KalVista Pharmaceuticals Reports Third Fiscal Quarter Results

Rhea-AI Summary

KalVista Pharmaceuticals, Inc. (NASDAQ: KALV) has provided an operational update and financial results for the third fiscal quarter ending January 31, 2022. The company initiated the Phase 3 KONFIDENT trial for KVD900, aimed at treating HAE attacks, with data expected in H2 2023. The Phase 2 KOMPLETE trial for KVD824 is on track, with anticipated data in mid-2023. Financially, KalVista reported a net loss of $22.5 million and no revenue for the quarter. Research and development expenses increased to $19.7 million, reflecting heightened clinical trial activities.

Positive

• Initiated Phase 3 KONFIDENT clinical trial for KVD900, with anticipated data in H2 2023.
• Continued enrollment in Phase 2 KOMPLETE trial for KVD824, with data expected in mid-2023.
• Presented promising data for KVD900 at AAAAI Annual Scientific Meeting.

Negative

• Net loss increased to $22.5 million compared to $10.0 million in the prior year.
• Research and development expenses rose to $19.7 million, indicating higher operational costs.

– KVD900 Phase 3 KONFIDENT Trial Initiated –

– KVD824 Phase 2 KOMPLETE Clinical Trial Enrollment on Track –

CAMBRIDGE, Mass. & SALISBURY, England--(BUSINESS WIRE)-- KalVista Pharmaceuticals, Inc. (NASDAQ: KALV), a clinical stage pharmaceutical company focused on the discovery, development, and commercialization of oral, small molecule protease inhibitors, today provided an operational update and released financial results for the third fiscal quarter ended January 31, 2022.

“We made many significant clinical advances this quarter,” said Andrew Crockett, Chief Executive Officer of KalVista. “We are excited that the KVD900 Phase 3 KONFIDENT trial for on-demand treatment of HAE attacks is now underway, and we are encouraged by the progress of our KVD824 Phase 2 KOMPLETE trial for HAE prophylaxis. Based on initial enrollment trends, we expect we will be able to provide data for both studies in 2023.”

Third Fiscal Quarter and Recent Business Highlights:

• Initiated KONFIDENT, the Phase 3 clinical trial of KVD900, that is expected to be sufficient to support an NDA filing. Data from this trial is currently anticipated in the second half of 2023.
• Continued to enroll KOMPLETE, the Phase 2 clinical trial of KVD824. As of early March, the trial is enrolling on track with the Company’s targets and it is currently anticipated that data from this trial will be available in mid-2023.
• Presented data for KVD900 at American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Scientific Meeting. Data presentations included two poster presentations with additional data from the Phase 2 clinical trial. The first poster showed that KVD900 was rapidly absorbed, leading to near-complete suppression of plasma kallikrein and significantly shorter time to symptom relief. The second poster provided data demonstrating that the Patient Global Impression of Change (PGI-C) scale was an effective tool to monitor attack symptoms and predict attack resolution for patients experiencing HAE attacks. PGI-C is the primary outcome measure in the KONFIDENT clinical trial.
• Continued progress in the Factor XIIa inhibitor program, with multiple compounds advancing in the preclinical stage and an expected first IND for an oral Factor XIIa inhibitor candidate in 2023.

Third Fiscal Quarter Financial Results:

• Revenue: No revenue was recognized for the three months ended January 31, 2022 or January 31, 2021.
• R&D Expenses: Research and development expenses were $19.7 million for the three months ended January 31, 2022, compared to $9.1 million for the same period in the prior fiscal year. The increase in R&D expenses during the quarter primarily reflects the initiation of the Phase 3 KONFIDENT clinical trial for KVD900, the ongoing Phase 2 KOMPLETE clinical trial for KVD824, and increased preclinical spending.
• G&A Expenses: General and administrative expenses were $6.9 million for the three months ended January 31, 2022, compared to $3.6 million for the same period in the prior fiscal year. The increase in G&A expenses was primarily due to an increase in compensation related expenses and to a lesser extent, increases in professional fees, commercial planning expenses, and other administrative costs.
• Net Loss: Net loss was $22.5 million, or $(0.92) per weighted average basic and diluted share, for the three months ended January 31, 2022, compared to net loss of $10.0 million, or $(0.56) per weighted average basic and diluted share for the same period in the prior fiscal year. The increase in net loss and net loss per share primarily resulted from the increase in operating expenses, primarily research and development.
• Cash Position: Cash, cash equivalents and marketable securities were $194.8 million as of January 31, 2022, compared to $248.9 million as of April 30, 2021. The decrease in the net cash position was due to increased operating expenses.

