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Lineage Cell Therapeutics, Inc. (Symbol: LCTX) is a clinical-stage biotechnology company that is pioneering the development and commercialization of novel therapies designed to address degenerative diseases. With a foundation built on pluripotent cell technology, Lineage Cell's innovative approach leverages cells capable of transforming into any type of cell in the human body. This groundbreaking capability allows for therapies aimed at regenerating or replacing damaged cells and tissues, providing hope for conditions that currently have no cure.
The company's pipeline is robust and diverse, encompassing several key product candidates:
- OpRegen: A retinal pigment epithelium transplant therapy targeting dry age-related macular degeneration, a leading cause of vision loss among the elderly.
- OPC1: An oligodendrocyte progenitor cell therapy designed to treat acute spinal cord injuries by promoting cell replacement and recovery.
- VAC2: An allogeneic cancer immunotherapy utilizing antigen-presenting dendritic cells to fight non-small cell lung cancer.
- ANP1: A promising therapy involving the transplant of allogeneic auditory neuron progenitor cells to combat hearing loss.
- PNC1: An innovative approach using allogeneic photoreceptor cell transplants aimed at treating vision loss.
Lineage Cell Therapeutics is committed to addressing large unmet medical needs through its cutting-edge technologies. The company's clinical-stage programs are supported by a premier collection of pluripotent cell assets, positioning it at the forefront of regenerative medicine.
Recent achievements include significant progress in clinical trials, strategic partnerships, and advancements in their product development pipeline. Financially, the company remains poised for growth with a clear focus on expanding its therapeutic offerings and enhancing shareholder value.
Stay informed with the latest updates and developments at Lineage Cell Therapeutics as they continue to advance their mission of transforming the treatment landscape for degenerative diseases.
Lineage Cell Therapeutics (LCTX) presented positive results from their Phase 1/2a clinical study of OpRegen at the 2023 ARVO Annual Meeting. The study focused on patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD). Key findings include:
- 7.6 letter gain in visual acuity observed in Cohort 4 over 12 months.
- Long-term vision preservation noted up to 4 years in treated eyes.
- Improved retinal structures correlated with the extent of OpRegen bleb coverage.
CEO Brian Culley expressed optimism about ongoing collaborations with Genentech and Roche. The ongoing Phase 2a study has started enrolling patients, highlighting the potential of OpRegen to address unmet medical needs in this debilitating condition.
Lineage Cell Therapeutics announced that CEO Brian M. Culley will present at the 2023 American Association of Pharmaceutical Scientists National Biotechnology Conference on April 25, 2023, at 10:00 am ET. His presentation is part of the “Evolution of Cellular Therapy Symposium”, which features discussions on advancements in cellular therapies. The conference runs from April 23-26, 2023, at the Philadelphia Marriott Downtown Hotel. Lineage specializes in allogeneic cell therapies and operates on a robust cell therapy platform, with multiple product candidates in development, including therapies for age-related macular degeneration and acute spinal cord injuries.
For more details, visit www.lineagecell.com.
Lineage Cell Therapeutics and the Christopher & Dana Reeve Foundation will host the 1st Annual Spinal Cord Injury Investor Symposium on
Lineage Cell Therapeutics announced the presentation of Phase 1/2a clinical study results for RG6501 (OpRegen) at the 2023 Retinal Cell and Gene Therapy Innovation Summit scheduled for April 21, 2023, in New Orleans, LA. OpRegen is being developed to treat geographic atrophy due to age-related macular degeneration (AMD) under a collaboration with Roche and Genentech. This therapy targets a compelling market need, as geographic atrophy affects over 5 million people globally, representing a significant opportunity for Lineage. The clinical presentation will be delivered by Eyal Banin, M.D., Ph.D., focusing on the implications of OpRegen in retinal therapy.
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