Jasper Therapeutics Presents Data from Preclinical Briquilimab Studies at the American Academy of Allergy, Asthma, and Immunology (AAAAI) Annual Meeting
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Insights
The preclinical results from Jasper Therapeutics regarding their novel antibody therapy, briquilimab, are indicative of the drug's potential efficacy in treating mast cell driven diseases. These diseases, including chronic spontaneous urticaria and allergic asthma, represent a significant burden for patients and current treatment options are often limited or come with various side effects. The use of the proprietary c-Kit Mouse™ model is a critical factor as it may increase the translatability of preclinical findings to human clinical trials. This model addresses the limitation of standard mouse models that do not bind antibodies directed at the human c-Kit receptor, potentially offering a more accurate prediction of human response.
The medical community would be particularly interested in the data suggesting that briquilimab could prevent severe allergic reactions and anaphylaxis. The reduction in lung mast cells and airway hyper-responsiveness in allergic asthma models is promising, as these are key pathology features in human asthma. If these results can be replicated in clinical trials, briquilimab may offer a novel therapeutic approach that could improve patient outcomes and reduce healthcare costs associated with managing these chronic conditions.
From a financial perspective, Jasper Therapeutics' announcement could have a positive impact on its stock performance, especially if the market perceives the preclinical data as a strong indicator of future clinical success. Investors often respond favorably to biotechnology firms that demonstrate progress in drug development, particularly in areas with high unmet medical needs such as mast cell driven diseases. The potential broad application of briquilimab across various conditions could represent a significant market opportunity, which might attract investment and partnerships.
However, it is important to note that preclinical success does not always translate into clinical success. The costs associated with moving from preclinical to clinical development are substantial and the company will likely require additional funding, which could lead to dilution for current shareholders or the need to secure partnership deals. Investors should monitor the company's progress closely, including its ability to secure regulatory approvals and the outcomes of subsequent clinical trials.
Understanding the competitive landscape is crucial for evaluating the potential market impact of briquilimab. The field of allergy and immunology is highly competitive, with numerous companies working on innovative treatments. The success of Jasper Therapeutics' briquilimab in preclinical studies positions it as a potential competitor in this space. However, the drug's differentiation in terms of efficacy, safety and cost will be key factors in determining its market position.
Market analysts will be interested in the prevalence of mast cell driven diseases and the size of the patient population that could benefit from briquilimab. Additionally, market penetration will depend on the drug's adoption by healthcare providers, which in turn will be influenced by the strength of clinical data and potential advantages over existing therapies. The company's strategy in targeting not just urticaria but also exploring other indications like allergic asthma suggests an awareness of the need to diversify its portfolio and address multiple market segments.
REDWOOD CITY, Calif., Feb. 23, 2024 (GLOBE NEWSWIRE) -- Jasper Therapeutics, Inc. (Nasdaq: JSPR) (Jasper), a biotechnology company focused on development of briquilimab, a novel antibody therapy targeting c-Kit (CD117) in mast cell driven diseases such as chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU), is presenting results from three preclinical studies evaluating briquilimab, at the 2024 American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting, being held February 23-26 in Washington, D.C. One study will be featured in an oral presentation and two studies in poster presentations.
Each of the studies being presented utilized Jasper’s proprietary c-Kit Mouse™, which was developed to enable direct testing of briquilimab across a number of disease models, overcoming the limitations of standard models which do not bind antibodies directed at the human c-Kit receptor. The two poster presentations cover separate studies that evaluated briquilimab in Mrgprb2-mediated drug-induced anaphylaxis (DIA) and passive systemic anaphylaxis (PSA). Results from both studies demonstrated that a single dose of briquilimab protected against anaphylaxis, as measured by significantly higher core body temperatures in animals treated with briquilimab vs. untreated animals. The oral presentation covers a study that evaluated briquilimab in allergic asthma, which demonstrated that a single dose of briquilimab significantly reduced the numbers of lung mast cells and bronchoalveolar lavage-recovered eosinophils. Additionally, airway-infiltrated eosinophils and neutrophils, as well as airway hyper-responsiveness, decreased in briquilimab-treated mice, suggesting briquilimab has the potential to prevent allergic asthma via mast cell depletion.
“We are excited to present promising preclinical results from multiple studies this year at AAAAI, which indicate that briquilimab may be able to mitigate the likelihood of severe allergic reaction and anaphylaxis,” said Wendy Pang, M.D., Ph.D., Senior Vice President, Research and Translational Medicine. “Each of these studies was conducted using the Jasper c-Kit Mouse™, which we believe enables the generation of preclinical data with superior clinical translatability, and in turn, informs our clinical development programs.”
“While our initial development efforts with subcutaneous briquilimab have focused on urticaria and other dermatological conditions, we are excited by its broad potential in a variety of mast cell driven diseases,” said Edwin Tucker, M.D., Chief Medical Officer. “The preclinical data being generated by our research team across numerous mast cell driven diseases is critical to determining the next indication for briquilimab clinical development this year.”
