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MARVEL BIOSCIENCES CORP - MBCOF STOCK NEWS

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Marvel Biosciences Corp., and its wholly owned subsidiary, Marvel Biotechnology Inc., is a Calgary-based pre-clinical stage pharmaceutical development biotechnology company that utilizes a 'drug redevelopment' approach to drug development. Marvel develops new synthetic chemical derivatives of known, off-patent drugs that inhibit the A2a adenosine receptor with applications in neurological diseases like depression, anxiety, Alzheimer's, ADHD, cancer, and non-alcoholic steatohepatitis. The company focuses on developing assets with significantly less risk, cost, and time compared to traditional biotechnology companies.
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Marvel Biosciences (TSXV: MRVL) (OTCQB: MBCOF) has reported promising new data from its preclinical Rett syndrome study of MB204, conducted with the iBraiN Institute. The study compared MB204 to Trofinetide, the only FDA and Health Canada approved Rett syndrome treatment. Key findings show MB204 demonstrated sustained post-treatment benefits lasting 21 days, outperforming Trofinetide's 14-day effects. The company plans to pursue FDA Orphan and rare disease designation for MB204, which could provide market exclusivity and other benefits. Full study results are expected in Q1 2025.

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Marvel Biosciences has been awarded a $300,000 Alberta Innovates AICE Validates grant to support the preclinical validation of MB204 for Alzheimer's disease treatment. The company's drug candidate, MB204, is an adenosine A2A receptor antagonist designed to target the underlying pathology of Alzheimer's, rather than just managing symptoms. The company has completed cGMP synthesis and 4-week GLP toxicology studies, and will conduct a chronic long-term preclinical study to validate MB204's effectiveness before moving to Phase 1 clinical trials.

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Marvel Biosciences (TSXV: MRVL, OTCQB: MBCOF) reported promising interim results from a preclinical study of MB204 as a potential treatment for Rett syndrome. Conducted by experts at the iBraiN Institute in France, the study showed that chronic oral dosing of MB204 restored social interaction behaviors to near-normal levels in a preclinical model of Rett syndrome. These improvements in cognitive function may represent a pivotal shift in therapy.

Led by Dr. Julie Le Merrer and Dr. Jerome Becker, the study found that 14 days of MB204 treatment (10 mg/kg oral dosing once daily) nearly reversed social and behavioral deficits. MB204 outperformed the approved drug Trofinetide (100 mg/kg via intraperitoneal injection once daily) on most studied endpoints and exhibited a distinct carry-over effect lasting at least 14 days after dosing cessation.

Marvel CSO Dr. Mark Williams noted that MB204 showed profound effects on restoring social behaviors, suggesting potential synaptic plasticity induction. Marvel CEO Rod Matheson emphasized the compelling nature of the data, hinting at improved therapies for Rett syndrome.

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Marvel Biosciences Corp. (TSXV: MRVL) (OTCQB: MBCOF) has reported positive results from a study on MB204 in the Oprm1 mouse model of autism. The research, conducted by Drs. Julie Le Merrer and Jerome Becker, showed that a single oral dose of MB204 successfully reversed social behavior deficits typically seen in the model within one hour of administration.

Key findings include:

  • A high dose (2.5 mg/kg) of MB204 significantly restored social behavior in all measured endpoints (p<0.0001)
  • A lower dose (1 mg/kg) also reversed nearly all social behavior deficits
  • The higher dose even outperformed normal (non-autistic) mice on several endpoints

The researchers noted that MB204 showed more improvement and a hyper-social effect compared to previously tested drugs. Marvel is now testing MB204 in other autism spectrum disorder models, including Rett syndrome (Mecp2) and Fragile X syndrome (Fmr1).

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Marvel Biosciences Corp. (TSXV: MRVL) (OTCQB: MBCOF) has announced a collaboration with the FRAXA Research Foundation to test its lead asset MB204 in a preclinical model of Fragile X syndrome (FXS). FXS is a common cause of inherited intellectual disability, affecting approximately 1 in 4000 males and 1 in 8000 females. The collaboration aims to explore MB204's potential as a treatment for FXS and other forms of autism spectrum disorder.

MB204 is an adenosine A2a receptor antagonist and a novel fluorinated derivative of the approved anti-Parkinson's drug Istradefylline. FRAXA will test MB204 through its internal screening program this year. The foundation previously identified BPN14770, which is currently in Phase 3 trials for Fragile X. Notably, there is currently no approved drug to treat FXS.

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Marvel Biosciences Corp. (TSXV: MRVL) has announced the grant of 1,475,000 incentive stock options to certain directors and officers. The options, approved on July 23, 2024, have an exercise price of $0.125 per share, matching the closing price on July 22, 2024. These options are exercisable until July 23, 2029, and will vest in three tranches: 1/3 immediately, 1/3 on the first anniversary, and 1/3 on the second anniversary of the grant. The stock options are subject to the company's stock option plan and TSX Venture Exchange requirements.

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Marvel Biosciences (TSXV: MRVL; OTCQB: MBCOF) has extended its collaboration with the iBraiN Institute to test its lead drug MB204 in a pre-clinical model of Rett syndrome, a rare genetic neurological disorder. This follows promising results from earlier tests on an autism model. The study will conduct a head-to-head comparison of MB204 against Trofinetide, the only approved treatment for Rett syndrome. Dr. Julie Le Merrer and Dr. Jerome Becker, lead investigators at the iBraiN Institute, believe modulating the adenosine A2a receptor could improve outcomes. Marvel's CEO Rod Matheson expressed optimism that the ongoing research will lead to significant insights and potential treatments for Rett syndrome.

