Welcome to our dedicated page for Kyverna Therapeutics news (Ticker: KYTX), a resource for investors and traders seeking the latest updates and insights on Kyverna Therapeutics stock.
Kyverna Therapeutics, Inc. (NASDAQ: KYTX) is a pioneering patient-centered, clinical-stage biopharmaceutical company dedicated to developing innovative cell therapies for patients suffering from autoimmune diseases. The company's primary focus is on advancing chimeric antigen receptor (CAR) T-cell therapies to address the unmet medical needs in autoimmune conditions.
Their lead product candidate, KYV-101, is an autologous CD19 CAR T-cell therapy designed to treat B cell-driven autoimmune diseases. This therapy specifically targets CD19, a protein found on the surface of B cells, which play a crucial role in various autoimmune conditions. KYV-101 is currently being evaluated in multiple clinical trials, including Phase 1 trials for lupus nephritis in the United States and Germany, and Phase 2 trials for multiple sclerosis (MS), myasthenia gravis, and systemic sclerosis.
Kyverna has also developed KYV-201, an allogeneic therapy using the same CAR as KYV-101, with the potential to treat multiple autoimmune diseases. The company's pipeline includes next-generation CAR T-cell therapies in both autologous and allogeneic formats, which are designed to be effective in B cell-driven autoimmune diseases.
Recently, Kyverna announced a collaboration with Stanford University to use KYV-101 in a Phase 1 investigator-initiated trial (IIT) for non-relapsing and progressive forms of MS. This collaboration aims to explore the safety, feasibility, and tolerance of KYV-101 in MS patients, and to understand the disease biology and potential for immune reset following the infusion.
Kyverna's robust clinical development program is supported by a solid financial foundation, with recent business highlights indicating significant progress. For the year ended December 31, 2023, Kyverna reported a net loss of $60.4 million due to substantial investments in its clinical programs. However, the company raised approximately $366.9 million in gross proceeds from its initial public offering in February 2024, bolstering its cash reserves and enabling continued advancements in its therapeutic pipeline.
The company operates on the forefront of medical research, collaborating with leading academic institutions like the National Institutes of Health (NIH) and the University Medical Center Hamburg-Eppendorf in Germany. These partnerships help Kyverna leverage cutting-edge scientific knowledge to push the boundaries of CAR T-cell therapy for autoimmune diseases.
At its core, Kyverna Therapeutics aims to transform the treatment paradigm for autoimmune diseases, providing new hope to patients through groundbreaking CAR T-cell therapies. For more information, visit Kyverna Therapeutics.
Kyverna Therapeutics (NASDAQ: KYTX) has appointed Naji Gehchan, M.D., MBA, as Chief Medical and Development Officer. Dr. Gehchan brings 20 years of U.S. and international experience, particularly in immunology, joining from Eli Lilly where he most recently led clinical development for imlunestrant.
In his new role, Dr. Gehchan will lead Kyverna's research, clinical development, and medical affairs functions as the company advances KYV-101 to late-stage development. He previously held senior leadership positions at Eli Lilly, including Associate VP of Sales for U.S. Diabetes and CMO for Lilly France, Belgium, and Netherlands.
As part of this transition, Dominic Borie, M.D., Ph.D., the founding CEO and recent President of R&D, will move to a Strategic Advisor role. The company will grant Dr. Gehchan an option to purchase 425,000 shares, vesting over four years with 25% vesting after one year and 1/48th monthly thereafter.
Kyverna Therapeutics (NASDAQ: KYTX) announced its 2025 strategic priorities, focusing on developing CAR T cell therapies for autoimmune diseases. The company reported 40% enrollment completion in their pivotal Phase 2 trial of KYV-101 for stiff person syndrome, targeting BLA filing in 2026. They're also advancing trials in myasthenia gravis and lupus nephritis.
Key upcoming milestones include completing pivotal Phase 2 enrollment for stiff person syndrome by mid-2025, reporting Phase 2 data in first half 2026, and filing for BLA in 2026. For myasthenia gravis, they plan to confirm the registrational path in first half 2025 and report interim Phase 2 data in second half 2025. The company is also developing KYV-102, featuring whole blood rapid manufacturing to improve patient access.
Kyverna maintains a strong financial position with $321.6 million in cash and equivalents as of September 30, 2024, providing runway into 2027.
Kyverna Therapeutics (NASDAQ: KYTX), a clinical-stage biopharmaceutical company specializing in cell therapies for autoimmune diseases, has announced its participation in the 43rd Annual J.P. Morgan Healthcare Conference. The company's CEO, Warner Biddle, will deliver a presentation outlining Kyverna's 2025 strategic priorities and key milestones on Monday, January 13, 2025, at 5:15 p.m. PST.
Interested parties can access a live audio webcast of the presentation through the Investors section of Kyverna's website at https://ir.kyvernatx.com/. The presentation recording will remain available on the website for 30 days after the conference.
