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Leap Therapeutics, Inc. - LPTX STOCK NEWS

Welcome to our dedicated page for Leap Therapeutics news (Ticker: LPTX), a resource for investors and traders seeking the latest updates and insights on Leap Therapeutics stock.

Leap Therapeutics, Inc. (Nasdaq: LPTX) is a pioneering clinical-stage biopharmaceutical company focused on developing novel targeted antibody therapies for cancer treatment. Headquartered in Cambridge, Massachusetts, Leap Therapeutics aims to discover and advance transformative cancer treatments by targeting tumor-promoting pathways, cancer-specific cell surface molecules, and activating the immune system against cancer cells.

The company's lead program, DKN-01, is a humanized monoclonal antibody that targets Dickkopf-related protein 1 (DKK1). This promising candidate is in clinical trials for treating esophagogastric, gynecologic, and colorectal cancers. Another key program, FL-301, targets Claudin18.2-expressing cells and is being developed for gastric and pancreatic cancer treatments. Leap Therapeutics also has two preclinical antibody programs, FL-302 and FL-501, which are advancing toward developing innovative cancer therapies.

Operating as a single segment dedicated to oncology, Leap Therapeutics has established several strategic collaborations to enhance its development pipeline, including a clinical collaboration with BeiGene for the DisTinGuish trial and partnerships with NovaRock Biotherapeutics and Adimab. The company's dedication to advancing targeted and immuno-oncology therapeutics underscores its commitment to addressing unmet needs in cancer treatment. Leap's research and development activities continue to make significant progress, with ongoing clinical trials and new data demonstrating the potential efficacy and safety of its therapeutic candidates.

In recent news, Leap Therapeutics announced the completion of enrollment in the randomized controlled Part C of the DisTinGuish study, evaluating DKN-01 in combination with tislelizumab and chemotherapy for advanced gastroesophageal junction and gastric cancer. Additionally, the company reported financial results for the first quarter of 2024, highlighting a successful $40 million financing that extends its cash runway into the second quarter of 2026. This funding will support the expansion and continued execution of the DKN-01 development program, including the expansion of the randomized controlled Part B of the DeFianCe study in second-line colorectal cancer patients.

For more information about Leap Therapeutics, visit www.leaptx.com or view their public filings with the SEC available via EDGAR at www.sec.gov or www.investors.leaptx.com.

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Leap Therapeutics, Inc. (LPTX) President and CEO, Douglas E. Onsi, to participate in fireside chat at Piper Sandler 35th Annual Healthcare Conference
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Leap Therapeutics, Inc. (Nasdaq:LPTX) Reports Q3 Financial Results and Development Updates for DKN-01 in Colorectal and Gastric Cancer Patients
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Leap Therapeutics to participate in two investor conferences
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Leap Therapeutics, Inc. (Nasdaq:LPTX) reported financial results for the second quarter ended June 30, 2023. The company announced positive data from Phase 2 studies of DKN-01 in treating colorectal and gastric cancer, leading to the initiation of randomized controlled trials. The company also presented long-term follow-up data at the 2023 ASCO Annual Meeting, demonstrating promising results. Financially, the company's net loss decreased to $13.4 million in the second quarter of 2023, compared to $17.0 million for the same period in 2022.
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Leap Therapeutics initiates Phase 2 study for its anti-DKK1 antibody in colorectal cancer patients.
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Leap Therapeutics, Inc. (NASDAQ: LPTX) announced its presentation of long-term follow-up data from Part A of the DisTinGuish study at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting, scheduled for June 2-6, 2023, in Chicago, IL. This Phase 2 clinical trial evaluates the efficacy of DKN-01, an anti-DICKKOPF-1 antibody, in combination with tislelizumab and chemotherapy for patients with advanced gastroesophageal adenocarcinoma (GEA). The presentation will occur on June 5, 2023, at 11:30 a.m. ET, featuring Samuel J. Klempner from Harvard Medical School. The study aims to assess the safety and effectiveness of DKN-01 in various patient groups, as Leap continues to develop targeted cancer therapies.

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Leap Therapeutics, Inc. (Nasdaq: LPTX) has completed enrollment in Part A of the Phase 2 DeFianCe study, which evaluates DKN-01, its anti-Dickkopf-1 antibody, in combination with bevacizumab and chemotherapy for advanced colorectal cancer (CRC).

This milestone is considered critical for the DKN-01 program, reflecting strong interest from investigators and patients. The study enrolled 33 patients in Part A and is set to expand into Part B with a total of 130 patients. The primary goal is to assess progression-free survival, with secondary objectives including overall response rate and overall survival.

DKN-01 is designed to disrupt the immune suppressive tumor microenvironment associated with CRC, offering potential therapeutic benefits. Initial data from the study is expected in mid-2023.

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FAQ

What is the current stock price of Leap Therapeutics (LPTX)?

The current stock price of Leap Therapeutics (LPTX) is $2.55 as of November 22, 2024.

What is the market cap of Leap Therapeutics (LPTX)?

The market cap of Leap Therapeutics (LPTX) is approximately 99.6M.

What does Leap Therapeutics, Inc. specialize in?

Leap Therapeutics specializes in developing targeted antibody therapies for cancer treatment, focusing on inhibiting tumor-promoting pathways, targeting cancer-specific cell surface molecules, and activating the immune system against cancer cells.

What is DKN-01?

DKN-01 is Leap Therapeutics' lead clinical candidate, a humanized monoclonal antibody targeting Dickkopf-related protein 1 (DKK1), being developed to treat esophagogastric, gynecologic, and colorectal cancers.

What are the latest developments in Leap Therapeutics' clinical trials?

Recent developments include the completion of enrollment in the Part C of the DisTinGuish study evaluating DKN-01 with tislelizumab and chemotherapy for advanced gastroesophageal junction and gastric cancer, and the expansion of the Part B of the DeFianCe study for second-line colorectal cancer.

Who are Leap Therapeutics' collaboration partners?

Leap Therapeutics collaborates with BeiGene for the DisTinGuish trial and has partnerships with NovaRock Biotherapeutics and Adimab.

What are the financial highlights from Leap Therapeutics' latest quarter?

For the first quarter of 2024, Leap Therapeutics reported a net loss of $13.8 million. Cash and cash equivalents totaled $54.9 million at the end of March 31, 2024. The company also completed a $40 million financing round in April 2024.

Where is Leap Therapeutics headquartered?

Leap Therapeutics is headquartered in Cambridge, Massachusetts.

What is FL-301?

FL-301 is one of Leap Therapeutics' clinical programs targeting Claudin18.2-expressing cells, being developed for gastric and pancreatic cancer treatments.

How does Leap Therapeutics plan to use the recent $40 million financing?

Leap Therapeutics intends to use the net proceeds to fund the continued development of its lead monoclonal antibody program, DKN-01, expand the randomized controlled Part B of the DeFianCe Study, enable data maturity in the Part C of the DisTinGuish study, and manufacture clinical trial material for Phase 3 readiness.

What are Leap Therapeutics' preclinical programs?

Leap Therapeutics has preclinical antibody programs, FL-302 and FL-501, which are aimed at developing new cancer treatments.

How can one access Leap Therapeutics' public filings?

Public filings can be accessed via EDGAR at the SEC's website (www.sec.gov) or through Leap Therapeutics' investor relations page (www.investors.leaptx.com).

Leap Therapeutics, Inc.

Nasdaq:LPTX

LPTX Rankings

LPTX Stock Data

99.63M
31.69M
17.29%
40.3%
2.64%
Biotechnology
Pharmaceutical Preparations
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United States of America
CAMBRIDGE