Details of the presentations are as follows:
Abstract Title: Briquilimab, An Anti-CD117 Antibody, Prevents Passive Systemic Anaphylaxis in Mice Expressing Chimeric Human and Mouse CD117 Through Mast Cell Depletion
Poster Number: 024
Session Title: Therapeutic Trials in Allergic Skin Disorders and Anaphylaxis 2024
Session Type: Poster Session
Session Date / Time: Friday, February 23, 2024; 3:15 p.m. - 4:15 p.m. EST
Abstract Title: Briquilimab, an Anti-CD117 Antibody, Prevents Cockroach Allergen Induced Allergic Asthma in Mice Expressing Chimeric Human and Mouse CD117
Publication Number: 441
Session Title: Old Therapeutics and New Targets in Asthma
Session Type: Oral Abstract Session
Session Date / Time: Saturday, February 24, 2024; 2:00 p.m. - 3:15 p.m. EST
Abstract Title: Amelioration Of Mrgprb2-Mediated Anaphylactoid Drug Reactions With Briquilimab, An Anti-CD117 Antibody, Through Mast Cell Depletion In Mice Expressing Chimeric Human And Mouse CD117
Poster Number: 747
Session Title: Around the Horn: Dermatology, Drug Allergy, Anaphylaxis, Insect Hypersensitivity
Session Type: Featured Poster Session
Session Date / Time: Sunday, February 25, 2024; 4:45 p.m. - 6:15 p.m. EST
About Briquilimab
Briquilimab (formerly JSP191) is a targeted aglycosylated monoclonal antibody that blocks stem cell factor from binding to the cell-surface receptor c-Kit, also known as CD117, thereby inhibiting signaling through the receptor. This inhibition disrupts the critical survival signal, leading to the depletion of the mast cells via apoptosis which removes the underlying source of the inflammatory response in mast cell driven diseases such as chronic urticaria. Jasper is currently conducting clinical studies of briquilimab as a treatment in patients with CSU or with CIndU. Briquilimab is also currently in clinical studies as a treatment for patients with LR-MDS and as a conditioning agent for cell and gene therapies for rare diseases. To date, briquilimab has a demonstrated efficacy and safety profile in more than 145 dosed participants and healthy volunteers, with clinical outcomes as a conditioning agent in severe combined immunodeficiency (SCID), acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), Fanconi Anemia (FA), and sickle cell disease (SCD).
About Jasper
Jasper is a clinical-stage biotechnology company developing briquilimab, a monoclonal antibody targeting c-Kit (CD117) as a therapeutic for chronic mast and stem cell diseases such as chronic urticaria and lower to intermediate risk MDS and as a conditioning agent for stem cell transplants for rare diseases such as SCD, FA and SCID. To date, briquilimab has a demonstrated efficacy and safety profile in more than 145 dosed participants and healthy volunteers, with clinical outcomes as a conditioning agent in SCID, AML, MDS, FA, and SCD. For more information, please visit us at www.jaspertherapeutics.com.
Forward-Looking Statements
Certain statements included in this press release that are not historical facts are forward-looking statements for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements are sometimes accompanied by words such as “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” “should,” “would,” “plan,” “predict,” “potential,” “seem,” “seek,” “future,” “outlook” and similar expressions that predict or indicate future events or trends or that are not statements of historical matters. These forward-looking statements include, but are not limited to, statements regarding briquilimab’s potential, including with respect to its potential in mast cell driven diseases such as CSU and CIndU, its potential to protect against anaphylaxis and prevent allergic asthma via mast cell depletion, its ability mitigate the likelihood of severe allergic reaction and anaphylaxis and its broad potential in a variety of mast cell driven diseases; the ability of the Jasper c-Kit Mouse™ to enable the generation of preclinical data with superior clinical translatability and its ability to inform Jasper’s clinical development programs; and Jasper’s expectations regarding briquilimab clinical development. These statements are based on various assumptions, whether or not identified in this press release, and on the current expectations of Jasper and are not predictions of actual performance. These forward-looking statements are provided for illustrative purposes only and are not intended to serve as, and must not be relied on by an investor as, a guarantee, an assurance, a prediction or a definitive statement of fact or probability. Many actual events and circumstances are beyond the control of Jasper. These forward-looking statements are subject to a number of risks and uncertainties, including general economic, political and business conditions; the risk that the potential product candidates that Jasper develops may not progress through clinical development or receive required regulatory approvals within expected timelines or at all; the risk that clinical trials may not confirm any safety, potency or other product characteristics described or assumed in this press release; the risk that Jasper will be unable to successfully market or gain market acceptance of its product candidates; the risk that prior study results may not be replicated; the risk that Jasper’s product candidates may not be beneficial to patients or successfully commercialized; patients’ willingness to try new therapies and the willingness of physicians to prescribe these therapies; the effects of competition on Jasper’s business; the risk that third parties on which Jasper depends for laboratory, clinical development, manufacturing and other critical services will fail to perform satisfactorily; the risk that Jasper’s business, operations, clinical development plans and timelines, and supply chain could be adversely affected by the effects of health epidemics; the risk that Jasper will be unable to obtain and maintain sufficient intellectual property protection for its investigational products or will infringe the intellectual property protection of others; and other risks and uncertainties indicated from time to time in Jasper’s filings with the SEC, including its Annual Report on Form 10-K for the year ended December 31, 2022 and subsequent Quarterly Reports on Form 10-Q. If any of these risks materialize or Jasper’s assumptions prove incorrect, actual results could differ materially from the results implied by these forward-looking statements. While Jasper may elect to update these forward-looking statements at some point in the future, Jasper specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing Jasper’s assessments of any date subsequent to the date of this press release. Accordingly, undue reliance should not be placed upon the forward-looking statements.
Contacts:
Joyce Allaire (investors)
LifeSci Advisors
617-435-6602
jallaire@lifesciadvisors.com
Alex Gray (investors)
Jasper Therapeutics
650-549-1454
agray@jaspertherapeutics.com
Lauren Walker (media)
Real Chemistry
646-564-2156
lbarbiero@realchemistry.com
FAQ
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