that its novel drug MIRA-55 has been ruled by the DEA as not being a controlled substance. This decision eliminates regulatory barriers for manufacturing, research, and commercialization. MIRA-55, aimed at treating neuropathic pain, anxiety, and cognitive decline, shows promise in enhancing memory and cognitive performance without the adverse effects associated with THC in marijuana. The drug also demonstrates stable anti-anxiety effects and reduced intoxicating effects, providing a significant advantage over traditional cannabis. With access to large neurological and cannabis markets, MIRA-55 represents a promising value for the company.