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Chinook Therapeutics, Inc. (NASDAQ: KDNY) is a clinical-stage biotechnology company focused on developing precision medicines specifically for kidney diseases. Kidney diseases pose a significant and growing health challenge globally, often requiring costly treatments like dialysis and transplantation. Chinook is at the forefront of addressing this need through advanced understanding of disease biology and cutting-edge translational platforms.
The company’s lead product candidates include atrasentan, a phase 3 endothelin receptor antagonist aimed at treating IgA nephropathy and proteinuric glomerular diseases, and zigakibart (BION-1301), an anti-APRIL monoclonal antibody undergoing a phase 1/2 trial for IgA nephropathy. Additionally, CHK-336, an oral small molecule LDHA inhibitor, is being developed for hyperoxalurias and other kidney stone disorders, currently in phase 1 trials.
Recent achievements highlight their commitment to innovation. Data from the phase 1 study of CHK-336 demonstrated hepatic LDH target engagement and decreased oxalate production, albeit with ongoing investigations into observed serious adverse events. The initiation of the phase 3 BEYOND study for zigakibart marks another milestone in providing new treatment options for patients with IgAN, reinforcing the potential of their therapies to modify disease progression.
Chinook’s approach leverages data from comprehensive kidney single-cell RNA sequencing and large chronic kidney disease (CKD) patient cohorts to identify key therapeutic targets. This strategy enables them to build a robust pipeline of precision medicines for rare and severe kidney diseases. Their research benefits from rich clinical data and patient samples, providing insights that drive the development of their innovative drug candidates.
Financially, Chinook remains focused on advancing its clinical programs while exploring strategic collaborations and partnerships to bolster its development efforts. Their strong scientific foundation and strategic focus positions them as a leader in the field of kidney disease therapeutics.
For more detailed updates and ongoing news, visit their official website at www.chinooktx.com.
Chinook Therapeutics, a biopharmaceutical company focused on kidney disease treatments, will participate in a virtual fireside chat at the 11th Annual SVB Leerink Global Healthcare Conference on February 16, 2022, at 10:00 am ET. The event will provide insights into their ongoing development of precision medicines, including their lead program, atrasentan, for IgA nephropathy. Interested parties can access the live webcast and recorded session through the company’s website, available for replay for 90 days following the event.
Chinook Therapeutics (Nasdaq: KDNY) announced an employment inducement grant of stock options for 150,000 shares to a new hire. The options have an exercise price of $12.90, equivalent to the stock's closing price on January 31, 2022. Vesting occurs over four years, with 25% on the start date and the remainder monthly. This grant adheres to Nasdaq's listing Rule 5635(c)(4). Chinook specializes in precision medicines for kidney diseases, with its lead program, atrasentan, currently in Phase 3 trials for IgA nephropathy.
Chinook Therapeutics (NASDAQ: KDNY) announced the appointment of Dr. Charlotte Jones-Burton as Senior Vice President of Product Development and Strategy. Her extensive background in nephrology and drug development is expected to enhance Chinook's efforts in advancing clinical trials for atrasentan and BION-1301, targeting IgA nephropathy, and the phase 1 trial of CHK-336 for primary hyperoxaluria. The company is focused on precision medicines for severe kidney diseases, leveraging innovative research to build its therapeutic pipeline.
Chinook Therapeutics, a biopharmaceutical company focused on kidney diseases, announced its participation in two upcoming virtual investor conferences. The H.C. Wainwright Bioconnect 2022 Conference features an on-demand fireside chat available from January 10 at 7:00 am EST, while the 40th Annual J.P. Morgan Healthcare Conference will include a presentation on January 12 at 1:30 pm EST. Additionally, Chinook will conduct 1x1 meetings. Archived webcasts of these events will be accessible for 30 days on the company's website.
Chinook Therapeutics, Inc. (Nasdaq: KDNY) announced that the European Commission granted orphan drug designation for atrasentan to treat primary IgA nephropathy (IgAN). This designation follows a favorable opinion from the EMA's Committee for Orphan Medicinal Products. Orphan drug status provides incentives such as market exclusivity and reduced fees, aiding the clinical development of atrasentan. The ongoing pivotal phase 3 ALIGN and phase 2 AFFINITY trials are enrolling patients to evaluate the drug's effectiveness in reducing proteinuria and combating kidney damage.
Chinook Therapeutics (Nasdaq: KDNY) announced a 50/50 joint venture with investor syndicate led by Frazier Healthcare Partners and Pivotal bioVenture Partners China to enhance its global reach for atrasentan and BION-1301 in the treatment of IgA nephropathy. The partnership grants SanReno exclusive rights to develop these therapies in China and surrounding regions, supported by a $40 million investment from the syndicate. Chinook retains rights outside this territory and will receive milestone payments and royalties based on product progress.
Chinook Therapeutics, a biopharmaceutical company focused on kidney diseases, will participate in two virtual investor conferences. The Piper Sandler 33rd Annual Virtual Healthcare Conference will have presentations available from November 22 to December 2, and a fireside chat at the 4th Annual Evercore ISI HealthCONx Conference is scheduled for November 30 at 4:45 pm EST. Additionally, 1x1 meetings will take place through Evercore ISI and Piper Sandler on November 30, December 1, and December 2. Archived webcasts will be accessible for 90 days on the company’s website.
Chinook Therapeutics (Nasdaq: KDNY) has completed an upsized public offering, selling 9,538,572 shares at $14.00 each, raising approximately $183.5 million in gross proceeds. The offering included the full exercise of the underwriters’ option to purchase an additional 1,710,000 shares and pre-funded warrants to acquire another 3,571,428 shares at $13.9999 each. Proceeds will support the phase 3 ALIGN trial for atrasentan in IgA nephropathy, phase 2 AFFINITY trial, and further development of other key therapeutics.
Chinook Therapeutics, Inc. (Nasdaq: KDNY) has priced its upsized public offering of 7,828,572 shares at $14.00 each, aiming for gross proceeds of $159.6 million before expenses. The offering includes pre-funded warrants for 3,571,428 shares at $13.9999 each. The proceeds will advance clinical trials for its lead product, atrasentan, and support development of other therapies. The deal is expected to close by November 15, 2021, pending standard conditions. SVB Leerink and Evercore ISI are the joint book-running managers.
Chinook Therapeutics (Nasdaq: KDNY) announced plans to offer 6,000,000 shares in a public offering, with a 30-day option for underwriters to purchase an additional 900,000 shares. Proceeds will fund the phase 3 ALIGN trial and phase 2 AFFINITY trial of atrasentan for kidney diseases, among other clinical development initiatives. SVB Leerink and Evercore ISI are the joint book-running managers. The offering follows a previously filed shelf registration statement. Completion is subject to market conditions.
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