Welcome to our dedicated page for Kronos Bio news (Ticker: KRON), a resource for investors and traders seeking the latest updates and insights on Kronos Bio stock.
About Kronos Bio, Inc.
Kronos Bio, Inc. (Nasdaq: KRON) is a clinical-stage biopharmaceutical company dedicated to developing innovative small molecule therapeutics that address cancers and autoimmune diseases driven by deregulated transcription. Transcriptional dysregulation is a hallmark of many complex diseases, and Kronos Bio employs its proprietary discovery engine to decode transcription factor regulatory networks, identifying druggable cofactors that play critical roles in disease progression. By targeting these cofactors in a disease-specific context, the company aims to transform patient outcomes in areas of significant unmet medical need.
Proprietary Technology and Expertise
Kronos Bio's competitive edge lies in its proprietary discovery platform, which integrates high-throughput screening strategies and small molecule microarray (SMM) technology. This platform enables the company to identify and optimize small molecules that specifically target transcriptional drivers of disease. The focus on transcription factor regulatory networks allows Kronos Bio to address historically recalcitrant targets, opening new therapeutic possibilities in oncology and autoimmune diseases.
Pipeline and Therapeutic Focus
The company's pipeline includes multiple drug candidates at various stages of development:
- Istisociclib (KB-0742): A CDK9 inhibitor designed to address MYC deregulation in solid tumors, currently being evaluated in a Phase 1/2 clinical trial for platinum-resistant high-grade serous ovarian cancer.
- KB-9558: A p300 lysine acetyltransferase (KAT) inhibitor targeting IRF4 dependence in multiple myeloma and HPV-driven tumors, with preclinical data demonstrating potential tumor suppression through restoration of p53 and Rb pathways.
- KB-7898: Kronos Bio's first autoimmune development candidate, targeting Sjögren’s disease. This p300 KAT inhibitor modulates inflammatory signaling pathways and has shown preclinical efficacy in reducing inflammatory cytokines and antibody production.
By focusing on these disease-specific mechanisms, Kronos Bio aims to provide therapeutic solutions for patient populations with limited or no treatment options.
Market Position and Challenges
Operating within the highly competitive biopharmaceutical industry, Kronos Bio faces challenges such as the inherent risks of drug development, regulatory hurdles, and the need for substantial financial resources. However, its emphasis on transcriptional dysregulation as a therapeutic target sets it apart from competitors, offering a unique value proposition. The company's focus on oncology and autoimmune diseases—markets with high unmet medical needs—positions it as a key player in these segments.
Commitment to Innovation
Kronos Bio's mission is underpinned by a commitment to scientific excellence and innovation. By leveraging its advanced discovery engine and expertise in transcriptional biology, the company continues to push the boundaries of what is possible in drug discovery and development. Its efforts are directed toward creating first-in-class therapies that have the potential to significantly improve the lives of patients worldwide.
Kronos Bio, Inc. (Nasdaq: KRON) announced the appointment of Dr. Elizabeth Olek as senior vice president of Clinical Development, effective February 1, 2022. Dr. Olek, previously at Loxo Oncology, will oversee the planning and execution of clinical trials for the company's investigational drugs, including entospletinib, which is currently in a pivotal Phase 3 AGILITY trial for NPM1-mutated acute myeloid leukemia. The company plans to initiate additional clinical trials this year, enhancing its pipeline focused on cancer therapies.
Kronos Bio, Inc. (Nasdaq: KRON) has initiated the Phase 3 AGILITY clinical trial of entospletinib, targeting acute myeloid leukemia (AML) with the NPM1 mutation. This trial, the first to utilize measurable residual disease (MRD) as its primary endpoint, aims for accelerated FDA approval. Approximately 180 adults will participate, with results anticipated in late 2023. The trial follows a $29 million milestone payment due to Gilead Sciences upon its initiation. If successful, entospletinib could be the first approved treatment for newly diagnosed patients with NPM1-mutated AML.
