MangoRx Initiates Efficacy Studies on its Patented Respiratory Illness Prevention Technology
MangoRx (NASDAQ: MGRX) has initiated efficacy studies on its patented respiratory illness prevention technology. The studies, pre-funded and expected to conclude in early Q3, will be conducted in collaboration with Vipragen Biosciences and IntraMont Technologies. The technology aims to reduce the incidence of respiratory illnesses, including H1N1 variants, Avian Flu, common cold, and Coronavirus.
The composition being tested contains a select tannin (enhanced polyphenol) and zinc gluconate. Previous research at Moscow State University showed a 93% decrease in active virus compared to the control group. The product is anticipated to be available as a lozenge or toothpaste, targeting the global influenza market valued at $8.28 billion in 2023.
MangoRx (NASDAQ: MGRX) ha avviato studi di efficacia sulla sua tecnologia brevettata per la prevenzione delle malattie respiratorie. Gli studi, finanziati in anticipo e previsti per concludersi all'inizio del terzo trimestre, saranno condotti in collaborazione con Vipragen Biosciences e IntraMont Technologies. L'obiettivo della tecnologia è ridurre l'incidenza delle malattie respiratorie, inclusi i varianti di H1N1, l'Influenza Aviaria, il raffreddore comune e il Coronavirus.
Il composta in fase di test contiene un tannino selezionato (polifenolo potenziato) e gluconato di zinco. Ricerche precedenti presso l'Università Statale di Mosca hanno mostrato una riduzione del 93% del virus attivo rispetto al gruppo di controllo. Il prodotto è previsto essere disponibile come pastiglia o dentifricio, mirando al mercato globale dell'influenza valutato a 8,28 miliardi di dollari nel 2023.
MangoRx (NASDAQ: MGRX) ha iniciado estudios de eficacia sobre su tecnología patentada para la prevención de enfermedades respiratorias. Los estudios, prefinanciados y que se espera concluyan a principios del tercer trimestre, se llevarán a cabo en colaboración con Vipragen Biosciences e IntraMont Technologies. La tecnología tiene como objetivo reducir la incidencia de enfermedades respiratorias, incluyendo variantes de H1N1, gripe aviar, resfriados comunes y coronavirus.
La composición que se está probando contiene un tanino selecto (polifenol mejorado) y gluconato de zinc. Investigaciones previas en la Universidad Estatal de Moscú mostraron una disminución del 93% del virus activo en comparación con el grupo de control. Se anticipa que el producto esté disponible como pastilla o pasta de dientes, apuntando al mercado global de la influenza valorado en 8,28 mil millones de dólares en 2023.
MangoRx (NASDAQ: MGRX)는 특허받은 호흡기 질환 예방 기술의 효능 연구를 시작했습니다. 이 연구는 사전 자금 지원을 받아 제3 분기 초에 마무리될 예정이며, Vipragen Biosciences 및 IntraMont Technologies와 협력하여 진행됩니다. 이 기술은 H1N1 변종, 조류 인플루엔자, 일반 감기 및 코로나바이러스를 포함한 호흡기 질환의 발생을 줄이는 것을 목표로 합니다.
시험 중인 조성물은 선택된 탄닌(향상된 폴리페놀)과 글루콘산 아연을 포함합니다. 모스크바 주립대학교의 이전 연구에서는 대조군에 비해 활성 바이러스가 93% 감소한 것으로 나타났습니다. 이 제품은 로제트 형태 또는 치약으로 제공될 것으로 예상되며, 2023년 82억 8천만 달러에 달하는 글로벌 인플루엔자 시장을 목표로 하고 있습니다.
MangoRx (NASDAQ: MGRX) a lancé des études d'efficacité sur sa technologie brevetée de prévention des maladies respiratoires. Les études, préfinancées et qui devraient se terminer début du troisième trimestre, seront menées en collaboration avec Vipragen Biosciences et IntraMont Technologies. La technologie vise à réduire l'incidence des maladies respiratoires, y compris les variantes H1N1, la grippe aviaire, le rhume et le coronavirus.
La composition testée contient un tannin sélectionné (polyphénol amélioré) et du gluconate de zinc. Des recherches antérieures à l'Université d'État de Moscou ont montré une diminution de 93 % du virus actif par rapport au groupe de contrôle. Le produit devrait être disponible sous forme de pastille ou de dentifrice, ciblant le marché mondial de la grippe évalué à 8,28 milliards de dollars en 2023.