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Marvel Biosciences Corp. (TSXV: MRVL) has closed its non-brokered private placement, raising $500,000 through the issuance of 5,000,000 units at $0.10 per unit. Each unit comprises one common share and one warrant, exercisable at $0.15 per share until July 19, 2026. The company paid $25,200 in finders fees and issued 252,000 finder's warrants. Proceeds will fund pre-clinic experiments on MB-204 in chronic Alzheimer's disease and Autism models, and general working capital. The offering is subject to TSX Venture Exchange approval, with securities having a four-month hold period.

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Marvel Biosciences Corp. (TSXV: MRVL) (OTCQB: MBCOF) highlighted a new research paper published by Dr. David Blum, a member of their scientific advisory board. The study, published in 'Brain', discovered that early increases in adenosine A2A receptor (A2aR) in neurons can result in memory loss in Alzheimer's mouse models, specifically linked to Tau phosphorylation at the AT8 site rather than amyloid plaques. Marvel's lead asset, MB204, an A2aR antagonist, has shown promise in reducing Tau phosphorylation in initial studies. This suggests that MB204 could be a valuable approach in treating Alzheimer's.

Marvel Biosciences, through its subsidiary Marvel Biotechnology, focuses on developing new synthetic derivatives of off-patent drugs to target diseases like Alzheimer's, depression, anxiety, ADHD, cancer, and non-alcoholic steatohepatitis. By repurposing existing drugs, Marvel aims to reduce development time, cost, and risk.

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On June 21, 2024, Marvel Biosciences (TSXV: MRVL) announced an update regarding its private placement unit offering. The TSX Venture Exchange (TSXV) has conditionally accepted Marvel's proposed non-brokered private placement, initially announced on May 16, 2024. Additionally, the company has been granted a two-week extension until July 17, 2024, to finalize its documentation related to the offering. This extension provides Marvel more time to complete necessary formalities for the private placement, which aims to raise funds for its ongoing business operations and research initiatives.

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FAQ

What is the current stock price of MARVEL BIOSCIENCES (MBCOF)?

The current stock price of MARVEL BIOSCIENCES (MBCOF) is $0.0714 as of December 19, 2024.

What is the market cap of MARVEL BIOSCIENCES (MBCOF)?

The market cap of MARVEL BIOSCIENCES (MBCOF) is approximately 5.0M.

What is Marvel Biosciences Corp. known for?

Marvel Biosciences Corp. is recognized for its innovative 'drug redevelopment' approach to pharmaceutical development, focusing on developing synthetic chemical derivatives of known drugs for new disease indications.

What neurological diseases do Marvel Biosciences Corp.'s products target?

Marvel Biosciences Corp. targets neurological diseases such as depression, anxiety, Alzheimer's, ADHD, and non-neurological conditions like cancer and non-alcoholic steatohepatitis with its A2a adenosine receptor inhibiting products.

What distinguishes Marvel Biosciences Corp. from traditional biotechnology companies?

Marvel Biosciences Corp. stands out by developing assets with significantly less risk, cost, and time than traditional biotechnology companies through its drug redevelopment strategy.

What are some key goals of Marvel Biosciences Corp.?

Marvel Biosciences Corp. aims to develop innovative pharmaceutical assets that address unmet medical needs in neurological and non-neurological conditions, providing effective treatments with lower development risks and costs.

Who are the key figures in Marvel Biosciences Corp. leadership?

Marvel Biosciences Corp. is led by J. Roderick (Rod) Matheson, the Chief Executive Officer, and Dr. Mark Williams, the President and Chief Science Officer.

What recent collaborations has Marvel Biosciences Corp. announced?

Marvel Biosciences Corp. recently announced collaborations with Professor Emmanuel Planel of Laval University and Dr. Julie Le Merrer and Dr. Jerome Becker at the iBrain Institute, Tours, France for innovative studies on MB-204 in neurological conditions.

What is the focus of Marvel Biosciences Corp.'s ongoing pre-clinical experiments?

Marvel Biosciences Corp. is conducting pre-clinical experiments to explore the effects of MB-204 in chronic Alzheimer's disease and Autism models, aiming to develop effective treatments with a focus on neurological conditions.

How does Marvel Biosciences Corp. plan to utilize the proceeds from its recent private placement?

Marvel Biosciences Corp. intends to allocate the proceeds from the private placement towards funding additional pre-clinical experiments, compounds and formulation, and general working capital purposes to further advance its innovative drug redevelopment projects.

What sets Marvel Biosciences Corp.'s drug development strategy apart?

Marvel Biosciences Corp.'s approach of developing synthetic chemical derivatives of known drugs for new disease indications allows for more efficient asset development with lower risks and costs compared to traditional drug development methods.

How does Marvel Biosciences Corp. aim to revolutionize treatment in neurological diseases?

Marvel Biosciences Corp. aims to revolutionize treatment in neurological diseases by leveraging its innovative A2a adenosine receptor inhibiting products to address conditions like depression, anxiety, Alzheimer's, ADHD, and other neurological disorders.

MARVEL BIOSCIENCES CORP

OTC:MBCOF

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4.95M
32.85M
26.66%
Biotechnology
Healthcare
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United States of America
Calgary