Kymera Therapeutics, Inc. - KYMR STOCK NEWS

Kymera Therapeutics (NASDAQ: KYMR) has initiated Phase 1 clinical trials for two first-in-class protein degraders: KT-333, targeting STAT3 for T cell malignancies, and KT-413, targeting IRAK4 for MYD88-mutant B cell lymphomas. The trials aim to assess the safety, tolerability, and pharmacokinetics of these treatments with initial data expected in the second half of 2022. KT-333 has also received Orphan Drug Designation from the FDA, emphasizing its potential in addressing rare diseases.

Kymera Therapeutics (NASDAQ: KYMR) received orphan drug designation from the FDA for KT-333, intended for treating Peripheral T-cell Lymphoma (PTCL). This first-in-class degrader targets STAT3, a protein crucial in PTCL disease modulation. Currently, PTCL lacks approved therapies targeting this pathway. The FDA designation provides development incentives such as tax credits and seven-year marketing exclusivity. KT-333 is in a Phase 1 trial for relapsed/refractory tumors, including aggressive lymphomas, with the potential to transform PTCL treatment.

Kymera Therapeutics (NASDAQ: KYMR) presented new preclinical data at EULAR 2022, showcasing the effectiveness of its investigational STAT3 degraders in blocking Th17 development and cytokine release, thereby preventing collagen-induced arthritis in a mouse model. The research confirms the potential of STAT3 targeting in treating autoimmune disorders, with significant suppression of pro-inflammatory cytokines observed. Kymera's STAT3 degrader, KT-333, currently in Phase 1 trials, is part of a broader strategy to address various immune-inflammatory diseases.

Kymera Therapeutics (NASDAQ: KYMR) presented significant data on its IRAK4 degrader KT-474 at the 2022 Society of Investigative Dermatology Annual Meeting. The findings indicated that KT-474 effectively degrades IRAK4 and inhibits cytokine production across various immune and skin cell types, supporting its potential for treating autoimmune diseases such as hidradenitis suppurativa (HS) and atopic dermatitis (AD). Notably, the Phase 1 clinical study demonstrated nearly complete IRAK4 degradation and cytokine inhibition in healthy volunteers, showcasing the drug's promise in inflammation-related conditions.

Kymera Therapeutics (NASDAQ: KYMR) revealed promising preclinical results at the AAI Annual Meeting 2022, highlighting the effectiveness of their novel protein degraders in treating inflammatory and autoimmune diseases. The data emphasized the advantages of IRAK4 and STAT3 degraders over traditional kinase inhibitors, demonstrating superior inhibition of immune signaling pathways and Th17 inflammation in animal models. These findings support further exploration into using these degraders for therapeutic applications in conditions like multiple sclerosis and rheumatoid arthritis, indicating significant clinical potential.

Kymera Therapeutics (NASDAQ: KYMR) reported key developments in its clinical programs and financial results for Q1 2022. The Phase 1 trial for IRAK4 degrader KT-474 has been amended to extend dosing from 14 to 28 days, allowing for enhanced efficacy evaluation. Clinical trials for STAT3 (KT-333) and IRAKIMiD (KT-413) oncology programs are underway. The company's cash balance stood at approximately $523 million as of March 31, 2022, providing a runway into 2025. Collaboration revenues were $9.6 million, down from $18.7 million in Q1 2021, while net loss increased to $36.7 million.

Kymera Therapeutics (NASDAQ: KYMR) will host its first quarterly call on May 3, 2022, at 8 AM ET to provide updates on its clinical-stage pipeline.

CEO Nello Mainolfi emphasized the commitment to transparency and stakeholder engagement following the company's IPO two years ago. The call will include financial results and program updates.

Kymera will also participate in multiple investor conferences through May, including the Bank of America Healthcare Conference and the UBS Global Healthcare Conference, showcasing its innovative drug development efforts.

Kymera Therapeutics (NASDAQ: KYMR) presented promising preclinical data on KT-253, a novel MDM2 degrader, at the AACR Annual Meeting 2022. KT-253 demonstrated superior potency, inhibiting tumor cell growth in the picomolar range, outperforming existing small molecule inhibitors (SMIs) by over 200-fold. In xenograft models for acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), a single low dose led to sustained tumor regression, highlighting its potential for improved efficacy in p53 wild-type tumors, which represent over 50% of malignancies. An IND is anticipated to be filed in 2022.

Kymera Therapeutics (NASDAQ: KYMR) announced participation in upcoming virtual investor conferences. Nello Mainolfi, PhD, Co-Founder, President, and CEO, will engage in fireside chats at:

• Cowen & Co. 42nd Annual Health Care Conference on March 8, 2022, at 9:50 a.m. ET
• Guggenheim Healthcare Talks on March 16, 2022, at 8:00 a.m. ET

Webcasts will be accessible in the Investors section of their website, with replays available for 90 days. Kymera is focused on targeted protein degradation to develop novel therapeutics for immune-inflammatory diseases and cancers.