Kyowa Kirin Presents Real-World Findings at ASBMR Annual Meeting Highlighting Progressive Disease Burden of X-linked Hypophosphatemia (XLH)
- High levels of XLH-related morbidities and extra-musculoskeletal manifestations were found in patients with X-linked hypophosphatemia
- Serious disease-related morbidities often start at a young age and accumulate over time
- Most patients had received conventional therapy prior to burosumab treatment
- Physical therapy use was observed across all age groups
- Patients with familial hypophosphatemia experienced multiple FH-related morbidities
- Patients with FH used healthcare services for managing orthopedic conditions at a significantly greater rate than the control group
- Depression, hypertension, and obesity were more common among patients with FH
- Monitoring and management practices to control FH and associated morbidities were more common among patients with FH
- None.
- Claims database analyses show increasing prevalence and impact of XLH-related morbidities with age, underscoring life-long burden of disease
"Because XLH is a progressive, life-long disease, it's important to understand the clinical characteristics and real-world impact on patients over time," said Zhiyi Li, MA, MBA, one of the study authors and director of health economics and outcomes research at Kyowa Kirin North America. "Both studies found that serious disease-related morbidities often start at a young age and accumulate over time, an important consideration for physicians when making decisions about patient care."
Real-world characteristics and disease history of patients with X-linked hypophosphatemia treated with burosumab: a
In this retrospective cohort study, researchers examined the patient characteristics and disease history of 1,358 people ≥6 months of age prior to initiation of treatment with burosumab using Komodo Health's Healthcare Map™, a real-world de-identified patient-level claims database assembled from clearinghouse, payer, and provider data sources.
Among the claims assessed, researchers found high levels of XLH-related morbidities and extra-musculoskeletal manifestations, including osteoarthritis, arthralgia (joint pain), fractures, muscle pain, spinal stenosis, hypertension, obesity, depression, renal disease and enthesopathy, a disorder that affects the site of attachment between bones and tendons or ligaments.1 Most of these complications were seen in early adulthood and increased with age group. Most patients had received some form of conventional therapy for XLH prior to burosumab treatment, with
There were several study limitations including the lack of a specific diagnosis code for XLH. Patients were identified using diagnosis codes for familial hypophosphatemia (FH) and other disorders of phosphorus metabolism; however, the inclusion of burosumab claims helped to minimize the inclusion of misdiagnosed patients, as XLH is the only disorder of FH for which burosumab is indicated. In addition, the study used non-primary insurer (open source) claims, which captures a higher number of medical claims as compared to payer-complete (closed source) claims; however, completeness is not guaranteed. Older patients were under-represented in the study population, limiting the generalizability of the findings to this group.
Clinical and treatment characteristics of pediatric and adult patients with familial hypophosphatemia compared with demographically matched controls
In this retrospective observational cohort study, researchers examined healthcare claims data from the Merative™ MarketScan® Commercial and Medicare Databases. The analysis compared 570 patients with at least one diagnosis code for FH to 1,710 people without FH in a matched control group. FH represents a group of rare genetic disorders characterized by impaired renal phosphate conservation; roughly
The study found patients with FH experienced multiple FH-related morbidities, supplemented with oral phosphate and active vitamin D, and used healthcare services for managing orthopedic conditions at a significantly greater rate than the control group. The differences between the study groups were apparent even among young children and persisted throughout a person's life. Key findings included:
- Kidney disease, joint pain, osteoarthritis, delayed growth/walking, muscle weakness, and fracture were the most common FH-related morbidities; all were significantly more common among patients with FH (P<0.001) and generally increased with age.
- Depression (FH:
22.5% vs. controls:5.6% ), hypertension (55.4% vs.17.4% ), and obesity (34.0% vs.16.4% ) were more common among patients with FH (P<0.001). - Most monitoring and management practices to control FH and associated morbidities were more common among patients with FH, including laboratory tests, physical therapy, and use of walking assistance devices (all P <0.001).
This study was limited to patients with commercial health insurance or Medicare coverage; results may not be generalizable to patients with other types of insurance (e.g., Medicaid) or the uninsured, and the study population may under-represent the true burden of disease. Patients with FH who received burosumab during the study period were excluded. The outcomes assessed in this study may differ for burosumab-treated patients.
About X-linked hypophosphatemia
X-linked hypophosphatemia is a rare, lifelong, genetic disease that can impact the bones and muscles in both children and adults.
In individuals with XLH, the body doesn't hold on to enough phosphorus, which is an essential mineral for bone health. This is due to the production of excess fibroblast growth factor 23 (FGF23), causing the body to release too much phosphorus through the urine. When phosphorus levels are too low (hypophosphatemia), it can cause the softening and weakening of growing bones in children (rickets) and mature bones in adults (osteomalacia).
In children, XLH typically appears as bowed legs or knock knees. Over time, bone weakening can also lead to bone abnormalities in the legs, delayed growth, and short stature. In adults, XLH may cause osteomalacia, fractures and pseudo-fractures, and hypophosphatemia.
