Welcome to our dedicated page for Kura Oncology news (Ticker: KURA), a resource for investors and traders seeking the latest updates and insights on Kura Oncology stock.
Kura Oncology, Inc. (symbol: KURA) is a clinical-stage biopharmaceutical company based in San Diego, dedicated to pioneering precision medicines for cancer treatment. Leveraging advances in cancer genomics, Kura develops targeted therapies and companion diagnostics designed to address the genetic underpinnings of various cancers, optimizing treatment efficacy and safety.
The company's flagship product candidate, Tipifarnib, is under investigation for treating both solid tumors and blood cancers. Tipifarnib is a potent farnesyl transferase inhibitor, currently undergoing Phase 1/2 trials in combination with alpelisib for patients with head and neck squamous cell carcinoma.
Another key candidate, Ziftomenib, targets acute myeloid leukemia (AML) with NPM1 and KMT2A mutations. Highlighted by its recent Breakthrough Therapy Designation from the FDA, Ziftomenib is involved in multiple clinical trials, including the KOMET-001 and KOMET-007 studies. Early results show promising efficacy and a favorable safety profile, particularly in the combination with current standards of care like venetoclax and azacitidine.
Kura is also advancing KO-2806, a next-generation farnesyl transferase inhibitor, in a Phase 1 dose-escalation trial as a monotherapy and in combination with other targeted therapies for renal and lung cancers.
Financially, Kura remains robust, with cash reserves projected to support operations through 2027. The company has an ongoing commitment to aggressive research, development, and pre-commercial activities, ensuring continued progression of its promising pipeline.
The company's recent achievements include reporting preliminary clinical data from the KOMET-007 trial and securing additional financing to reinforce its financial position. Kura continues its mission to bring life-saving therapies to patients with high unmet medical needs, aiming to improve and extend the lives of those battling cancer.
Kura Oncology, Inc. (Nasdaq: KURA) announced the acceptance of four abstracts for presentation at the AACR Annual Meeting in New Orleans, from April 8-13, 2022. The presentations will focus on the company’s farnesyl transferase inhibitor program, particularly tipifarnib, which aims to delay drug resistance in cancer treatment. The CEO, Troy Wilson, emphasized the importance of ongoing trials for non-small cell lung cancer and the advancement of KO-2806. Detailed presentations will be available on Kura’s website following the conference.
Kura Oncology, Inc. (Nasdaq: KURA) announced that CEO Troy Wilson will participate in two investor conferences in March 2022. He will join a panel on "Leukemias/MPN" at the Cowen 42nd Annual Health Care Conference on March 7 at 10:30 a.m. ET, followed by a fireside chat at the Barclays Global Healthcare Conference in Miami on March 15 at 11:15 a.m. ET. Audio webcasts of both events will be available on Kura's website, with replays archived post-event. Kura focuses on precision cancer medicines and has notable candidates like Ziftomenib and Tipifarnib in clinical trials.
Kura Oncology reported its financial results for Q4 and full year 2021, emphasizing advancements in its clinical programs, particularly in the KOMET-001 Phase 1b study of ziftomenib for acute myeloid leukemia (AML). The company has resumed patient enrollment and expects to complete it by Q2 2022, with top-line data anticipated by Q3 2022. Kura has $518 million in cash, providing operational stability into 2024. Significant data readouts are expected in the upcoming year, marking a pivotal phase for the company's drug development pipeline.
Kura Oncology, Inc. (Nasdaq: KURA) will announce its fourth quarter and full year 2021 financial results on February 24, 2022, after U.S. markets close. A conference call and webcast will be held at 4:30 p.m. ET to discuss the results and provide updates. Kura is focused on precision medicines for cancer treatment, with key developments including KO-539 in clinical trials for acute myeloid leukemia and tipifarnib for HRAS mutant head and neck squamous cell carcinoma, which has received Breakthrough Therapy Designation.
Kura Oncology, a clinical-stage biopharmaceutical company, announced its participation in the 11th Annual SVB Leerink Global Healthcare Conference. CEO Troy Wilson will join a virtual fireside chat on February 17, 2022, at 12:40 p.m. PT. The event will be accessible via a live audio webcast on Kura's website, with a replay available afterward. Kura focuses on precision cancer medicines and is advancing its pipeline of cancer treatments, including KO-539 for AML and Tipifarnib for HRAS mutant HNSCC patients.
Kura Oncology expands its leadership team with key promotions to enhance growth. Mollie Leoni, M.D., becomes Senior Vice President of Clinical Development; Pete De Spain is now Senior Vice President of Investor Relations and Corporate Communications; and Tom Doyle is appointed Senior Vice President of Finance and Accounting. Former CFO Marc Grasso steps down effective February 4, 2022, to focus on family, while remaining as an advisor. The new roles aim to strengthen Kura's strategic objectives in advancing precision medicines for cancer treatment.
The FDA has lifted the partial clinical hold on Kura Oncology's KOMET-001 Phase 1b study of KO-539 for relapsed or refractory acute myeloid leukemia (AML). This decision follows an agreement on a mitigation strategy for differentiation syndrome. Kura is resuming patient screening and enrollment, with promising safety and clinical activity observed in current patients. The trial aims to determine the recommended Phase 2 dose for KO-539, targeting patients with NPM1 mutations and KMT2A rearrangements.
Kura Oncology has initiated the first patient dose in its KURRENT trial, investigating the combination of tipifarnib and alpelisib for treating patients with HRAS- and/or PIK3CA-dependent head and neck squamous cell carcinoma (HNSCC). This trial aims to expand treatment options for up to 50% of HNSCC patients. Preclinical data suggests these oncogenes are co-dependent, and the combination therapy could offer enhanced anti-tumor effects. Tipifarnib has received Breakthrough Therapy designation, focusing on a significant unmet medical need in HNSCC.
Kura Oncology reported promising results from a Phase 2 study of tipifarnib, showing a 56% overall response rate and a median overall survival of 32.8 months in patients with advanced angioimmunoblastic T-cell lymphoma (AITL). Conducted on 65 patients, the study highlighted the effectiveness of farnesyl transferase inhibition in treating this aggressive cancer type. The response rate for AITL patients was notably high at 56%. Tipifarnib was well-tolerated, with common side effects being hematological and gastrointestinal. These findings underscore the potential of tipifarnib in cancer treatments.
Kura Oncology announced new preclinical findings for KO-539, a selective menin inhibitor, at the ASH Annual Meeting in Atlanta. These data demonstrate KO-539's ability to induce growth inhibition and differentiation in AML cells with KMT2A rearrangements or NPM1 mutations. The combination of KO-539 with the standard of care, venetoclax, shows synergistic effects, enhancing survival in aggressive AML models. KO-539 is currently in a Phase 1b clinical trial for relapsed/refractory AML, with an Orphan Drug Designation from the FDA.
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