KalVista Announces Publication of Additional KVD900 Data in Clinical & Experimental Allergy

Rhea-AI Summary

KalVista Pharmaceuticals (NASDAQ: KALV) announced new data on KVD900, a potent oral inhibitor targeting plasma kallikrein, crucial for hereditary angioedema (HAE) treatment. Published in Clinical & Experimental Allergy, the data highlight rapid absorption and effective plasma kallikrein inhibition. This supports ongoing Phase 3 KONFIDENT trials for KVD900 as an on-demand therapy for HAE attacks, reinforcing its potential to block harmful bradykinin generation.

Positive

• Publication of positive KVD900 data in a reputable journal strengthens credibility.
• KVD900 demonstrates rapid absorption and effective plasma kallikrein inhibition.
• Support for ongoing Phase 3 KONFIDENT trial for HAE treatment potential.

Negative

• None.

CAMBRIDGE, Mass. & SALISBURY, England--(BUSINESS WIRE)-- KalVista Pharmaceuticals, Inc. (NASDAQ: KALV), a clinical stage pharmaceutical company focused on the discovery, development, and commercialization of oral, small molecule protease inhibitors, today announced the publication of new data in Clinical & Experimental Allergy characterizing KVD900, a novel, potent and selective oral inhibitor of plasma kallikrein, a critical mediator of attacks in patients with hereditary angioedema (HAE). In this new publication, orally administered KVD900 was shown to be quickly absorbed and provided rapid and near-complete inhibition of plasma kallikrein and strong suppression of kallikrein-kinin system activation in patients with HAE.

“Based on these results, on-demand administration of KVD900 is further demonstrated to block the generation of plasma kallikrein and bradykinin in HAE patient plasma and thereby may provide an opportunity to halt and reverse HAE attacks,” said Andrew Crockett, Chief Executive Officer of KalVista. “These data provide the underlying basis for the clinical results we reported for our phase 2 trial of KVD900 in on-demand treatment of HAE attacks, and further support our ongoing phase 3 KONFIDENT trial for KVD900 in the same indication.”

Additional details can be found in the manuscript, which is available at: http://doi.org/10.1111/cea.14122. Clinical & Experimental Allergy is the official journal of the British Society for Allergy & Clinical Immunology.

About KalVista Pharmaceuticals, Inc.
KalVista Pharmaceuticals, Inc. is a pharmaceutical company focused on the discovery, development, and commercialization of oral, small molecule protease inhibitors for diseases with significant unmet need. KalVista has developed a proprietary portfolio of novel, small molecule plasma kallikrein inhibitors initially targeting hereditary angioedema (HAE) and diabetic macular edema (DME). KalVista is developing KVD900 as an oral on-demand therapy for acute HAE attacks and has initiated the Phase 3 KONFIDENT clinical trial. KVD824 is in development for prophylactic treatment of HAE, with the Phase 2 KOMPLETE clinical trial underway. In addition, KalVista’s oral Factor XIIa inhibitor program represents a new generation of therapies that may further improve the treatment of HAE for patients. In DME, an intravitreally administered plasma kallikrein inhibitor, called KVD001, has completed a Phase 2 clinical trial.

For more information about KalVista, please visit www.kalvista.com.
For more information on the KVD900 HAE on-demand Phase 3 KONFIDENT study, please visit www.konfidentstudy.com.
For more information on the KVD824 HAE prophylaxis Phase 2 KOMPLETE study, please visit www.kompletestudy.com.

Forward-Looking Statements
This press release contains "forward-looking" statements within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by words such as: "anticipate," "intend," "plan," "goal," "seek," "believe," "project," "estimate," "expect," "strategy," "future," "likely," "may," "should," "will" and similar references to future periods. These statements are subject to numerous risks and uncertainties, including the potential impact of COVID-19, that could cause actual results to differ materially from what we expect. Examples of forward-looking statements include, among others, timing or outcomes of communications with the FDA, our expectations about safety and efficacy of our product candidates and timing of clinical trials and its results, our ability to commence clinical studies or complete ongoing clinical studies, including our Phase 3 KONFIDENT and Phase 2 KOMPLETE clinical trials, and to obtain regulatory approvals for KVD900, KVD824 and other candidates in development, the ability of KVD900, KVD824 and other candidates in development to treat HAE or DME, and the future progress and potential success of our oral Factor XIIa program. Further information on potential risk factors that could affect our business and financial results are detailed in our filings with the Securities and Exchange Commission, including in our annual report on Form 10-K for the year ended April 30, 2021, our quarterly reports on Form 10-Q, and our other reports that we may make from time to time with the Securities and Exchange Commission. We undertake no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.

View source version on businesswire.com: https://www.businesswire.com/news/home/20220322005365/en/

KalVista Pharmaceuticals, Inc.

Ben Palleiko

CBO & CFO

857-999-0890

investors@kalvista.com

 

Source: KalVista Pharmaceuticals, Inc.

FAQ

What recent data has KalVista Pharmaceuticals published about KVD900?

KalVista Pharmaceuticals published data in Clinical & Experimental Allergy highlighting KVD900's rapid absorption and effective inhibition of plasma kallikrein.

What is the current status of KalVista's KVD900 clinical trials?

KVD900 is currently undergoing a Phase 3 KONFIDENT trial for on-demand treatment of hereditary angioedema (HAE) attacks.

How does KVD900 work in treating hereditary angioedema?

KVD900 is a potent oral inhibitor that blocks plasma kallikrein, thereby halting the generation of bradykinin, which is responsible for HAE attacks.

What are the implications of the new data for KalVista Pharmaceuticals' stock (KALV)?

The positive data publication and ongoing trials may enhance investor confidence and positively impact KalVista's stock performance.