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Kymera Therapeutics, Inc. (NASDAQ: KYMR) is a biotechnology company harnessing the power of targeted protein degradation (TPD) to develop transformative treatments for previously untreatable diseases. Founded in 2016, and headquartered in Watertown, Massachusetts, Kymera is at the forefront of biotechnology, utilizing the body's innate protein recycling machinery to degrade disease-causing proteins rather than merely inhibiting them.
The company's pioneering platform, Pegasus™, leverages proprietary predictive modeling and an integrated degradation approach to address disease targets previously deemed intractable. This novel modality allows Kymera to target and degrade proteins involved in various critical pathways, including those in immunological diseases and oncology. Key drugs in their pipeline include:
- KT-474: An IRAK4 degrader currently in Phase 2 trials for immuno-inflammatory conditions.
- KT-333: A STAT3 degrader in Phase 1 trials, targeting hematological malignancies and solid tumors.
- KT-253: An MDM2 degrader undergoing Phase 1 trials, aimed at cancers with p53 pathway involvement.
- KT-621: A STAT6 degrader poised to enter Phase 1 trials, showing promising preclinical results for treating TH2-driven diseases like asthma and atopic dermatitis.
Kymera's achievements include successful partnerships with leading pharmaceutical companies such as Sanofi, ongoing collaborations with research institutions, and securing significant financial backing with over $745 million in cash reserves to support operations into 2027. The company's innovative approach and robust pipeline have earned it recognition as one of Boston’s top workplaces.
Kymera continues to make significant strides in drug discovery and development, with a focus on delivering highly effective, convenient oral therapies. Recent updates include positive preclinical and clinical data presentations at major medical conferences, highlighting the potential of their degradation technology to revolutionize treatment paradigms across various diseases.
For more information, visit Kymera Therapeutics or follow them on X (formerly Twitter) and LinkedIn.
Kymera Therapeutics (NASDAQ: KYMR), a biopharmaceutical company focused on targeted protein degradation, has announced upcoming investor events. The management team will participate in the Cowen 43rd Annual Health Care Conference in Boston, MA from March 6-8, 2023, with CEO Nello Mainolfi presenting a fireside chat on March 6 at 10:30 AM ET, alongside hosting 1x1 meetings. Additionally, the Jefferies Biotech on the Bay Summit in Miami, FL will take place on March 16-17, 2023, where the company will conduct 1x1 meetings only. A live webcast of the fireside chat will be available on their website.
Kymera Therapeutics (NASDAQ: KYMR) reported significant developments in its drug programs during its Q4 2022 results, highlighting continued progress in targeted protein degradation. The company plans to initiate Phase 2 trials for IRAK4 degrader KT-474, backed by a strong cash balance of approximately $560 million, ensuring funding through mid-2025. The KT-474 Phase 1 trials yielded positive results in treating hidradenitis suppurativa and atopic dermatitis. In addition, ongoing trials for KT-333 and KT-413 have shown promising early results. The company aims to launch the KT-253 Phase 1 trial in early 2023, further expanding its innovative pipeline.
Kymera Therapeutics (NASDAQ: KYMR) will announce its Q4 and full year 2022 financial results on February 23, 2023, followed by a conference call at 8:30 a.m. ET. The company focuses on targeted protein degradation to develop innovative therapies for challenging disease targets. Upcoming investor engagements include the Guggenheim Oncology Conference on February 8 and others through February 21. The company aims to advance therapies targeting IRAK4, IRAKIMiD, STAT3, and MDM2, with expectations to progress its clinical trials and maintain a solid financial runway into H2 2025.
X-Chem has expanded its collaboration with Kymera Therapeutics (NASDAQ: KYMR), now the primary provider of DNA-encoded library (DEL) screening services. The partnership covers 12 targets, granting Kymera exclusive rights to discovered compounds. This collaboration aims to enhance Kymera's efforts in developing innovative protein degraders, crucial for addressing challenging disease targets. Kymera's CEO praised X-Chem’s libraries for their quality and scientific rigor, reflecting a commitment to revolutionizing medicine through targeted protein degradation.
Kymera Therapeutics (NASDAQ: KYMR) announced its 2023 goals after a pivotal 2022, where its lead program KT-474 demonstrated an encouraging safety profile in inflammatory diseases. The company ended 2022 with approximately $560 million in cash, expected to fund operations into 2025. Major objectives for 2023 include initiating Phase 2 trials for KT-474, demonstrating clinical activity in oncology programs KT-413 and KT-333, and commencing Phase 1 trials for KT-253. The company aims to leverage its discovery platform to develop novel therapeutics targeting disease-causing proteins.
Kymera Therapeutics (NASDAQ: KYMR) appointed Ellen Chiniara, J.D., as Chief Legal Officer and Corporate Secretary. Chiniara brings extensive legal experience from biopharmaceutical companies and will oversee Kymera’s legal and governance functions. CEO Nello Mainolfi highlighted her leadership in advancing the company as it aims to become a fully integrated global biopharmaceutical entity. Chiniara previously served at Alexion Pharmaceuticals and Alere, enhancing legal operations and corporate social responsibility initiatives.
Kymera Therapeutics, Inc. (NASDAQ: KYMR) announced its participation in the 41st Annual J.P. Morgan Healthcare Conference on January 10, 2023, at 9:00 AM PST. CEO Nello Mainolfi will discuss the company's advancements and goals for 2023. Kymera is pioneering targeted protein degradation, developing innovative small molecule therapies to address previously inaccessible disease targets. Its pipeline includes candidates targeting IRAK4, IRAKIMiD, STAT3, and MDM2, aimed at treating various immune-inflammatory diseases and cancers. A live webcast will be available on their website.
Kymera Therapeutics (NASDAQ: KYMR) has reported promising results from its KT-474 Phase 1 clinical trial for hidradenitis suppurativa (HS) and atopic dermatitis (AD). The study demonstrated significant IRAK4 knockdown in blood and skin lesions, alongside a favorable safety profile. Notably, after four weeks of dosing, a majority of patients showed substantial clinical improvement. Following these results, Sanofi has committed to advancing KT-474 into Phase 2 trials. The company is also progressing with its oncology programs, including KT-413, KT-333, and KT-253.
Kymera Therapeutics (NASDAQ: KYMR) announced promising preclinical data at the ASH Annual Meeting regarding the efficacy of its STAT3 and IRAKIMiD degraders for treating specific blood cancers. Study results showed that a STAT3 degrader led to significant disease improvement in a model of cutaneous T-cell lymphoma (CTCL). Additionally, combining IRAKIMiDs with a BCL-2 inhibitor demonstrated strong antitumor effects in MYD88-mutant diffuse large B-cell lymphoma (DLBCL). These findings support the progression of both compounds into clinical trials.
Kymera Therapeutics (NASDAQ: KYMR) presented promising preclinical data for KT-253 at the ASH Annual Meeting, demonstrating its capability to induce rapid apoptosis and tumor regression in acute myeloid leukemia (AML) models. The data indicates that KT-253, in combination with the BCL-2 inhibitor venetoclax, yields durable tumor responses, even in venetoclax-resistant models. The compound also shows potential in other hematologic malignancies, such as DLBCL. Kymera anticipates entering clinical trials for KT-253, aimed at advancing treatment options for wild-type p53 cancers.
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