Kyverna Therapeutics announced three key leadership appointments to support its next growth phase in developing cell therapies for autoimmune diseases. Dan Maziasz joins as Chief Business Officer, bringing 25 years of experience from companies like Atara Biotherapeutics and Kite Pharma. Cara Bauer becomes Chief Human Resources Officer, with over 25 years of global HR leadership experience, notably at Kite and Netflix. Tracy Rossin joins as SVP of Corporate Affairs, Communications and Investor Relations, bringing 20 years of strategic communications experience from Kite and AstraZeneca.
As part of his appointment, Maziasz received an inducement grant of options to purchase 350,000 shares at $4.86 per share, vesting over four years with 25% vesting after one year and the remainder monthly.
Kyverna Therapeutics presented updated clinical data for KYV-101, their CD19 CAR T-cell therapy for lupus nephritis (LN) treatment. The data shows sustained efficacy and durability in patients treated with the target dose of 1×108 CD19 CAR T cells, with four out of six patients having at least six months of follow-up. Key findings demonstrate deep B cell depletion, immune system reset, stabilized eGFR, preserved kidney function, and improved SLE activity. The treatment allowed elimination of immunosuppressants and reduction of glucocorticoids while maintaining a manageable safety profile with no high-grade CRS or ICANS observed.
Kyverna Therapeutics reported Q3 2024 financial results and business updates. The company appointed Warner Biddle as CEO and made multiple key leadership appointments. They presented clinical data for KYV-101 in various autoimmune conditions at ECTRIMS and plan to share updated lupus nephritis data at ACR Convergence 2024.
The company reported a net loss of $34.3 million ($0.80 per share) for Q3 2024, compared to $15.5 million in Q3 2023. Cash position remains strong at $321.6 million as of September 30, 2024. Net cash used in operations was $77.2 million for the first nine months of 2024.
Kyverna Therapeutics, Inc. (KYTX) has appointed Mert Aktar as an independent director to its Board of Directors. Mr. Aktar brings over two decades of biopharmaceutical experience, combining technical leadership in cell and gene therapy with a proven track record in corporate development. He currently serves as CEO of Receptive Bio and holds board positions with UCLA Technology Development Group and ReAlta Life Sciences.
Previously, Mr. Aktar was Senior Vice President and Global Head of Corporate Development & Strategy at Kite Pharma, where he played a key role in establishing Kite's global leadership in cell therapy. He also held senior leadership positions at various biotech and large pharma organizations, including Shire, where he facilitated multi-billion-dollar transactions and led large-scale manufacturing operations.
Kyverna's CEO, Warner Biddle, expressed confidence that Mr. Aktar's strategic experience and technical expertise in cell therapy will be invaluable as the company advances KYV-101 into later stages of development and builds on its CAR T leadership in autoimmune diseases.
Kyverna Therapeutics presented patient data at ECTRIMS 2024, showcasing the potential of KYV-101 for treating neuroinflammatory diseases. The company shared case reports from 11 patients with stiff-person syndrome, myasthenia gravis, and multiple sclerosis, demonstrating initial efficacy and safety of KYV-101. Key biomarkers indicate its potential to durably modify neuroinflammatory diseases through immune system reset.
Highlights include:
- Improved mobility and reduced autoantibody titers in stiff-person syndrome patients
- Sustained disease control in myasthenia gravis patients
- Significant reduction in oligoclonal bands in multiple sclerosis patients
- No severe CRS or ICANS observed across 41 treated patients
Kyverna also presented posters on the design and methods of its clinical trials for KYV-101 in neuroinflammatory diseases.
Kyverna Therapeutics (KYTX) announced key leadership changes. Warner Biddle has been appointed as the new Chief Executive Officer and Board member, replacing Peter Maag. Biddle brings over 30 years of experience in commercial and franchise leadership, including successful CAR T therapy launches at Kite Pharma. Christi Shaw, a seasoned life sciences executive, joins the Board of Directors, succeeding Brian Kotzin.
These appointments aim to strengthen Kyverna's leadership as it advances its CAR T cell therapies for autoimmune diseases. The company's lead candidate, KYV-101, is progressing into later development stages. Biddle's experience in commercializing cell therapies and Shaw's broad industry expertise are expected to guide Kyverna through its next growth phase, focusing on market preparation and expansion in the autoimmune disease space.
Kyverna Therapeutics (KYTX), a clinical-stage biopharmaceutical company focusing on cell therapies for autoimmune diseases, has announced its participation in three major investor conferences in September 2024:
- Morgan Stanley Global Healthcare Conference in New York, NY on September 4
- Wells Fargo Healthcare Conference in Boston, MA on September 5
- Cantor Global Healthcare Conference in New York, NY on September 17
At each event, Kyverna executives will engage in fireside chats and host investor meetings. This series of appearances provides significant opportunities for the company to showcase its progress and connect with potential investors.
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