MangoRx (NASDAQ: MGRX) hat Wirksamkeitsstudien zu seiner patentierten Technologie zur Prävention von Atemwegserkrankungen gestartet. Die vorfinanzierten Studien, die voraussichtlich Anfang des dritten Quartals abgeschlossen werden, werden in Zusammenarbeit mit Vipragen Biosciences und IntraMont Technologies durchgeführt. Die Technologie zielt darauf ab, die Inzidenz von Atemwegserkrankungen, einschließlich H1N1-Varianten, Vogelgrippe, Erkältungen und Coronavirus, zu reduzieren.
Die getestete Zusammensetzung enthält ein ausgewähltes Tannin (verbessertes Polyphenol) und Zinkgluconat. Frühere Forschungsarbeiten an der Staatlichen Universität Moskau zeigten eine Verringerung des aktiven Virus um 93 % im Vergleich zur Kontrollgruppe. Das Produkt wird voraussichtlich als Lutschtablette oder Zahnpasta erhältlich sein und richtet sich an den globalen Influenza-Markt, der im Jahr 2023 auf 8,28 Milliarden Dollar geschätzt wird.
- Pre-funded efficacy studies, requiring no additional capital
- Patented technology targeting a wide range of respiratory illnesses
- Previous research showed 93% decrease in active virus
- Potential to address the $8.28 billion global influenza market
- Plans for follow-up study on H5N1 strain if current trials yield positive results
- None.
The initiation of efficacy studies for MangoRx's patented respiratory illness prevention technology is a significant milestone. This development is particularly noteworthy because the trials are pre-funded, eliminating the need for additional capital, which shows sound financial planning. The use of active ingredients like tannin and zinc gluconate holds promise due to their established antiviral properties. Prior research, such as studies from Moscow State University, has shown a 93% reduction in active virus in controlled environments, which bodes well for the current trials. The move to an oral application—rather than nasal—addresses previous safety concerns with zinc-based nasal applications, making this a safer alternative. Should the technology prove effective, it could offer a novel, accessible method for preventing respiratory illnesses, potentially impacting a global market valued at $8.28 billion in 2023.
From a financial perspective, MangoRx's initiation of these studies without needing additional capital is a strong indicator of the company's fiscal health. Pre-funding ensures stability and reduces the risk of shareholder dilution. The respiratory illness prevention market is substantial, with the influenza market alone valued at $8.28 billion. Success in these trials could open significant revenue streams, considering the global demand for effective respiratory illness prevention solutions. Additionally, the company's globally recognized patent portfolio could grant it a competitive edge, potentially leading to licensing opportunities or partnerships. This news should be seen as a positive development for investors, indicating potential for future growth and increased market share.
The technological innovation behind MangoRx's respiratory illness prevention solution is impressive. Utilizing a combination of a specific tannin and zinc gluconate, the technology is designed to bind to virus protein spikes, effectively neutralizing them. The transition from nasal sprays to oral applications solves significant issues, such as the risk of anosmia associated with zinc. The technology's effectiveness, validated by rigorous ASTM E1052 standard test methods, enhances its credibility. If the upcoming studies confirm these findings, the technology could be a breakthrough in antiviral prophylactics. The ability to adapt this technology into user-friendly formats like lozenges or toothpaste further increases its commercial viability and user compliance, potentially revolutionizing how respiratory illnesses are prevented.
Dallas, Texas, July 24, 2024 (GLOBE NEWSWIRE) -- Mangoceuticals, Inc. (NASDAQ: MGRX) (“MangoRx” or the “Company”), a leader in men’s health and wellness products including erectile dysfunction (ED), hair growth, weight loss, and hormone replacement therapies, is excited to announce the initiation of efficacy studies on its patented respiratory illness prevention technology in collaboration with Vipragen Biosciences and IntraMont Technologies, Inc. Notably, these trials have been pre-funded, ensuring that the Company does not need to raise any additional capital for the completion of these studies, which are anticipated to be concluded in the earlier part of the 3rd quarter.
The recently acquired patented technology by MangoRx is designed to reduce the incidence of respiratory illnesses, including, but not limited to, H1N1 variants, Avian Flu, the common cold, Coronavirus and others. The studies are set to commence within the next few weeks with results anticipated to be concluded in the earlier part of the 3rd quarter. These include animal studies to quantify the prophylactic performance of the technology against select viruses and viral strains. The composition being tested contains a very select tannin (an enhanced polyphenol) and zinc gluconate as its primary active ingredients.