Kronos Bio, Inc. (Nasdaq: KRON) unveiled positive interim data from its Phase 1/2 trial for KB-0742, a selective CDK9 inhibitor targeting MYC-amplified solid tumors. The trial, ongoing with a three-day on, four-day off schedule, reported a 24-hour terminal half-life for the drug and evidence of dose-dependent target engagement. Out of 12 patients, results showed favorable pharmacokinetics with low-to-moderate patient variability. The next step involves further dose escalation to define a recommended Phase 2 dose, aiming for anti-tumor activity assessment in later stages.
Kronos Bio, Inc. (Nasdaq: KRON), a biopharmaceutical company focused on cancer therapies, announced participation in two upcoming investor conferences. Management will engage in fireside chats at Piper Sandler’s 33rd Annual Virtual Healthcare Conference on November 30, 2021, and Evercore ISI’s 4th Annual HealthCONx on December 2, 2021. Both chats will be accessible through the company’s website, with replays available for a month afterward. Kronos Bio specializes in targeting dysregulated transcription factors, with a focus on treatments for acute myeloid leukemia and solid tumors.
Kronos Bio, Inc. (Nasdaq: KRON) announced the appointment of Roshawn Blunt to its Board of Directors. With over 25 years in the biopharmaceutical sector, Blunt is the managing director of 1798, LLC and has held key roles at Amgen and Johnson & Johnson. CEO Norbert Bischofberger expressed confidence in her expertise, particularly in commercialization and patient access, which will support upcoming product launches. Blunt's background includes strategic positions focused on health economics, enhancing Kronos Bio's capacity as it advances investigational products toward market approval.
Kronos Bio reported third-quarter financial results and significant pipeline advancements. The company has $398.4 million in cash as of September 30, 2021, and is set to present interim data from its Phase 1/2 trial of CDK9 inhibitor KB-0742 by year-end. Kronos initiated two new discovery programs targeting MYC and AR transcriptional regulatory networks. Additionally, the FDA cleared its IND for lanraplenib, allowing a Phase 1b/2 trial for AML. R&D expenses were $24.7 million, contributing to a net loss of $33.6 million for the quarter.
Kronos Bio, Inc. (Nasdaq: KRON) and Tempus have announced a multi-year collaboration that enhances Kronos' access to Tempus' genomic and transcriptomic data, vital tools, and analytics. This partnership aims to accelerate the clinical development of Kronos' cancer therapies, such as KB-0742, by utilizing organoid models and virtual cohorts for refined biomarker hypotheses testing. The agreement builds on prior collaborations, including molecular characterization of patient samples in ongoing clinical studies, enhancing the potential for more effective cancer treatments.
Kronos Bio, Inc. (Nasdaq: KRON) announced participation in the BMO Biopharma Spotlight Series on November 8. Charles Lin, Ph.D., Senior Vice President, Biology, will speak on a panel about emerging trends in oncology. A replay will be available on the company’s website for a month. Kronos Bio focuses on developing therapies for cancer, including its lead investigational drug, entospletinib, for NPM1-mutated acute myeloid leukemia, and KB-0742, a treatment for MYC-amplified solid tumors.
Kronos Bio, Inc. (Nasdaq: KRON) announced it will present preclinical data on its oral CDK9 inhibitor, KB-0742, at the AACR-NCI-EORTC Virtual International Conference from Oct. 7-10, 2021. This data builds on previous findings and aims to treat MYC-amplified solid tumors. The company anticipates sharing preliminary clinical results from an ongoing Phase 1/2 study in Q4 2021. With CDK9 targeting critical cancer pathways, the upcoming presentation may influence investor sentiment regarding the drug's potential in oncology.
Kronos Bio, Inc. (Nasdaq: KRON) announced the appointment of Marni Kottle as the senior vice president of Corporate Communications and Investor Relations. With over 20 years of experience, Kottle previously served as vice president of Corporate Communications at Gilead Sciences. Her expertise will enhance Kronos Bio's communications strategy during a critical growth phase. The company focuses on developing therapies for cancer, including its lead investigational drug, entospletinib, for treating NPM1-mutated acute myeloid leukemia.
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