About KalVista Pharmaceuticals, Inc.

KalVista Pharmaceuticals, Inc. is a pharmaceutical company focused on the discovery, development, and commercialization of oral, small molecule protease inhibitors for diseases with significant unmet need. KalVista has developed a proprietary portfolio of novel, small molecule plasma kallikrein inhibitors initially targeting hereditary angioedema (HAE) and diabetic macular edema (DME). KalVista is developing KVD900 as an oral on-demand therapy for acute HAE attacks and has initiated the Phase 3 KONFIDENT clinical trial. KVD824 is in development for prophylactic treatment of HAE, with the Phase 2 KOMPLETE clinical trial underway. In addition, KalVista’s oral Factor XIIa inhibitor program represents a new generation of therapies that may further improve the treatment of HAE for patients. In DME, an intravitreally administered plasma kallikrein inhibitor, called KVD001, has completed a Phase 2 clinical trial.

For more information about KalVista, please visit www.kalvista.com.
For more information on the KVD900 HAE on-demand Phase 3 KONFIDENT study, please visit www.konfidentstudy.com.
For more information on the KVD824 HAE prophylaxis Phase 2 KOMPLETE study, please visit www.kompletestudy.com.

Forward-Looking Statements

This press release contains "forward-looking" statements within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as: "anticipate," "intend," "plan," "goal," "seek," "believe," "project," "estimate," "expect," "strategy," "future," "likely," "may," "should," "will" and similar references to future periods. These statements are subject to numerous risks and uncertainties, including the potential impact of COVID-19, that could cause actual results to differ materially from what we expect. Examples of forward-looking statements include, among others, timing or outcomes of communications with the FDA, our expectations about safety and efficacy of our product candidates and timing of clinical trials and its results, our ability to commence clinical studies or complete ongoing clinical studies, including our Phase 3 KONFIDENT and Phase 2 KOMPLETE clinical trials, and to obtain regulatory approvals for KVD900, KVD824 and other candidates in development, the ability of KVD900, KVD824 and other candidates in development to treat HAE or DME, and the future progress and potential success of our oral Factor XIIa program. Further information on potential risk factors that could affect our business and financial results are detailed in our filings with the Securities and Exchange Commission, including in our annual report on Form 10-K for the year ended April 30, 2021, our quarterly reports on Form 10-Q, and our other reports that we may make from time to time with the Securities and Exchange Commission. We undertake no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.

KalVista Pharmaceuticals Inc.
Condensed Consolidated Balance Sheets
(in thousands, except share and per share amounts)
(Unaudited)
		January 31,				April 30,
		2022				2021
Assets
Current assets:
Cash and cash equivalents		$	45,577			$	50,592
Marketable securities			149,212				198,337
Research and development tax credit receivable			11,287				10,418
Prepaid expenses and other current assets			8,388				4,917
Total current assets			214,464				264,264
Property and equipment, net			2,215				1,791
Right of use assets			8,180				5,758
Other assets			193				200
Total assets		$	225,052			$	272,013
Liabilities and stockholders' equity
Current liabilities:
Accounts payable		$	2,185			$	1,981
Accrued expenses			6,450				6,930
Lease liability - current portion			1,014				863
Total current liabilities			9,649				9,774
Long-term liabilities:
Lease liability - net of current portion			7,467				5,046
Total long-term liabilities			7,467				5,046
Stockholders’ equity:
Common stock, $0.001 par value			24				24
Additional paid-in capital			436,313				426,437
Accumulated deficit			(226,062	)			(167,836	)
Accumulated other comprehensive loss			(2,339	)			(1,432	)
Total stockholders’ equity			207,936				257,193
Total liabilities and stockholders' equity		$	225,052			$	272,013