Jacob Cohen, Co-Founder and CEO of MangoRx stated, "Our global patent portfolio enables us to make a meaningful impact on global health. The initiation of these studies is a crucial step in demonstrating the efficacy of our innovative technology. We anticipate that our solution will play a vital role in managing respiratory illness outbreaks."
The studies will be conducted by Vipragen Biosciences, an AAALAC-accredited preclinical CRO located in Mysuru, India, in collaboration with IntraMont Technologies, Inc. The specific studies include an efficacy study of an anti-viral oral spray in treating influenza infection in mice. This study will evaluate the therapeutic potential and effectiveness of the anti-viral oral spray in combating influenza infections in a controlled mouse model, aiming to provide critical data on the spray's ability to reduce viral load, alleviate symptoms, and improve survival rates in treated subjects. Additionally, the evaluation of antiviral efficacy will be conducted using the ASTM E1052 standard test method assay, which rigorously assesses the antiviral efficacy of the technology, measuring the ability of the antiviral agents to inactivate specific viruses and providing essential insights into their potential for broader antiviral applications.
James Intrator, CEO of Intramont Technologies, Inc. and one of the original inventors of the intellectual property and technology commented, “the primary focus will be on testing the durability of the prophylactic coating towards viral infections. Polyphenolic nasal sprays have been successfully used to block select respiratory viruses, and the company is enhancing this approach by transitioning the concept of nasal spray to an oral-only application for better distribution and user compliance. The technology features biosafe ingredients that readily bind to protein spikes on the surface of virions (virus particles). Additionally, polyphenols bind to the oral and oropharyngeal membranes, acting as a tissue barrier.”
Previous research has highlighted the potential of this technology. In studies conducted by Moscow State University in late 2020 and early 2021, researchers used cell cultures with a pseudo virus simulant of SARS-CoV-2, combining a specific commercial tannin with zinc gluconate. The results demonstrated a significant reduction in active virus, showing a
Before someone can develop certain respiratory infections, the virus must first infect the mouth or back of the throat (surface of the pharynx) and incubate. Various research groups, including Columbia University (de Vries et al., 2021), Cornell (Shapira et al., 2022), and Berkeley (Zhu et al., 2022), have demonstrated success in preventing respiratory infections through the application of daily-use nasal sprays. These sprays have shown effectiveness even up to 12 hours after initial exposure to the virus. In some published results, the principal active ingredient of the nasal spray was a polyphenol.
Importantly, zinc in nasal applications can cause anosmia due to Zn+2 damage to the olfactory epithelium nerves (Alexander & Davidson, 2006). This can cause some people to lose their sense of smell, in some cases permanently. This led the FDA to prohibit the use of zinc salts directly in the nasal passages. However, there are no reported problems from zinc in oral applications, such as lozenges, mouthwashes, or toothpastes, where zinc salts retain a distinct presence even after repeated rinsing (Gilbert et al., 1989). This makes the oral application of this technology particularly safe and effective. The technology uses zinc gluconate in its formulation to ensure safety and efficacy in preventing respiratory infections.
MangoRx’s patent portfolio for this innovative technology is globally recognized, enabling the company to address respiratory health concerns worldwide. The Company anticipates that the product will initially be available as a lozenge or a toothpaste providing a convenient and effective means of preventing the onset and spread of respiratory illnesses. The global influenza market alone was valued at
Should the current trials yield positive results, MangoRx will promptly initiate a subsequent study specific to the H5N1 strain. This study will aim to evaluate the technology's potential in addressing avian influenza, a pressing concern for poultry farms across the US. This follow-up study is particularly relevant given the recent rise in avian flu outbreaks, emphasizing the potential broader applications of this innovative prophylactic technology.
With respiratory infections posing an increasing threat, MangoRx is actively exploring the potential of its patented technology to mitigate the impact of this global health concern.
About MangoRx
MangoRx is focused on developing a variety of men's health and wellness products and services via a secure telemedicine platform. To date, the Company has identified men's wellness telemedicine services and products as a growing sector and especially related to the area of erectile dysfunction (ED), hair growth and hormone replacement therapies. Interested consumers can use MangoRx’s telemedicine platform for a smooth experience. Prescription requests will be reviewed by a physician and, if approved, fulfilled and discreetly shipped through MangoRx’s partner compounding pharmacy and right to the patient’s doorstep. To learn more about MangoRx’s mission and other products, please visit www.MangoRx.com or on social media @Mango.Rx.
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