Welcome to our dedicated page for Lyell Immunopharma news (Ticker: LYEL), a resource for investors and traders seeking the latest updates and insights on Lyell Immunopharma stock.
Lyell Immunopharma, Inc. (Nasdaq: LYEL) is a clinical-stage company pioneering T-cell reprogramming to create cell therapies for patients with solid tumors. By employing advanced genetic and epigenetic technologies, Lyell aims to overcome major challenges in current cell-based immunotherapies, including T-cell exhaustion and lack of durable stemness. Their innovative approach has led to a robust pipeline featuring product candidates like LYL797, LYL119, and LYL845.
Lyell's product portfolio is designed to address the unmet needs in cancer treatment. LYL797 targets ROR1-positive cancers such as triple-negative breast cancer and non-small cell lung cancer, incorporating genetic reprogramming to overexpress c-Jun and epigenetic reprogramming for enhanced durability. LYL119 is another ROR1-targeted CAR T-cell therapy that uses four reprogramming technologies for sustained function and cytotoxicity. LYL845, a tumor-infiltrating lymphocyte (TIL) product, is enhanced with Lyell's proprietary Epi-R™ protocol to improve potency and durability.
Recent achievements include the FDA granting Orphan Drug Designation for LYL845 in advanced melanoma. The company's innovative Epi-R P2 manufacturing process has shown potential to reduce TIL culture time significantly. Lyell is also advancing collaborations, such as with Outpace Bio, to develop localized IL-12 activity in tumors, enhancing the efficacy of T-cell therapies.
Lyell's business strategy has been bolstered by a strong financial position, with cash reserves extending operational capabilities into 2027. Despite macroeconomic challenges, Lyell continues to focus on generating clinical data and advancing its clinical programs, aiming to deliver transformative treatments for cancer patients.
For the latest updates on Lyell Immunopharma, including their financial performance and ongoing clinical trials, visit their official website.
Lyell Immunopharma has announced initial clinical data from its Phase 1 trial of LYL797, a ROR1-targeted CAR-T cell product enhanced with anti-exhaustion technology. Key findings include a 40% objective response rate (ORR) and a 60% clinical benefit rate (CBR) at the highest dose of 150 million CAR T cells in patients with triple-negative breast cancer (TNBC). The trial demonstrated that LYL797 can proliferate, infiltrate tumors, and kill cancer cells. No dose-limiting toxicities were reported in patients without lung metastases, although treatable pneumonitis was observed in those with lung involvement. Lyell is expanding the trial to include other ROR1+ cancers and has submitted an IND for LYL119, their next-generation product. An investor webcast will be held today at 8:30 am ET.
Lyell Immunopharma, a clinical-stage company specializing in T-cell reprogramming for solid tumor cell therapies, announced participation in the Goldman Sachs 45th Annual Global Healthcare Conference. The event is scheduled for June 10 at 4:00 pm ET. Senior management will present during this conference, and a live webcast will be accessible through Lyell's investor section on www.lyell.com. A replay will also be made available post-presentation.
Lyell Immunopharma, a clinical-stage T-cell reprogramming company, will participate in the BofA Securities Health Care Conference on May 14, 2024. The company will showcase its diverse pipeline of cell therapies for solid tumors. Investors can access the live webcast on the Company's website.
Lyell Immunopharma, Inc. (Nasdaq: LYEL) reported business highlights for Q1 2024, including strong financial position with $526.3 million in cash and ongoing advancement of diverse cell therapy pipeline. Key updates include initial clinical data expected for LYL797 and LYL845, IND submission for LYL119, and promising nonclinical data presented at AACR Annual Meeting 2024.
FAQ
What is the current stock price of Lyell Immunopharma (LYEL)?
What is the market cap of Lyell Immunopharma (LYEL)?
What does Lyell Immunopharma do?
What are Lyell's main product candidates?
What recent achievements has Lyell reported?
What technologies does Lyell use in their therapies?
What is the financial outlook for Lyell?
Where is Lyell Immunopharma located?
What is Epi-R™ manufacturing protocol?
What type of cancers are Lyell's therapies targeting?
How can I get updates on Lyell Immunopharma's developments?
What is Lyell's approach to addressing T-cell exhaustion?