KalVista Pharmaceuticals Inc.
Condensed Consolidated Statement of Operations
(in thousands, except share and per share amounts)
(Unaudited)
		Three Months Ended								Nine Months Ended
		January 31,								January 31,
		2022				2021				2022				2021
Revenue		$	—			$	—			$	—			$	—
Operating expenses:
Research and development			19,738				9,097				50,954				29,409
General and administrative			6,945				3,560				18,848				10,472
Total operating expenses			26,683				12,657				69,802				39,881
Operating loss			(26,683	)			(12,657	)			(69,802	)			(39,881	)
Other income:
Interest income			258				137				822				589
Foreign currency exchange (loss) gain			(198	)			301				(529	)			715
Other income			4,156				2,171				11,283				7,289
Total other income			4,216				2,609				11,576				8,593
Net loss		$	(22,467	)		$	(10,048	)		$	(58,226	)		$	(31,288	)
Net loss per share, basic and diluted		$	(0.92	)		$	(0.56	)		$	(2.38	)		$	(1.75	)
Weighted average common shares outstanding, basic and diluted			24,479,660				17,961,802				24,449,788				17,905,926

KalVista Pharmaceuticals Inc.
Condensed Consolidated Statements of Cash Flows
(in thousands, unaudited)
		Nine Months Ended
		January 31,
		2022				2021
Cash flows from operating activities
Net loss		$	(58,226	)		$	(31,288	)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization			408				397
Stock-based compensation expense			8,432				3,677
Realized loss (gain) from sale of marketable securities			296				(192	)
Non-cash operating lease expense			153				25
Amortization of premium on marketable securities			2,081				247
Foreign currency exchange loss (gain)			698				(441	)
Changes in operating assets and liabilities:
Research and development tax credit receivable			(1,477	)			10,135
Prepaid expenses and other current assets			(3,659	)			35
Accounts payable			228				(1,182	)
Accrued expenses			(279	)			(539	)
Net cash used in operating activities			(51,345	)			(19,126	)
Cash flows from investing activities
Purchases of marketable securities			(84,415	)			(26,814	)
Sales and maturities of marketable securities			130,686				45,692
Acquisition of property and equipment			(845	)			(49	)
Net cash provided by investing activities			45,426				18,829
Cash flows from financing activities
Issuance of common stock , net of offering expenses			-				1,648
Issuance of common stock from equity incentive plans			1,443				161
Net cash provided by financing activities			1,443				1,809
Effect of exchange rate changes on cash and cash equivalents			(539	)			426
Net (decrease) increase in cash and cash equivalents			(5,015	)			1,938
Cash and cash equivalents at beginning of period			50,592				15,789
Cash and cash equivalents at end of period		$	45,577			$	17,727

 

View source version on businesswire.com: https://www.businesswire.com/news/home/20220310005245/en/

KalVista Pharmaceuticals, Inc.

Ben Palleiko

CBO & CFO

857-999-0890

investors@kalvista.com

Source: KalVista Pharmaceuticals, Inc.

FAQ

What are the latest clinical trials for KalVista Pharmaceuticals (KALV)?

KalVista has initiated the Phase 3 KONFIDENT trial for KVD900 and is enrolling in the Phase 2 KOMPLETE trial for KVD824.

When can we expect data from KalVista's clinical trials?

Data from the KONFIDENT trial is expected in the second half of 2023, while data from the KOMPLETE trial is anticipated in mid-2023.

What were KalVista Pharmaceuticals' financial results for Q3 2022?

KalVista reported a net loss of $22.5 million and no revenue for the three months ended January 31, 2022.

How have KalVista's expenses changed in recent quarters?

Research and development expenses increased to $19.7 million in Q3 2022, up from $9.1 million in the same period last year.