About CRYSVITA® (burosumab-twza) Injection
CRYSVITA is a recombinant fully human monoclonal IgG1 antibody, discovered by Kyowa Kirin, which binds to and inhibits the biological activity of FGF23, the underlying cause of hypophosphatemia in XLH. By blocking FGF23, CRYSVITA helps to restore phosphorus reabsorption in the kidneys and increase the production of active vitamin D, which enhances intestinal absorption of phosphate and calcium.
CRYSVITA is a fibroblast growth factor (FGF23) blocking antibody indicated for the treatment of X-linked hypophosphatemia (XLH) in adult and pediatric patients 6 months of age and older.
Important Safety Information
CONTRAINDICATIONS
CRYSVITA is contraindicated:
- In concomitant use with oral phosphate and/or active vitamin D analogs (e.g., calcitriol, paricalcitol, doxercalciferol, calcifediol) due to the risk of hyperphosphatemia.
- When serum phosphorus is within or above the normal range for age.
In patients with severe renal impairment or end stage renal disease because these conditions are associated with abnormal mineral metabolism.
WARNINGS AND PRECAUTIONS
Hypersensitivity
- Hypersensitivity reactions (e.g., rash, urticaria) have been reported in patients with CRYSVITA. Discontinue CRYSVITA if serious hypersensitivity reactions occur and initiate appropriate medical treatment.
Hyperphosphatemia and Risk of Nephrocalcinosis
- Increases in serum phosphorus to above the upper limit of normal may be associated with an increased risk of nephrocalcinosis. For patients already taking CRYSVITA, dose interruption and/or dose reduction may be required based on a patient's serum phosphorus levels.
Injection Site Reactions
- Administration of CRYSVITA may result in local injection site reactions. Discontinue CRYSVITA if severe injection site reactions occur and administer appropriate medical treatment.
ADVERSE REACTIONS
Pediatric Patients
- Adverse reactions reported in
10% or more of CRYSVITA-treated pediatric XLH patients across three studies are: pyrexia (55% ,44% , and62% ), injection site reaction (52% ,67% , and23% ), cough (52% ), vomiting (41% ,48% , and46% ), pain in extremity (38% ,46% , and23% ), headache (34% and73% ), tooth abscess (34% ,15% , and23% ), dental caries (31% ), diarrhea (24% ), vitamin D decreased (24% ,37% , and15% ), toothache (23% and15% ), constipation (17% ), myalgia (17% ), rash (14% and27% ), dizziness (15% ), and nausea (10% ). - Post-marketing experience reported in CRYSVITA-treated pediatric XLH patients: blood phosphorus increased.
Adult Patients
- Adverse reactions reported in more than
5% of CRYSVITA-treated adult XLH patients and in at least 2 patients more than placebo in one study are: back pain (15% ), headache (13% ), tooth infection (13% ), restless legs syndrome (12% ), vitamin D decreased (12% ), dizziness (10% ), constipation (9% ), muscle spasms (7% ), and blood phosphorus increased (6% ). - Spinal stenosis is prevalent in adults with XLH, and spinal cord compression has been reported. It is unknown if CRYSVITA therapy exacerbates spinal stenosis or spinal cord compression.
USE IN SPECIFIC POPULATIONS
- There are no available data on CRYSVITA use in pregnant women to inform a drug-associated risk of adverse developmental outcomes. Serum phosphorus levels should be monitored throughout pregnancy. Report pregnancies to the Kyowa Kirin, Inc. Adverse Event reporting line at 1-844-768-3544.
- There is no information regarding the presence of CRYSVITA in human milk or the effects of CRYSVITA on milk production or the breastfed infant. Therefore, the developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for CRYSVITA and any potential adverse effects on the breastfed infant from CRYSVITA or from the underlying maternal condition.
PATIENT COUNSELING INFORMATION
- Advise patients not to use any oral phosphate and/or active vitamin D analog products.
- Instruct patients to contact their physician if hypersensitivity reactions, injection site reactions, and restless legs syndrome induction or worsening of symptoms occur.
You may report side effects to the FDA at (800)FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Kyowa Kirin, Inc. at 1-844-768-3544.
For important risk and use information, please see the full Prescribing Information for CRYSVITA.
About Kyowa Kirin
Kyowa Kirin strives to create and deliver novel medicines with life-changing value. As a
References
- Sudoł-Szopińska I, Kwiatkowska B, Prochorec-Sobieszek M, et al. Enthesopathies and enthesitis. part 1. J Ultrason. 2015;15(60):72-84.
- Jagtap VS, Sarathi V, Lila AR, et al. Hypophosphatemic rickets. Indian J Endocrinol and Metab. 2012;16(2):177-182.
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SOURCE Kyowa Kirin
FAQ
What were the findings of the studies presented by Kyowa Kirin at the ASBMR annual meeting?
What treatments did most patients with X-linked hypophosphatemia receive prior to burosumab treatment?
What were the common morbidities experienced by patients with familial hypophosphatemia?
Did patients with familial hypophosphatemia use healthcare services more than the control group?